Central Regulation of Metabolism in the Pers Group
The Pers Group investigates molecular processes driving susceptibility to obesity and type 2 diabetes with a particular focus on identifying and characterizing molecular pathways mediating polygenic risk through brain circuits. Their vision is to generate scientific knowledge that can accelerate more effective prevention and treatment of these two diseases.
The overarching aim of the Pers Group is to identify molecular pathways in the brain mediating genetic susceptibility to metabolic disease.
Obesity and type 2 diabetes are a heritable multifactorial disease with incompletely understood etiologies. The Pers group investigates the role of the brain in the control of metabolic fuel homeostasis with a focus on how polygenetic liability in energy and blood glucose-regulatory systems contribute to the pathogenesis of obesity and diabetes. The group leverages computational techniques, human genetics and single-cell sequencing data, pharmacological and physiological studies to explore how rodent and human brain cell populations are involved in the response to an array of humoral signals, including FGF1, GLP-1, leptin, insulin, and nutrients such as glucose.
“A genetic map of the mouse dorsal vagal complex and its role in obesity”
Published in Nature Metabolism in 2021, this article presents a transcriptional and chromatin-accessibility single-cell atlas of the mouse dorsal vagal complex and uses body mass index genome-wide association data and Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools to show that some of them control feeding.
“Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission”
Published in Nature Communications in 2020, this article uses single-cell RNA sequencing and histological techniques to show that sustained diabetes remission induced by intracerebroventricular fibroblast growth factor 1 is dependent on intact melanocortin receptor 4 signaling.
"Genetic mapping of etiologic brain cell types for obesity"
Published in eLife in 2020 this study integrates published single-cell RNA-sequencing data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index genome-wide association study data to pinpoint brain cell populations likely mediating polygenetic for obesity.
|Aalling, Nadia Nielsen||Postdoc||+4535330289|
|Abay-Nørgaard, Zehra Caldwell||PhD Student||+4535325894|
|Ahwazi, Danial||PhD Student||+4535325398|
|Brown, Jenny Marie||Postdoc||+4535334806|
|Egerod, Kristoffer Lihme||Research Consultant||+4535337057|
|Jørgensen, Anja Moltke||Bioinformatician||+4535324174|
|Kapel, Benedicte Schultz||Research Assistant|
|Lilja-Fischer, Helle Kinggaard||Laboratory Technician||+4526719296|
|Ludwig, Mette Q||Postdoc||+4535331377|
|López Navarro, Miriam||Master Student||+4535336264|
|Mottelson, Noah Wulff||PhD Fellow|
|Pers, Tune H||Associate Professor - Promotion Programme||+4535335755|
|Rodriguez Garcia, Paula||Master Student|
|Thomas, Cecilia Engel||Postdoc|
|Todorov, Petar Vladimirov||PhD Student||+4535335309|