Central Regulation of Metabolism in the Pers Group
The Pers Group investigates molecular processes driving susceptibility to obesity and type 2 diabetes with a particular focus on identifying and characterize molecular pathways exhibiting sustained effects on metabolic health. Their vision is to generate scientific knowledge that can accelerate more effective prevention and treatment of these two diseases.
Type 2 diabetes and obesity are a heritable multifactorial disease with incompletely understood etiologic biological pathways. Previous studies have shown that the considerable heterogeneity in phenotypic characteristics and treatment responses of type 2 diabetes patients, subgrouping of patients may yield more effective treatment procedures.
The Pers Group has a particular focus on identifying and characterizing central mechanisms through which genetic variants associated with obesity and diabetes are exerting their effects on disease susceptibility.
To better understand how dysregulation of the brain may impact susceptibility towards obesity and type 2 diabetes, they use in vivo rodent models, human clinical data, single-cell transcriptomics and epigenomics techniques and computational integration of single-cell data with large-scale human genetic association data.
”Nationwide prediction of type 2 diabetes comorbidities”
Published in Scientific Reports this article evaluates the extent to which commonly used machine learning methods when applied on comprehensive Danish nationwide health register data could predict selected type 2 diabetes comorbidities and suggests that Danish health registers may be used to develop nationwide in silico screening approaches to identify chronic disease patients at risk of developing comorbidities.
“Gene set analysis for interpreting genetic studies”
Published in Human Molecular Genetics in 2016 this review examines different types of gene sets, discusses how inconsistencies in gene set definitions impact on gene set analysis, describes how gene set analysis has helped to elucidate biology and outlines potential future directions.
“Biological interpretation of genome-wide association studies using predicted gene functions”
Published in Nature Communications in 2015 this article presents DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed.
|Aalling, Nadia Nielsen||Postdoc||Pers Group, Central Regulation of Metabolism||+45 353-30289|
|Abay-Nørgaard, Zehra Caldwell||PhD student||Pers Group, Central Regulation of Metabolism||+45 353-25894|
|Alegbe, Tobi||Master student||Pers Group, Central Regulation of Metabolism|
|Bentsen, Marie Aare||International Researcher||Pers Group, Central Regulation of Metabolism|
|Dworzynski, Piotr||Research assistant||Pers Group, Central Regulation of Metabolism||+45 353-35549|
|Holm, Amalie||Master student|
|Honnens de Lichtenberg, Kristian||Postdoc||Pers Group, Central Regulation of Metabolism||+45 29 26 47 37|
|Jørgensen, Anja Moltke||Bioinformatician||Pers Group, Central Regulation of Metabolism||+45 353-24174|
|Kapel, Benedicte Schultz||Academic staff||Pers Group, Central Regulation of Metabolism|
|Koefoed, Thomas Gade||Academic Staff||Pers Group, Central Regulation of Metabolism||+45 353-31472|
|Ludwig, Mette Q||PhD student||Pers Group, Central Regulation of Metabolism||+45 353-31377|
|Nielsen, Duy Anh Gurskov||Master student||Pers Group, Central Regulation of Metabolism|
|Pers, Tune H||Associate professor||Platform Coordinator, Single Cell Omics Platform; Group Leader, Pers Group, Central Regulation of Metabolismder, Pers Group, Central Regulation of Metabolism||+45 353-35755|
|Rausch, Dylan Matthew||PhD student||Pers Group, Central Regulation of Metabolism||+45 353-26151|
|Steinke, Malte Jonas Peter||Master student||Pers Group, Central Regulation of Metabolism|
|Todorov, Petar Vladimirov||PhD student||Pers Group, Central Regulation of Metabolism||+45 353-35309|
From the left: Pytrik folkertsma, Pascal Timshel, Helle Kinggaard Lilja-Fischer, Rikard Fred, Julie Lee, Tune H. Pers, Maria Madrona, Mette Ludwig, Dylan Rausch, Birgitte Kornum, Jonatan Thomson and Kristoffer Egerod.