Translational Cell Metabolism in the Schéele Group
The Schéele Group investigates human brown adipose tissue heterogeneity and inter-organ crosstalk. We are combining human organ-on-chip and 3D co culture models with high-content screening and aim to identify new drug targets against metabolic diseases including obesity and type 2 diabetes.
The Schéele Group investigates the hypothesis that BAT is a regulatory organ in adult human metabolism, which communicates with central and peripheral metabolic units by secreted factors known as batokines. The group has a long experience in working with mesenchymal stem cells derived from adipose tissue biopsies which can be differentiated in vitro into mature adipocytes.
The group study cell identity of progenitors from BAT and WAT at single cell level and maps cell type specific secretomes. Current work includes development of 3D co-culture and organ-on-a-chip cell models, also including other cell types such as neurons and pancreatic alpha cells. “Our goal is to identify batokines that can counteract the development of obesity and type 2 diabetes.”
“Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine”
Published in Cell Metabolism in 2019 this study is mapping the secretomes of human brown and white adipocytes and identifies several novel batokines, including EPDR1, exclusively identified in brown adipocytes cell media and necessary for brown fat differentiation.
“A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.”
Published in Cell Metabolism in 2013, this study was among the first to provide a molecular characterization of brown fat in adult humans, and furthermore demonstrated that brown fat progenitor cells could be isolated and maintain their brown fat identity when differentiated in vitro.
"Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation."
Published in Cell Metabolism 2020 this study combined human in vivo experiments, by the group of André Carpentier, with experiments in human brown adipocytes and demonstrated that in humans, brown adipose tissue lipolysis and thermogenesis occur through β2-Adrenergic receptor signaling.
|Grønning, Alexander G Bjørnholt||Postdoc|
|Henningsen, Jo Beldring||Postdoc||+4535326112|
|Horváth-Rudigier, Carla Petra||Postdoc||+4535327045|
|Lisdorf, Birgitte Romme||Biomedical Laboratory Technician||+4535328119|
|Palani, Nagendra Prasad||Postdoc||+4535326352|
|Pontoppidan, Axel Bergishagen Priem||Bachelor student|
|Schéele, Camilla Charlotte||Associate Professor||+4535330762|
From the left: Verena H. Jensen, Mai C.K. Severinsen, Camilla Schéele, Naja Jespersen, Susanna Søberg and Lone Peijs.