Circadian Biology in the Zierath Group
The Zierath Group investigates the interactions between intrinsic biorhythms and external perturbations such as exercise and nutrient provision to identify novel translational strategies for prevention and treatment of metabolic disease.
Physical exercise and diet have both individual and synergistic effects on metabolism, including alterations in glucose homeostasis and insulin sensitivity. Furthermore, the timing of a meal or exercise bout can optimize metabolic health. Therefore, there is a burgeoning appreciation of circadian rhythmicity in peripheral tissues such as skeletal muscle, liver and adipose tissue, as well as exercise and nutrition acting as zeitgebers of circadian rhythmicity. The precise interactions between endogenous rhythms, external zeitgebers and their health promoting effects remains to be fully elucidated.
- "Circadian Rhythms and Exercise – Re-Setting the Clock in Metabolic Disease"
Published in Nature Reviews Endocrinology in 2019, this article provides a comprehensive overview of how exercise influences the circadian clock and its potential to reset the clock in metabolic disease.
- "Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients"
Published in Molecular Metabolism in 2016 this study investigates how epigenetic modifications contribute to the etiology of type 2 diabetes and finds that obesity appears to shift the epigenome to increase lipid production and insulin resistance.
- "Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis"
Published in Cell Metabolism in 2019, this study examines how exercise at two distinct times-of-day results in a differential utilization of energy substrates resulting in divergent transcriptional activation.
- "Acute exercise remodels promoter methylation in human skeletal muscle"
Published in Cell Metabolism in 2012 this study examines the role DNA methylation plays in exercise-induced gene expression and shows that acute gene activation is associated with a dynamic change in DNA methylation in skeletal muscle and suggest that DNA hypomethylation is an early event in contraction-induced gene activation.
Professor Zierath also has a research group at Karolinska Institutet in Stockholm that focuses on epigenetic control and the molecular resolution of insulin resistance in diabetes as well as tissue-crosstalk and metabolic regulation of Type 2 diabetes.
|Altintas, Ali||Assistant professor||Zierath Group, Circadian Biology||+45 353-30625|
|Ashcroft, Stephen Paul||Postdoc||Zierath Group, Circadian Biology||+45 353-34677|
|Basse, Astrid Linde||Staff scientist||Treebak Group, Molecular Metabolism||+45 353-33028|
|Dalbram, Emilie||PhD student||Treebak Group, Molecular Metabolism||+45 353-33791|
|Ehrlich, Amy Melissa||Postdoc||Zierath Group, Circadian Biology||+45 353-32397|
|Gonzalez-Franquesa, Alba||Postdoc||Deshmukh Group, Functional Proteomics in Metabolism||+45 353-37618|
|Lundell, Leonidas||Postdoc||Zierath Group, Circadian Biology||+45 353-24862|
|Small, Lewin Barkla||Postdoc||Zierath Group, Circadian Biology||+45 91 10 82 78|
|Stocks, Ben Nicholas||Postdoc||Deshmukh Group, Functional Proteomics in Metabolism||+45 353-32944|
|Thomsen, Jane Sohn||Senior research coordinator||Administration, Zierath Group, Circadian Biology||+45 353-37043|
|Zierath, Juleen R||Professor||Executive Director||+45 353-37048|
From the left: Gonzalez-Franquesa, Lundell, Juleen R. Zierath, Emilie Dalbram, Ali Altintas, Astrid Linde Basse and Søren Madsen.