Effect of sex in the MRMT-1 model of cancer-induced bone pain
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- Falk et al_F1000Research_2015_445_v3
Final published version, 4.24 MB, PDF document
An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.
Original language | English |
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Article number | 445 |
Journal | F1000Research |
Volume | 4 |
Issue number | 445 |
Pages (from-to) | 1-18 |
Number of pages | 18 |
ISSN | 2046-1402 |
DOIs | |
Publication status | Published - 2015 |
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