Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

Research output: Contribution to journalJournal articlepeer-review

AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.

METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.

RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.

CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.

CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.

Original languageEnglish
JournalEpigenomics
Volume11
Issue number8
Pages (from-to)861-873
Number of pages14
ISSN1750-1911
DOIs
Publication statusPublished - 2019

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