Thomas Michael Frimurer

Thomas Michael Frimurer

Associate Professor

Introductory remarks on publicationslist

Publications: Author or co-author on > 40 papers in peer-reviewed, medium to high profile scientific journals. Involved in innovation and commercialization activities. Patents: Author or co-author on > 15 patents on chemical leads and drug candidates for the treatment of obesity, type-2 diabetes, asthma inflammation and pain. Most recently (Mar. 2014) we patented a strong chemical package on oral available small molecule GPR39 agonists – a potential obesity and type-2 diabetes target. Invited talks: Participated in multiple oral presentations at international and national scientific meetings.


  1. 2020
  2. Published

    Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands

    Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2020, In : Current Opinion in Cell Biology. 63, p. 38-48

    Research output: Contribution to journalReviewResearchpeer-review

  3. 2019
  4. Published

    Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

    Lückmann, Michael, Trauelsen, Mette, Bentsen, Marie Aare, Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, Mads Mørup, bqz445, bqz445, Lindorff-Larsen, Kresten, Schwartz, Thue W. & Frimurer, Thomas Michael, 2 Apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures

    Sørensen, A. B., Madsen, J. J., Frimurer, Thomas Michael, Overgaard, M. T., Gandhi, P. S., Persson, E. & Olsen, O. H., 2019, In : Biophysical Journal. 116, 10, p. 1823-1835

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

    Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In : Frontiers in Immunology. 10, 14 p., 2156.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids

    Nakamura, Kyosuke, Saredi, G., Becker, J. R., Foster, B. M., Nguyen, N. V., Elaine Beyer, Tracey, Cesa, Laura, Faull, P. A., Lukauskas, S., Frimurer, Thomas Michael, Chapman, J. R., Bartke, T. & Groth, Anja, 2019, In : Nature Cell Biology. 21, 3, p. 311-318

    Research output: Contribution to journalLetterResearchpeer-review

  8. Published

    Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

    Chen, S., Lu, M., Liu, D., Yang, L., Yi, C., Ma, L., Zhang, H., Liu, Q., Frimurer, Thomas Michael, Wang, M., Schwartz, Thue W., Stevens, R. C., Wu, B., Wuthrich, K. & Zhao, Q., 2019, In : Nature Communications. 10, 8 p., 638.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase

    Ulsund, A. H., Dahl, M., Frimurer, Thomas Michael, Manfra, O., Schwartz, Thue W., Levy, F. O. & Andressen, K. W., 2019, In : FASEB Journal. 33, 3, p. 3870-3886

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

    Larsen, Olav, Lückmann, Michael, van der Velden, Wijnand Jacobus C, Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In : ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2018
  12. Published
  13. Published

    Ligand-selective small molecule modulators of the constitutively active vGPCR US28

    Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, K., Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In : European Journal of Medicinal Chemistry. 155, p. 244-254

    Research output: Contribution to journalJournal articleResearchpeer-review

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