Thomas Michael Frimurer

Thomas Michael Frimurer

Associate Professor

Introductory remarks on publicationslist

Publications: Author or co-author on > 40 papers in peer-reviewed, medium to high profile scientific journals. Involved in innovation and commercialization activities. Patents: Author or co-author on > 15 patents on chemical leads and drug candidates for the treatment of obesity, type-2 diabetes, asthma inflammation and pain. Most recently (Mar. 2014) we patented a strong chemical package on oral available small molecule GPR39 agonists – a potential obesity and type-2 diabetes target. Invited talks: Participated in multiple oral presentations at international and national scientific meetings.

 


  1. 2022
  2. Published

    Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures

    Madsen, J. J., Ye, L., Frimurer, Thomas Michael & Olsen, O. H., 2022, In: Protein Science. 31, 11, 16 p., e4456.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action

    Lückmann, Michael, Iliyaz, Aslihan Shenol, Nissen, T. A. D., Petersen, Jacob Emil, Kouvchinov, David, Schwartz, Thue W. & Frimurer, Thomas Michael, 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast

    Lengger, B., Hoch-Schneider, E. E., Jensen, C. N., Jakočiū Nas, T., Petersen, A. A., Frimurer, Thomas Michael, Jensen, E. D. & Jensen, M. K., 2022, In: ACS Sensors. 7, 5, p. 1323-1335

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2021
  6. Published

    Discovery of GPR183 Agonists Based on an Antagonist Scaffold

    Kjær, V. M. S., Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

    Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner-Osborne, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor

    Smit, F. X., van der Velden, W. J. C., Kizilkaya, Hüsün Sheyma, Nørskov, A., Lückmann, Michael, Hansen, T. N., wbf943, wbf943, Qvotrup, K., Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: Structure. 29, 7, p. 679-693.e6 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Molecular mechanism of ligand binding pathways and activation of the succinate receptor

    Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.

    Research output: Contribution to journalConference abstract in journalResearch

  11. Published

    Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist

    Grunddal, K. V., Diep, T. A., Petersen, N., Tough, I. R., Skov, Louise Julie, Liu, Lingzhi, Buijink, J. A., Mende, F., Jin, C., Jepsen, Sara Lind, Sørensen, L. M. E., Achiam, Michael Patrick, Strandby, R. B., Bach, Anders, Hartmann, Bolette, Frimurer, Thomas Michael, Hjorth, Siv Annegrethe, Bouvier, M., Cox, H. & Holst, Birgitte, 2021, In: Molecular Metabolism. 49, 14 p., 101207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The Zinc-Sensing Receptor GPR39 in Physiology and as a Pharmacological Target

    Laitakari, Anna Isabella, Liu, Lingzhi, Frimurer, Thomas Michael & Holst, Birgitte, 2021, In: International Journal of Molecular Sciences. 22, 8, 22 p., 3872.

    Research output: Contribution to journalReviewResearchpeer-review

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