Dietary data in the Malmö offspring study–reproducibility, method comparison and validation against objective biomarkers

Research output: Contribution to journalJournal articleResearchpeer-review

  • Sophie Hellstrand
  • Filip Ottosson
  • Einar Smith
  • Louise Brunkwall
  • Ramne, Stina
  • Emily Sonestedt
  • Peter M. Nilsson
  • Olle Melander
  • Marju Orho-Melander
  • Ulrika Ericson

Irregular dietary intakes impairs estimations from food records. Biomarkers and method combinations can be used to improve estimates. Our aim was to examine reproducibility from two assessment methods, compare them, and validate intakes against objective biomarkers. We used the Malmö Offspring Study (55% women, 18–71 y) with data from a 4-day food record (4DFR) and a short food frequency questionnaire (SFFQ) to compare (1) repeated intakes (n = 180), (2) intakes from 4DFR and SFFQ (n = 1601), and (3) intakes of fatty fish, fruits and vegetables, and citrus with plasma biomarkers (n = 1433) (3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid [CMPF], β-carotene and proline betaine). We also combined 4DFR and SFFQ estimates using principal component analysis (PCA). Moderate correlations were seen between repeated intakes (4DFR median ρ = 0.41, SFFQ median ρ = 0.59) although lower for specific 4DFR-items, especially fatty/lean fish (ρ ≤ 0.08). Between-method correlations (median ρ = 0.33) were higher for intakes of overall food groups compared to specific foods. PCA scores for citrus (proline betaine ρ = 0.53) and fruits and vegetables (β-carotene: ρ = 0.39) showed the highest biomarker correlations, whereas fatty fish intake from the SFFQ per se showed the highest correlation with CMPF (ρ = 0.46). To conclude, the reproducibility of SFFQ data was superior to 4DFR data regarding irregularly consumed foods. Method combination could slightly improve fruit and vegetable estimates, whereas SFFQ data gave most valid fatty fish intake.

Original languageEnglish
Article number1579
JournalNutrients
Volume13
Issue number5
ISSN2072-6643
DOIs
Publication statusPublished - May 2021
Externally publishedYes

Bibliographical note

Funding Information:
Funding: This research was funded by European Research Council, grant number ERC-CoG-2014-649021 (for Orho-Melander); the Swedish Research Council, grant number Dnr 2013-08009; the EFSD/Lilly Award 2014, grant number Dnr 2015/338; EXODIAB (Swedish Research Council-Strategic Research Area), grant number Dnr 2009-1039; LUDC-IRC (Swedish Foundation for Strategic Research), grant number Dnr IRC15-006; the Region Skåne, grant number ALFSKANE 441261; the Heart-and Lung Foundation, grant number Dnr 014/379; the Novo Nordic Foundation, grant number NNF14OC0011049; the Swedish Diabetes foundation, grant number DIA2012-096 and DIA2015-037; the Albert Påhlsson Research Foundation, grant number FB2014-0036 and the Lund University Infrastructure grant “Malmö population-based cohorts” (STYR 2019/2046).

Funding Information:
This research was funded by European Research Council, grant number ERC-CoG-2014-649021 (for Orho-Melander); the Swedish Research Council, grant number Dnr 2013-08009; the EFSD/Lilly Award 2014, grant number Dnr 2015/338; EXODIAB (Swedish Research Council-Strategic Research Area), grant number Dnr 2009-1039; LUDC-IRC (Swedish Foundation for Strategic Re-search), grant number Dnr IRC15-006; the Region Sk?ne, grant number ALFSKANE 441261; the Heart-and Lung Foundation, grant number Dnr 014/379; the Novo Nordic Foundation, grant number NNF14OC0011049; the Swedish Diabetes foundation, grant number DIA2012-096 and DIA2015-037; the Albert P?hlsson Research Foundation, grant number FB2014-0036 and the Lund University Infrastructure grant ?Malm? population-based cohorts? (STYR 2019/2046).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

    Research areas

  • Biomarker, Citrus, Dietary assessment methods, Fish, Food intake, Fruits, Reproducibility, Validation, Vegetables

ID: 288801713