Grarup Group

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  1. 2013
  2. Published

    The effect of GWAS identified BMI loci on changes in body weight among middle-aged danes during a five year period

    Sandholt, C. H., Allin, K. H., Toft, U., Borglykke, A., Ribel-Madsen, R., Sparsø, T. H., Justesen, Johanne Marie, Harder, M. N., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 26 Jun 2013, In: Obesity. 22, 3, p. 901-908 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Gene x Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

    Ahmad, S., Rukh, G., Varga, T. V., Ali, A., Kurbasic, A., Shungin, D., Ericson, U., Koivula, R. W., Chu, A. Y., Rose, L. M., Ganna, A., Qi, Q., Stancakova, A., Sandholt, C. H., Elks, C. E., Curhan, G., Jensen, M. K., Tamimi, R. M., Allin, K. H., Jorgensen, T. & 26 others, Brage, S., Langenberg, C., Aadahl, Mette, Grarup, Niels, Linneberg, Allan René, Pare, G., Magnusson, P. K. E., Pedersen, N. L., Boehnke, M., Hamsten, A., Mohlke, K. L., Pasquale, L. T., Pedersen, Oluf Borbye, Scott, R. A., Ridker, P. M., Ingelsson, E., Laakso, M., Hansen, Torben, Qi, L., Wareham, N. J., Chasman, D. I., Hallmans, G., Hu, F. B., Renstrom, F., Orho-Melander, M. & Franks, P. W., Jul 2013, In: PLOS Genetics. 9, 7

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry

    Ahmad, S., Rukh, G., Varga, T. V., Ali, A., Kurbasic, A., Shungin, D., Ericson, U., Koivula, R. W., Chu, A. Y., Rose, L. M., Ganna, A., Qi, Q., Stančáková, A., Sandholt, C. H., Elks, C. E., Curhan, G., Jensen, M. K., Tamimi, R. M., Allin, K. H., Jørgensen, T. & 27 others, Brage, S., Langenberg, C., Aadahl, M., Grarup, Niels, Linneberg, Allan René, Paré, G., Magnusson, P. K. E., Pedersen, N. L., Boehnke, M., Hamsten, A., Mohlke, K. L., Pasquale, L. T., Pedersen, Oluf Borbye, Scott, R. A., Ridker, P. M., Ingelsson, E., Laakso, M., Hansen, Torben, Qi, L., Wareham, N. J., Chasman, D. I., Hallmans, G., Hu, F. B., Renström, F., Orho-Melander, M., Franks, P. W. & InterAct Consortium, I. C., Jul 2013, In: P L o S Genetics (Online). 9, 7, p. e1003607

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up

    Galijatovic, E. A. A., Allin, K. H., Sandholt, C. H., Borglykke, A., Lau, C. J., Ribel-Madsen, R., Sparsø, T., Justesen, Johanne Marie, Harder, M. N., Jørgensen, M. E., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 8 Jul 2013, In: Diabetes. 62, 10, p. 3610 3617 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes

    Snogdal, L. S., Grarup, Niels, Banasik, Karina, Wod, M., Jørgensen, T., Witte, D. R., Lauritzen, T., Nielsen, A. A., Brandslund, I., Christensen, C., Pedersen, Oluf Borbye, Yderstræde, K. B., Beck-Nielsen, H., Henriksen, J. E., Hansen, Torben & Højlund, K., 25 Oct 2013, In: BMC Medical Genetics. 14, 1, p. 113

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

    Dimas, A. S., Lagou, V., Barker, A., Knowles, J. W., Mägi, R., Hivert, M-F., Benazzo, A., Rybin, D., Jackson, A. U., Stringham, H. M., Song, C., Fischer-Rosinsky, A., Boesgaard, T. W., Grarup, N., Abbasi, F. A., Assimes, T. L., Hao, K., Yang, X., Lecoeur, C., Barroso, I. & 31 others, Bonnycastle, L. L., Böttcher, Y., Bumpstead, S., Chines, P. S., Erdos, M. R., Graessler, J., Kovacs, P., Morken, M. A., Narisu, N., Payne, F., Stancakova, A., Swift, A. J., Tönjes, A., Bornstein, S. R., Cauchi, S., Froguel, P., Meyre, D., Schwarz, P. E. H., Häring, H., Smith, U., Boehnke, M., Bergman, R. N., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Quertemous, T., Lind, L., Hansen, Torben, Pedersen, Oluf Borbye, Walker, M. & on behalf of the MAGIC investigators, O. B. O. T. M. I., 2 Dec 2013, In: Diabetes. 63, 6, p. 2158-2171 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes

    Lohmueller, K. E., Sparsø, T. H., Li, Q., Galijatovic, E. A. A., Korneliussen, T. S., Albrechtsen, A., Banasik, K., Grarup, N., Hallgrimsdottir, I., Kiil, K., Oskari Kilpeläinen, T., Krarup, N. T., Pers, T. H., Sanchez, G., Hu, Y., DeGiorgio, M., Jørgensen, T., Sandbæk, A., Lauritzen, T., Brunak, S. & 6 others, Kristiansen, Karsten, Li, Y., Hansen, Torben, Wang, J., Nielsen, Rasmus & Pedersen, Oluf Borbye, 5 Dec 2013, In: American Journal of Human Genetics. 93, 6, p. 1072-1086 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2014
  10. Published

    A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

    Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O. & 3 others, Nielsen, R., Albrechtsen, Anders & Hansen, Torben, 2014, In: Nature. 512, 7513, p. 190-193 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  11. Published

    Blood pressure levels in male carriers of Arg82Cys in CD300LG

    Støy, J., Grarup, Niels, Hørlyck, A., Ibsen, L., Rungby, J., Poulsen, P. L., Brandslund, I., Christensen, C., Hansen, Torben, Pedersen, Oluf Borbye, Møller, N. & Kampmann, U., 2014, In: PLOS ONE. 9, 10, 6 p., e109646.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Identification of Mislabeled Samples and Sample Mix-ups in Genotype Data using Barcode Genotypes

    Have, C. T., Appel, E. V. R., Grarup, Niels, Hansen, Torben & Bork-Jensen, J., 2014, In: International Journal of Bioscience, Biochemistry and Bioinformatics. 4, 5, p. 355-360 5 p., 370.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population

    Li, S., Besenbacher, S., Li, Y., Kristiansen, Karsten, Grarup, Niels, Albrechtsen, Anders, Sparsø, T. H., Korneliussen, Thorfinn Sand, Hansen, Torben, Wang, J., Nielsen, Rasmus, Pedersen, Oluf Borbye, Bolund, L. & Schierup, M. H., 2014, In: European Journal of Human Genetics. 22, p. 1040-1045 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification

    Husemoen, L. L. N., Skaaby, T., Jørgensen, T., Thuesen, B. H., Fenger, M., Grarup, Niels, Sandholt, C. H., Hansen, Torben, Pedersen, Oluf Borbye & Linneberg, Allan René, 24 Jan 2014, In: European Journal of Nutrition. 53, 7, p. 1549-59 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

    Steinthorsdottir, V., Thorleifsson, G., Sulem, P., Helgason, H., Grarup, N., Sigurdsson, A., Helgadottir, H. T., Johannsdottir, H., Magnusson, O. T., Gudjonsson, S. A., Justesen, J. M., Harder, M. N., Jørgensen, M. E., Christensen, C., Brandslund, I., Sandbæk, A., Lauritzen, T., Vestergaard, H., Linneberg, A., Jørgensen, T. & 14 others, Hansen, Torben, Daneshpour, M. S., Fallah, M., Hreidarsson, A. B., Sigurdsson, G., Azizi, F., Benediktsson, R., Masson, G., Helgason, A., Kong, A., Gudbjartsson, D. F., Pedersen, Oluf Borbye, Thorsteinsdottir, U. & Stefansson, K., 26 Jan 2014, In: Nature Genetics. 46, 3, p. 294-300 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

    Flannick, J., Thorleifsson, G., Beer, N. L., Jacobs, S. B. R., Grarup, N., Burtt, N. P., Mahajan, A., Fuchsberger, C., Atzmon, G., Benediktsson, R., Blangero, J., Bowden, D. W., Brandslund, I., Brosnan, J., Burslem, F., Chambers, J., Cho, Y. S., Christensen, C., Douglas, D. A., Duggirala, R. & 31 others, Dymek, Z., Farjoun, Y., Fennell, T., Fontanillas, P., Forsén, T., Gabriel, S., Glaser, B., Gudbjartsson, D. F., Hanis, C., Hansen, Torben, Hreidarsson, A. B., Hveem, K., Ingelsson, E., Isomaa, B., Johansson, S., Jørgensen, T., Jørgensen, M. E., Kathiresan, S., Kong, A., Kooner, J., Kravic, J., Laakso, M., Lee, J., Lind, L., Lindgren, C. M., Linneberg, Allan René, Masson, G., Meitinger, T., Ribel-Madsen, R., Pedersen, Oluf Borbye & Go-T2D Consortium, G. C., Apr 2014, In: Nature Genetics. 46, 4, p. 357-63 7 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  17. Published

    Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

    Grarup, Niels, Sandholt, C. H., Hansen, Torben & Pedersen, Oluf Borbye, Aug 2014, In: Diabetologia. 57, 8, p. 1528-41 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

    Guigas, B., de Leeuw van Weenen, J. E., van Leeuwen, N., Simonis-Bik, A. M., van Haeften, T. W., Nijpels, G., Houwing-Duistermaat, J. J., Beekman, M., Deelen, J., Havekes, L. M., Penninx, B. W. J. H., Vogelzangs, N., van 't Riet, E., Dehghan, A., Hofman, A., Witteman, J. C., Uitterlinden, A. G., Grarup, N., Jørgensen, T., Witte, D. R. & 15 others, Lauritzen, T., Hansen, Torben, Pedersen, Oluf Borbye, Hottenga, J., Romijn, J. A., Diamant, M., Kramer, M. H. H., Heine, R. J., Willemsen, G., Dekker, J. M., Eekhoff, E. M., Pijl, H., de Geus, E. J., Slagboom, P. E. & 't Hart, L. M., Aug 2014, In: Diabetic Medicine. 31, 8, p. 1001-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2015
  20. Published

    A glycogene mutation map for discovery of diseases of glycosylation

    Hansen, Lars, Lind-Thomsen, A., Joshi, Hiren Jitendra, Pedersen, N. B., Have, C. T., Kong, Y., Wang, S., Sparso, T., Grarup, Niels, Vester-Christensen, M. B., Schjoldager, Katrine Ter-Borch Gram, Freeze, H. H., Hansen, Torben, Pedersen, Oluf Borbye, Henrissat, B., Mandel, Ulla, Clausen, Henrik, Wandall, Hans H. & Bennett, Eric Paul, 2015, In: Glycobiology. 25, 2, p. 211-224 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study

    Hollensted, M., Ahluwalia, Tarun Veer Singh, Have, C. T., Grarup, Niels, Fonvig, C. E., Nielsen, T. R. H., Trier, C., Paternoster, L., Pedersen, Oluf Borbye, Holm, Jens-Christian, Sørensen, Thorkild I.A. & Hansen, Torben, 2015, In: BMC Medical Genetics. 16, 9 p., 105.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Diabetes in population isolates: lessons from Greenland

    Grarup, Niels, Moltke, Ida, Albrechtsen, Anders & Hansen, Torben, 2015, In: The Review of Diabetic Studies. 12, 3-4, p. 320-329 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  23. Published

    Genome-wide association studies of human adiposity: Zooming in on synapses.

    Sandholt, C. H., Grarup, Niels, Pedersen, Oluf Borbye & Hansen, Torben, 2015, In: Molecular and Cellular Endocrinology. 418, Part 2, p. 90-100 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Greenlandic Inuit show genetic signatures of diet and climate adaptation

    Fumagalli, M., Moltke, Ida, Grarup, Niels, Racimo, F., Bjerregaard, P., Jørgensen, M. E., Korneliussen, Thorfinn Sand, Gerbault, P., Skotte, L., Linneberg, Allan René, Christensen, C., Brandslund, I., Jørgensen, T., Huerta-Sánchez, E., Schmidt, E. B., Pedersen, Oluf Borbye, Hansen, T., Albrechtsen, Anders & Nielsen, Rasmus, 2015, In: Science (New York, N.Y.). 349, 6254, p. 1343-1347 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Reduced CD300LG mRNA tissue expression, increased intramyocellular lipid content and impaired glucose metabolism in healthy male carriers of Arg82Cys in CD300LG: a novel genometabolic cross-link between CD300LG and common metabolic phenotypes

    Støy, J., Kampmann, U., Mengel, A., Magnusson, N. E., Jessen, N., Grarup, Niels, Rungby, Jørgen, Stødkilde-Jørgensen, H., Brandslund, I., Christensen, C., Hansen, Torben, Pedersen, Oluf Borbye & Møller, N., 2015, In: BMJ open diabetes research & care. 3, 1, p. 1-12 12 p., e000095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The Type 2 Diabetes Risk Allele of TMEM154-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes

    Balslev-Harder, M., Appel, E. V. R., Grarup, Niels, Gjesing, A. M. P., Ahluwalia, Tarun Veer Singh, Jørgensen, T., Christensen, C., Brandslund, I., Linneberg, Allan René, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 2015, In: PLOS ONE. 10, 3, p. 1-13 13 p., e0120890.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

    Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., Kelly, T. N., Saleheen, D., Lehne, B., Mateo Leach, I., Drong, A. W., Abbott, J., Wahl, S., Tan, S-T., Scott, W. R., Campanella, G., Chadeau-Hyam, M., Afzal, U., Ahluwalia, T. V. S., Bonder, M. J. & 31 others, Chen, P., Dehghan, A., Edwards, T. L., Esko, T., Go, M. J., Harris, S. E., Hartiala, J., Kasela, S., Kasturiratne, A., Khor, C., Kleber, M. E., Li, H., Mok, Z. Y., Nakatochi, M., Sapari, N. S., Saxena, R., Stewart, A. F. R., Stolk, L., Tabara, Y., Teh, A. L., Wu, Y., Wu, J., Grarup, Niels, Justesen, Johanne Marie, Sparsø, T. H., Hansen, Torben, Jørgensen, T., Linneberg, Allan René, Pedersen, Oluf Borbye, Sørensen, Thorkild I.A. & BIOS Consortium, B. C., 2015, In: Nature Genetics. 47, 11, p. 1282-93 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Uncovering the genetic history of the present-day greenlandic population

    Moltke, Ida, Fumagalli, M., Korneliussen, Thorfinn Sand, Crawford, J. E., Bjerregaard, P., Jørgensen, M. E., Grarup, Niels, Gulløv, H. C., Linneberg, Allan René, Pedersen, Oluf Borbye, Hansen, Torben, Nielsen, Rasmus & Albrechtsen, Anders, 2015, In: American Journal of Human Genetics. 96, 1, p. 54-69 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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