- 2018
- Published
Genetic risk score of insulin resistance risk variants is associated with increased risk of coronary artery disease in patients referred to coronary angiography
Skals, R. K., Krogager, M. L., Appel, E. V. R., Schnurr, T. M., Have, C. T., Gislason, Gunnar Hilmar, Poulsen, Henrik Enghusen, Køber, Lars Valeur, Engstrøm, Thomas, Stender, S., Hansen, Torben, Grarup, Niels, Andersson, C., Torp-Pedersen, C. & Weeke, P. E., 2018, In: European Heart Journal. 39, p. 752-753Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention
Svendstrup, M., Allin, K. H., Sørensen, Thorkild I.A., Hansen, T. H., Grarup, Niels, Hansen, Torben & drb459, drb459, 2018, In: International Journal of Obesity. 42, 3, p. 370-375 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography
Krogager, M. L., Skals, R. K., Appel, E. V. R., Schnurr, T. M., pjx571, pjx571, Have, C. T., Pedersen, Oluf Borbye, Engstrøm, Thomas, Roden, D. M., Gislason, Gunnar Hilmar, Poulsen, Henrik Enghusen, Køber, Lars Valeur, Stender, Steen, Hansen, Torben, Grarup, Niels, Andersson, C., Torp-Pedersen, Christian & Weeke, P. E., 2018, In: P L o S One. 13, 12, p. 1-17 e0208645.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity
Niazi, R. K., Gjesing, A. P., Hollensted, M., Have, C. T., Grarup, Niels, Pedersen, Oluf Borbye, Ullah, A., Shahid, G., Ahmad, W., Gul, A. & Hansen, Torben, 2018, In: BMC Medical Genetics. 19, 1, p. 1-8 199.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interethnic analyses of blood pressure loci in populations of East Asian and European descent
The International Genomics of Blood Pressure (iGEN-BP) Consortium, T. I. G. O. B. P. (. C., 2018, In: Nature Communications. 9, 5052.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
Grarup, Niels, Moltke, Ida, Lepola, Mette Andersen, Dalby, M., Vitting-Seerup, K., Kern, T. S., Mahendran, Y., Jørsboe, E., Larsen, C. V. L., Dahl-Petersen, I. K., Gilly, A., Suveges, D., Dedoussis, G., Zeggini, E., Pedersen, Oluf Borbye, Andersson, Robin, Bjerregaard, P., Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 2018, In: Nature Genetics. 50, 2, p. 172-174 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meta-analysis of exome array data identifies six novel genetic loci for lung function
Jackson, V. E., Latourelle, J. C., Wain, L. V., Smith, A. V., Grove, M. L., Bartz, T. M., Obeidat, M., Province, M. A., Gao, W., Qaiser, B., Porteous, D. J., Cassano, P. A., Ahluwalia, T. S., Grarup, N., Li, J., Altmaier, E., Marten, J., Harris, S. E., Manichaikul, A., Pottinger, T. D. & 31 others, , 2018, In: Wellcome Open Research. 3, p. 1-28Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures
Svendstrup, M., Appel, E. V. R., Sandholt, C. H., Ahluwalia, Tarun Veer Singh, Ängquist, Lars, Thuesen, B. H., Jørgensen, M. E., Pedersen, Oluf Borbye, Grarup, Niels, Hansen, Torben, Sørensen, Thorkild I.A. & drb459, drb459, 2018, In: Obesity. 26, 4, p. 747-754 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot, V., Lu, Y., Highland, H. M., Bang, L. E., Benn, M., Kamstrup, P. R., Bork-Jensen, J., Frikke-Schmidt, R., Gjesing, A. P., Grarup, N., Hansen, T., Have, C. T., Jørgensen, T., Nielsen, S. F., Linneberg, A. R., Pedersen, O., Pers, T. H., Vestergaard, H., Nordestgaard, B., Tybjærg-Hansen, A. & 15 others, , 1 Jan 2018, In: Nature Genetics. 50, p. 26-41 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs-Guarch, S., Guindo-Martínez, M., Miguel-Escalada, I., Grarup, N., Sebastian, D., Rodriguez-Fos, E., Sánchez, F., Planas-Fèlix, M., Cortes-Sánchez, P., González, S., Timshel, P., Pers, T. H., Morgan, C. C., Moran, I., Atla, G., González, J. R., Puiggros, M., Martí, J., Andersson, E. A., Díaz, C. & 23 others, , 22 Jan 2018, In: Nature Communications. 9, 14 p., 321.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., Guo, X., Lu, Y., Li, M., Jensen, R. A., Hu, Y., Huo, S., Lohman, K. K., Zhang, W., Cook, J. P., Prins, B. P. & 32 others, , Apr 2018, In: Nature Genetics. 50, 4, p. 559-571 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Prins, B. P., Mead, T. J., Brody, J. A., Sveinbjornsson, G., Ntalla, I., Bihlmeyer, N. A., van den Berg, M., Bork-Jensen, J., Cappellani, S., Van Duijvenboden, S., Klena, N. T., Gabriel, G. C., Liu, X., Gulec, C., Grarup, N., Haessler, J., Hall, L. M., Iorio, A., Isaacs, A., Li-Gao, R. & 31 others, , 17 Jul 2018, In: Genome Biology. 19, 17 p., 87.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese
Graae, A. S., Hollensted, M., Kloppenborg, J. T., Mahendran, Y., Schnurr, T. M., Appel, E. V. R., Rask, J., Nielsen, T. R. H., Johansen, M., Linneberg, Allan René, Jørgensen, M. E., Grarup, Niels, Kadarmideen, H. N., Holst, Birgitte, Pedersen, Oluf Borbye, Holm, Jens-Christian & Hansen, Torben, Aug 2018, In: Diabetologia. 61, 8, p. 1769-1779Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population
Grarup, Niels, Moltke, Ida, Lepola, Mette Andersen, Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Jørsboe, E., Tiwari, H. K., Hopkins, S. E., Wiener, H. W., Boyer, B. B., Linneberg, Allan René, Pedersen, Oluf Borbye, Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 1 Sep 2018, In: Diabetologia. 61, 9, p. 2005–2015Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training
Blond, Martin Bæk, Schnurr, T. M., Rasenkilde, M., Quist, Jonas Salling, Gram, A. S., Reichkendler, M. H., Auerbach, P. L., Nordby, P., Skovgaard, Lene Theil, Ribel-Madsen, R., Justesen, Johanne Marie, Kilpeläinen, Tuomas O., Ploug, Thorkil, Stallknecht, Bente Merete & Hansen, Torben, 2019, In: Physiological Genomics. 51, 6, p. 254-260Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria
Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 others, , 2019, In: Diabetologia. 62, 2, p. 292-305Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
Bradfield, J. P., Vogelezang, S., Felix, J. F., Chesi, A., Helgeland, O., Horikoshi, M., Karhunen, V., Lowry, E., Cousminer, D. L., Ahluwalia, T. S., Thiering, E., Boh, E. T-H., Zafarmand, M. H., Vilor-Tejedor, N., Wang, C. A., Joro, R., Chen, Z., Gauderman, W. J., Pitkanen, N., Parra, E. J. & 79 others, , 2019, In: Human Molecular Genetics. 28, 19, p. 3327-3338Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations
Graae, A-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A., Kiens, B. & 10 others, , 2019, In: Diabetes. 68, 3, p. 502-514Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis
Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., Atalay, M., Lind, M. V., Heikkinen, S., Frithioff-Bøjsøe, C., Fonvig, C. E., Grarup, N., Kähönen, M., Carrasquilla, G. D., Larnkjær, A., Pedersen, O., Michaelsen, K. F., Lakka, T. A., Holm, J-C., Lehtimäki, T. & 3 others, , 2019, In: American Journal of Clinical Nutrition. 110, 5, p. 1079-1087 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis
Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T., Leth-Møller, K. B. & 27 others, , 2019, In: Addiction. 114, 2, p. 216-225 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations
Andersson, C., Krogager, M. L., Skals, R. K., Appel, E. V. R., Have, C. T., Grarup, N., Pedersen, O., Jeppesen, J. L., Pedersen, O. D., Dominguez, H., Dixen, U., Engstrøm, T., Tønder, N., Roden, D. M., Stender, S., Gislason, G. H., Enghusen-Poulsen, H., Hansen, T., Køber, L., Torp-Pedersen, C. & 1 others, , 2019, In: P L o S One. 14, 2, 12 p., e0211690.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit
Rønn, P. F., Jørgensen, M. E., Smith, L. S., Bjerregaard, P., Dahl-Petersen, I. K., Larsen, C. V. L., Grarup, Niels & Andersen, G. S., 2019, In: Diabetes Research and Clinical Practice. 150, p. 129-137 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
Tanigawa, Y., Li, J., Justesen, Johanne Marie, Horn, H., Aguirre, M., DeBoever, C., Chang, C., Narasimhan, B., Lage, K., Hastie, T., Park, C. Y., Bejerano, G., Ingelsson, E. & Rivas, M. A., 2019, In: Nature Communications. 10, 14 p., 4064.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does genetic predisposition to higher fat expandability attenuate the impact of weight gain on cardiometabolic risk?
Carrasquilla, Germán D., Linneberg, Allan René, Jørgensen, T., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2019, In: European Journal of Human Genetics. 27, Suppl. 2, p. 1764 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, Tuomas O., Grarup, Niels, Linneberg, Allan René, Zhang, Y., Vaughan, R., Loos, Ruth, Lazar, M. A. & Friedman, J. M., 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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Estimation of allele frequency and association mapping using next-generation sequencing data
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Genome-wide association study of preserved ratio impaired spirometry (PRISm)
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GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal
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