Grarup Group

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  1. 2020
  2. Published

    Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

    Yaghootkar, H., Zhang, Y., Spracklen, C. N., Karaderi, T., Huang, L. O., Bradfield, J., Schurmann, C., Fine, R. S., Preuss, M. H., Kutalik, Z., Wittemans, L. B., Lu, Y., Metz, S., Willems, S. M., Li-Gao, R., Grarup, N., Wang, S., Molnos, S., Sandoval-Zárate, A. A., Nalls, M. A. & 32 others, Lange, L. A., Haesser, J., Guo, X., Lyytikäinen, L., Feitosa, M. F., Sitlani, C. M., Venturini, C., Mahajan, A., Kacprowski, T., Wang, C. A., Chasman, D. I., Amin, N., Broer, L., Robertson, N., Young, K. L., Allison, M., Auer, P. L., Blüher, M., Borja, J. B., Bork-Jensen, J., Carrasquilla, Germán D., Christofidou, P., Demirkan, A., Doege, C. A., Jakupovic, Hermina, Li, J., Lind, L., Kovacs, P., Hansen, Torben, Loos, R. J., Kilpeläinen, Tuomas O. & Leptin Exomechip Collaboration, L. E. C., 2020, In: Diabetes. 69, 11, 93 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Vogelezang, S., Bradfield, J. P., Ahluwalia, Tarun Veer Singh, Curtin, J. A., Grarup, Niels, Schnurr, T. M., Hansen, Torben, Michaelsen, Kim F., Pedersen, Oluf Borbye, Stokholm, Jakob, Lind, M. V., Frithioff-Bøjsøe, C., Holm, Jens-Christian, Felix, J. F. & Early Growth Genetics Consortium, E. G. G. C., 2020, In: P L o S Genetics. 16, 10, 26 p., e1008718.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

    Schnurr, T. M., Jakupovic, Hermina, Carrasquilla, Germán D., Ängquist, Lars, Grarup, Niels, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2020, In: Diabetologia. 63, 7, p. 1324-1332 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

    Williams, K., Ingerslev, L. R., Bork-Jensen, J., Wohlwend, M., Hansen, Ann Normann, Small, Lewin Barkla, Ribel-Madsen, R., Astrup, A., Pedersen, Oluf Borbye, Auwerx, J., Workman, C. T., Grarup, Niels, Hansen, Torben & Barrès, Romain, 2020, In: Nature Communications. 11, 16 p., 2695.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The Polygenic and Monogenic Basis of Blood Traits and Diseases

    Vuckovic, D., Bao, E. L., Akbari, P., Lareau, C. A., Mousas, A., Jiang, T., Chen, M-H., Raffield, L. M., Tardaguila, M., Huffman, J. E., Ritchie, S. C., Megy, K., Ponstingl, H., Penkett, C. J., Albers, P. K., Wigdor, E. M., Sakaue, S., Moscati, A., Manansala, R., Lo, K. S. & 31 others, Qian, H., Akiyama, M., Bartz, T. M., Ben-Shlomo, Y., Beswick, A., Bork-Jensen, J., Bottinger, E. P., Brody, J. A., van Rooij, F. J. A., Chitrala, K. N., Wilson, P. W. F., Choquet, H., Danesh, J., Di Angelantonio, E., Dimou, N., Ding, J., Elliott, P., Esko, T., Evans, M. K., Felix, S. B., Floyd, J. S., Broer, L., Grarup, Niels, Guo, M. H., Guo, Q., Greinacher, A., Hansen, Torben, Linneberg, Allan René, Pedersen, Oluf Borbye, Loos, R. J. F. & VA Million Veteran Program, V. M. V. P., 2020, In: Cell. 182, 5, p. 1214-1231 29 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

    Andersen, M. K., Jørsboe, E., Skotte, L., Hanghøj, K., Sandholt, C. H., Moltke, I., Grarup, N., Kern, T., Mahendran, Y., Søborg, B., Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Tiwari, H. K., Feenstra, B., Koch, A., Wiener, H. W., Hopkins, S. E., Pedersen, O., Melbye, M. & 4 others, Boyer, B. B., Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 2020, In: PLOS Genetics. 16, 1, 17 p., e1008544.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland

    Overvad, M., Diaz, L. J., Bjerregaard, P., Pedersen, M. L., Larsen, C. V. L., Senftleber, N., Grarup, Niels, Hansen, Torben & Jørgensen, M. E., 2020, In: Scientific Reports. 10, 9 p., 22081.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

    Chen, M-H., Raffield, L. M., Mousas, A., Sakaue, S., Huffman, J. E., Moscati, A., Trivedi, B., Jiang, T., Akbari, P., Vuckovic, D., Bao, E. L., Zhong, X., Manansala, R., Laplante, V., Chen, M., Lo, K. S., Qian, H., Lareau, C. A., Beaudoin, M., Hunt, K. A. & 31 others, Akiyama, M., Bartz, T. M., Ben-Shlomo, Y., Beswick, A., Bork-Jensen, J., Bottinger, E. P., Brody, J. A., van Rooij, F. J. A., Chitrala, K., Cho, K., Choquet, H., Correa, A., Danesh, J., Di Angelantonio, E., Dimou, N., Ding, J., Elliott, P., Esko, T., Evans, M. K., Floyd, J. S., Broer, L., Grarup, Niels, Guo, M. H., Greinacher, A., Haessler, J., Hansen, Torben, Howson, J. M. M., Linneberg, Allan René, Pedersen, Oluf Borbye, Loos, R. J. F. & VA Million Veteran Program, V. M. V. P., 2020, In: Cell. 182, 5, p. 1198-+ 30 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans: a cross-sectional study

    Rønn, P. F., Andersen, G. S., Lauritzen, T., Christensen, Dirk Lund, Aadahl, Mette, Carstensen, Bendix, Grarup, Niels & Jørgensen, M. E., 14 Sep 2020, In: BMJ Open. 10, 9, 11 p., e038071.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2021
  12. Published

    Abdominal and gluteofemoral fat depots show opposing associations with postprandial lipemia

    Christiansen, Malene Revsbech, García Ureña, Mario, Borisevich, D., Grarup, Niels, Martínez, J. A., Oppert, J., Sørensen, Thorkild I.A., Hansen, Torben, Blaak, E. E. & Kilpeläinen, Tuomas O., 2021, In: American Journal of Clinical Nutrition. 114, 4, p. 1467–1475 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Acute metabolic effects of melatonin - A randomized crossover study in healthy young men

    Kampmann, U., Lauritzen, E. S., Grarup, Niels, Jessen, N., Hansen, Torben, Møller, N. & Stoy, J., 2021, In: Journal of Pineal Research. 70, 2, 13 p., 12706.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Combinatorial, additive and dose-dependent drug–microbiome associations

    Forslund, S. K., Chakaroun, R., Zimmermann-Kogadeeva, M., Markó, L., Aron-Wisnewsky, J., Nielsen, T., Moitinho-Silva, L., Schmidt, T. S. B., Falony, G., Vieira-Silva, S., Adriouch, S., Alves, R. J., Assmann, K., Bastard, J. P., Birkner, T., Caesar, R., Chilloux, J., Coelho, L. P., Fezeu, L., Galleron, N. & 23 others, Helft, G., Isnard, R., Ji, B., Kuhn, M., Le Chatelier, E., Myridakis, A., Olsson, L., Pons, N., Prifti, E., Quinquis, B., Roume, H., Lewinter, C., Søndertoft, N. B., Pedersen, H. K., Hansen, T. H., Hartmann, Bolette, Holst, Jens Juul, Hornbak, M., Jørgensen, Niklas Rye, Justesen, Johanne Marie, Krarup, N., Svendstrup, M. & The MetaCardis Consortium*, T. M. C., 2021, In: Nature. 600, p. 500-517 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    DeepFake electrocardiograms using generative adversarial networks are the beginning of the end for privacy issues in medicine

    Thambawita, Vajira Lasantha Bandara, Isaksen, Jonas L., Hicks, S. A., Ghouse, Jonas, Ahlberg, G., Linneberg, Allan René, Grarup, Niels, Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., Holstein-Rathlou, N., Strümke, I., Hammer, H. L., Maleckar, M. M., Halvorsen, P., Riegler, M. A. & Kanters, Jørgen K., 2021, In: Scientific Reports. 11, 1, 8 p., 21896.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

    Goodrich, J. K., Singer-Berk, M., Son, R., Sveden, A., Wood, J., England, E., Cole, J. B., Weisburd, B., Watts, N., Caulkins, L., Dornbos, P., Koesterer, R., Zappala, Z., Zhang, H., Maloney, K. A., Dahl, A., Aguilar-Salinas, C. A., Atzmon, G., Barajas-Olmos, F., Barzilai, N. & 31 others, Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E., Bowden, D. W., Centeno-Cruz, F., Chambers, J. C., Chami, N., Chan, E., Chan, J., Cheng, C. Y., Cho, Y. S., Contreras-Cubas, C., Córdova, E., Correa, A., DeFronzo, R. A., Duggirala, R., Dupuis, J., Garay-Sevilla, M. E., García-Ortiz, H., Gieger, C., Glaser, B., González-Villalpando, C., Gonzalez, M. E., Grarup, Niels, Groop, L., Gross, M., Hansen, Torben, Linneberg, Allan René, Pedersen, Oluf Borbye & AMP-T2D-GENES Consortia, A. C., 2021, In: Nature Communications. 12, 15 p., 3505.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

    Hicks, S. A., Isaksen, Jonas L., Thambawita, V., Ghouse, Jonas, Ahlberg, Gustav, Linneberg, Allan René, Grarup, Niels, Strümke, I., Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., von Holstein-Rathlou, Niels-Henrik, Halvorsen, P., Maleckar, M. M., Riegler, M. A. & Kanters, Jørgen K., 2021, In: Scientific Reports. 11, 1, 11 p., 10949.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    FGL1 as a modulator of plasma D-dimer levels: exome-wide marker analysis of plasma tPA, PAI-1 and D-dimer

    Thibord, F., Song, C., Pattee, J., Rodriguez, B. A. T., Chen, M-H., O'Donnell, C. J., Kleber, M. E., Delgado, G. E., Guo, X., Yao, J., Taylor, K. D., Ozel, A. B., Brody, J. A., McKnight, B., Gyorgy, B., Simonsick, E., Leonard, H. L., Carrasquilla, G. D., Guindo-Martinez, M., Silveira, A. & 30 others, Temprano-Sagrera, G., Yanek, L. R., Becker, D. M., Mathias, R. A., Becker, L. C., Raffield, L. M., Kilpeläinen, Tuomas O., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Linneberg, Allan René, Hamsten, A., Watkins, H., Sabater-Lleal, M., Nalls, M. A., Trégouët, D., Morange, P., Psaty, B. M., Tracy, R. P., Smith, N. L., Desch, K. C., Cushman, M., Rotter, J. I., de Vries, P. S., Pankratz, N. D., Folsom, A. R., Morrison, A. C., März, W., Tang, W. & Johnson, A. D., 2021, In: Journal of Thrombosis and Haemostasis. 19, 8, p. 2019-2028

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

    Aasbrenn, M., Svendstrup, M., Schnurr, T. M., Hansen, D. L., Worm, Dorte, Balslev-Harder, M., Grarup, Niels, Burgdorf, Kristoffer Sølvsten, drb459, drb459, Pedersen, Oluf Borbye, Ängquist, Lars, Fenger, M., Sørensen, Thorkild I.A., Madsbad, Sten & Hansen, Torben, 2021, In: PLoS ONE. 16, 5, 11 p., 0252525.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

    Deshmukh, H. A., Madsen, A. L., Viñuela, A., Have, C. T., Grarup, N., Tura, A., Mahajan, A., Heggie, A. J., Koivula, R. W., De Masi, F., Tsirigos, K. K., Linneberg, A., Drivsholm, T., Pedersen, O., Sørensen, T. I. A., Astrup, A., Gjesing, A. A. P., Pavo, I., Wood, A. R., Ruetten, H. & 14 others, Jones, A. G., Koopman, A. D. M., Cederberg, H., Rutters, F., Ridderstrale, M., Laakso, M., McCarthy, M. I., Frayling, T. M., Ferrannini, E., Franks, P. W., Pearson, E. R., Mari, A., Hansen, T. & Walker, M., 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. 80-90 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

    Jonsson, Anna Elisabet, Stinson, Sara, Torekov, Signe Sørensen, Clausen, Tine Dalsgaard, Færch, K., Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth, Damm, Peter, Witte, D. R., Jørgensen, M. E., Pedersen, Oluf Borbye, Holst, Jens Juul & Hansen, Torben, 2021, In: BMC Medical Genomics. 14, 7 p., 3.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

    Skals, R., Krogager, M. L., Appel, E. V. R., Schnurr, T. M., Have, C. T., Gislason, Gunnar Hilmar, Poulsen, Henrik Enghusen, Køber, Lars Valeur, Engstrøm, Thomas, Stender, Steen, Hansen, Torben, Grarup, Niels, Lee, C. J., Andersson, C., Torp-Pedersen, Christian & Weeke, P. E., 2021, In: PLoS ONE. 16, 6, 11 p., 0252855.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

    Moen, G., Beaumont, R. N., Grarup, Niels, Sommer, C., Shields, B. M., Lawlor, D. A., Freathy, R. M., Evans, D. M. & Warrington, N. M., 2021, In: International Journal of Epidemiology. 50, 1, p. 179-189 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

    Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

    Kizilkaya, Hüsün Sheyma, Sørensen, Kimmie Vestergaard, Kibsgaard, C. J., Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, wbf943, wbf943, Grarup, Niels & Rosenkilde, Mette, 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 749607.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations

    Borisevich, D., Schnurr, T. M., pjx571, pjx571, Rakitko, A., Ängquist, Lars, Ilinsky, V., Aadahl, Mette, Grarup, Niels, Pedersen, Oluf Borbye, Sørensen, Thorkild I.A. & Hansen, Torben, 2021, In: PLoS ONE. 16, 10, 16 p., e0258748.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers

    Schnurr, T. M., Jørsboe, E., Chadt, A., Dahl-Petersen, I. K., Kristensen, Jonas Møller, Wojtaszewski, Jørgen F P, Springer, C., Bjerregaard, P., Brage, S., Pedersen, Oluf Borbye, Moltke, Ida, Grarup, Niels, Al-Hasani, H., Albrechtsen, Anders, Jørgensen, M. E. & Hansen, Torben, 2021, In: Diabetologia. 64, p. 1795-1804

    Research output: Contribution to journal › Journal article › Research › peer-review

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