Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Research output: Contribution to journal › Journal article › Research › peer-review

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Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. / Willems, Sara M; et al. ; Grarup, Niels; Linneberg, Allan; Schnurr, Theresia M; Pedersen, Oluf; GEFOS Any-Type of Fracture Consortium ; Hansen, Torben.

In: Nature Communications, Vol. 8, 16015, 12.07.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Willems, SM, et al., Grarup, N, Linneberg, A, Schnurr, TM, Pedersen, O, GEFOS Any-Type of Fracture Consortium & Hansen, T 2017, 'Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness', Nature Communications, vol. 8, 16015. https://doi.org/10.1038/ncomms16015

APA

Willems, S. M., et al., Grarup, N., Linneberg, A., Schnurr, T. M., Pedersen, O., GEFOS Any-Type of Fracture Consortium, & Hansen, T. (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8, [16015]. https://doi.org/10.1038/ncomms16015

Vancouver

Willems SM, et al., Grarup N, Linneberg A, Schnurr TM, Pedersen O et al. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications. 2017 Jul 12;8. 16015. https://doi.org/10.1038/ncomms16015

Author

Willems, Sara M ; et al. ; Grarup, Niels ; Linneberg, Allan ; Schnurr, Theresia M ; Pedersen, Oluf ; GEFOS Any-Type of Fracture Consortium ; Hansen, Torben. / Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. In: Nature Communications. 2017 ; Vol. 8.

Bibtex

@article{08883a1533de4b208dda2cfc9fc0010a,
title = "Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness",
abstract = "Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10-8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.",
author = "Willems, {Sara M} and {et al.} and Niels Grarup and Allan Linneberg and Schnurr, {Theresia M} and Oluf Pedersen and {GEFOS Any-Type of Fracture Consortium} and Torben Hansen",
year = "2017",
month = jul,
day = "12",
doi = "10.1038/ncomms16015",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

AU - Willems, Sara M

AU - et al.

AU - Grarup, Niels

AU - Linneberg, Allan

AU - Schnurr, Theresia M

AU - Pedersen, Oluf

AU - GEFOS Any-Type of Fracture Consortium

AU - Hansen, Torben

PY - 2017/7/12

Y1 - 2017/7/12

N2 - Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10-8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.

AB - Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10-8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.

U2 - 10.1038/ncomms16015

DO - 10.1038/ncomms16015

M3 - Journal article

C2 - 29313844

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 16015

ER -

ID: 190845770