Hansen Group

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  1. 2023
  2. Published

    Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists

    Umapathysivam, M. M., Araldi, E., Hastoy, B., Dawed, A. Y., Vatandaslar, H., Sengupta, S., Kaufmann, A., Thomsen, S., Hartmann, B., Jonsson, A. E., Kabakci, H., Thaman, S., Grarup, N., Have, C. T., Færch, K., Gjesing, A. P., Nawaz, S., Cheeseman, J., Neville, M. J., Pedersen, O. & 12 others, Walker, M., Jennison, C., Hattersley, A. T., Hansen, Torben, Karpe, F., Holst, Jens Juul, Jones, A. G., Ristow, M., McCarthy, M. I., Pearson, E. R., Stoffel, M. & Gloyn, A. L., 2023, medRxiv, 35 p.

    Research output: Working paper › Preprint › Research

  3. Published

    Unanswered questions about the causes of obesity

    Speakman, J. R., Sørensen, Thorkild I.A., Hall, K. D. & Allison, D. B., 2023, In: Science. 381, 6661, p. 944-946 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Usefulness of Heat Map Explanations for Deep-Learning-Based Electrocardiogram Analysis

    Storås, A. M., Andersen, O. E., Lockhart, S., Thielemann, Roman, Gnesin, Filip Jurijevitj, Thambawita, Vajira Lasantha Bandara, Hicks, S. A., Kanters, Jørgen K., Strümke, I., Halvorsen, P. & Riegler, M. A., 2023, In: Diagnostics. 13, 14, 11 p., 2345.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Variants in EFCAB7 underlie nonsyndromic postaxial polydactyly

    Bilal, M., Khan, H., Khan, M. J., Haack, T. B., Buchert, R., Liaqat, K., Ullah, K., Ahmed, S., Bharadwaj, T., Acharya, A., Peralta, S., Najumuddin, Ali, H., Hasni, M. S., Schrauwen, I., Ullah, A., Ahmad, W. & Leal, S. M., 2023, In: European Journal of Human Genetics. 31, 11, p. 1270-1274

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Whole exome sequencing identified a novel splice donor site variant in interleukin 2 receptor alpha chain

    Waheed, N., Naseer, M., Haider, N., Suleman, Sufyan & Ullah, A., 2023, In: Immunogenetics. 75, p. 71-79

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2022
  8. Published

    14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes

    Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, Rungby, Jørgen & Hansen, Torben, 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment

    Bharadwaj, T., Schrauwen, I., Rehman, S., Liaqat, K., Acharya, A., Giese, A. P. J., Nouel-Saied, L. M., Nasir, A., Everard, J. L., Pollock, L. M., Zhu, S., Bamshad, M. J., Nickerson, D. A., Ali, R. H., Ullah, A., Wali, A., Ali, G., Santos-Cortez, R. L. P., Ahmed, Z. M., McDermott, B. M. & 4 others, Ansar, M., Riazuddin, S., Ahmad, W. & Leal, S. M., 2022, In: European Journal of Human Genetics. 30, p. 22-33

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

    Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D. & 32 others, Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Zhao, J. H., Aadahl, Mette, Bork-Jensen, J., Møllehave, L. T., Liu, J., Wang, J., drb459, drb459, Jackson, R. D., Kovacs, P., Pedersen, Oluf Borbye, Hansen, Torben, Lind, L., Loos, Ruth, Christensen, K., Linneberg, Allan René, Grarup, Niels, Dantoft, T. M., Karpe, F., Wei, W. Q., Sun, Y. V., Million Veterans Program, M. V. P. & Global Lipids Genetics Consortium, G. L. G. C., 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    A novel homozygous variant in the GLI1 underlies postaxial polydactyly in a large consanguineous family with intra familial variable phenotypes

    Bakar, A., Ullah, A., Bibi, N., Khan, H., Rahman, A. U., Ahmad, W. & Khan, B., 2022, In: European Journal of Medical Genetics. 65, 10, 104599.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    A novel nonsense variant in EXOC8 underlies a neurodevelopmental disorder

    Ullah, A., Krishin, J., Haider, N., Aurangzeb, B., Abdullah, Suleman, Sufyan, Ahmad, W., Hansen, Torben & Basit, S., 2022, In: Neurogenetics. 23, p. 203-212

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    A saturated map of common genetic variants associated with human height

    Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S-H., Ferreira, T., Highland, H. H., Ji, Y. & 37 others, Karaderi, Tugce, Lin, K., Lull, K., Malden, D. E., Lepola, Mette Andersen, Appadurai, V., Bork-Jensen, J., Burgdorf, Kristoffer Sølvsten, Hansen, Thomas Folkmann, Jonsson, Anna Elisabet, Jorgensen, T., Liu, J., Møllehave, Line Tang, Smit, Roelof Adriaan Johan, Zhao, J., Bisgaard, H., Bønnelykke, Klaus, Dantoft, T. M., Grarup, Niels, Hansen, Torben, Jackson, R. D., Karpe, F., Kovacs, P., Lind, L., Linneberg, Allan René, Pedersen, Oluf Borbye, Werge, Thomas, Sun, Y., Loos, Ruth, Winkler, T. W., 23andMe Res Team, 2. R. T., VA Million Vet Program, V. M. V. P., DiscovEHR DiscovEHR MyCode Communi, D. D. M. C., eEMERGE Elect Med Records Genomics, E. E. M. R. G., LifeLines Cohort Study, L. C. S., PRACTICAL consortium, P. C. & Understanding Soc Sci Grp, U. S. S. G., 2022, In: Nature. 610, p. 704–712

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention

    Jørsboe, E., Andersen, M. K., Skotte, L., Stæger, F. F., Færgeman, N. J., Hanghøj, K., Santander, C. G., Senftleber, N. K., Diaz, L. J., Overvad, M., Waples, R. K., Geller, F., Bjerregaard, P., Melbye, M., Larsen, C. V. L., Feenstra, B., Anders Koch, K., Jørgensen, M. E., Grarup, N., Moltke, I. & 2 others, Albrechtsen, Anders & Hansen, Torben, 2022, In: Human Genetics and Genomics Advances. 3, 4, 10 p., 100118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    An adult-based genetic risk score for hepatic fat associates with liver and lipid traits in Danish children and adolescents

    Huang, Yun, Stinson, Sara, Juel, H. B., Lund, Morten Asp Vonsild, Holm, L. A., Fonvig, Cilius Esmann, Grarup, Niels, Pedersen, Oluf Borbye, Christiansen, Michael, Krag, A., Stender, S., Holm, Jens-Christian & Hansen, Torben, 2022, In: Journal of Hepatology. 77, p. S450-S450 1 p., FRI104.

    Research output: Contribution to journal › Conference abstract in journal › Research

  16. Published

    An integrated model of obesity pathogenesis that revisits causal direction

    Ludwig, D. S. & Sørensen, Thorkild I.A., 2022, In: Nature Reviews Endocrinology. 18, p. 261-262 2 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  17. Published

    Association of general health and lifestyle factors with the salivary microbiota – Lessons learned from the ADDITION-PRO cohort

    Poulsen, C. S., Nygaard, Nikoline, Constancias, F., Stankevic, Evelina, Kern, T., Witte, D. R., Vistisen, D., Grarup, Niels, Pedersen, Oluf Borbye, Midjord-Belstrøm, Daniel & Hansen, Torben, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 15 p., 1055117.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Association of milk intake with hay fever, asthma, and lung function: a Mendelian randomization analysis

    Skaaby, T., Kilpeläinen, Tuomas O., Mahendran, Y., Huang, L. O., Sallis, H., Thuesen, B. H., Kårhus, L. L., Leth-Møller, K. B., Grarup, Niels, Hansen, Torben, Pedersen, Oluf Borbye, Burgess, S., Munafò, M. R. & Linneberg, Allan René, 2022, In: European Journal of Epidemiology. 37, p. 713-722

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Binge drinking induces an acute burst of markers of hepatic fibrogenesis (PRO-C3)

    Torp, N., Israelsen, M., Nielsen, M. J., Åstrand, C. P., Juhl, P., Johansen, S., Hansen, C. D., Madsen, B., Villesen, I. F., Leeming, D. J., Thiele, M., Hansen, Torben, Karsdal, M. & Krag, A., 2022, In: Liver International. 42, 1, p. 92-101

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts

    Silventoinen, K., Li, W., Jelenkovic, A., Sund, R., Yokoyama, Y., Aaltonen, S., Piirtola, M., Sugawara, M., Tanaka, M., Matsumoto, S., Baker, L. A., Tuvblad, C., Tynelius, P., Rasmussen, F., Craig, J. M., Saffery, R., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Martin, N. G. & 37 others, Medland, S. E., Montgomery, G. W., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Christensen, K., Skytthe, A., Kyvik, K. O., Saudino, K. J., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Ullemar, V., Almqvist, C., Magnusson, P. K. E., Corley, R. P., Huibregtse, B. M., Knafo-Noam, A., Mankuta, D., Abramson, L., Haworth, C. M. A., Plomin, R., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Duncan, G. E., Buchwald, D., Burt, S. A., Klump, K. L., Llewellyn, C. H., Fisher, A., Boomsma, D., Sørensen, Thorkild I.A. & Kaprio, J., 2022, In: International Journal of Obesity. 46, p. 1901–1909 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study

    Durda, P., Raffield, L. M., Lange, E. M., Olson, N. C., Jenny, N. S., Cushman, M., Deichgraeber, P., Grarup, Niels, Jonsson, Anna Elisabet, Hansen, Torben, Mychaleckyj, J. C., Psaty, B. M., Reiner, A. P., Tracy, R. P. & Lange, L. A., 2022, In: Journal of the American Heart Association. 11, 21, 14 p., e024374.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Clinical and genetic characterization of patients segregating variants in KPTN, MINPP1, NGLY1, AP4B1, and SON underlying neurodevelopmental disorders: Genetic and phenotypic expansion

    Ullah, A., Shah, A. A., Alluqmani, M., Haider, N., Aman, H., Alfadhli, F., Almatrafi, A. M., Albalawi, A. M., Krishin, J., Ullah Khan, F., Anjam, B. A., Abdullah, Peña Lozano, Elionora, Samad, A., Ahmad, W., Hansen, Torben, Xia, K. & Basit, S., 2022, In: International Journal of Developmental Neuroscience. 82, 8, p. 788-804

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    DeepFake electrocardiograms: the key for open science for artificial intelligence in medicine

    Thambawita, V., Isaksen, Jonas L., Hicks, S. A., Ghouse, Jonas, Ahlberg, Gustav, Linneberg, Allan René, Grarup, Niels, Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., Holstein-Rathlou, N., Strümke, I., Hammer, H. L., Maleckar, M., Halvorsen, P., Riegler, M. A. & Kanters, Jørgen K., 2022, 17 p. (medRxiv).

    Research output: Working paper › Preprint › Research

  24. Published

    Do gene-environment interactions have implications for the precision prevention of type 2 diabetes?

    Sørensen, Thorkild I.A., Metz, Sophia & Kilpeläinen, Tuomas O., 2022, In: Diabetologia. 65, p. 1804–1813 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  25. Published

    Early detection of childhood overweight and related complications in a Danish population-based cohort aged 2–8 years

    Frithioff-Bøjsøe, C., Lund, Morten Asp Vonsild, Lausten-Thomsen, U., Fonvig, Cilius Esmann, Lankjær, I. O. J., Hansen, T., Hansen, Torben, Baker, J. L. & Holm, Jens-Christian, 2022, In: Obesity Research and Clinical Practice. 16, 3, p. 228-234 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial

    Larsen, E. L., Kjær, L. K., Lundby-Christensen, L., Boesgaard, T. W., Breum, Leif, Gluud, C., Hedetoft, C., Krarup, T., Lund, S. S., Mathiesen, Elisabeth, Perrild, Hans, Sneppen, S. B., Tarnow, L., Thorsteinsson, B., drb459, drb459, Poulsen, Henrik Enghusen, Madsbad, Sten & Almdal, Thomas Peter, 2022, In: Free Radical Biology and Medicine. 178, p. 18-25 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Efficient approaches for large-scale GWAS with genotype uncertainty

    Jørsboe, E. & Albrechtsen, Anders, 2022, In: G3: Genes, Genomes, Genetics (Bethesda). 12, 1, 9 p., jkab385.

    Research output: Contribution to journal › Journal article › Research › peer-review

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