Hansen Group

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  1. 1993
  2. Published

    Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus

    Almind, K., Bjørbaek, C., drb459, drb459, Hansen, Torben, Echwald, S. M. & Pedersen, Oluf Borbye, 2 Oct 1993, In: Lancet. 342, 8875, p. 828-32 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus

    Hansen, Torben, Bjørbaek, C., drb459, drb459, Grønskov, K., Bak, J. F. & Pedersen, Oluf Borbye, Dec 1993, In: The Journal of clinical endocrinology and metabolism. 77, 6, p. 1500-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 1994
  5. Published

    Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM

    Bjørbaek, C., Echwald, S. M., Hubricht, P., drb459, drb459, Hansen, Torben, Zierath, Juleen R & Pedersen, Oluf Borbye, Aug 1994, In: Diabetes. 43, 8, p. 976-83 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 1995
  7. Published

    Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity

    Echwald, S. M., Bjørbaek, C., Hansen, Torben, Clausen, J. O., drb459, drb459, Zierath, Juleen R, Printz, R. L., Granner, D. K. & Pedersen, Oluf Borbye, Mar 1995, In: Diabetes. 44, 3, p. 347-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 2007
  9. Published

    The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

    Sparsø, T., Andersen, G., Nielsen, T., Burgdorf, K. S., Gjesing, A. M. P., Nielsen, A. L., Albrechtsen, Anders, Rasmussen, S. S., Jørgensen, T., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Madsbad, Sten, Hansen, Torben & Pedersen, Oluf Borbye, 2007, In: Diabetologia. 51, 1, p. 70-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Studies of the associations between functional beta2-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects

    Gjesing, A. P., Andersen, G., Burgdorf, Kristoffer Sølvsten, Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, Mar 2007, In: Diabetologia. 50, 3, p. 563-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2008
  12. Published

    The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes.

    Nielsen, T., Burgdorf, K. S., Grarup, Niels, Borch-Johnsen, K., Hansen, T., Jørgensen, T., Pedersen, Oluf Borbye & Andersen, G., 2008, In: Journal of Hypertension. 26, 11, p. 2142-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2009
  14. Published

    A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

    Rose, C. S., Grarup, Niels, Krarup, N. T., Poulsen, P., Wegner, L., Nielsen, T., Banasik, Karina, Faerch, K., Andersen, G., Albrechtsen, Anders, Borch-Johnsen, K., Clausen, J. O., Jørgensen, T., Vaag, Allan, Pedersen, Oluf Borbye & Hansen, Torben, 2009, In: Diabetologia. 52, 10, p. 2122-2129 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans

    Sparsø, T., Bonnefond, A., Andersson, E., Bouatia-Naji, N., Holmkvist, J., Wegner, L., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., Marchand, M., Vaxillaire, M., Charpentier, G., Jarvelin, M-R., Tichet, J., Balkau, B., Marre, M., Lévy-Marchal, C., Faerch, K., Borch-Johnsen, K. & 36 others, Jørgensen, T., Madsbad, Sten, Poulsen, P., Vaag, Allan, Dina, C., Hansen, T., Pedersen, Oluf Borbye, Froguel, P., Sparsø, T., Bonnefond, A., Andersson, E., Bouatia-Naji, N., Holmkvist, J., Wegner, L., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., Marchand, M., Vaxillaire, M., Charpentier, G., Jarvelin, M., Tichet, J., Balkau, B., Marre, M., Lévy-Marchal, C., Faerch, K., Borch-Johnsen, K., Jørgensen, T., Madsbad, Sten, Poulsen, P., Vaag, A., Dina, C., Hansen, T., Pedersen, O. & Froguel, P., 2009, In: Diabetes. 58, 6, p. 1450-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

    Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., Paolisso, G., Walker, M., Palmer, C. N. A., Payne, F., Young, E., Herder, C., Narisu, N., Morken, M. A., Bonnycastle, L. L., Owen, K. R. & 38 others, Shields, B., Knight, B., Bennett, A., Groves, C. J., Ruokonen, A., Jarvelin, M. R., Pearson, E., Pascoe, L., Ferrannini, E., Bornstein, S. R., Stringham, H. M., Scott, L. J., Kuusisto, J., Nilsson, Carl Martin Peter, Neptin, M., Gjesing, A. P., Pisinger, C., Lauritzen, T., Sandbaek, A., Sampson, M., Zeggini, M. E., Lindgren, C. M., Steinthorsdottir, V., Thorsteinsdottir, U., Hansen, T., Schwarz, Peter, Illig, T., Laakso, M., Stefansson, K., Morris, A. D., Groop, L., Pedersen, Oluf Borbye, Boehnke, M., Barroso, I., Wareham, N. J., Hattersley, A. T., McCarthy, M. I. & Frayling, T. M., 2009, In: Human Molecular Genetics. 19, 3, p. 535-44 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2010
  18. Published

    Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

    Saxena, R., Hivert, M-F., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A. U., Kao, W. H. L., Li, M., Glazer, N. L., Manning, A. K., Luan, J., Stringham, H. M., Prokopenko, I., Johnson, T., Grarup, N., Boesgaard, T. W. & 31 others, Lecoeur, C., Shrader, P., O'Connell, J., Ingelsson, E., Couper, D. J., Rice, K., Song, K., Andreasen, C. H., Dina, C., Köttgen, A., Le Bacquer, O., Pattou, F., Taneera, J., Steinthorsdottir, V., Rybin, D., Ardlie, K., Sampson, M., Qi, L., van Hoek, M., Weedon, M. N., Aulchenko, Y. S., Voight, B. F., Grallert, H., Balkau, B., Bergman, R. N., Borch-Johnsen, K., Jørgensen, T., Sparsø, T., Hansen, Torben, Pedersen, Oluf Borbye & GIANT Consortium, G. C., 1 Feb 2010, In: Nature Genetics. 42, 2, p. 142-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P. & 31 others, Grallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, Niels, Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., Jørgensen, T., Hansen, Torben, Pedersen, Oluf Borbye & DIAGRAM Consortium, D. C., 1 Feb 2010, In: Nature Genetics. 42, 2, p. 105-16 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

    Burgdorf, K. S., Sandholt, C. H., Sparsø, T., Andersen, G., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Sørensen, Thorkild I.A., Madsbad, Sten, Hansen, Torben & Pedersen, Oluf Borbye, 1 Jul 2010, In: European Journal of Endocrinology. 163, 1, p. 81-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

    Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Langenberg, C., Hofmann, O. M. & 31 others, Dupuis, J., Qi, L., Segrè, A. V., van Hoek, M., Navarro, P., Ardlie, K., Balkau, B., Benediktsson, R., Bennett, A. J., Blagieva, R., Boerwinkle, E., Bonnycastle, L. L., Bengtsson Boström, K., Bravenboer, B., Bumpstead, S., Burtt, N. P., Charpentier, G., Chines, P. S., Cornelis, M., Couper, D. J., Crawford, G., Doney, A. S. F., Elliott, K. S., Elliott, A. L., Erdos, M. R., Grarup, Niels, Jørgensen, T., Sparsø, T., Hansen, Torben, Pedersen, Oluf Borbye & MAGIC investigators, M. I., 1 Jul 2010, In: Nature Genetics. 42, 7, p. 579-89 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation

    Wegner, L., Anthonsen, S., Bork-Jensen, J., Dalgaard, L., Hansen, Torben, Pedersen, Oluf Borbye, Poulsen, P. & Vaag, Allan, Aug 2010, In: The Journal of clinical endocrinology and metabolism. 95, 8, p. 3884-92 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

    Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J-P. P. M., Kranendonk, S. E., Zeebregts, C. J. A. M., van Sterkenburg, S. M., Geelkerken, R. H., van Rij, A. M., Williams, M. J. A., Boll, A. P. M., Kostic, J. P., Jonasdottir, A., Jonasdottir, A., Walters, G. B., Masson, G., Sulem, P., Saemundsdottir, J. & 82 others, Mouy, M., Magnusson, K. P., Tromp, G., Elmore, J. R., Sakalihasan, N., Limet, R., Defraigne, J., Ferrell, R. E., Ronkainen, A., Ruigrok, Y. M., Wijmenga, C., Grobbee, D. E., Shah, S. H., Granger, C. B., Quyyumi, A. A., Vaccarino, V., Patel, R. S., Zafari, A. M., Levey, A. I., Austin, H., Girelli, D., Pignatti, P. F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L. C., Becker, D. M., Reilly, M. P., Rader, D. J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vasquez, V., Fontcuberta, J., España, F., Grarup, Niels, Jørgensen, T., Witte, D. R., Hansen, Torben, Pedersen, Oluf Borbye, Aben, K. K., de Graaf, J., Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D. A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E. M., Magnadottir, H. B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M. K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P. T., Thorgeirsson, G., Kiemeney, L. A., Powell, J. T., Carey, D. J., Kuivaniemi, H., Lindholt, J. S., Jones, G. T., Kong, A., Blankensteijn, J. D., Matthiasson, S. E., Thorsteinsdottir, U. & Stefansson, K., 1 Aug 2010, In: Nature Genetics. 42, 8, p. 692-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

    Boesgaard, T. W., Grarup, Niels, Jørgensen, T., Borch-Johnsen, K., Hansen, Torben, Pedersen, Oluf Borbye & Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), M. O. G. A. I. T. C. (., 1 Aug 2010, In: Diabetologia. 53, 8, p. 1647-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight

    Andersson, E. A., Pilgaard, K., Pisinger, C., Harder, M. N., Grarup, Niels, Faerch, K., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, Allan, Hansen, Torben & Pedersen, Oluf Borbye, 1 Sep 2010, In: Diabetologia. 53, 9, p. 1908-16 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., Luan, J., Mägi, R., Randall, J. C., Vedantam, S., Winkler, T. W., Lu, Q., Workalemahu, T., Heid, I. M., Steinthorsdottir, V., Stringham, H. M., Weedon, M. N., Wheeler, E. & 31 others, Wood, A. R., Ferreira, T., Weyant, R. J., Segrè, A. V., Estrada, K., Liang, L., Nemesh, J., Park, J., Gustafsson, S., Kilpeläinen, Tuomas O., Yang, J., Bouatia-Naji, N., Esko, T., Feitosa, M. F., Kutalik, Z., Mangino, M., Raychaudhuri, S., Scherag, A., Smith, A. V., Welch, R., Zhao, J. H., Aben, K. K., Absher, D. M., Amin, N., Dixon, A. L., Gjesing, A. P., Jørgensen, T., Witte, D. R., Hansen, Torben, Pedersen, Oluf Borbye & MAGIC, M., 1 Nov 2010, In: Nature Genetics. 42, 11, p. 937-48 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

    Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Mägi, R., Workalemahu, T., White, C. C., Bouatia-Naji, N., Harris, T. B., Berndt, S. I., Ingelsson, E., Willer, C. J., Weedon, M. N., Luan, J., Vedantam, S. & 31 others, Esko, T., Kilpeläinen, Tuomas O., Kutalik, Z., Li, S., Monda, K. L., Dixon, A. L., Holmes, C. C., Kaplan, L. M., Liang, L., Min, J. L., Moffatt, M. F., Molony, C., Nicholson, G., Schadt, E. E., Zondervan, K. T., Feitosa, M. F., Ferreira, T., Allen, H. L., Weyant, R. J., Wheeler, E., Wood, A. R., Estrada, K., Goddard, M. E., Lettre, G., Mangino, M., Gjesing, A. P., Witte, D. R., Hansen, Torben, Jørgensen, T., Pedersen, Oluf Borbye & MAGIC, M., 1 Nov 2010, In: Nature Genetics. 42, 11, p. 949-60 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations

    Pruhova, S., Dusatkova, P., Sumnik, Z., Kolouskova, S., Pedersen, Oluf Borbye, Hansen, Torben, Cinek, O. & Lebl, J., 1 Dec 2010, In: Pediatric Diabetes Online. 11, 8, p. 529-35 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes

    Pilgaard, K., Færch, K., Carstensen, B., Poulsen, P., Pisinger, C., Pedersen, Oluf Borbye, Witte, D. R., Hansen, Torben, Jørgensen, T. & Vaag, Allan, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2526-30 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Physiologic characterization of type 2 diabetes-related loci

    Grarup, Niels, Sparsø, T. & Hansen, Torben, 1 Dec 2010, In: Current Diabetes Reports. 10, 6, p. 485-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2011
  32. Published

    Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum

    Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., Batto, J-M., dos Santos, M. B. Q., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K. & 31 others, Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H. B., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E. G., Wang, J., Guarner, F., Pedersen, Oluf Borbye, de Vos, W. M., Brunak, Søren, Doré, J., Antolín, M., Artiguenave, F., Blottiere, H. M., Almeida, M., Brechot, C., Cara, C., Chervaux, C., Cultrone, A., Delorme, C., Denariaz, G., Kristiansen, Karsten & MetaHIT Consortium, M. C., 2011, In: Nature. 473, 7346, p. 174-180 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Estimation of allele frequency and association mapping using next-generation sequencing data

    Kim, S. Y., Lohmueller, K. E., Albrechtsen, Anders, Li, Y., Korneliussen, Thorfinn Sand, Tian, G., Grarup, Niels, Jiang, T., Andersen, G., Witte, D., Jorgensen, T., Hansen, Torben, Pedersen, Oluf Borbye, Wang, J. & Nielsen, Rasmus, 2011, In: B M C Bioinformatics. 12, p. 231 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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