- 2011
- Published
Genome wide association study identifies KCNMA1 contributing to human obesity
Jiao, H., Arner, P., Hoffstedt, J., Brodin, D., Dubern, B., Czernichow, S., van't Hooft, F., Axelsson, T., Pedersen, Oluf Borbye, Hansen, Torben, Sørensen, Thorkild I.A., Hebebrand, J., Kere, J., Dahlman-Wright, K., Hamsten, A., Clement, K. & Dahlman, I., 2011, In: B M C Medical Genomics. 4, p. 51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
Hribal, M. L., Presta, I., Procopio, T., Marini, M. A., Stancáková, A., Kuusisto, J., Andreozzi, F., Hammarstedt, A., Jansson, P., Grarup, Niels, Hansen, Torben, Walker, M., Stefan, N., Fritsche, A., Häring, H. U., Pedersen, Oluf Borbye, Smith, U., Laakso, M., Sesti, G. & EUGENE2 Consortium, E. C., 2011, In: Diabetologia. 54, 4, p. 795-802 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1
Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O. & 1 others, , 2011, In: Diabetologia. 54, 11, p. 2820-31 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intrafamilial Variability of Early-Onset Diabetes due to an INS Mutation
Fredheim, S., Svensson, Jannet, Pørksen, S., Hansen, L., Hansen, Torben, Pedersen, Oluf Borbye, Mortensen, H. B., Barbetti, F. & Nielsen, L. B., 2011, In: Case Reports in Genetics. 2011, p. 258978Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test
Møller, J. B., Jusko, W. J., Gao, W., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Overgaard, R. V., Madsen, H. & Ingwersen, S. H., 2011, In: Journal of Pharmacokinetics and Pharmacodynamics. 38, 6, p. 713-25 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
Lohmueller, K. E., Albrechtsen, Anders, Li, Y., Kim, S. Y., Korneliussen, Thorfinn Sand, Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Feder, A. F., Grarup, Niels, Jørgensen, T., Jiang, T., Witte, D. R., Sandbæk, A., Hellmann, I., Lauritzen, T., Hansen, Torben, Pedersen, Oluf Borbye, Wang, J. & Nielsen, Rasmus, 2011, In: P L o S Genetics. 7, 10, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
Burgdorf, K. S., Grarup, Niels, Justesen, Johanne Marie, Harder, M. N., Witte, D. R., Jørgensen, T., Sandbæk, A., Lauritzen, T., Madsbad, Sten, Hansen, Torben, DIAGRAM Consortium, D. C. & Pedersen, Oluf Borbye, 2011, In: P L o S One. 6, 1, p. e15813 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility
Jafar-Mohammadi, B., Groves, C. J., Gjesing, A. P., Herrera, B. M., Winckler, W., Stringham, H. M., Morris, A. P., Lauritzen, T., Doney, A. S. F., Morris, A. D., Weedon, M. N., Swift, A. J., Kuusisto, J., Laakso, M., Altshuler, D., Hattersley, A. T., Collins, F. S., Boehnke, M., Hansen, T., Pedersen, O. & 5 others, , Jan 2011, In: Diabetologia. 54, 1, p. 111-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
Stacey, S. N., Sulem, P., Jonasdottir, A., Masson, G., Gudmundsson, J., Gudbjartsson, D. F., Magnusson, O. T., Gudjonsson, S. A., Sigurgeirsson, B., Thorisdottir, K., Ragnarsson, R., Benediktsdottir, K. R., Nexø, B. A., Tjønneland, A., Overvad, K., Rudnai, P., Gurzau, E., Koppova, K., Hemminki, K., Corredera, C. & 31 others, , 1 Jan 2011, In: Nature Genetics. 43, 11, p. 1098-1103 6 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study
Thyssen, Jacob Pontoppidan, Linneberg, Allan René, Carlsen, B. C., Johansen, Jeanne Duus, Engkilde, K., Hansen, Torben, Pociot, Flemming, Pedersen, Oluf Borbye, Meldgaard, M., Szecsi, P. B., Stender, Steen & Menné, T., 1 Jan 2011, In: BMJ Open. 1, 1, p. e000062 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease
Banasik, Karina, Justesen, Johanne Marie, Hornbak, M., Krarup, N. T., Gjesing, A. P., Sandholt, C. H., Søndergaard Jensen, T., Grarup, Niels, Andersson, Åsa, Jørgensen, T., Witte, D. R., Sandbæk, A., Lauritzen, T., Thorens, B., Brunak, Søren, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2011, In: P L o S One. 6, 1, p. e16542Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test
Gjesing, A. P., Kjems, L. L., Vestmar, M. A., Grarup, Niels, Linneberg, Allan René, Deacon, Carolyn F., Holst, Jens Juul, Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2011, In: Diabetologia. 54, 1, p. 103-10 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Corrigendum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Mägi, R., Workalemahu, T., White, C. C., Bouatia-Naji, N., Harris, T. B., Berndt, S. I., Ingelsson, E., Willer, C. J., Weedon, M. N., Luan, J., Vedantam, S. & 280 others, , 1 Jan 2011, In: Nature Genetics. 43, 11, p. 1164 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes
Gjesing, A. P., Nielsen, A. A., Brandslund, I., Christensen, C., Sandbæk, A., Jørgensen, T., Witte, D., Bonnefond, A., Froguel, P., Hansen, Torben & Pedersen, Oluf Borbye, 1 Jan 2011, In: B M C Medical Genetics. 12, p. 99 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
Sandholt, C. H., Vestmar, M. A., Bille, D. S., Borglykke, A., Almind, K., Hansen, L., Sandbæk, A., Lauritzen, T., Witte, D., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2011, In: P L o S One. 6, 9, p. e23531 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of PCSK1 Variants on Waist, Waist-Hip Ratio and Glucose Metabolism Is Modified by Sex and Glucose Tolerance Status
Gjesing, A. P., Vestmar, M. A., Jørgensen, T., Heni, M., Holst, Jens Juul, Witte, D. R., Hansen, Torben & Pedersen, Oluf Borbye, 1 Jan 2011, In: P L o S One. 6, 9, p. e23907 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The FOXO3A rs2802292 G-Allele Associates with Improved Peripheral and Hepatic Insulin Sensitivity and Increased Skeletal Muscle-FOXO3A mRNA Expression in Twins
Banasik, Karina, Ribel-Madsen, R., Gjesing, A. P., Wegner, L., Andersson, Åsa, Poulsen, P., Borglykke, A., Witte, D. R., Pedersen, Oluf Borbye, Hansen, Torben & Vaag, Allan, 1 Jan 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 1, p. E119-24Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load
Hornbak, M., Banasik, Karina, Justesen, Johanne Marie, Krarup, N. T., Sandholt, C. H., Andersson, Åsa, Sandbaek, A., Lauritzen, T., Pisinger, C., Witte, D. R., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 6 Jan 2011, In: BMC Medical Genetics. 12, 1, p. 4 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes
Pers, T. H., Hansen, N. T., Hansen, K. L., Koefoed, P., Dworzynski, P., Miller, M. L., Flint, T. J., Mellerup, E., Dam, H., Andreassen, O. A., Djurovic, S., Melle, I., Børglum, A. D., Werge, T., Purcell, S., Ferreira, M. A., Kouskoumvekaki, I., Workman, C., Hansen, T., Mors, O. & 1 others, , 11 Apr 2011, In: Genetic Epidemiology. 35, 5, p. 318-332 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations
Gonsorcikova, L., Vaxillaire, M., Pruhova, S., Dechaume, A., Dusatkova, P., Cinek, O., Pedersen, Oluf Borbye, Froguel, P., Hansen, Torben & Lebl, J., 1 May 2011, In: Pediatric Diabetes. 12, 3pt2, p. 266-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes
Bille, D. S., Banasik, Karina, Justesen, Johanne Marie, Sandholt, C. H., Sandbæk, A., Lauritzen, T., Jørgensen, T., Witte, D. R., Holm, Jens-Christian, Hansen, Torben & Pedersen, Oluf Borbye, 1 Jun 2011, In: P L o S One. 6, 6, p. e20640 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of Accuracy of Diabetes Risk Score and Components of the Metabolic Syndrome in Assessing Risk of Incident Type 2 Diabetes in Inter99 Cohort
Shafizadeh, T. B., Moler, E. J., Kolberg, J. A., Nguyen, U. T., Hansen, Torben, Jørgensen, T., Pedersen, Oluf Borbye & Borch-Johnsen, K., 1 Jul 2011, In: P L o S One. 6, 7, p. e22863 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals
Burgdorf, K. S., Gjesing, A. P., Grarup, Niels, Justesen, Johanne Marie, Sandholt, C. H., Witte, D. R., Jørgensen, T., Madsbad, Sten, Hansen, Torben & Pedersen, Oluf Borbye, 28 Sep 2011, In: Diabetologia. 55, 1, p. 105-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge
Andersson, E. A., Harder, M. N., Pilgaard, K., Pisinger, C., Stancáková, A., Kuusisto, J., Grarup, Niels, Færch, K., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, Allan, Laakso, M., Pedersen, Oluf Borbye & Hansen, Torben, Nov 2011, In: P L o S One. 6, 11, p. e27096 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Oskari Kilpeläinen, T., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E., Ahmad, T., Mora, S., Kaakinen, M., Sandholt, C. H., Holzapfel, C., Autenrieth, C. S., Hyppönen, E., Cauchi, S., He, M., Kutalik, Z., Kumari, M., Stancáková, A., Meidtner, K., Balkau, B. & 96 others, , 1 Nov 2011, In: P L o S Medicine (Online). 8, 11, p. e1001116Research output: Contribution to journal › Journal article › Research › peer-review
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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Estimation of allele frequency and association mapping using next-generation sequencing data
Research output: Contribution to journal › Journal article › Research › peer-review
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Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection
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