- 2022
- Published
Loss of sucrase-isomaltase function increases acetate levels and improves metabolic health in Greenlandic cohorts
Andersen, M. K., Skotte, L., Jørsboe, E., Polito, R., Stæger, F. F., Aldiss, P., Hanghøj, K., Waples, R. K., Santander, C. G., Grarup, N., Dahl-Petersen, I. K., Diaz, L. J., Overvad, M., Senftleber, N. K., Søborg, B., Larsen, C. V. L., Lemoine, C., Pedersen, O., Feenstra, B., Bjerregaard, P. & 9 others, , 2022, In: Gastroenterology. 162, 4, p. 1171-1182.e3Research output: Contribution to journal › Journal article › Research › peer-review
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Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity
Carrasquilla, Germán D., García Ureña, Mario, Fall, T., Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2022, In: eLife. 11, 25 p., e70386.Research output: Contribution to journal › Journal article › Research › peer-review
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- Published
Mendelian randomization suggests a causal effect of abdominal obesity on postprandial lipemia
Christiansen, Malene Revsbech, Hansen, Torben, Sørensen, Thorkild I.A., Grarup, Niels, García Ureña, Mario, Borisevich, D., Oppert, J., Martinez Hernandez, J. A., Blaak, E. & Kilpeläinen, Tuomas O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 184 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling
Maimets, Martti, Pedersen, M. T., Guiu, J., Dreier, J., Thodberg, Malte, Antoku, Yasuko, Schweiger, P. J., Rib, Leonor, Bardini Bressan, Raul, Miao, Y., Garcia, K. C., Sandelin, Albin Gustav, Serup, Palle & Jensen, Kim Bak, 2022, In: Nature Communications. 13, 12 p., 715.Research output: Contribution to journal › Journal article › Research › peer-review
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Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation
Solomon, O., Huen, K., Yousefi, P., Küpers, L. K., González, J. R., Suderman, M., Reese, S. E., Page, C. M., Gruzieva, O., Rzehak, P., Gao, L., Bakulski, K. M., Novoloaca, A., Allard, C., Pappa, I., Llambrich, M., Vives, M., Jima, D. D., Kvist, T., Baccarelli, A. & 65 others, , 2022, In: Mutation Research - Reviews in Mutation Research. 789, 108415.Research output: Contribution to journal › Review › Research › peer-review
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Metabolic and Genetic Risk Factors Are the Strongest Predictors of Severity of Alcohol-Related Liver Fibrosis
Israelsen, M., Juel, H. B., Detlefsen, S., Madsen, B. S., Rasmussen, D. N., Larsen, T. R., Kjærgaard, M., Fernandes Jensen, M. J., Stender, S., Hansen, Torben, Krag, A., Thiele, M. & GALAXY and MicrobLiver consortiak, G. A. M. C., 2022, In: Clinical Gastroenterology and Hepatology. 20, 8, p. 1784-1794.e9 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Microbiome and metabolome features of the cardiometabolic disease spectrum
Fromentin, S., Forslund, S. K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M. T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R. & 44 others, , 2022, In: Nature Medicine. 28, 2, p. 303-314Research output: Contribution to journal › Journal article › Research › peer-review
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Mild Cognitive Impairment Is Associated with Poorer Nutritional Status on Hospital Admission and after Discharge in Acutely Hospitalized Older Patients
Bornæs, O., Andersen, A. L., Houlind, Morten Baltzer, Kallemose, T., Tavenier, J., Aharaz, A., Nielsen, Rikke Linnemann, Jørgensen, L. M., Beck, A. M., Andersen, Ove, Petersen, Janne & Pedersen, Mette Merete, 2022, In: Geriatrics (Switzerland). 7, 5, 16 p., 95.Research output: Contribution to journal › Journal article › Research › peer-review
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Modulation of gut microbiota by Mantequilla and Melipona honeys decrease low-grade inflammation caused by high fructose corn syrup or sucrose in rats
Coutiño-Hernández, D., Sánchez-Tapia, M., Leal-Vega, F., Bobadilla del Valle, M., Ledezma, H., Cervantes, R., Pedraza-Chaverri, J., Granados-Portillo, O., Díaz, D., Antunes-Ricardo, M., Gutiérrez-Uribe, J., Maya, Otoniel, Olin-Sandoval, V., Tovar, A. R. & Torres, N., 2022, In: Food Research International. 151, 13 p., 110856.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular Insights into the Role of Pathogenic nsSNPs in GRIN2B Gene Provoking Neurodevelopmental Disorders
Shah, A. A., Amjad, M., Hassan, J. U., Ullah, A., Mahmood, A., Deng, H., Ali, Y., Gul, F. & Xia, K., 2022, In: Genes. 13, 8, 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy
Daggag, H., Gjesing, A. P., Mohammad, A., Ängquist, Lars, Shobi, B., Antony, S., Haj, D., Al Tikriti, A., Buckley, A., Hansen, Torben & Barakat, M. T., 2022, In: Metabolism open. 16, 7 p., 100213.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S-H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B-J., Chiou, J. & 31 others, , 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model
Lorenzen, E., Contreras, V., Olsen, A. W., Andersen, P., Desjardins, D., Rosenkrands, I., Juel, H. B., Delache, B., Langlois, S., Delaugerre, C., Joubert, C., Dereuddre-Bosquet, N., Bébéar, C., De Barbeyrac, B., Touati, A., McKay, P. F., Shattock, R. J., Le Grand, R., Follmann, F. & Dietrich, J., 2022, In: Frontiers in Immunology. 13, 13 p., 1057375.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiomics signatures of type 1 diabetes with and without albuminuria
Clos-Garcia, M., Ahluwalia, Tarun Veer Singh, Winther, S. A., Henriksen, P., Ali, M., Fan, Yong, Stankevic, Evelina, Lyu, Liwei, Vogt, J. K., Hansen, Torben, Legido-Quigley, C., Rossing, Peter & Pedersen, Oluf Borbye, 2022, In: Frontiers in Endocrinology. 13, 17 p., 1015557.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neonatal Anthropometrics and Obesity Treatment Response in Children and Adolescents
Lausten-Thomsen, U., Lund, Morten Asp Vonsild, Stinson, Sara, Frithioff-Bøjsøe, C., Holm, L. A., Baker, J. L., Fonvig, Cilius Esmann, Christiansen, M., Ängquist, Lars, Hansen, Torben & Holm, Jens-Christian, 2022, In: Journal of Pediatrics. 242, p. 74-78.e2 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Noninvasive proteomic biomarkers for alcohol-related liver disease
Niu, Lili, Thiele, M., Geyer, P. E., Rasmussen, D. N., Webel, Henry, Santos, A., Gupta, R., Meier, F., Strauss, Maximilian, Kjaergaard, M., Lindvig, K., Jacobsen, S., Rasmussen, Simon, Hansen, Torben, Krag, A. & Mann, Matthias, 2022, In: Nature Medicine. 28, 6, p. 1277-1287 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
Okbay, A., Wu, Y., Wang, N., Jayashankar, H., Bennett, M., Nehzati, S. M., Sidorenko, J., Kweon, H., Goldman, G., Gjorgjieva, T., Jiang, Y., Hicks, B., Tian, C., Hinds, D. A., Ahlskog, R., Magnusson, P. K. E., Oskarsson, S., Hayward, C., Campbell, A., Porteous, D. J. & 31 others, , 2022, In: Nature Genetics. 54, 4, p. 437-449 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Possible prediction of obesity-related liver disease in children and adolescents using indices of body composition
Johansen, M. J., Lund, Morten Asp Vonsild, Ängquist, Lars, Fonvig, Cilius Esmann, Holm, L. A., Chabanova, E., Thomsen, Henrik S., Hansen, Torben & Holm, Jens-Christian, 2022, In: Pediatric Obesity. 17, 10, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication
Mikkelsen, Christina, Larsen, M. A. H., Sørensen, E., Hansen, Thomas Folkmann, Mikkelsen, S., Erikstrup, C., Nielsen, K. R., Bruun, M. T., Hjalgrim, Henrik, Kessing, Lars Vedel, Werge, Thomas, Ullum, H., Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Thørner, L. W. & Didriksen, Maria, 2022, In: Psychiatry Research. 318, 7 p., 114944.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes
Hindy, G., Dornbos, P., Chaffin, M. D., Liu, D. J., Wang, M., Selvaraj, M. S., Zhang, D., Park, J., Aguilar-Salinas, C. A., Antonacci-Fulton, L., Ardissino, D., Arnett, D. K., Aslibekyan, S., Atzmon, G., Ballantyne, C. M., Barajas-Olmos, F., Barzilai, N., Becker, L. C., Bielak, L. F., Bis, J. C. & 33 others, , 2022, In: American Journal of Human Genetics. 109, 1, p. 81-96 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes
O'Connor, M. J., Schroeder, P., Huerta-Chagoya, A., Cortés-Sánchez, P., Bonàs-Guarch, S., Guindo Martínez, Marta, Cole, J. B., Kaur, V., Torrents, D., Veerapen, K., Grarup, Niels, Kurki, M., Friis, Carsten, Pedersen, Oluf Borbye, Brandslund, I., Linneberg, Allan René, Hansen, Torben, Leong, A., Florez, J. C. & Mercader, J. M., 2022, In: Diabetes. 71, 3, p. 554–565Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recombinant human β-defensin 2 delivery improves smoking-induced lung neutrophilia and bacterial exacerbation
Milad, N., Pineault, M., Bouffard, G., Maranda-Robitaille, M., Lechasseur, A., Beaulieu, M. J., Aubin, S., Jensen, Benjamin Anderschou Holbech & Morissette, M. C., 2022, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 323, 1, p. L37-L47 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study
Erikstrup, C., Laksafoss, A. D., Gladov, J., Kaspersen, K. A., Mikkelsen, S., Hindhede, L., Boldsen, J. K., Jørgensen, S. W., Ethelberg, S., Holm, D. K., Bruun, M. T., Nissen, J., Schwinn, M., Brodersen, T., Mikkelsen, C., Sækmose, S. G., Sørensen, E., Harritshøj, L. H., Aagaard, B., Dinh, K. M. & 7 others, , 2022, In: The Lancet Regional Health - Europe. 21, 100479.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis
Fred, Rikard Göran, Steen Pedersen, J., Thompson, J. J., Lee, J., Timshel, P. N., Stender, S., Rygg, M. O., Gluud, Lise Lotte, Bjerregaard Kristiansen, V., Bendtsen, Flemming, Hansen, Torben & Pers, Tune H, 2022, In: Scientific Reports. 12, 1, 13 p., 13484.Research output: Contribution to journal › Journal article › Research › peer-review
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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Estimation of allele frequency and association mapping using next-generation sequencing data
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