Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Interethnic analyses of blood pressure loci in populations of East Asian and European descent. / The International Genomics of Blood Pressure (iGEN-BP) Consortium.

In: Nature Communications, Vol. 9, 5052, 2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

The International Genomics of Blood Pressure (iGEN-BP) Consortium 2018, 'Interethnic analyses of blood pressure loci in populations of East Asian and European descent', Nature Communications, vol. 9, 5052. https://doi.org/10.1038/s41467-018-07345-0

APA

The International Genomics of Blood Pressure (iGEN-BP) Consortium (2018). Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications, 9, [5052]. https://doi.org/10.1038/s41467-018-07345-0

Vancouver

The International Genomics of Blood Pressure (iGEN-BP) Consortium. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications. 2018;9. 5052. https://doi.org/10.1038/s41467-018-07345-0

Author

The International Genomics of Blood Pressure (iGEN-BP) Consortium. / Interethnic analyses of blood pressure loci in populations of East Asian and European descent. In: Nature Communications. 2018 ; Vol. 9.

Bibtex

@article{e78e97f7bb1e41acaac2adde4178dce8,
title = "Interethnic analyses of blood pressure loci in populations of East Asian and European descent",
abstract = "Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.",
author = "Fumihiko Takeuchi and Masato Akiyama and Nana Matoba and Tomohiro Katsuya and Masahiro Nakatochi and Yasuharu Tabara and Akira Narita and Saw, {Woei Yuh} and Sanghoon Moon and Spracklen, {Cassandra N.} and Chai, {Jin Fang} and Kim, {Young Jin} and Liang Zhang and Chaolong Wang and Huaixing Li and Honglan Li and Wu, {Jer Yuarn} and Rajkumar Dorajoo and Nierenberg, {Jovia L.} and Wang, {Ya Xing} and Jing He and Bennett, {Derrick A.} and Atsushi Takahashi and Yukihide Momozawa and Makoto Hirata and Koichi Matsuda and Hiromi Rakugi and Eitaro Nakashima and Masato Isono and Matsuyuki Shirota and Atsushi Hozawa and Sahoko Ichihara and Tatsuaki Matsubara and Ken Yamamoto and Katsuhiko Kohara and Michiya Igase and Sohee Han and Penny Gordon-Larsen and Wei Huang and Lee, {Nanette R.} and Adair, {Linda S.} and Hwang, {Mi Yeong} and Ahluwalia, {Tarunveer S.} and Niels Grarup and Husemoen, {Lise L.N.} and Justesen, {Johanne M.} and Torben Hansen and Torben J{\o}rgensen and Allan Linneberg and Oluf Pedersen and {The International Genomics of Blood Pressure (iGEN-BP) Consortium}",
year = "2018",
doi = "10.1038/s41467-018-07345-0",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Interethnic analyses of blood pressure loci in populations of East Asian and European descent

AU - Takeuchi, Fumihiko

AU - Akiyama, Masato

AU - Matoba, Nana

AU - Katsuya, Tomohiro

AU - Nakatochi, Masahiro

AU - Tabara, Yasuharu

AU - Narita, Akira

AU - Saw, Woei Yuh

AU - Moon, Sanghoon

AU - Spracklen, Cassandra N.

AU - Chai, Jin Fang

AU - Kim, Young Jin

AU - Zhang, Liang

AU - Wang, Chaolong

AU - Li, Huaixing

AU - Li, Honglan

AU - Wu, Jer Yuarn

AU - Dorajoo, Rajkumar

AU - Nierenberg, Jovia L.

AU - Wang, Ya Xing

AU - He, Jing

AU - Bennett, Derrick A.

AU - Takahashi, Atsushi

AU - Momozawa, Yukihide

AU - Hirata, Makoto

AU - Matsuda, Koichi

AU - Rakugi, Hiromi

AU - Nakashima, Eitaro

AU - Isono, Masato

AU - Shirota, Matsuyuki

AU - Hozawa, Atsushi

AU - Ichihara, Sahoko

AU - Matsubara, Tatsuaki

AU - Yamamoto, Ken

AU - Kohara, Katsuhiko

AU - Igase, Michiya

AU - Han, Sohee

AU - Gordon-Larsen, Penny

AU - Huang, Wei

AU - Lee, Nanette R.

AU - Adair, Linda S.

AU - Hwang, Mi Yeong

AU - Ahluwalia, Tarunveer S.

AU - Grarup, Niels

AU - Husemoen, Lise L.N.

AU - Justesen, Johanne M.

AU - Hansen, Torben

AU - Jørgensen, Torben

AU - Linneberg, Allan

AU - Pedersen, Oluf

AU - The International Genomics of Blood Pressure (iGEN-BP) Consortium

PY - 2018

Y1 - 2018

N2 - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

AB - Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

U2 - 10.1038/s41467-018-07345-0

DO - 10.1038/s41467-018-07345-0

M3 - Journal article

C2 - 30487518

AN - SCOPUS:85057523899

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 5052

ER -

ID: 212125694