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GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment
Gabe, M. B. N., Skov-Jeppesen, Kirsa, Gasbjerg, Lærke Smidt, Schiellerup, S. P., Martinussen, C., Gadgaard, S., Boer, G. A., Oeke, J., Pedersen, Lola Julie Torz, Veedfald, Simon, Svane, M. S., Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, M. M., 2022, In: Pharmacological Research. 176, 106058.Research output: Contribution to journal › Journal article › Research › peer-review
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GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists
Holst, Jens Juul & Rosenkilde, M. M., 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 8, p. E2710-E2716 7 p.Research output: Contribution to journal › Review › Research › peer-review
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GIP infusion in patients with type 1 diabetes seems to attenuate post-prandial glucose excursions after prandial insulin over-dose and physical activity
Hoe, B., Heimburger, S. M. N., Gasbjerg, L. S., Lanng, A. R., Lynggaard, M. B., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Lund, A., Engberg, S., Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Diabetologia. 63, Suppl. 1, p. S117 1 p., 232.Research output: Contribution to journal › Conference abstract in journal › Research
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GIP receptor deletion in mice confers resistance to HFD-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism
Boer, G. A., Keenan, S. N., Miotto, P. M., Holst, Jens Juul & Watt, M. J., 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, 4, p. E835-E845 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2
Gasbjerg, Lærke Smidt, Hartmann, Bolette, Christensen, Mikkel Bring, Lanng, A. R., Vilsbøll, Tina, Jørgensen, Niklas Rye, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 130, 6 p., 115079 .Research output: Contribution to journal › Journal article › Research › peer-review
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GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release
wbf943, wbf943, Gabe, M. N., Gasbjerg, Lærke Smidt, Christiansen, Charlotte Bayer, Svendsen, B., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2017, In: Biochemical Pharmacology. 131, p. 78-88Research output: Contribution to journal › Journal article › Research › peer-review
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GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study
Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Hartmann, Bolette, Lanng, A. R., wbf943, wbf943, Gabe, M. B. N., Dela, Flemming, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, Feb 2018, In: Diabetologia. 61, 2, p. 413-423Research output: Contribution to journal › Journal article › Research › peer-review
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GIP-induced vasodilation in human adipose tissue involves capillary recruitment
Asmar, M., Asmar, A., Simonsen, L., Dela, Flemming, Holst, Jens Juul & Bulow, J., Jun 2019, In: Endocrine Connections. 8, 6, p. 806-813Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 - Incretin and pleiotropic hormone with pharmacotherapy potential. Increasing secretion of endogenous GLP-1 for diabetes and obesity therapy
Holst, Jens Juul, Jepsen, Sara Lind & Modvig, Ida Marie, 2022, In: Current Opinion in Pharmacology. 63, p. 1-7 102189.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Amidation Efficiency Along the Length of the Intestine in Mice, Rats and Pigs and in GLP-1 Secreting Cell Lines
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Svendsen, B., Hartmann, Bolette & Holst, Jens Juul, 31 Jan 2014, In: Peptides. 55, p. 52-57 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report
Iepsen, E. W., Have, C. T., Veedfald, Simon, Madsbad, Sten, Holst, Jens Juul, Grarup, Niels, Pedersen, Oluf Borbye, Brandslund, I., Holm, Jens-Christian, Hansen, Torben & Torekov, Signe Sørensen, 2020, In: Cell Reports Medicine. 1, 1, 8 p., 100006.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats
van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 effect on ß-cell function varies according to diabetes remission status after RYGB
Shah, A., Prasad, M., Mark, V., Holst, Jens Juul & Laferrère, B., 2022, In: Diabetes, Obesity and Metabolism. 24, 11, p. 2081-2089Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women
Iepsen, E. P. W., Lundgren, J. R., Hartmann, Bolette, Pedersen, Oluf Borbye, Hansen, Torben, Jørgensen, Niklas Rye, Jensen, J. B., Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2015, In: The Journal of clinical endocrinology and metabolism. 100, 8, p. 2909 –2917 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals
Larsson, M., Patrone, C., von Euler, M., Holst, Jens Juul & Nathanson, D., 2019, In: Cardiovascular Diabetology. 18, 8 p., 91.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in pre-hypertensive rats
Jensen, E. P., Møller, S., Hviid, A. V. R., Veedfald, Simon, Holst, Jens Juul, Pedersen, Jens, Ørskov, Cathrine & Sorensen, Charlotte Mehlin, 2020, In: American Journal of Physiology: Renal Physiology. 318, 6, p. F1409-F1417Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men
Skov-Jeppesen, Kirsa, Svane, M. S., Martinussen, C., Gabe, M. B. N., Gasbjerg, Lærke Smidt, Veedfald, Simon, Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2019, In: Bone. 125, p. 178-185Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1
Guan, X., Stoll, B., Lu, X., Tappenden, K. A., Holst, Jens Juul, Hartmann, Bolette & Burrin, D. G., Jul 2003, In: Gastroenterology. 125, 1, p. 136-47 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass
Guimarães, M., Rodrigues, P., Pereira, S. S., Nora, M., Gonçalves, G., Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Holst, Jens Juul & Monteiro, M. P., 2015, In: Endocrinology, Diabetes & Metabolism Case Reports. 2015, p. 1-5 5 p., 150049.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness
Svendsen, B., Pais, R., Engelstoft, M. S., Milev, N. B., Richards, P., Christiansen, Charlotte Bayer, Egerod, Kristoffer Lihme, Jensen, S. M., Habib, A. M., Gribble, F. M., Schwartz, Thue W., Reimann, F. & Holst, Jens Juul, 2016, In: Journal of Endocrinology. 228, 1, p. 39-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report
Zhang, J., Juhl, C. R., Hylten-Cavallius, L., Olesen, Morten Steen Salling, Linneberg, Allan René, Holst, Jens Juul, Hansen, Torben, Kanters, Jørgen K. & Torekov, Signe Sørensen, 2020, In: B M C Endocrine Disorders. 20, 5 p., 38.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake
Gether, I. M., Jensen, M. M., Nexøe-Larsen, C. C., Jorsal, T., Gasbjerg, Lærke Smidt, Naver, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2022, In: Obesity Surgery. 32, p. 1385–1390Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric Bypass with Different Biliopancreatic Limb Lengths Results in Similar Post-absorptive Metabolomics Profiles
Jarak, I., Pereira, S. S., Carvalho, R. A., Oliveira, P. F., Alves, M. G., Guimarães, M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2020, In: Obesity Surgery. 30, 3, p. 1068-1078 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric Emptying and Distal Gastrectomy Independently Enhance Postprandial Glucagon-Like Peptide-1 Release After a Mixed Meal and Improve Glycemic Control in Subjects Having Undergone Pancreaticoduodenectomy
Steiner, E., Breuer, R., Kazianka, L., Wewalka, M., Stimpfl, T., Reiter, B., Holst, Jens Juul & Miholic, J., 2019, In: Pancreas. 48, 7, p. 953-957Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric Residual to Predict Necrotizing Enterocolitis in Preterm Piglets As Models for Infants
Kappel, S. S., Sangild, Per Torp, Hilsted, Linda, Hartmann, Bolette, Thymann, Thomas & Aunsholt, Lise, 2021, In: Journal of Parenteral and Enteral Nutrition. 45, 1, p. 87-93Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study
Wolnerhanssen, B. K., Drewe, J., Verbeure, W., le Roux, C. W., Dellatorre-Teixeira, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Hartmann, Bolette, Tack, J., Peterli, R., Beglinger, C. & Meyer-Gerspach, A. C., 2021, In: Diabetes, Obesity and Metabolism. 23, 6, p. 1311-1321Research output: Contribution to journal › Journal article › Research › peer-review
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Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg)
Fatima, F., Hjelmesæth, J., Birkeland, K. I., Hanne, G. L., Hertel, J. K., Svanevik, M., Sandbu, R., Småstuen, M. C., Hartmann, Bolette, Holst, Jens Juul & Hofsø, D., 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 2, p. e756-e766 11 p., dgab643.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastrointestinal hormones and appetite ratings after weight loss induced by diet or bariatric surgery
Aukan, M. I., Skårvold, S., Brandsaeter, I. Ø., Rehfeld, Jens Frederik, Holst, Jens Juul, Nymo, S., Coutinho, S. & Martins, C., 2023, In: Obesity. 31, 2, p. 399-411 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis
Broberg, B., Madsen, J. L., Fuglsang, S., Holst, Jens Juul, Christensen, Karl Bang, Rydahl, C., Idorn, T., Feldt-Rasmussen, Bo & Hornum, Mads, 2019, In: Neurogastroenterology and Motility. 31, 4, e13554.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastrointestinal motility, gut hormone secretion, and energy intake after oral loads of free fatty acid or triglyceride in older and middle-aged men
Madsen, J. L., Damgaard, Morten, Fuglsang, S., Dirksen, C., Holst, Jens Juul & Graff, J., 2019, In: Appetite. 132, p. 18-24 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test
Jonsson, Anna Elisabet, Stinson, Sara, Torekov, Signe Sørensen, Clausen, Tine Dalsgaard, Færch, K., Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth, Damm, Peter, Witte, D. R., Jørgensen, M. E., Pedersen, Oluf Borbye, Holst, Jens Juul & Hansen, Torben, 2021, In: BMC Medical Genomics. 14, 7 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin Does Not Directly Stimulate Secretion of Glucagon-like Peptide-1
Jepsen, Sara Lind, Vestergaard, E. T., Larraufie, P., Gribble, F. M., Reimann, F., Jorgensen, J. O. L., Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 1, p. 266-275Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin secretion in humans - a role for the vagus nerve?
Veedfald, Simon, Plamboeck, A., Hartmann, Bolette, Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F., Svendsen, Lars Bo & Holst, Jens Juul, Jun 2018, In: Neurogastroenterology and Motility. 30, 6, e13295.Research output: Contribution to journal › Journal article › Research › peer-review
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Glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, for patients with short bowel syndrome: a randomised phase 2 trial
Naimi, R. M., Hvistendahl, M., Enevoldsen, L. H., Madsen, J. L., Fuglsang, S., Poulsen, Steen Seier, Kissow, Hannelouise, Pedersen, Jens, Nerup, N., Ambrus, R., Achiam, Michael Patrick, Svendsen, L. B., Holst, Jens Juul, Hartmann, Bolette, Hansen, S. H., Dragsted, Lars Ove, Steensberg, A., Mouritzen, U., Hansen, M. B. & Jeppesen, Palle Bekker, 2019, In: The Lancet Gastroenterology and Hepatology. 4, 5, p. 354-363 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon 100 years. Important, but still enigmatic
Holst, Jens Juul, 2023, In: Peptides. 161, 6 p., 170942.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon Clearance is Preserved in Type 2 Diabetes
Grøndahl, M. F. G., Lund, A., Bagger, J. I., Petersen, Tonny Studsgaard, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: Diabetes. 71, 1, db210024.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon Receptor Signaling and Glucagon Resistance
Janah, L., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Stojanovska, E., Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences. 20, 13, 27 p., 3314.Research output: Contribution to journal › Review › Research › peer-review
- Published
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Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic Steatosis
Suppli, M. P., Bagger, J. I., Lund, A., Demant, M., van Hall, Gerrit, Strandberg, C., Kønig, M. J., Rigbolt, K., Langhoff, J. L., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Diabetes. 69, 6, p. 1090-1099 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis
Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., Treebak, J. T., Gillum, M. P., Torekov, S. S., Windeløv, J. A., Hunt, J. E., Kjeldsen, S. A. S., Jepsen, S. L., Vasilopoulou, C. G., Knop, F. K., Ørskov, C. & 7 others, , 2020, In: Molecular Metabolism. 42, 18 p., 101080.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity
Holst, Jens Juul, 2022, In: Frontiers in Nutrition. 9, 8 p., 964406.Research output: Contribution to journal › Review › Research › peer-review
- Published
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Galsgaard, Katrine Douglas, Elmelund, E., Johansen, C. D., Billeschou, Anna, Kizilkaya, Hüsün Sheyma, Ceutz, F., Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Winther-Sørensen, Marie, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Rosenkilde, Mette, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Molecular Metabolism. 66, 14 p., 101639.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon receptor signaling is not required for N-carbamoyl glutamate- And L-citrulline-induced ureagenesis in mice
Galsgaard, Katrine Douglas, Pedersen, Jens, Kjeldsen, Sasha Alexandra Sampson, Winther-Sørensen, Marie, Stojanovska, E., Vilstrup, H., Ørskov, Cathrine, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2020, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 318, 5, p. G912-G927Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-Like Peptide 1 and Atrial Natriuretic Peptide in a Female Mouse Model of Obstructive Pulmonary Disease
Balk-Møller, E., Windeløv, Johanne Agerlin, Svendsen, B., Dal, Jenna Elizabeth Hunt, Ghiasi, S. M., Sorensen, Charlotte Mehlin, Holst, Jens Juul & Kissow, Hannelouise, 2020, In: Endocrine Research. 4, 1, 19 p., bvz034.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study
Hansen, N. L., Brønden, Andreas, Nexoe-Larsen, C. C., Christensen, A. S., Sonne, D. P., Rehfeld, Jens Frederik, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2020, In: Clinical and Translational Gastroenterology. 11, 12, 9 p., e00257.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans
Halim, M. A., Degerblad, M., Sundbom, M., Karlbom, U., Holst, Jens Juul, Webb, D. & Hellstrom, P. M., 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 2, p. 575-585Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-Like Peptide-1 Is Associated With Systemic Inflammation in Pediatric Patients Treated With Hematopoietic Stem Cell Transplantation
Sørum, Maria Ebbesen, Kissow, Hannelouise, Hartmann, Bolette, Kielsen, K., Sørensen, K., Stinson, Sara, Frithioff-Bojsoe, C., Fonvig, Cilius Esmann, Holm, Jens-Christian, Hansen, Torben, Holst, Jens Juul & Müller, K. G., 2021, In: Frontiers in Immunology. 12, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 1 (GLP-1)
Mueller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W., Meier, J. J., Nauck, M. A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D. A., Schwartz, T. W., Seeley, R. J. & 5 others, , 2019, In: Molecular Metabolism. 30, p. 72-130Research output: Contribution to journal › Review › Research › peer-review
- Published
Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice
Thulesen, J., Hartmann, Bolette, Hare, K. J., Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens Juul & Poulsen, Steen Seier, Aug 2004, In: Gut. 53, 8, p. 1145-1150 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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