Juul Holst Group

  1. Published

    GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment

    Gabe, M. B. N., Skov-Jeppesen, Kirsa, Gasbjerg, Lærke Smidt, Schiellerup, S. P., Martinussen, C., Gadgaard, S., Boer, G. A., Oeke, J., Pedersen, Lola Julie Torz, Veedfald, Simon, Svane, M. S., Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, M. M., 2022, In: Pharmacological Research. 176, 106058.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists

    Holst, Jens Juul & Rosenkilde, M. M., 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 8, p. E2710-E2716 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    GIP infusion in patients with type 1 diabetes seems to attenuate post-prandial glucose excursions after prandial insulin over-dose and physical activity

    Hoe, B., Heimburger, S. M. N., Gasbjerg, L. S., Lanng, A. R., Lynggaard, M. B., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Lund, A., Engberg, S., Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Diabetologia. 63, Suppl. 1, p. S117 1 p., 232.

    Research output: Contribution to journalConference abstract in journalResearch

  4. Published

    GIP receptor deletion in mice confers resistance to HFD-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism

    Boer, G. A., Keenan, S. N., Miotto, P. M., Holst, Jens Juul & Watt, M. J., 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, 4, p. E835-E845 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published
  6. Published

    GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

    wbf943, wbf943, Gabe, M. N., Gasbjerg, Lærke Smidt, Christiansen, Charlotte Bayer, Svendsen, B., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2017, In: Biochemical Pharmacology. 131, p. 78-88

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published
  8. Published

    GIP-induced vasodilation in human adipose tissue involves capillary recruitment

    Asmar, M., Asmar, A., Simonsen, L., Dela, Flemming, Holst, Jens Juul & Bulow, J., Jun 2019, In: Endocrine Connections. 8, 6, p. 806-813

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    GLP-1 - Incretin and pleiotropic hormone with pharmacotherapy potential. Increasing secretion of endogenous GLP-1 for diabetes and obesity therapy

    Holst, Jens Juul, Jepsen, Sara Lind & Modvig, Ida Marie, 2022, In: Current Opinion in Pharmacology. 63, p. 1-7 102189.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    GLP-1 Amidation Efficiency Along the Length of the Intestine in Mice, Rats and Pigs and in GLP-1 Secreting Cell Lines

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Svendsen, B., Hartmann, Bolette & Holst, Jens Juul, 31 Jan 2014, In: Peptides. 55, p. 52-57 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

    Iepsen, E. W., Have, C. T., Veedfald, Simon, Madsbad, Sten, Holst, Jens Juul, Grarup, Niels, Pedersen, Oluf Borbye, Brandslund, I., Holm, Jens-Christian, Hansen, Torben & Torekov, Signe Sørensen, 2020, In: Cell Reports Medicine. 1, 1, 8 p., 100006.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    GLP-1 and Intestinal Diseases

    Dal, Jenna Elizabeth Hunt, Holst, Jens Juul, Jeppesen, Palle Bekker & Kissow, Hannelouise, 2021, In: Biomedicines. 9, 4, 14 p., 383.

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    GLP-1 effect on ß-cell function varies according to diabetes remission status after RYGB

    Shah, A., Prasad, M., Mark, V., Holst, Jens Juul & Laferrère, B., 2022, In: Diabetes, Obesity and Metabolism. 24, 11, p. 2081-2089

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women

    Iepsen, E. P. W., Lundgren, J. R., Hartmann, Bolette, Pedersen, Oluf Borbye, Hansen, Torben, Jørgensen, Niklas Rye, Jensen, J. B., Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2015, In: The Journal of clinical endocrinology and metabolism. 100, 8, p. 2909 –2917 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    GLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals

    Larsson, M., Patrone, C., von Euler, M., Holst, Jens Juul & Nathanson, D., 2019, In: Cardiovascular Diabetology. 18, 8 p., 91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in pre-hypertensive rats

    Jensen, E. P., Møller, S., Hviid, A. V. R., Veedfald, Simon, Holst, Jens Juul, Pedersen, Jens, Ørskov, Cathrine & Sorensen, Charlotte Mehlin, 2020, In: American Journal of Physiology: Renal Physiology. 318, 6, p. F1409-F1417

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men

    Skov-Jeppesen, Kirsa, Svane, M. S., Martinussen, C., Gabe, M. B. N., Gasbjerg, Lærke Smidt, Veedfald, Simon, Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2019, In: Bone. 125, p. 178-185

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1

    Guan, X., Stoll, B., Lu, X., Tappenden, K. A., Holst, Jens Juul, Hartmann, Bolette & Burrin, D. G., Jul 2003, In: Gastroenterology. 125, 1, p. 136-47 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass

    Guimarães, M., Rodrigues, P., Pereira, S. S., Nora, M., Gonçalves, G., Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Holst, Jens Juul & Monteiro, M. P., 2015, In: Endocrinology, Diabetes & Metabolism Case Reports. 2015, p. 1-5 5 p., 150049.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness

    Svendsen, B., Pais, R., Engelstoft, M. S., Milev, N. B., Richards, P., Christiansen, Charlotte Bayer, Egerod, Kristoffer Lihme, Jensen, S. M., Habib, A. M., Gribble, F. M., Schwartz, Thue W., Reimann, F. & Holst, Jens Juul, 2016, In: Journal of Endocrinology. 228, 1, p. 39-48 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report

    Zhang, J., Juhl, C. R., Hylten-Cavallius, L., Olesen, Morten Steen Salling, Linneberg, Allan René, Holst, Jens Juul, Hansen, Torben, Kanters, Jørgen K. & Torekov, Signe Sørensen, 2020, In: B M C Endocrine Disorders. 20, 5 p., 38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake

    Gether, I. M., Jensen, M. M., Nexøe-Larsen, C. C., Jorsal, T., Gasbjerg, Lærke Smidt, Naver, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2022, In: Obesity Surgery. 32, p. 1385–1390

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Gastric Bypass with Different Biliopancreatic Limb Lengths Results in Similar Post-absorptive Metabolomics Profiles

    Jarak, I., Pereira, S. S., Carvalho, R. A., Oliveira, P. F., Alves, M. G., Guimarães, M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2020, In: Obesity Surgery. 30, 3, p. 1068-1078 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Gastric Emptying and Distal Gastrectomy Independently Enhance Postprandial Glucagon-Like Peptide-1 Release After a Mixed Meal and Improve Glycemic Control in Subjects Having Undergone Pancreaticoduodenectomy

    Steiner, E., Breuer, R., Kazianka, L., Wewalka, M., Stimpfl, T., Reiter, B., Holst, Jens Juul & Miholic, J., 2019, In: Pancreas. 48, 7, p. 953-957

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Gastric Residual to Predict Necrotizing Enterocolitis in Preterm Piglets As Models for Infants

    Kappel, S. S., Sangild, Per Torp, Hilsted, Linda, Hartmann, Bolette, Thymann, Thomas & Aunsholt, Lise, 2021, In: Journal of Parenteral and Enteral Nutrition. 45, 1, p. 87-93

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study

    Wolnerhanssen, B. K., Drewe, J., Verbeure, W., le Roux, C. W., Dellatorre-Teixeira, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Hartmann, Bolette, Tack, J., Peterli, R., Beglinger, C. & Meyer-Gerspach, A. C., 2021, In: Diabetes, Obesity and Metabolism. 23, 6, p. 1311-1321

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg)

    Fatima, F., Hjelmesæth, J., Birkeland, K. I., Hanne, G. L., Hertel, J. K., Svanevik, M., Sandbu, R., Småstuen, M. C., Hartmann, Bolette, Holst, Jens Juul & Hofsø, D., 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 2, p. e756-e766 11 p., dgab643.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Gastrointestinal hormones and appetite ratings after weight loss induced by diet or bariatric surgery

    Aukan, M. I., Skårvold, S., Brandsaeter, I. Ø., Rehfeld, Jens Frederik, Holst, Jens Juul, Nymo, S., Coutinho, S. & Martins, C., 2023, In: Obesity. 31, 2, p. 399-411 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis

    Broberg, B., Madsen, J. L., Fuglsang, S., Holst, Jens Juul, Christensen, Karl Bang, Rydahl, C., Idorn, T., Feldt-Rasmussen, Bo & Hornum, Mads, 2019, In: Neurogastroenterology and Motility. 31, 4, e13554.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Gastrointestinal motility, gut hormone secretion, and energy intake after oral loads of free fatty acid or triglyceride in older and middle-aged men

    Madsen, J. L., Damgaard, Morten, Fuglsang, S., Dirksen, C., Holst, Jens Juul & Graff, J., 2019, In: Appetite. 132, p. 18-24 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

    Jonsson, Anna Elisabet, Stinson, Sara, Torekov, Signe Sørensen, Clausen, Tine Dalsgaard, Færch, K., Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth, Damm, Peter, Witte, D. R., Jørgensen, M. E., Pedersen, Oluf Borbye, Holst, Jens Juul & Hansen, Torben, 2021, In: BMC Medical Genomics. 14, 7 p., 3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Ghrelin Does Not Directly Stimulate Secretion of Glucagon-like Peptide-1

    Jepsen, Sara Lind, Vestergaard, E. T., Larraufie, P., Gribble, F. M., Reimann, F., Jorgensen, J. O. L., Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 1, p. 266-275

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Ghrelin secretion in humans - a role for the vagus nerve?

    Veedfald, Simon, Plamboeck, A., Hartmann, Bolette, Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F., Svendsen, Lars Bo & Holst, Jens Juul, Jun 2018, In: Neurogastroenterology and Motility. 30, 6, e13295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, for patients with short bowel syndrome: a randomised phase 2 trial

    Naimi, R. M., Hvistendahl, M., Enevoldsen, L. H., Madsen, J. L., Fuglsang, S., Poulsen, Steen Seier, Kissow, Hannelouise, Pedersen, Jens, Nerup, N., Ambrus, R., Achiam, Michael Patrick, Svendsen, L. B., Holst, Jens Juul, Hartmann, Bolette, Hansen, S. H., Dragsted, Lars Ove, Steensberg, A., Mouritzen, U., Hansen, M. B. & Jeppesen, Palle Bekker, 2019, In: The Lancet Gastroenterology and Hepatology. 4, 5, p. 354-363 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Glucagon 100 years. Important, but still enigmatic

    Holst, Jens Juul, 2023, In: Peptides. 161, 6 p., 170942.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Glucagon Clearance is Preserved in Type 2 Diabetes

    Grøndahl, M. F. G., Lund, A., Bagger, J. I., Petersen, Tonny Studsgaard, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: Diabetes. 71, 1, db210024.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Glucagon Receptor Signaling and Glucagon Resistance

    Janah, L., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Stojanovska, E., Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences. 20, 13, 27 p., 3314.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Glucagon Receptor Signaling and Lipid Metabolism

    Galsgaard, Katrine Douglas, Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: Frontiers in Physiology. 10, 11 p., 413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic Steatosis

    Suppli, M. P., Bagger, J. I., Lund, A., Demant, M., van Hall, Gerrit, Strandberg, C., Kønig, M. J., Rigbolt, K., Langhoff, J. L., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Diabetes. 69, 6, p. 1090-1099 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis

    Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., Treebak, J. T., Gillum, M. P., Torekov, S. S., Windeløv, J. A., Hunt, J. E., Kjeldsen, S. A. S., Jepsen, S. L., Vasilopoulou, C. G., Knop, F. K., Ørskov, C. & 7 others, Werge, M. P., Bisgaard, Hanne Cathrine, Eriksen, P. L., Vilstrup, H., Gluud, Lise Lotte, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Molecular Metabolism. 42, 18 p., 101080.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity

    Holst, Jens Juul, 2022, In: Frontiers in Nutrition. 9, 8 p., 964406.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published
  44. Published

    Glucagon receptor signaling is not required for N-carbamoyl glutamate- And L-citrulline-induced ureagenesis in mice

    Galsgaard, Katrine Douglas, Pedersen, Jens, Kjeldsen, Sasha Alexandra Sampson, Winther-Sørensen, Marie, Stojanovska, E., Vilstrup, H., Ørskov, Cathrine, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2020, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 318, 5, p. G912-G927

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Glucagon-Like Peptide 1 and Atrial Natriuretic Peptide in a Female Mouse Model of Obstructive Pulmonary Disease

    Balk-Møller, E., Windeløv, Johanne Agerlin, Svendsen, B., Dal, Jenna Elizabeth Hunt, Ghiasi, S. M., Sorensen, Charlotte Mehlin, Holst, Jens Juul & Kissow, Hannelouise, 2020, In: Endocrine Research. 4, 1, 19 p., bvz034.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study

    Hansen, N. L., Brønden, Andreas, Nexoe-Larsen, C. C., Christensen, A. S., Sonne, D. P., Rehfeld, Jens Frederik, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2020, In: Clinical and Translational Gastroenterology. 11, 12, 9 p., e00257.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans

    Halim, M. A., Degerblad, M., Sundbom, M., Karlbom, U., Holst, Jens Juul, Webb, D. & Hellstrom, P. M., 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 2, p. 575-585

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Glucagon-Like Peptide-1 Is Associated With Systemic Inflammation in Pediatric Patients Treated With Hematopoietic Stem Cell Transplantation

    Sørum, Maria Ebbesen, Kissow, Hannelouise, Hartmann, Bolette, Kielsen, K., Sørensen, K., Stinson, Sara, Frithioff-Bojsoe, C., Fonvig, Cilius Esmann, Holm, Jens-Christian, Hansen, Torben, Holst, Jens Juul & Müller, K. G., 2021, In: Frontiers in Immunology. 12, 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Glucagon-like peptide 1 (GLP-1)

    Mueller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W., Meier, J. J., Nauck, M. A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D. A., Schwartz, T. W., Seeley, R. J. & 5 others, Stemmer, K., Tang-Christensen, M., Woods, S. C., DiMarchi, R. D. & Tschoep, M. H., 2019, In: Molecular Metabolism. 30, p. 72-130

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice

    Thulesen, J., Hartmann, Bolette, Hare, K. J., Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens Juul & Poulsen, Steen Seier, Aug 2004, In: Gut. 53, 8, p. 1145-1150 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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