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Proglucagon processing in porcine and human pancreas
Holst, Jens Juul, Bersani, M., Johnsen, A. H., Kofod, H., Hartmann, Bolette & Ørskov, Cathrine, 1994, In: Journal of Biological Chemistry. 269, 29, p. 18827-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications
Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381Research output: Contribution to journal › Journal article › Research › peer-review
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What is Diabetes Remission?
Holst, Jens Juul & Madsbad, Sten, 2021, In: Diabetes Therapy. 12, p. 641-646 6 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Methods and Guidelines for Measurement of Glucagon in Plasma
Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences (Online). 20, 10 p., 5416.Research output: Contribution to journal › Review › Research › peer-review
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Secretion and Impact of Gut Hormones in Obesity and Diabetes
Holst, Jens Juul, 2023, Encyclopedia of Cell Biology: Systems, Translational and Specialized Cell Aspects of Cell Biology. Bradshaw, R. A., Hart, G. W. & Stahl, P. D. (eds.). 2 ed. Elsevier, Vol. 6. p. 543-550 8 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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What combines best with GLP-1 for obesity treatment: GIP receptor agonists or antagonists?
Holst, Jens Juul, 2021, In: Cell Reports Medicine. 2, 5, 2 p., 100284.Research output: Contribution to journal › Comment/debate › Research
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The role of incretins on insulin function and glucose homeostasis
Holst, Jens Juul, Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2021, In: Endocrinology. 162, 7, 10 p., bqab065.Research output: Contribution to journal › Review › Research › peer-review
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Incretin therapy for diabetes mellitus type 2
Holst, Jens Juul, 2020, In: Current Opinion in Endocrinology, Diabetes and Obesity. 27, 1, p. 2-10Research output: Contribution to journal › Review › Research › peer-review
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Long-acting glucagon-like peptide-1 receptor agonist-status December 2018
Holst, Jens Juul, 2019, In: Annals of Translational Medicine. 7, 5, 6 p., 83 .Research output: Contribution to journal › Editorial › Research
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Incretin-based therapy of metabolic disease
Holst, Jens Juul, 2023, In: Danish Medical Journal. 70, 1, A10220597.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 (GLP-1): are its roles as endogenous hormone and therapeutic wizard congruent?
Holst, Jens Juul, 2022, In: Journal of Internal Medicine. 291, 5, p. 557-573Research output: Contribution to journal › Review › Research › peer-review
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Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture
Holst, Jens Juul, 2021, In: Diabetes. 70, 11, p. 2468-2475 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity
Holst, Jens Juul, 2022, In: Frontiers in Nutrition. 9, 8 p., 964406.Research output: Contribution to journal › Review › Research › peer-review
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Discovery of the GI Effects of GLP-1: An Historical Perspective
Holst, Jens Juul, 2022, In: Digestive Diseases and Sciences. 67, p. 2716-2720Research output: Contribution to journal › Review › Research › peer-review
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Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate
Holst, Jens Juul, Hartmann, Bolette, Gottschalck, I. B., Jeppesen, Palle Bekker, Miholic, J. & Henriksen, D. B., Jul 2007, In: Scandinavian Journal of Gastroenterology. 42, 7, p. 814-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recent advances of GIP and future horizons
Holst, Jens Juul & Rosenkilde, Mette, 2020, In: Peptides. 125, 6 p., 170230.Research output: Contribution to journal › Review › Research › peer-review
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Which to choose, an oral or an injectable glucagon-like peptide-1 receptor agonist?
Holst, Jens Juul, 2019, In: The Lancet. 394, 10192, p. 4-6Research output: Contribution to journal › Editorial › Research › peer-review
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GLP-1 - Incretin and pleiotropic hormone with pharmacotherapy potential. Increasing secretion of endogenous GLP-1 for diabetes and obesity therapy
Holst, Jens Juul, Jepsen, Sara Lind & Modvig, Ida Marie, 2022, In: Current Opinion in Pharmacology. 63, p. 1-7 102189.Research output: Contribution to journal › Journal article › Research › peer-review
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GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists
Holst, Jens Juul & Rosenkilde, M. M., 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 8, p. E2710-E2716 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Glucagon 100 years. Important, but still enigmatic
Holst, Jens Juul, 2023, In: Peptides. 161, 6 p., 170942.Research output: Contribution to journal › Journal article › Research › peer-review
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Searching for the physiological role of glucose-dependent insulinotropic polypeptide
Holst, Jens Juul, Windeløv, Johanne Agerlin, Boer, G. A., Pedersen, Jens, Svendsen, B., Christensen, M., Torekov, Signe Sørensen, Asmar, M., Hartmann, Bolette & Nissen, A., 1 Apr 2016, In: Journal of Diabetes Investigation. 7, S1, p. 8-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy
Holst, Jens Juul, 2019, In: Frontiers in Endocrinology. 10, 10 p., 260.Research output: Contribution to journal › Review › Research › peer-review
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The incretin system in healthy humans: The role of GIP and GLP-1
Holst, Jens Juul, 2019, In: Metabolism. 96, p. 46-55Research output: Contribution to journal › Journal article › Research › peer-review
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Actions of glucagon-like peptide-1 receptor ligands in the gut
Holst, Jens Juul, Andersen, Daniel Bjørklund & Grunddal, Kaare Villum, 2022, In: British Journal of Pharmacology. 179, 4, p. 727-742Research output: Contribution to journal › Review › Research › peer-review
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New Lessons from the gut: Studies of the role of gut peptides in weight loss and diabetes resolution after gastric bypass and sleeve gastrectomy
Holst, Jens Juul, Madsbad, Sten, Bojsen-Møller, Kirstine Nyvold, Dirksen, C. & Svane, M., 2024, In: Peptides. 176, 9 p., 171199.Research output: Contribution to journal › Review › Research › peer-review
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Glucagon-like peptides 1 and 2, enteroglucagon, glicentin and oxyntomodulin
Holst, Jens Juul, Deacon, Carolyn F., Hartmann, Bolette & Pedersen, Jens, 2013, Handbook of Biologically Active Peptides . Kastin, AJ. (ed.). 2 ed. Elsevier, p. 1241-1250 10 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Dietary impact on fasting and stimulated GLP-1 secretion in different metabolic conditions - a narrative review
Huber, H., Schieren, A., Holst, Jens Juul & Simon, M., 2024, In: The American Journal of Clinical Nutrition. 119, 3, p. 599-627Research output: Contribution to journal › Review › Research › peer-review
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Glucose- and Bile Acid-Stimulated Secretion of Gut Hormones in the Isolated Perfused Intestine Is Not Impaired in Diet-Induced Obese Mice
Dal, Jenna Elizabeth Hunt, Holst, Jens Juul & Jepsen, Sara Lind, 2022, In: Frontiers in Endocrinology. 13, 10 p., 884501.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2 dependent pathway in mice
Dal, Jenna Elizabeth Hunt, Billeschou, Anna, Windeløv, Johanne Agerlin, Hartmann, Bolette, Ullmer, C., Holst, Jens Juul & Kissow, Hannelouise, 2020, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 318, 6, p. G980-G987Research output: Contribution to journal › Journal article › Research › peer-review
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Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice
Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Schoonjans, K., Holst, Jens Juul & Kissow, Hannelouise, 2021, In: Frontiers in Endocrinology. 12, 10 p., 640602.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors
Dal, Jenna Elizabeth Hunt, Yassin, M., Olsen, Jørgen, Hartmann, Bolette, Holst, Jens Juul & Kissow, Hannelouise, 2021, In: Frontiers in Endocrinology. 12, 7 p., 695145.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of liraglutide treatment on jejunostomy output in patients with short bowel syndrome: An open-label pilot study
Hvistendahl, M., Brandt, C. F., Tribler, S., Naimi, R. M., Hartmann, Bolette, Holst, Jens Juul, Rehfeld, Jens Frederik, Hornum, Mads, Andersen, Jens Rikardt, Henriksen, B. M., Brøbech Mortensen, P. & Jeppesen, Palle Bekker, 2018, In: Journal of Parenteral and Enteral Nutrition. 42, 1, p. 112-121 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes
Hygum, K., Starup-Linde, J., Harslor, T., Jørgensen, Niklas Rye, Hartmann, Bolette, Holst, Jens Juul & Langdahl, B. L., 2019, In: European Journal of Endocrinology. 181, 3, p. 221-231Research output: Contribution to journal › Journal article › Research › peer-review
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Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia
Hyltén-Cavallius, L., Iepsen, E. W., Albrechtsen, Nicolai Jacob Wewer, Svendstrup, M., Lubberding, Anniek Frederike, Hartmann, Bolette, Jespersen, Thomas, Linneberg, Allan René, Christiansen, M., drb459, drb459, Pedersen, Oluf Borbye, Holst, Jens Juul, Kanters, Jørgen K., Hansen, Torben & Torekov, Signe Sørensen, 2017, In: Circulation. 135, 18, p. 1705-1719 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endogenous glucagon-like peptide- 1 and 2 are essential for regeneration after acute intestinal injury in mice
Hytting-Andreasen, R., Balk-Møller, E., Hartmann, Bolette, Pedersen, Jens, Windeløv, Johanne Agerlin, Holst, Jens Juul & Kissow, Hannelouise, 2018, In: PLoS ONE. 13, 6, p. 1-14 e0198046.Research output: Contribution to journal › Journal article › Research › peer-review
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The glucagon receptor antagonist LY2409021 does not affect gastrointestinal-mediated glucose disposal or the incretin effect in individuals with and without type 2 diabetes
Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., Forman, Julie Lyng, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 187, 4, p. 507-518 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes
Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of glucagon in the acute therapeutic effects of SGLT2 inhibition
Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 12, p. 2619-2629 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women
Iepsen, E. P. W., Lundgren, J. R., Hartmann, Bolette, Pedersen, Oluf Borbye, Hansen, Torben, Jørgensen, Niklas Rye, Jensen, J. B., Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2015, In: The Journal of clinical endocrinology and metabolism. 100, 8, p. 2909 –2917 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adults with pathogenic MC4R mutations have increased final height and thereby increased bone mass
Iepsen, E. W., Zhang, J., Hollensted, M., Madsbad, Sten, Hansen, Torben, Holst, Jens Juul, Jørgensen, Niklas Rye, Holm, Jens-Christian & Torekov, Signe Sørensen, 2020, In: Journal of Bone and Mineral Metabolism. 38, 1, p. 117-125 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report
Iepsen, E. W., Have, C. T., Veedfald, Simon, Madsbad, Sten, Holst, Jens Juul, Grarup, Niels, Pedersen, Oluf Borbye, Brandslund, I., Holm, Jens-Christian, Hansen, Torben & Torekov, Signe Sørensen, 2020, In: Cell Reports Medicine. 1, 1, 8 p., 100006.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of aerobic training and semaglutide treatment on pancreatic β-cell secretory function in patients with type 2 diabetes
Ingersen, Arthur, Schmücker, Malte, Alexandersen, C., Graungaard, B., Thorngreen, T., Borch, Jacob, Holst, Jens Juul, Helge, Jørn Wulff & Dela, Flemming, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2798–2811Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon Receptor Signaling and Glucagon Resistance
Janah, L., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Stojanovska, E., Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences. 20, 13, 27 p., 3314.Research output: Contribution to journal › Review › Research › peer-review
- Published
Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men
Janus, C., Vistisen, D., Amadid, H., Witte, D. R., Lauritzen, T., Brage, S., Bjerregaard, A., Hansen, Torben, Holst, Jens Juul, Jørgensen, M. E., Pedersen, Oluf Borbye, Færch, K. & Torekov, Signe Sørensen, 2019, In: Endocrine Connections. 8, 12, p. 1607–1617 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric Bypass with Different Biliopancreatic Limb Lengths Results in Similar Post-absorptive Metabolomics Profiles
Jarak, I., Pereira, S. S., Carvalho, R. A., Oliveira, P. F., Alves, M. G., Guimarães, M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2020, In: Obesity Surgery. 30, 3, p. 1068-1078 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery
Jensen, C. Z., Bojsen-Møller, K. N., Svane, M. S., Holst, L. M., Hermansen, K., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Kristiansen, V. B., Rehfeld, Jens Frederik, Clausen, T. R., Holst, Jens Juul & Madsbad, Sten, 2020, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 318, 4, p. G661-G672 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in pre-hypertensive rats
Jensen, E. P., Møller, S., Hviid, A. V. R., Veedfald, Simon, Holst, Jens Juul, Pedersen, Jens, Ørskov, Cathrine & Sorensen, Charlotte Mehlin, 2020, In: American Journal of Physiology: Renal Physiology. 318, 6, p. F1409-F1417Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent
Jensen, M. E., Galli, A., Thomsen, M., Jensen, Kathrine Louise, Thomsen, G. K., Klausen, M. K., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul, Owens, A., Robertson, S., Daws, L., Zanella, D., Gether, Ulrik, Knudsen, Gitte Moos & Fink-Jensen, Anders, 2020, In: Neurochemistry International. 138, 9 p., 104772.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of dietary carbohydrate restriction beyond weight loss on health-related quality of life and cognition
Jensen, N. J., Wodschow, H. Z., fbg982, fbg982, Samkani, A., Astrup, A., Frystyk, J., Hartmann, Bolette, Holst, Jens Juul, Larsen, T. M., Madsbad, Sten, Magkos, Faidon, Miskowiak, Kamilla, Rungby, Jørgen, Haugaard, Steen Bendix & Thomsen, M. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 62-63 114.Research output: Contribution to journal › Conference abstract in journal › Research
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Reply - Letter to the editor - On carbohydrate restriction and health-related quality of life and cognition in type 2 diabetes
Jensen, N. J., Thomsen, M. N., Skytte, M. J., Astrup, A., Holst, Jens Juul, Madsbad, Sten, Magkos, Faidon, Miskowiak, Kamilla, Haugaard, Steen Bendix, Krarup, T. & Rungby, Jørgen, 2022, In: Clinical Nutrition. 41, 9, p. 2061-2062 2 p.Research output: Contribution to journal › Comment/debate › Research
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Weight-loss induced by carbohydrate restriction does not negatively affect health-related quality of life and cognition in people with type 2 diabetes: A randomised controlled trial
Jensen, N. J., Wodschow, H. Z., Skytte, M. J., Samkani, A., Astrup, A., Frystyk, J., Hartmann, Bolette, Holst, Jens Juul, Larsen, T. M., Madsbad, Sten, Magkos, Faidon, Miskowiak, Kamilla, Haugaard, Steen Bendix, Krarup, T., Rungby, Jørgen & Thomsen, M. N., 2022, In: Clinical Nutrition. 41, 7, p. 1605-1612 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Weight loss maintenance with exercise and liraglutide improves glucose tolerance, glucagon response, and beta cell function
Jensen, Simon Birk Kjær, Juhl, C. R., Janus, C., Lundgren, J. R., Martinussen, C., Wiingaard, C., Knudsen, C., Frikke-Schmidt, Ruth, Stallknecht, Bente Merete, Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2023, In: Obesity. 31, 4, p. 977-989 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
Jensen, Simon Birk Kjær, Janus, C., Lundgren, J. R., Juhl, C. R., Sandsdal, Rasmus Michael, Olsen, L. M., Andresen, A., Borg, S. A., Jacobsen, I. C., Finlayson, G., Stallknecht, Bente Merete, Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2022, In: Nature Communications. 13, 1, 11 p., 4770.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet
Jensen, Simon Birk Kjær, Lundgren, J. R., Janus, C., Juhl, C. R., Olsen, L. M., Rosenkilde, M., Holst, Jens Juul, Stallknecht, Bente Merete, Madsbad, Sten & Torekov, Signe Sørensen, 2019, In: BMJ Open. 9, 11, 10 p., e031431.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon
Jeppesen, Palle Bekker, Hartmann, Bolette, Thulesen, J., Graff, J., Lohmann, J., Hansen, B. S., Tofteng, F., Poulsen, Steen Seier, Madsen, J. L., Holst, Jens Juul & Mortensen, P. B., Mar 2001, In: Gastroenterology. 120, 4, p. 806-815 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
Jeppesen, Palle Bekker, Hartmann, Bolette, Thulesen, J., Hansen, B. S., Holst, Jens Juul, Poulsen, Steen Seier & Mortensen, P. B., Sep 2000, In: Gut. 47, 3, p. 370-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner
Jepsen, Sara Lind, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Farb, T. B., Kissow, Hannelouise, Pedersen, J., Deacon, Carolyn F., Martin, R. E. & Holst, Jens Juul, 2021, In: JCI insight. 6, 4, 15 p., e143228.Research output: Contribution to journal › Journal article › Research › peer-review
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Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice
Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin Does Not Directly Stimulate Secretion of Glucagon-like Peptide-1
Jepsen, Sara Lind, Vestergaard, E. T., Larraufie, P., Gribble, F. M., Reimann, F., Jorgensen, J. O. L., Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 1, p. 266-275Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial
Johansen, M. Y., Karstoft, K., MacDonald, C. S., Hansen, K. B., Ellingsgaard, H., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Vaag, A. A., Holst, Jens Juul, Pedersen, Bente Klarlund & Ried-Larsen, M., 2020, In: Diabetologia. 63, p. 2410-2422 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficacy and safety of meal-time administration of short-acting exenatide for glycaemic control in type 1 diabetes (MAG1C): a randomised, double-blind, placebo-controlled trial
Johansen, N. J., Dejgaard, T. F., Lund, A., Schluntz, C., Frandsen, C. S., Forman, Julie Lyng, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Pedersen-Bjergaard, Ulrik, Madsbad, Sten, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2020, In: The Lancet Diabetes & Endocrinology. 8, 4, p. 313-324 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of short-acting exenatide added three times daily to insulin therapy on bone metabolism in type 1 diabetes
Johansen, N. J., Dejgaard, T. F., Lund, A., Schlüntz, Camilla, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 221-227Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test
Jonsson, Anna Elisabet, Stinson, Sara, Torekov, Signe Sørensen, Clausen, Tine Dalsgaard, Færch, K., Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth, Damm, Peter, Witte, D. R., Jørgensen, M. E., Pedersen, Oluf Borbye, Holst, Jens Juul & Hansen, Torben, 2021, In: BMC Medical Genomics. 14, 7 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass
Jonsson, I., Bojsen-Moller, K. N., Kristiansen, V. B., Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer, Clausen, T. R., Kuhre, Rune Ehrenreich, Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Svane, M. S., 2021, In: Frontiers in Endocrinology. 12, 11 p., 681116.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery
Jorsal, T., Wewer Albrechtsen, N. J., Christensen, M. M., Mortensen, B., Wandall, E., Langholz, E., Friis, S., Worm, D., Ørskov, C., Støving, R. K., Andries, A., Juhl, C. B., Sørensen, F., Forman, J. L., Falkenhahn, M., Musholt, P. B., Theis, S., Larsen, P. J., Holst, J. J., Vrang, N. & 3 others, , 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6403–6416 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial
Juel, C. T. B., Lund, A., Andersen, M. M., Hansen, C. P., Storkholm, J. H., Rehfeld, Jens Frederik, van Hall, G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2020, In: Diabetologia. 63, p. 1285-1298Research output: Contribution to journal › Journal article › Research › peer-review
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Endogenous incretin levels and risk of first incident cancer: a prospective cohort study
Jujic, A., Godina, C., Belting, M., Melander, O., Holst, Jens Juul, Ahlqvist, E., Gomez, M. F., Nilsson, P. M., Jernstrom, H. & Magnusson, M., 2023, In: Scientific Reports. 13, 1, 11 p., 382.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness
Jujic, A., Nilsson, P. M., Atabaki-Pasdar, N., Dieden, A., Tuomi, T., Franks, P. W., Holst, Jens Juul, Torekov, Signe Sørensen, Ravassa, S., Diez, J., Persson, M., Ahlqvist, E., Melander, O., Gomez, M. F., Groop, L. & Magnusson, M., 2021, In: Diabetes Care. 44, 1, p. 224-230 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality: a prospective study
Jujic, A., Atabaki-Pasdar, N., Nilsson, P. M., Almgren, P., Hakaste, L., Tuomi, T., Berglund, L. M., Franks, P. W., Holst, Jens Juul, Prasad, R. B., Torekov, Signe Sørensen, Ravassa, S., Diez, J., Persson, M., Melander, O., Gomez, M. F., Groop, L., Ahlqvist, E. & Magnusson, M., May 2020, In: Diabetologia. 63, 5, p. 1043-1054Research output: Contribution to journal › Journal article › Research › peer-review
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Pros and cons of Roux en-Y gastric bypass surgery in obese patients with type 2 diabetes
Justinussen, T., Madsbad, Sten, Holst, Jens Juul & Bojsen-Moller, K. N., 2019, In: Expert Review of Endocrinology & Metabolism. 14, 4, p. 243-257Research output: Contribution to journal › Review › Research › peer-review
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Effect of the Incretin Hormones on the Endocrine Pancreas in End-Stage Renal Disease
Jørgensen, M. B., Idorn, T., Rydahl, C., Hansen, H. P., Bressendorff, I., Brandi, Lisbet, Wewer Albrechtsen, N. J., van Hall, Gerrit, Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e564-e574Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose metabolism, gut-brain hormones, and acromegaly treatment: an explorative single centre descriptive analysis
Jørgensen, N. T., Erichsen, T. M., Jørgensen, M. B., Idorn, T., Feldt-Rasmussen, Bo, Holst, Jens Juul, Feldt-Rasmussen, Ulla & Klose, M., 2023, In: Pituitary. 26, p. 152–163Research output: Contribution to journal › Journal article › Research › peer-review
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Sustained Improvements in Glucose Metabolism Late After Roux-En-Y Gastric Bypass Surgery in Patients with and Without Preoperative Diabetes
Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Martinussen, C., Svane, M. S., Kristiansen, V. B., Holst, Jens Juul & Madsbad, Sten, 2019, In: Scientific Reports. 9, 1, 10 p., 15154.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery
Kandel, D., Bojsen-Møller, K. N., Svane, M. S., Samkani, A., Astrup, A., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2019, In: American Journal of Clinical Nutrition. 110, 2, p. 296-304 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gastric Residual to Predict Necrotizing Enterocolitis in Preterm Piglets As Models for Infants
Kappel, S. S., Sangild, Per Torp, Hilsted, Linda, Hartmann, Bolette, Thymann, Thomas & Aunsholt, Lise, 2021, In: Journal of Parenteral and Enteral Nutrition. 45, 1, p. 87-93Research output: Contribution to journal › Journal article › Research › peer-review
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Exogenous glucagon-like peptide-2 (GLP-2) prevents chemotherapy-induced mucositis in rat small intestine
Kissow, Hannelouise, Viby, N., Hartmann, Bolette, Holst, Jens Juul, Timm, M., Thim, L. & Poulsen, Steen Seier, 2012, In: Cancer Chemotherapy and Pharmacology. Supplement. 70, 1, p. 39-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice
Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Markers of Glucagon Resistance Improve With Reductions in Hepatic Steatosis and Body Weight in Type 2 Diabetes
Kjeldsen, Sasha Alexandra Sampson, Thomsen, M. N., Skytte, M. J., Samkani, A., Richter, Michael Martin, Frystyk, J., Magkos, Faidon, Hansen, E., Thomsen, Henrik S., Holst, Jens Juul, Madsbad, Sten, Haugaard, Steen Bendix, Krarup, T. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of the Endocrine Society. 7, 11, 11 p., bvad122.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol
Kjeldsen, S. A. S., Richter, M. M., Jensen, N. J., Nilsson, M. S. D., Heinz, N., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Madsbad, S., Vilstrup, H., Schiødt, F. V., Møller, A., Nørgaard, K., Schmidt, S., Rashu, E. B., Gluud, L. L., Haugaard, S. B., Holst, J. J., Rungby, J. & 1 others, , 2023, In: Peptides. 161, 10 p., 170938.Research output: Contribution to journal › Journal article › Research › peer-review
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Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy
Kjeldsen, S. A. S., Gluud, L. L., Werge, M. P., Pedersen, J. S., Bendtsen, F., Alexiadou, K., Tan, T., Torekov, S. S., Iepsen, E. W., Jensen, N. J., Richter, M. M., Goetze, J. P., Rungby, J., Hartmann, B., Holst, J. J., Holst, B., Holt, J., Gustafsson, F., Madsbad, S., Svane, M. S. & 2 others, , 2023, In: iScience. 26, 11, 13 p., 108190.Research output: Contribution to journal › Journal article › Research › peer-review
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Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial
Klausen, M. K., Jensen, M. E., Møller, M., le Dous, N., Jensen, A-M. Ø., Zeeman, V. A., Johannsen, C-F., Lee, A. M., Thomsen, G. K., Macoveanu, J., Fisher, P. M., Gillum, M. P., Jørgensen, N. R., Bergmann, M. L., Enghusen Poulsen, H., Becker, U., Holst, J. J., Benveniste, H., Volkow, N. D., Vollstädt-Klein, S. & 5 others, , 2022, In: JCI insight. 19, 20 p., e159863.Research output: Contribution to journal › Journal article › Research › peer-review
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Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)
Knorr, S., Bytoft, B., Lohse, Z., Boisen, A. B., Clausen, Tine Dalsgaard, Jensen, R. B., Damm, Peter, Beck-Nielsen, H., Holst, Jens Juul, Hartmann, Bolette, Moller, H. J., Hojlund, K., Gravholt, C. H. & Jensen, D. M., 2019, In: Diabetes Care. 42, 8, p. 1560-1568Research output: Contribution to journal › Journal article › Research › peer-review
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Pancreatic Polypeptide in Parkinson's Disease: A Potential Marker of Parasympathetic Denervation
Knudsen, K., Hartmann, Bolette, Fedorova, T. D., Østergaard, K., Krogh, K., Møller, N., Holst, Jens Juul & Borghammer, P., 2017, In: Journal of Parkinson's Disease. 7, 4, p. 645-652 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study
Koopen, A., Witjes, J., Wortelboer, K., Majait, S., Prodan, A., Levin, E., Herrema, H., Winkelmeijer, M., Aalvink, S., Bergman, J. J. G. H. M., Havik, S., Hartmann, B., Levels, H., Bergh, P-O., van Son, J., Balvers, M., Bastos, D. M., Stroes, E., Groen, A. K., Henricsson, M. & 8 others, , 2022, In: Gut. 71, p. 1577-1587 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of fecal microbiota transplantation combined with Mediterranean diet on insulin sensitivity in subjects with metabolic syndrome
Koopen, A. M., Almeida, E. L., Attaye, I., Witjes, J. J., Rampanelli, E., Majait, S., Kemper, M., Levels, J. H. M., Schimmel, A. W. M., Herrema, H., Scheithauer, T. P. M., Frei, W., Dragsted, Lars Ove, Hartmann, Bolette, Holst, Jens Juul, O’Toole, P. W., Groen, A. K. & Nieuwdorp, M., 2021, In: Frontiers in Microbiology. 12, 15 p., 662159.Research output: Contribution to journal › Journal article › Research › peer-review
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The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.Research output: Contribution to journal › Journal article › Research › peer-review
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No direct effect of SGLT2 activity on glucagon secretion
Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023Research output: Contribution to journal › Journal article › Research › peer-review
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Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019Research output: Contribution to journal › Review › Research › peer-review
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Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine
Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Feb 2015, In: Diabetes. 64, 2, p. 370-382 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion
Kuhre, Rune Ehrenreich, Modvig, Ida Marie, Jepsen, Sara Lind, Kizilkaya, Hüsün Sheyma, Bæch-Laursen, C., Smith, C. A., Reimann, F., Gribble, F. M., Rosenkilde, Mette & Holst, Jens Juul, 2021, In: Frontiers in Endocrinology. 12, 12 p., 690387.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: Journal of Visualized Experiments. 144, e58533.Research output: Contribution to journal › Journal article › Research › peer-review
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What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.Research output: Contribution to journal › Review › Research › peer-review
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Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
Kuhre, Rune Ehrenreich, Gribble, F. M., Hartmann, Bolette, Reimann, F., Windeløv, Johanne Agerlin, Rehfeld, Jens Frederik & Holst, Jens Juul, 1 Apr 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 306, 7, p. G622-30 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuromedin U Does Not Act as a Decretin in Rats
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose Stimulates GLP-1 Secretion from Isolated Perfused Rat Small Intestine by SGLT1 and GLUT2 Mediated Uptake, Causing V-gated Calcium Channel Activation
Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Jun 2014, In: Diabetes. 63, suppl 1, p. A491 1 p., Abstract no 1915-P.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2 leading to cell depolarization and calcium influx
Kuhre, Rune Ehrenreich, Bechmann, L. E., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 21 Apr 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 308, 12, p. E1123–E1130 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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Glucagon-like peptide 1 (GLP-1)
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Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial
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