Kilpeläinen Group

  1. Published

    In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048)

    Aaltonen, N., Kedzierska, E., Orzelska-Górka, J., Lehtonen, M., Navia-Paldanius, D., Jakupovic, Hermina, Savinainen, J. R., Nevalainen, T., Laitinen, J. T., Parkkari, T. & Gynther, M., Oct 2016, In: Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 62-72 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

    Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 others, Pedersen, Oluf Borbye, Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, Peter, Kilpeläinen, Tuomas O. & Hansen, Torben, 2019, In: Diabetologia. 62, 2, p. 292-305

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Editorial: Novel biomarkers for type 2 diabetes

    Ahluwalia, T. S., Kilpeläinen, Tuomas O., Singh, S. & Rossing, Peter, 1 Sep 2019, In: Frontiers in Endocrinology. 10, p. 1-3 3 p., 649.

    Research output: Contribution to journalEditorialResearchpeer-review

  4. Published

    Gene coexpression network analysis reveals perirenal adipose tissue as an important target of prenatal malnutrition in sheep

    Ahmad, S., Drag, Markus Hodal, Salleh, S. M., Cai, Z. & Nielsen, M. O., 2023, In: Physiological Genomics. 55, 9, p. 392-413 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Transcriptomics analysis of differentially expressed genes in subcutaneous and perirenal adipose tissue of sheep as affected by their pre- and early postnatal malnutrition histories

    Ahmad, S., Drag, Markus Hodal, Salleh, S. M., Cai, Z. & Nielsen, M. O., 2021, In: BMC Genomics. 22, 1, 21 p., 338.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

    Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., Schwander, K., Chasman, D. I., Lim, E., Deng, X., Guo, X., Liu, J., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F. & 32 others, Richard, M. A., Noordam, R., Baker, J., Chen, G., Aschard, H., Bartz, T. M., Ding, J., Dorajoo, R., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Zhao, W., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Evangelou, E., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., Hartwig, F. P., Zhao, J. H., Christensen, K., Kilpeläinen, Tuomas O., Wang, J., Loos, Ruth, COGENT-Kidney Consortium, C. C. & V Varga, Tibor, Apr 2019, In: Nature Genetics. 51, 4, p. 636-648 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

    Blond, Martin Bæk, Schnurr, T. M., Rasenkilde, M., Quist, Jonas Salling, Gram, A. S., Reichkendler, M. H., Auerbach, P. L., Nordby, P., Skovgaard, Lene Theil, Ribel-Madsen, R., Justesen, Johanne Marie, Kilpeläinen, Tuomas O., Ploug, Thorkil, Stallknecht, Bente Merete & Hansen, Torben, 2019, In: Physiological Genomics. 51, 6, p. 254-260

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Does genetic predisposition to higher fat expandability attenuate the impact of weight gain on cardiometabolic risk?

    Carrasquilla, Germán D., Linneberg, Allan René, Jørgensen, T., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2019, In: European Journal of Human Genetics. 27, Suppl. 2, p. 1764 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  9. Published

    Causality between physical activity, sedentary behavior and obesity: A Mendelian randomization study

    Carrasquilla, Germán D., García Ureña, Mario, Fall, T., Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 536-536 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  10. Published

    Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies

    Carrasquilla, Germán D., Frumento, P., Berglund, A., Borgfeldt, C., Bottai, M., Chiavenna, C., Eliasson, M., Engstrom, G., Hallmans, G., Jansson, J., Magnusson, P. K., Nilsson, P. M., Pedersen, N. L., Wolk, A. & Leander, K., Nov 2017, In: PLoS Medicine. 14, 11

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause? A population-based case-control study

    Carrasquilla, Germán D., Berglund, A., Gigante, B., Landgren, B., de Faire, U., Hallqvist, J. & Leander, K., Jun 2015, In: Menopause . 22, 6, p. 598-606

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. E-pub ahead of print

    Estimating causality between smoking and abdominal obesity by Mendelian randomization

    Carrasquilla, Germán D., García Ureña, Mario, Romero Lado, María José & Kilpeläinen, Tuomas O., 2024, (E-pub ahead of print) In: Addiction.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity

    Carrasquilla, Germán D., García Ureña, Mario, Fall, T., Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2022, In: eLife. 11, 25 p., e70386.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Dietary Fat and the Genetic Risk of Type 2 Diabetes

    Carrasquilla, Germán D., Jakupovic, Hermina & Kilpeläinen, Tuomas O., 2019, In: Current Diabetes Reports. 19, 6 p., 109.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease

    Carrasquilla, Germán D., Ängquist, Lars, Sørensen, Thorkild I.A., Kilpeläinen, Tuomas O. & Loos, Ruth, 2024, In: Diabetologia. 67, p. 864–873 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published
  17. Published

    The Genetic Basis of Hypertriglyceridemia

    Carrasquilla, Germán D., Christiansen, Malene Revsbech & Kilpeläinen, Tuomas O., 2021, In: Current Atherosclerosis Reports. 23, 10 p., 39.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Estimating the causal relationship between smoking and abdominal adiposity using Mendelian randomization

    Carrasquilla, Germán D., García Ureña, Mario, Sharma, S. & Kilpeläinen, Tuomas O., 2022, Cold Spring Harbor Laboratory, (bioRxiv).

    Research output: Working paperPreprintResearch

  19. Published

    Impact of abdominal obesity on postprandial lipid concentrations

    Christiansen, Malene Revsbech, Sørensen, Thorkild I.A., Hansen, Torben & Kilpeläinen, Tuomas O., 2020, In: European Journal of Human Genetics. 28, Suppl. 1, p. 279-280 2 p.

    Research output: Contribution to journalConference abstract in journalResearch

  20. Published

    Abdominal and gluteofemoral fat depots show opposing associations with postprandial lipemia

    Christiansen, Malene Revsbech, García Ureña, Mario, Borisevich, D., Grarup, Niels, Martínez, J. A., Oppert, J., Sørensen, Thorkild I.A., Hansen, Torben, Blaak, E. E. & Kilpeläinen, Tuomas O., 2021, In: American Journal of Clinical Nutrition. 114, 4, p. 1467–1475 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Mendelian randomization suggests a causal effect of abdominal obesity on postprandial lipemia

    Christiansen, Malene Revsbech, Hansen, Torben, Sørensen, Thorkild I.A., Grarup, Niels, García Ureña, Mario, Borisevich, D., Oppert, J., Martinez Hernandez, J. A., Blaak, E. & Kilpeläinen, Tuomas O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 184 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  22. Published

    Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss

    Christiansen, Malene Revsbech, Kilpeläinen, Tuomas O. & McCaffery, J. M., 2023, In: Diabetes. 72, 10, p. 1424-1432 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

    Dallner, O. S., Marinis, J. M., Lu, Y., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, Tuomas O., Grarup, Niels, Linneberg, Allan René, Zhang, Y., Vaughan, R., Loos, Ruth, Lazar, M. A. & Friedman, J. M., 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Cell-free DNA and RNA - measurement and applications in clinical diagnostics with focus on metabolic disorders

    Drag, Markus Hodal & Kilpeläinen, Tuomas O., 2021, In: Physiological Genomics. 53, 1, p. 33-46

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

    Drag, Markus Hodal, Debes, Karina Poulsdóttir, Franck, C. S., Flethøj, M., Lyhne, Mille Kronborg, Møller, J. E., Ludvigsen, Trine Pagh, Jespersen, Thomas, Olsen, Lisbeth Høier & Kilpeläinen, Tuomas O., 2023, In: Epigenetics. 18, 1, 17 p., 2199374.

    Research output: Contribution to journalJournal articleResearchpeer-review

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