Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2002
  2. Published

    Fat mass measured by DXA varies with scan velocity

    Black, E., Petersen, L., Kreutzer, M., Toubro, S., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Astrup, A., 2002, In: Obesity. 10, 2, p. 69-77 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function

    Hansen, S. K., Párrizas, M., Jensen, M. L., Pruhova, S., Ek, J., Boj, S. F., Johansen, A., Maestro, M. A., Rivera, F., Eiberg, Hans Rudolf Lytchoff, Andel, M., Lebl, J., Pedersen, Oluf Borbye, Ferrer, J. & Hansen, Torben, 2002, In: Journal of Clinical Investigation. 110, 6, p. 827-33 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Jagten på de genetiske determinanter for de formodede polygene former for type 2-diabetes. Status og perspektivering

    Pedersen, Oluf Borbye, Hansen, Torben, Hansen, L., Echwald, S. M. & Urhammer, S. A., 2002, In: Ugeskrift for Laeger. 164, 16, p. 2163-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome

    Buhl, E. S., Jessen, N., Pold, R., Ledet, T., Flyvbjerg, A., Pedersen, Steen, Pedersen, Oluf Borbye, Schmitz, O. & Lund, S., 2002, In: Diabetes. 51, 7, p. 2199-206 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Maturity-onset diabetes of the young--MODY. Molekylaergenetiske, patofysiologiske og kliniske karakteristika

    Hansen, Torben, Urhammer, S. A. & Pedersen, Oluf Borbye, 2002, In: Ugeskrift for Laeger. 164, 15, p. 2017-22 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients

    Jacobsen, P., Grarup, Niels, Tarnow, L., Parving, H. & Pedersen, Oluf Borbye, 2002, In: Nephrology, Dialysis, Transplantation. 17, 8, p. 1408-12 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians

    Rasmussen, S. K., Urhammer, S. A., Berglund, L. E., Jensen, J. N., Hansen, L., Echwald, S. M., Borch-Johnsen, K., Horikawa, Y., Mashima, H., Lithell, H., Cox, N. J., Hansen, Torben, Bell, G. I. & Pedersen, Oluf Borbye, 2002, In: Diabetes. 51, 12, p. 3561-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha

    Almind, K., Delahaye, L., Hansen, Torben, Van Obberghen, E., Pedersen, Oluf Borbye & Kahn, C. R., 19 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 2124-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

    Haderslev, Kent Valentin, Jeppesen, Palle Bekker, Hartmann, Bolette, Thulesen, J., Sorensen, H. A., Graff, J., Tofteng, F., Poulsen, S. S., Madsen, J. L., Holst, Jens Juul, Staun, Michael, Mortensen, P. B. & Poulsen, Steen Seier, 1 Apr 2002, In: Scandinavian Journal of Gastroenterology. 37, 4, p. 392-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Normocalcemia and persistent elevated serum concentrations of 1-84 parathyroid hormone after operation for sporadic parathyroid adenoma: evidence of increased morbidity from cardiovascular disease

    drb459, drb459 & ØStergaard Kristensen, L., Jun 2002, In: World Journal of Surgery. 26, 6, p. 657-60 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2003
  13. Published

    A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

    Muller, Y. L., Bogardus, C., Pedersen, Oluf Borbye & Baier, L., 2003, In: Diabetes. 52, 3, p. 895-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity

    Frayling, T. M., Lindgren, C. M., Chevre, J. C., Menzel, S., Wishart, M., Benmezroua, Y., Brown, A., Evans, J. C., Rao, P. S., Dina, C., Lecoeur, C., Kanninen, T., Almgren, P., Bulman, M. P., Wang, Y., Mills, J., Wright-Pascoe, R., Mahtani, M. M., Prisco, F., Costa, A. & 9 others, Cognet, I., Hansen, Torben, Pedersen, Oluf Borbye, Ellard, S., Tuomi, T., Groop, L. C., Froguel, P., Hattersley, A. T. & Vaxillaire, M., 2003, In: Diabetes. 52, 3, p. 872-81 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects

    Nielsen, E. D., Hansen, L., Echwald, S. M., Drivsholm, Thomas, Borch-Johnsen, K., Ekstrøm, C. T., Hansen, Torben & Pedersen, Oluf Borbye, 2003, In: Pharmacogenetics and Genomics. 13, 7, p. 417-23 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate

    Gaede, P., Hansen, H. P., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Nephrology, Dialysis, Transplantation. 18, 3, p. 539-42 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?

    Poulsen, P., Andersen, G., Fenger, M., Hansen, Torben, Echwald, S. M., Vølund, A., Beck-Nielsen, H., Pedersen, Oluf Borbye & Vaag, Allan, 2003, In: Diabetes. 52, 1, p. 194-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Injected TFF1 and TFF3 bind to TFF2-immunoreactive cells in the gastrointestinal tract in rats

    Poulsen, Steen Seier, Thulesen, J., Hartmann, Bolette, Kissow, Hannelouise, Nexø, E. & Thim, L., 2003, In: Regulatory Peptides. 115, 2, p. 91-99 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Insulin resistance and maximal oxygen uptake

    Seibaek, M., drb459, drb459, Burchardt, H., Sloth, C., Torp-Pedersen, Christian, Nielsen, S. L., Hildebrandt, P. & Pedersen, Oluf Borbye, 2003, In: Clinical Cardiology. 26, 11, p. 515-20 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Intensified multifactorial intervention and cardiovascular outcome in type 2 diabetes: the Steno-2 study

    Pedersen, Oluf Borbye & Gaede, P., 2003, In: Metabolism. 52, 8 Suppl 1, p. 19-23 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes

    Gaede, P., Vedel, P., Larsen, N., Jensen, G. V. H., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Briefings from the New England Journal of Medicine. 348, 5, p. 383-93 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Steno-2-studiet: intensiv multifaktoriel behandling reducerer forekomsten af kardiovaskulaer sygdom hos patienter med type 2-diabetes

    Gaede, P. H., Jepsen, P. V., Larsen, J. N. B., Jensen, G. V., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Ugeskrift for Laeger. 165, 26, p. 2658-61 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

    Nielsen, E. D., Hansen, L., Carstensen, Bendix, Echwald, S. M., Drivsholm, Thomas, Glümer, C., Thorsteinsson, B., Borch-Johnsen, K., Hansen, Torben & Pedersen, Oluf Borbye, 2003, In: Diabetes. 52, 2, p. 573-7 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain

    Aznar, S., Qian, Z., Shah, R., Kornum, Birgitte Rahbek & Knudsen, Gitte Moos, 3 Jan 2003, In: Brain Research. 959, 1, p. 58-67 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Activity-induced and developmental downregulation of the Nogo receptor

    Josephson, A., Trifunovski, A., Schéele, Camilla Charlotte Nielsen, Widenfalk, J., Wahlestedt, C., Brené, S., Olson, L. & Spenger, C., Mar 2003, In: Cell and Tissue Research. 311, 3, p. 333-42 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects

    Sørensen, L. B., Flint, A., Raben, Anne, Hartmann, Bolette, Holst, Jens Juul & Astrup, A., Apr 2003, In: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 27, 4, p. 450-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

    Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development

    Petersen, Y. M., Hartmann, Bolette, Holst, Jens Juul, Le Huerou-Luron, I., Bjørnvad, Charlotte Reinhard & Sangild, Per Torp, Jun 2003, In: Journal of Nutrition. 133, 6, p. 1781-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1

    Guan, X., Stoll, B., Lu, X., Tappenden, K. A., Holst, Jens Juul, Hartmann, Bolette & Burrin, D. G., Jul 2003, In: Gastroenterology. 125, 1, p. 136-47 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

    Gual, P., Gonzalez, T., Grémeaux, T., Barrès, Romain, Le Marchand-Brustel, Y. & Tanti, J., 18 Jul 2003, In: Journal of Biological Chemistry. 278, 29, p. 26550-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety

    Schmidt, P. T., Näslund, E., Grybäck, P., Jacobsson, H., Hartmann, Bolette, Holst, Jens Juul & Hellström, P. M., 15 Nov 2003, In: Regulatory Peptides. 116, 1-3, p. 21-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling

    Le Marchand-Brustel, Y., Gual, P., Grémeaux, T., Gonzalez, T., Barrès, Romain & Tanti, J., Dec 2003, In: Biochemical Society Transactions. 31, Pt 6, p. 1152-6 5 p.

    Research output: Contribution to journal › Journal article › Communication

  33. 2004
  34. Published

    A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects

    Nielsen, E. D., Hansen, L., Lajer, M., Andersen, K. L., Echwald, S. M., Urhammer, S. A., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Clinical Biochemistry. 37, 8, p. 660-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene

    Højlund, K., Hansen, Torben, Lajer, M., Henriksen, J. E., Levin, K., Lindholm, J., Pedersen, Oluf Borbye & Beck-Nielsen, H., 2004, In: Diabetes. 53, 6, p. 1592-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites

    Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625

    Research output: Patent

  37. Published

    Cyclic Quinoline compounds for use in MCH receptor related disorders

    Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371

    Research output: Patent

  38. Published

    EMPRR: A high-dimensional EM-based piecewise regression algorithm

    Arumugam, Mani & Scott, S. D., 2004, Proceedings of the 2004 International Conference on Machine Learning and Applications, ICMLA '04. Kantardzic, M., Nasraoui, O. & Milanova, M. (eds.). p. 264-271 8 p. (Proceedings of the 2004 International Conference on Machine Learning and Applications, ICMLA '04).

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

  39. Published

    Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes

    Hansen, L., Gaster, M., Oakeley, E. J., Brusgaard, K., Damsgaard Nielsen, E., Beck-Nielsen, H., Pedersen, Oluf Borbye & Hemmings, B. A., 2004, In: Biochemical and Biophysical Research Communications. 323, 2, p. 685-95 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Facilitated processing of visual stimuli associated with the body

    Whiteley, Louise, Kennett, S., Taylor-Clarke, M. & Haggard, P., 2004, In: Perception. 33, 3, p. 307-14 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Genome sequence of the Brown Norway rat yields insights into mammalian evolution

    Gibbs, R. A., Weinstock, G. M., Metzker, M. L., Muzny, D. M., Sodergren, E. J., Scherer, S., Scott, G., Steffen, D., Worley, K. C., Burch, P. E., Okwuonu, G., Hines, S., Lewis, L., DeRamo, C., Delgado, O., Dugan-Rocha, S., Miner, G., Morgan, M., Hawes, A., Gill, R. & 31 others, Celera, Holt, R. A., Adams, M. D., Amanatides, P. G., Baden-Tillson, H., Barnstead, M., Chin, S., Evans, C. A., Ferriera, S., Fosler, C., Glodek, A., Gu, Z., Jennings, D., Kraft, C. L., Nguyen, T., Pfannkoch, C. M., Sitter, C., Sutton, G. G., Venter, J. C., Woodage, T., Smith, D., Lee, H., Gustafson, E., Cahill, P., Kana, A., Doucette-Stamm, L., Weinstock, K., Fechtel, K., Weiss, R. B., Arumugam, Mani & Rat Genome Sequencing Project Consortium, R. G. S. P. C., 2004, In: Nature. 428, 6982, p. 493-521 29 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Grey-box modelling of pharmacokinetic/pharmacodynamic systems

    Tornøe, C. W., Jacobsen, Judith Lone, Pedersen, Oluf Borbye, Hansen, Torben & Madsen, H. T., 2004, In: Journal of Pharmacokinetics and Pharmacodynamics. 31, 5, p. 401-17 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Handlingsplan om diabetes

    Pedersen, Oluf Borbye, 2004, In: Ugeskrift for Laeger. 166, 12, p. 1099

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Identification of rat genes by TWINSCAN gene prediction, RT-PCR, and direct sequencing

    Wu, J. Q., Shteynberg, D., Arumugam, Mani, Gibbs, R. A. & Brent, M. R., 2004, In: Genome Research. 14, 4, p. 665-71 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population

    Lauenborg, J., Hansen, Torben, Jensen, D. M., drb459, drb459, Mølsted-Pedersen, L., Hornnes, P., Locht, H., Pedersen, Oluf Borbye & Damm, Peter, 2004, In: Diabetes Care. 27, 5, p. 1194-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Intensive integrated therapy of type 2 diabetes: implications for long-term prognosis

    Gaede, P. & Pedersen, Oluf Borbye, 2004, In: Diabetes. 53 Suppl 3, p. S39-47

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?

    Saudek, F., Pruhová, S., Boucek, P., Lebl, J., Adamec, M., Ek, J., Pedersen, Oluf Borbye & Hansen, Torben, 2004, In: Transplantation. 77, 8, p. 1298-301 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

    Echwald, S. M., Andersen, K. L., Sørensen, Thorkild I.A., Larsen, L. H., Andersen, T., Tonooka, N., Tomura, H., Takeda, J. & Pedersen, Oluf Borbye, 2004, In: Human Mutation. 24, 5, p. 381-387 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Quinoline compounds for use in MCH receptor related disorders

    Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052370

    Research output: Patent

  50. Published

    Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria

    Gaede, P., Tarnow, L., Vedel, P., Parving, H. & Pedersen, Oluf Borbye, 2004, In: Nephrology, Dialysis, Transplantation. 19, 11, p. 2784-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes

    Gaede, P. & Pedersen, Oluf Borbye, 2004, In: Annals of Medicine. 36, 5, p. 355-66 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites

    Hamid, Y. H., Urhammer, S. A., Jensen, D. P., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Diabetes. 53, 12, p. 3342-5 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Increased mortality in patients hospitalized with primary hyperparathyroidism during the period 1977-1993 in Denmark

    Øgard, C. G., Engholm, G., Almdal, Thomas Peter & drb459, drb459, Jan 2004, In: World Journal of Surgery. 28, 1, p. 108-11 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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