- 2021
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Six-day sc GIP infusion increases plasma NEFA without altering the adipose tissue transcriptome, GIPR levels or plasma markers of inflammation in patients with type 1 diabetes
Heimburger, S. M. N., Hoe, B., Nielsen, C. N., Hartmann, Bolette, Holst, Jens Juul, Dela, Flemming, Overgaard, J., Størling, Joachim, Vilsbøll, Tina, Dejgaard, T. F., Pyke, C., Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 258-258 494.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The effect of 6-day subcutaneous glucose-dependent insulinotropic polypeptide infusion on time in glycaemic range in patients with type 1 diabetes: a randomised, double-blind, placebo-controlled crossover trial
Heimbürger, S. M. N., Hoe, B., Nielsen, C. N., Bergmann, N. C., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2021, In: Diabetologia. 64, p. 2425-2431Research output: Contribution to journal › Journal article › Research › peer-review
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The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism
Heiss, C. N., Mannerås-Holm, L., Lee, Y. S., Serrano-Lobo, J., Håkansson Gladh, A., Seeley, R. J., Drucker, D. J., Bäckhed, F. & Olofsson, L. E., 2021, In: Cell Reports. 35, 8, 16 p., 109163.Research output: Contribution to journal › Journal article › Research › peer-review
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Brown Adipose Tissue: A Metabolic Regulator in a Hypothalamic Cross Talk?
Henningsen, J. B. & Schéele, Camilla Charlotte Nielsen, 2021, In: Annual Review of Physiology. 83, p. 279-301 23 p.Research output: Contribution to journal › Review › Research › peer-review
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Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease
Henningsen, J. B., Soylu-Kucharz, R., Bjorkqvist, M. & Petersen, Å., 2021, In: Heliyon. 7, 8, 9 p., 07808.Research output: Contribution to journal › Journal article › Research › peer-review
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Explaining deep neural networks for knowledge discovery in electrocardiogram analysis
Hicks, S. A., Isaksen, Jonas L., Thambawita, V., Ghouse, Jonas, Ahlberg, Gustav, Linneberg, Allan René, Grarup, Niels, Strümke, I., Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., von Holstein-Rathlou, Niels-Henrik, Halvorsen, P., Maleckar, M. M., Riegler, M. A. & Kanters, Jørgen K., 2021, In: Scientific Reports. 11, 1, 11 p., 10949.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies
Hindsø, M., Svane, M. S., Hedbäck, N., Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2021, In: Surgery for Obesity and Related Diseases. 17, 7, p. 1383-1391Research output: Contribution to journal › Review › Research › peer-review
- Published
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis
Hinrichsen, F., Hamm, J., Westermann, M., Schröder, L., Shima, K., Mishra, N., Walker, A., Sommer, N., Klischies, K., Prasse, D., Zimmermann, J., Kaiser, S., Bordoni, D., Fazio, A., Marinos, G., Laue, G., Imm, S., Tremaroli, V., Basic, M., Häsler, R. & 10 others, , 2021, In: Cell Metabolism. 33, 12, p. 2355-2366.e8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
What is Diabetes Remission?
Holst, Jens Juul & Madsbad, Sten, 2021, In: Diabetes Therapy. 12, p. 641-646 6 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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The role of incretins on insulin function and glucose homeostasis
Holst, Jens Juul, Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2021, In: Endocrinology. 162, 7, 10 p., bqab065.Research output: Contribution to journal › Review › Research › peer-review
- Published
Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture
Holst, Jens Juul, 2021, In: Diabetes. 70, 11, p. 2468-2475 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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What combines best with GLP-1 for obesity treatment: GIP receptor agonists or antagonists?
Holst, Jens Juul, 2021, In: Cell Reports Medicine. 2, 5, 2 p., 100284.Research output: Contribution to journal › Comment/debate › Research
- Published
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
Huang, L. O., Rauch, A., Mazzaferro, E., Preuss, M., Carobbio, S., Bayrak, C. S., Chami, N., Wang, Z., Schick, U. M., Yang, N., Itan, Y., Vidal-Puig, A., den Hoed, M., Mandrup, S., Kilpeläinen, Tuomas O. & Loos, R. J. F., 2021, In: Nature Metabolism. 3, 2, p. 228-243 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Do genetic risk scores for childhood adiposity operate independent of BMI of their mothers?
Huang, L. O., Morgen, C. S., Ängquist, Lars, Nohr, E. A., Kilpeläinen, Tuomas O., Hansen, Torben, Sørensen, Thorkild I.A. & Schnurr, T. M., 2021, In: International Journal of Obesity. 45, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis
Johnsen, Cecilie Hundahl, Kotzbeck, P., Burm, Hayley Beth, Christiansen, S. H., Pedersen, Lola Julie Torz, zmw799, zmw799, Madsen, M. P., Ratner, C., Serup, A. K., Thompson, J. J., Eichmann, T. O., Pers, Tune H, Woldbye, David Paul Drucker, Piomelli, D., Kiens, Bente, Zechner, R., Skov, Louise Julie & Holst, Birgitte, 2021, In: Molecular Metabolism. 47, 16 p., 101174.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice
Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Schoonjans, K., Holst, Jens Juul & Kissow, Hannelouise, 2021, In: Frontiers in Endocrinology. 12, 10 p., 640602.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors
Dal, Jenna Elizabeth Hunt, Yassin, M., Olsen, Jørgen, Hartmann, Bolette, Holst, Jens Juul & Kissow, Hannelouise, 2021, In: Frontiers in Endocrinology. 12, 7 p., 695145.Research output: Contribution to journal › Journal article › Research › peer-review
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"Visceral Consciousness": The Gut-Brain Axis in Victorian Sleep and Sleeplessness in Britain and America, 1850-1914
Hussey, Kristin D., 2021, In: Bulletin of the History of Medicine. 95, 3, p. 350-378Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Book Review: Exploring Emotion, Care, and Enthusiasm in “Unloved” Museum Collections. eds. Anna Woodham, Alison Hess, and Rhianedd Smith
Hussey, Kristin D., 2021, In: Museums Worlds: Advances in Research. 9, p. 222-223 2 p.Research output: Contribution to journal › Literature review › Research
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Imperial Bodies in London: Empire, Mobility, and the Making of British Medicine, 1870-1914
Hussey, Kristin D., 2021, University of Pittsburgh Press. 256 p.Research output: Book/Report › Book › Research › peer-review
- Published
Clinical images, imperial power and Bhau Daji’s secret treatment for leprosy at the Royal College of Physicians Museum
Hussey, Kristin D. & Biggins, M., 2021, In: Science Museum Group Journal. Spring 2021, 15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Replacing Red Meat with Other Nonmeat Food Sources of Protein is Associated with a Reduced Risk of Type 2 Diabetes in a Danish Cohort of Middle-Aged Adults
Ibsen, D. B., Jakobsen, M. U., Halkjær, J., Tjønneland, Anne, Kilpeläinen, Tuomas O., Parner, E. T. & Overvad, K., 2021, In: The Journal of Nutrition. 151, 5, p. 1241-1248 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in intake of dairy product subgroups and risk of type 2 diabetes: modelling specified food substitutions in the Danish Diet, Cancer and Health cohort
Ibsen, D. B., Overvad, K., Laursen, A. S. D., Halkjær, J., Tjønneland, Anne, Kilpeläinen, Tuomas O., Parner, E. T. & Jakobsen, M. U., 2021, In: European Journal of Nutrition. 60, p. 3449–3459 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanism of ligand binding pathways and activation of the succinate receptor
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication
Israelsen, M., Kim, M., Suvitaival, T., Madsen, B. S., Hansen, C. D., Torp, N., Trost, K., Thiele, M., Hansen, Torben, Legido-Quigley, C., Krag, A. & MicrobLiver Consortium, M. C., 2021, In: JHEP Reports. 3, 5, 11 p., 100325.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
Jensen, B. A. H., Holm, J. B., Larsen, I. S., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S. A., Rivollier, A., Agrinier, A. L., Sulek, K., Arnoldussen, Y. J., Fjære, E., Marette, A., Angell, I. L., Rudi, K., Treebak, J. T., Madsen, L., Åkesson, C. P. & 5 others, , 2021, In: Nature Communications. 12, 19 p., 1093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies
Jensen, J. B., Møller, A. B., Just, J., Mose, M., de Paoli, F. V., Billeskov, T. B., Fred, Rikard Göran, Pers, Tune H, Pedersen, S. B., Petersen, K. K., Bjerre, M., Farup, J. & Jessen, N., 2021, In: American Journal of Physiology - Cell Physiology. 321, 2, p. C257-C268 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of dietary carbohydrate restriction beyond weight loss on health-related quality of life and cognition
Jensen, N. J., Wodschow, H. Z., fbg982, fbg982, Samkani, A., Astrup, A., Frystyk, J., Hartmann, Bolette, Holst, Jens Juul, Larsen, T. M., Madsbad, Sten, Magkos, Faidon, Miskowiak, Kamilla, Rungby, Jørgen, Haugaard, Steen Bendix & Thomsen, M. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 62-63 114.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner
Jepsen, Sara Lind, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Farb, T. B., Kissow, Hannelouise, Pedersen, J., Deacon, Carolyn F., Martin, R. E. & Holst, Jens Juul, 2021, In: JCI insight. 6, 4, 15 p., e143228.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amyotrophic lateral sclerosis in the Faroe Islands - a genealogical study
Johansen, M., Svenstrup, K., Mortensen, O., Andorsdottir, G., Steig, B. A., Joensen, P., Hansen, Torben & Petersen, M. S., 2021, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 22, 7-8, p. 571-575 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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r-cubed: Guiding the overwhelmed scientist from random wrangling to Reproducible Research in R
Johnston, L., Juel, H., Lengger, B., Witte, D., Chatwin, H., Christiansen, Malene Revsbech & Isaksen, A., 2021, In: Journal of Open Source Education. 4, 44, 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test
Jonsson, Anna Elisabet, Stinson, Sara, Torekov, Signe Sørensen, Clausen, Tine Dalsgaard, Færch, K., Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth, Damm, Peter, Witte, D. R., Jørgensen, M. E., Pedersen, Oluf Borbye, Holst, Jens Juul & Hansen, Torben, 2021, In: BMC Medical Genomics. 14, 7 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass
Jonsson, I., Bojsen-Moller, K. N., Kristiansen, V. B., Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer, Clausen, T. R., Kuhre, Rune Ehrenreich, Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Svane, M. S., 2021, In: Frontiers in Endocrinology. 12, 11 p., 681116.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus
Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness
Jujic, A., Nilsson, P. M., Atabaki-Pasdar, N., Dieden, A., Tuomi, T., Franks, P. W., Holst, Jens Juul, Torekov, Signe Sørensen, Ravassa, S., Diez, J., Persson, M., Ahlqvist, E., Melander, O., Gomez, M. F., Groop, L. & Magnusson, M., 2021, In: Diabetes Care. 44, 1, p. 224-230 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute metabolic effects of melatonin - A randomized crossover study in healthy young men
Kampmann, U., Lauritzen, E. S., Grarup, Niels, Jessen, N., Hansen, Torben, Møller, N. & Stoy, J., 2021, In: Journal of Pineal Research. 70, 2, 13 p., 12706.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastric Residual to Predict Necrotizing Enterocolitis in Preterm Piglets As Models for Infants
Kappel, S. S., Sangild, Per Torp, Hilsted, Linda, Hartmann, Bolette, Thymann, Thomas & Aunsholt, Lise, 2021, In: Journal of Parenteral and Enteral Nutrition. 45, 1, p. 87-93Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly
Karcher, N., Nigro, E., Puncochar, M., Blanco-Miguez, A., Ciciani, M., Manghi, P., Zolfo, M., Cumbo, F., Manara, S., Golzato, D., Cereseto, A., Arumugam, Mani, Bui, T. P. N., Tytgat, H. L. P., Valles-Colomer, M., de Vos, W. M. & Segata, N., 2021, In: Genome Biology. 22, 24 p., 209.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
Karlsson, H. K. R., Kasahara, A., Ikeda, M., Chibalin, A. V., Harada, J., Rydén, M., Krook, A., Kato, M., Kubota, K. & Zierath, Juleen R, 2021, In: Metabolism. 118, 7 p., 154726.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes
Kim, A., Knudsen, J. G., Madara, J. C., Benrick, A., Hill, T. G., Kadir, L. A., Kellard, J. A., Mellander, L., Miranda, C., Lin, H., James, T., Suba, K., Spigelman, A. F., Wu, Y., Macdonald, P. E., Asterholm, I. W., Magnussen, T., Christensen, M., Vilsbøll, T., Salem, V. & 4 others, , 2021, In: eLife. 10, 29 p., e72919.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial: non-selective beta blockers—in and out of circulation
Kimer, N., Mortensen, C. & Hobolth, L., Mar 2021, In: Alimentary Pharmacology and Therapeutics. 53, 5, p. 632-633 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Revision rates of trapeziometacarpal total joint arthroplasty in relation to occupational hand force requirements
Kirkeby, L., Frost, Poul, Svendsen, S. W. & Hansen, Torben, 2021, In: Journal of Hand Surgery: European Volume. 46, 9, p. 968-974 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes
Kizilkaya, Hüsün Sheyma, Sørensen, Kimmie Vestergaard, Kibsgaard, C. J., Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, wbf943, wbf943, Grarup, Niels & Rosenkilde, Mette, 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 749607.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism
Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of GPR183 Agonists Based on an Antagonist Scaffold
Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
Klein, A. B., Nicolaisen, T. S., Ørtenblad, N., Gejl, K. D., Jensen, R., Fritzen, A. M., Larsen, E. L., Karstoft, K., Poulsen, H. E., Morville, T., Sahl, R. E., Helge, J. W., Lund, J., Falk, S., Lyngbæk, M., Ellingsgaard, H., Pedersen, B. K., Lu, W., Finan, B., Jørgensen, S. B. & 5 others, , 2021, In: Nature Communications. 12, 9 p., 1041.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
Koeninger, L., Osbelt, L., Berscheid, A., Wendler, J., Berger, J., Hipp, K., Lesker, T. R., Pils, M. C., Malek, N. P., Jensen, Benjamin Anderschou Holbech, Brötz-Oesterhelt, H., Strowig, T. & Jan Wehkamp, W., 2021, In: Communications Biology . 4, 1, 11 p., 47.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of fecal microbiota transplantation combined with Mediterranean diet on insulin sensitivity in subjects with metabolic syndrome
Koopen, A. M., Almeida, E. L., Attaye, I., Witjes, J. J., Rampanelli, E., Majait, S., Kemper, M., Levels, J. H. M., Schimmel, A. W. M., Herrema, H., Scheithauer, T. P. M., Frei, W., Dragsted, Lars Ove, Hartmann, Bolette, Holst, Jens Juul, O’Toole, P. W., Groen, A. K. & Nieuwdorp, M., 2021, In: Frontiers in Microbiology. 12, 15 p., 662159.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner
Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, Kei, Salt, I. P. & Göransson, O., 2021, In: Biochemical Journal. 478, 3, p. 633-646 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gut microbial metabolites as multi-kingdom intermediates
Krautkramer, K. A., Fan, J. & Backhed, F., 2021, In: Nature Reviews. Microbiology. 19, p. 77-94 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Novel Anti-inflammatory Treatments in Cirrhosis. A Literature-Based Study
Kronborg, T. M., Lambert, Henriette Ytting, Hobolth, L., Møller, Søren & Kimer, N., 2021, In: Frontiers in Medicine. 8, 718896.Research output: Contribution to journal › Review › Research › peer-review
- Published
Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019Research output: Contribution to journal › Review › Research › peer-review
- Published
L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion
Kuhre, Rune Ehrenreich, Modvig, Ida Marie, Jepsen, Sara Lind, Kizilkaya, Hüsün Sheyma, Bæch-Laursen, C., Smith, C. A., Reimann, F., Gribble, F. M., Rosenkilde, Mette & Holst, Jens Juul, 2021, In: Frontiers in Endocrinology. 12, 12 p., 690387.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.Research output: Contribution to journal › Review › Research › peer-review
- Published
Large-scale association analyses identify host factors influencing human gut microbiome composition
Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Rühlemann, M. C., Turpin, W., Moon, J. Y., Kim, H. N., Lüll, K., Barkan, E. & 84 others, , 2021, In: Nature Genetics. 53, p. 156-165 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol for a randomised, double-blinded, placebo-controlled, double-dummy 6-week clinical trial comparing the treatment effects of the glucagon-like peptide 1 receptor agonist liraglutide versus the bile acid sequestrant colesevelam on bile acid malabsorption
Kårhus, M. L., Brønden, A., Forman, Julie Lyng, Haaber, A., Vilsbøll, Tina, Sonne, D. P. & Knop, Filip Krag, 2021, In: BMJ Open. 11, 2, e044711.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Authors’ Reply to Letter to the Editor: Continued improvement to genetic diversity indicator for CBD
Laikre, L., Hohenlohe, P. A., Allendorf, F. W., Bertola, L. D., Breed, M. F., Bruford, M. W., Funk, W. C., Gajardo, G., González-Rodríguez, A., Grueber, C. E., Hedrick, P. W., Heuertz, M., Hunter, M. E., Johannesson, K., Liggins, L., MacDonald, A. J., Mergeay, J., Moharrek, F., O’Brien, D., Ogden, R. & 11 others, , Aug 2021, In: Conservation Genetics. 22, 4, p. 533-536 4 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
The Zinc-Sensing Receptor GPR39 in Physiology and as a Pharmacological Target
Laitakari, Anna Isabella, Liu, L., Frimurer, Thomas Michael & Holst, Birgitte, 2021, In: International Journal of Molecular Sciences. 22, 8, 22 p., 3872.Research output: Contribution to journal › Review › Research › peer-review
- Published
Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring
Laker, R. C. C., Altıntaş, Ali, Lillard, T. S., Zhang, M., Connelly, J. J., Sabik, O. L., Onengut, S., Rich, S. S., Farber, C. R., Barrès, Romain & Yan, Z., 2021, In: Journal of Applied Physiology. 130, 3, p. 605-616Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metformin Lowers Body Weight But Fails to Increase Insulin Sensitivity in Chronic Heart Failure Patients without Diabetes: a Randomized, Double-Blind, Placebo-Controlled Study
Larsen, A. H., Wiggers, H., Dollerup, O. L., Jespersen, N. R., Hansson, N. H., Frokiaer, J., Brøsen, K., Norrelund, H., Bøtker, H. E., Møller, N. & Jessen, N., 2021, In: Cardiovascular Drugs and Therapy. 35, p. 491-503 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fungal lysozyme leverages the gut microbiota to curb DSS-induced colitis
Larsen, I. S., Jensen, Benjamin Anderschou Holbech, Bonazzi, E., Choi, Beatrice So-Yun, Kristensen, N. N., Schmidt, E. G. W., Süenderhauf, A., Morin, L., Olsen, P. B., Hansen, L. B. S., Schröder, T., Sina, C., Chassaing, B. & Marette, A., 2021, In: Gut Microbes. 13, 1, 20 p., 1988836.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute erythropoietin injection increases muscle mitochondrial respiratory capacity in young men: A double-blinded randomized crossover trial
Larsen, Steen, Søndergård, S. D., Sahl, Ronni Eg, Frandsen, J., Morville, T., Dela, Flemming & Helge, Jørn Wulff, 2021, In: Journal of Applied Physiology. 131, 4, p. 1340-1347Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of preceding glucose decline rate on low-dose glucagon efficacy in individuals with type 1 diabetes: A randomized crossover trial
Laugesen, C., Schmidt, S., Holst, Jens Juul, Nørgaard, Kirsten & Ranjan, A. G., 2021, In: Diabetes, Obesity and Metabolism. 23, 4, p. 1057-1062 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of melatonin on incretin hormones: results from experimental and randomized clinical studies
Lauritzen, E. S., Støy, J., Bæch-Laursen, C., Grarup, Niels, Jessen, N., Hansen, Torben, Møller, N., Hartmann, Bolette, Holst, Jens Juul & Kampmann, U., 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 12, p. e5109-e5123 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urbanized microbiota in infants, immune constitution and later risk of atopic diseases
Lehtimäki, J., Thorsen, Jonathan Jan Ilve, Rasmussen, Morten Arendt, Hjelmsø, M., Shah, S., Mortensen, M. S., Trivedi, Urvish, Vestergaard, G., Bønnelykke, Klaus, Chawes, Bo Lund Krogsgaard, Brix, S., Sørensen, Søren Johannes, Bisgaard, H. & Stokholm, Jakob, 2021, In: Journal of Allergy and Clinical Immunology. 148, 1, p. 234-243 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Superficial fungal infections and patients with hidradenitis suppurativa: a study under the Danish Blood Donor Study
Lindso Andersen, P., Andersen, Rune Kjærsgaard, Jemec, Gregor, Ullum, H., Erikstrup, C., Nielsen, K. R., Bruun, M. T., Hjalgrim, Henrik, Sørensen, E., Burgdorf, K. S., Dinh, K. M., Banasik, Karina, Hansen, T., Saunte, Ditte Marie & Pedersen, Oluf Borbye, 2021, In: Clinical and Experimental Dermatology. 46, 3, p. 571-573 3 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
The genetics of obesity: from discovery to biology
Loos, Ruth & Yeo, G. S. H., 2021, In: Nature Reviews Genetics. 23, p. 120-133Research output: Contribution to journal › Review › Research › peer-review
- Published
Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V
Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genetic map of the mouse dorsal vagal complex and its role in obesity
Ludwig, M. Q., Cheng, W., Gordian, D., Lee, J., Paulsen, S. J., Hansen, S. N., Egerod, Kristoffer Lihme, Barkholt, P., Rhodes, C. J., Secher, A., Knudsen, L. B., Pyke, C., Myers, M. G. & Pers, Tune H, 2021, In: Nature Metabolism. 3, p. 530-545Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex
Ludwig, M. Q., Todorov, Petar Vladimirov, Egerod, Kristoffer Lihme, Olson, D. P. & Pers, Tune H, 2021, In: Diabetes. 70, 9, p. 1945-1955 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined
Lundgren, J. R., Janus, C., Jensen, Simon Birk Kjær, Juhl, C. R., Olsen, L. M., Christensen, R. M., Svane, M. S., Bandholm, Thomas Quaade, Bojsen-Møller, K. N., Blond, Martin Bæk, Jensen, Jens-Erik Beck, Stallknecht, Bente Merete, Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 6 May 2021, In: New England Journal of Medicine. 384, p. 1719-1730 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cold-induction of afadin in brown fat supports its thermogenic capacity
Lundh, M., Altıntaş, Ali, Tozzi, M., Fabre, O., Ma, Tao, Shamsi, F., Gerhart-Hines, Zach, Barrès, Romain, Tseng, Y. & Emanuelli, Brice, 2021, In: Scientific Reports. 11, 11 p., 9794.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application
Löffler, M. C., Betz, M. J., Blondin, D. P., Augustin, R., Sharma, A. K., Tseng, Y. H., Schéele, Camilla Charlotte Nielsen, Zimdahl, H., Mark, M., Hennige, A. M., Wolfrum, C., Langhans, W., Hamilton, B. S. & Neubauer, H., 2021, In: Molecular Metabolism. 51, 15 p., 101237.Research output: Contribution to journal › Review › Research › peer-review
- Published
The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle
Maasar, M. F., Turner, D. C., Gorski, P. P., Seaborne, R. A., Strauss, J. A., Shepherd, S. O., Cocks, M., Pillon, N. J., Zierath, Juleen R, Hulton, A. T., Drust, B. & Sharples, A. P., 2021, In: Frontiers in Physiology. 12, 17 p., 619447.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain
Madsen, J. J. & Olsen, O. H., 2021, In: Biomolecules. 11, 4, 16 p., 549.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fecal microbiota transplantation in hepatic encephalopathy: a systematic review
Madsen, M., Kimer, N., Bendtsen, Flemming & Petersen, Andreas Munk, 2021, In: Scandinavian Journal of Gastroenterology. 56, 5, p. 560-569 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
Manell, E., Puuvuori, E., Svensson, A., Velikyan, I., Hulsart-Billström, G., Hedenqvist, P., Holst, Jens Juul, Jensen Waern, M. & Eriksson, O., 2021, In: B M J Open Diabetes Research & Care. 9, 10 p., e002083.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skeletal muscle
Markby, G. R. & Sakamoto, Kei, 1 Jan 2021, Autophagy in Health and Disease. Elsevier, p. 213-225 13 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals
Martinussen, C., Svane, M. S., Bojsen-Møller, K. N., Jensen, Christian Zinck, Kristiansen, V. B., Bookout, A. L., Jorgensen, S. B., Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Madsbad, Sten & Kuhre, Rune Ehrenreich, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. p. E443-E452 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
Massart, J., Sjögren, R. J. O., Egan, B., Garde, C., Lindgren, M., Gu, W., Ferreira, D. M. S., Katayama, M., Ruas, J. L., Barrès, Romain, O'Gorman, D. J., Zierath, Juleen R & Krook, A., 2021, In: Nature Communications. 12, 1, 13 p., 5948.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat
Mathiesen, D. S., Lund, A., Vilsbøll, Tina, Knop, Filip Krag & Bagger, J. I., 2021, In: Frontiers in Endocrinology. 11, 617400.Research output: Contribution to journal › Review › Research › peer-review
- Published
No effect of dietary fish oil supplementation on the recruitment of brown and brite adipocytes in mice or humans under thermoneutral conditions
Maurer, S. F., Dieckmann, S., Lund, Jens, Fromme, T., Hess, A. L., Colson, C., Kjølbæk, Louise, Astrup, A., Gillum, M. P., Larsen, L. H., Liebisch, G., Amri, E. & Klingenspor, M., 2021, In: Molecular Nutrition & Food Research. 65, 2, 15 p., 2000681.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptome analysis uncover differential regulation in cell cycle, immunity, and metabolism in Anopheles albimanus during immune priming with Plasmodium berghei
Maya-Maldonado, K., Cime-Castillo, J., Maya, Otoniel, Argotte-Ramos, R., Rodríguez, M. C. & Lanz-Mendoza, H., 2021, In: Developmental and Comparative Immunology. 120, 104046.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of bile acids on the postprandial secretion of gut hormones: A randomized crossover study
McGlone, E. R., Malallah, K., Cuenco, J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vincent, R. P., Ling, C., Khan, O. A., Verma, S., Ahmed, A. R., Walters, J. R. F., Khoo, B., Bloom, S. R. & Tan, T. M. M., 2021, In: American Journal of Physiology - Endocrinology and Metabolism. 320, 4, p. E671-E679Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictors of Improvement in Quality of Life When Treating Hypothyroidism
Medici, B. B., Lerche la Cour, J., Knop, Filip Krag, Krakauer, M., Michaelsson, L. F., Faber, Jens, Watt, Torquil & Nygaard, Birte, 2021, In: Journal of Thyroid Research. 2021, 7 p., 5577217.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men
Meessen, E. C. E., Bakker, G. J., Nieuwdorp, M., Dallinga-Thie, G. M., Kemper, E. M., Olde Damink, S. W., Romijn, J. A., Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag, Groen, A. K., Schaap, F. G. & Soeters, M. R., 2021, In: Clinical Nutrition. 40, 3, p. 1013-1021Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A metabolomic study of Gomphrena agrestis in Brazilian Cerrado suggests drought-adaptive strategies on metabolism
Melo, G. A., Abreu, I. N., de Oliveira, M. B., Budzinski, I. G. F., Silva, L. V., Silva Pimenta, M. A. & Moritz, Thomas, 2021, In: Scientific Reports. 11, 13 p., 12933.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of the natural sweetener xylitol on gut hormone secretion and gastric emptying in humans: A pilot dose-ranging study
Meyer-Gerspach, A. C., Drewe, J., Verbeure, W., Le Roux, C. W., Dellatorre-Teixeira, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Hartmann, Bolette, Tack, J., Peterli, R., Beglinger, C. & Wölnerhanssen, B. K., 2021, In: Nutrients. 13, 1, 21 p., 174.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N., Vaez, A., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Jan Bonder, M., Boomsma, D. I., Christiansen, M. W., Claringbould, A., Deelen, P., Esko, T., Favé, M-J. & 33 others, , 2021, In: Nature Human Behaviour. 5, p. 1717-1730Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M., Bretherick, A. D., Richardson, T. G., Klughammer, J., Iotchkova, V., Sharp, G., Al Khleifat, A., Shatunov, A., Iacoangeli, A., McArdle, W. L., Ho, K. M. & 31 others, , 2021, In: Nature Genetics. 53, 9, p. 1311-1321 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reporting guidelines for human microbiome research: the STORMS checklist
Mirzayi, C., Renson, A., Furlanello, C., Sansone, S. A., Zohra, F., Elsafoury, S., Geistlinger, L., Kasselman, L. J., Eckenrode, K., van de Wijgert, J., Loughman, A., Marques, F. Z., MacIntyre, D. A., Arumugam, M., Azhar, R., Beghini, F., Bergstrom, K., Bhatt, A., Bisanz, J. E., Braun, J. & 32 others, , 2021, In: Nature Medicine. 27, 11, p. 1885-1892 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans
Modrzynska, J., Klein, C. F., Iversen, Kasper, Bundgård, Henning, Hartmann, Bolette, Mose, M., Rittig, N., Møller, N., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Connections. 10, 2, p. 205-213 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms
Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight
Moen, G., Beaumont, R. N., Grarup, Niels, Sommer, C., Shields, B. M., Lawlor, D. A., Freathy, R. M., Evans, D. M. & Warrington, N. M., 2021, In: International Journal of Epidemiology. 50, 1, p. 179-189 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome
Moreno-Asso, A., Altıntaş, Ali, McIlvenna, L. C., Patten, R. K., Botella, J., McAinch, A. J., Rodgers, R. J., Barrès, Romain & Stepto, N. K., 2021, In: Journal of Molecular Endocrinology. 68, 1, p. 63-76Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overweight in childhood of exclusively breastfed infants with a high weight at 5 months
Morgen, C. S., Larsson, M. W., Ängquist, Lars, Sørensen, Thorkild I.A. & Michaelsen, Kim F., 2021, In: Maternal and Child Nutrition. 17, 1, 10 p., e13057.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
β-Lactoglobulin Is Insulinotropic Compared with Casein and Whey Protein Ingestion during Catabolic Conditions in Men in a Double-Blinded Randomized Crossover Trial
Mose, M., Møller, N., Jessen, N., Mikkelsen, U. R., Christensen, B., Rakvaag, E., Hartmann, Bolette, Holst, Jens Juul, Jørgensen, J. O. L. & Rittig, N., 2021, In: Journal of Nutrition. 151, 6, p. 1462-1472 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Too narrow and too broad: Differentiating late-onset dementiafrom its historical entanglement with Alzheimer’s disease
Moseholm, Kristine Frøsig, Tybjerg, Karin, Jensen, Majken Karoline & Westendorp, Rudi GJ, Mar 2021, In: Aging Brain. 1, 100010.Research output: Contribution to journal › Journal article › Research
- Published
Author's reply to Kahn's comment
Møller, G., Ritz, C., Kjølbæk, Louise, Vuholm, S., Korndal, S. K., Larsen, T. M., Pedersen, Oluf Borbye, Saris, W. H., Astrup, A., Lauritzen, Lotte, Kristensen, M. B. & Lind, M. V., 2021, In: Nutrition, Metabolism & Cardiovascular Diseases. 31, 6, p. 1940-1941 2 p.Research output: Contribution to journal › Comment/debate › Research
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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