Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. Published

    Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women

    Åkerström, T., Stolpe, Malene Norup, Widmer, R., Dejgaard, T. F., Højberg, J. M., Møller, Kirsten, Hansen, J. S., Trinh, B., Holst, Jens Juul, Thomsen, C., Pedersen, Bente Klarlund & Ellingsgaard, H., 2022, In: Journal of the Endocrine Society. 6, 9, p. 1-8 8 p., bvac111.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Improving the calculation of statistical significance in genome-wide scans

    Ängquist, Lars & Hössjer, O., 1 Oct 2005, In: Biostatistics. 6, 4, p. 520-538 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Rising rural body-mass index is the main driver of the global obesity epidemic in adults

    Ängquist, Lars, Baker, J. L., Damsgaard, Camilla Trab, Eliasen, M., Linneberg, Allan René, Michaelsen, Kim F., Molbo, Drude, Mortensen, Erik Lykke, Sørensen, Thorkild I.A., Jørgensen, T., Tang Møllehave, L., Thuesen, B. H., Osler, Merete & NCD Risk Factor Collaboration (NCD-RisC), N. R. F. C., 2019, In: Nature. 569, 7755, p. 260-264 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  4. Published

    Strategies for conditional two-locus nonparametric linkage analysis

    Ängquist, Lars, Hössjer, O. & Groop, L., 1 Jul 2008, In: Human Heredity. 66, 3, p. 138-156 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Using importance sampling to improve simulation in linkage analysis

    Ängquist, Lars & Hössjer, O., 1 Jan 2004, In: Statistical Applications in Genetics and Molecular Biology. 3, 1, 5.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Stata tip 92: Manual implementation of permutations and bootstraps

    Ängquist, Lars, 1 Dec 2010, In: Stata Journal. 10, 4, p. 686-688 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications (Summary)

    Ängquist, Lars, 2007, In: Qvartilen. 22, 2, p. 25-26

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A Somewhat Subjective Introduction to Gene Mapping through Nonparametric Linkage Analysis

    Ängquist, Lars, 2008, Genetic Recombination Research Progress. Schultz, J. H. (ed.). Nova Biomedical Books, 60 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  9. Published

    A Unified Discussion on the Concept of Score Functions Used in the Context of Nonparametric Linkage Analysis

    Ängquist, Lars, 2008, In: Bioinformatics and Biology Insights. 2, p. 119-132 PMID:19812770.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Ängquist, Lars, 2007, 250 p.

    Research output: Book/Report › Ph.D. thesis › Research

  11. Published

    Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

    ÿstergaard, J. N., Grønbaek, M., Schnohr, P., Sørensen, Thorkild I.A. & Heitmann, Berit, 2010, In: International Journal of Obesity. 34, 4, p. 760-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease

    Ádori, C., Glück, L., Barde, S., Yoshitake, T., Kovacs, G. G., Mulder, J., Maglóczky, Z., Havas, L., Bölcskei, K., Mitsios, N., Uhlén, M., Szolcsányi, J., Kehr, J., Rönnbäck, A., Schwartz, Thue W., Rehfeld, Jens Frederik, Harkany, T., Palkovits, M., Schulz, S. & Hökfelt, T., Apr 2015, In: Acta Neuropathologica. 129, 4, p. 541-63 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Urinary biomarkers are associated with incident cardiovascular disease, all-cause mortality and deterioration of kidney function in type 2 diabetic patients with microalbuminuria

    von Scholten, B. J., Reinhard, H., Hansen, Tine Willum, Oellgaard, J., Parving, H., Jacobsen, P. K. & Rossing, Peter, Jul 2016, In: Diabetologia. 59, 7, p. 1549–1557

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Aetiological factors behind adipose tissue inflammation: an unexplored research area

    von Scholten, B. J., Andresen, E. N., Sørensen, Thorkild I.A. & Jess, T., 2013, In: Public Health Nutrition. 16, 1, p. 27-35 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite

    Holstein-Rønsbo, Stephanie & Gillum, M. P., 2019, In: The Journal of Physiology. 597, 14, p. 3539-3548 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

    von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., Karstoft, K., Vandenbeuch, A., Anderson, C. B., Cassell, M. D., Thompson, A. P., Solomon, T. P., Rahmouni, K., Kinnamon, S. C., Pieper, A. A., Gillum, M. P. & 1 others, Potthoff, M. J., 9 Feb 2016, In: Cell Metabolism. 23, 2, p. 335-43 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Molecular and in vivo phenotyping of missense variants of the human glucagon receptor

    van der Velden, W. J. C., Lindquist, Peter, Madsen, Jakob Sture, Stassen, R. H. M. J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, M. M., 2022, In: Journal of Biological Chemistry. 298, 2, 101413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    A novel common variant in DCST2 is associated with length in early life and height in adulthood

    van der Valk, R. J. P., Kreiner-Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A., Bradfield, J. P., Geller, F., Hayes, M. G., Cousminer, D. L., Körner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkänen, N., Ntalla, I. & 31 others, Horikoshi, M., Veijola, R., Freathy, R. M., Teo, Y., Barton, S. J., Evans, D. M., Kemp, J. P., St Pourcain, B., Ring, S. M., Davey Smith, G., Bergström, A., Kull, I., Hakonarson, H., Mentch, F. D., Bisgaard, H., Chawes, Bo Lund Krogsgaard, Stokholm, Jakob, Waage, J., Eriksen, P., Sevelsted, A., Melbye, M., van Duijn, C. M., Medina-Gomez, C., Hofman, A., de Jongste, J. C., Taal, H. R., Uitterlinden, A. G., Armstrong, L. L., Pers, Tune H, Bønnelykke, Klaus & Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, E. G. A. L. E. (. C., 15 Feb 2015, In: Human Molecular Genetics. 24, 4, p. 1155-68 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Chenodeoxycholic acid reduces intestinal permeability in newly weaned piglets

    van der Meer, Y., Gerrits, W. J. J., van den Bosch, M., Holst, Jens Juul, Moreto, M., Buurman, W. A., Kulik, W. & van Kempen, T. A. T. G., Dec 2012, In: Journal of Animal Science. 90 Suppl 4, p. 302-4 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

    van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernandez, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleo, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J. & 81 others, Moreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illan-Gala, I., Wei, W., Jeune, B., Orellana, A., Bergh, F. T., Wang, X., Hulsman, M., Beker, N., Tesi, N., Morris, C. M., Indakoetxea, B., Collij, L. E., Scherer, M., Morenas-Rodriguez, E., Ironside, J. W., van Berckel, B. N. M., Alcolea, D., Wiendl, H., Strickland, S. L., Pastor, P., Rodriguez Rodriguez, E., Boeve, B. F., Petersen, R. C., Ferman, T. J., van Gerpen, J. A., Reinders, M. J. T., Uitti, R. J., Tarraga, L., Maier, W., Dols-Icardo, O., Kawalia, A., Dalmasso, M. C., Boada, M., Zettl, U. K., van Schoor, N. M., Beekman, M., Allen, M., Masliah, E., Lopez de Munain, A., Pantelyat, A., Wszolek, Z. K., Ross, O. A., Dickson, D. W., Graff-Radford, N. R., Knopman, D., Rademakers, R., Lemstra, A. W., Pijnenburg, Y. A. L., Scheltens, P., Gasser, T., Chinnery, P. F., Hemmer, B., Huisman, M. A., Troncoso, J., Moreno, F., Nohr, E. A., Sørensen, Thorkild I.A., Heutink, P., Sanchez-Juan, P., Posthuma, D., Clarimon, J., Christensen, K., Ertekin-Taner, N., Scholz, S. W., Ramirez, A., Ruiz, A., Slagboom, E., van der Flier, W. M. & Holstege, H., 2019, In: Acta Neuropathologica. 138, 2, p. 237-250 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    52 Genetic Loci Influencing Myocardial Mass

    van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, L-P., Polašek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., Müller-Nurasyid, M. & 140 others, Smith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M, F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B., Haugen, E., Heinig, M., Hernandez, D. G., Hillege, H. L., Hirschhorn, J. N., Hofman, A., Hubner, N., Hwang, S., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, I. K., Kooner, J. S., Kors, J. A., Lakatta, E. G., Lage, K., Launer, L. J., Levy, D., Lundby, Alicia, Macfarlane, P. W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A. S., Nutile, T., Okin, P. M., Olsen, Jesper Velgaard, Oostra, B. A., Penninger, J. M., Pennacchio, L. A., Pers, Tune H, Perz, S., Peters, A., Pinto, Y. M., Pfeufer, A., Pilia, M. G., Pramstaller, P. P., Prins, B. P., Raitakari, O. T., Raychaudhuri, S., Rice, K. M., Rossin, E. J., Rotter, J. I., Schafer, S., Schlessinger, D., Schmidt, C. O., Sehmi, J., Silljé, H. H. W., Sinagra, G., Sinner, M. F., Slowikowski, K., Soliman, E. Z., Spector, T. D., Spiering, W., Stamatoyannopoulos, J. A., Stolk, R. P., Strauch, K., Tan, S., Tarasov, K. V., Trinh, B., Uitterlinden, A. G., van den Boogaard, M., van Duijn, C. M., van Gilst, W. H., Viikari, J. S., Visscher, P. M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C. X., Westra, H., Wijmenga, C., Wolffenbuttel, B. H., Yang, J., Bezzina, C. R., Munroe, P. B., Snieder, H., Wright, A. F., Rudan, I., Boyer, L. A., Asselbergs, F. W., van Veldhuisen, D. J., Stricker, B. H., Psaty, B. M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J. F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J. W., Kääb, S., Gudnason, V., Felix, S. B., Heckbert, S. R., de Boer, R. A., Newton-Cheh, C., Hicks, A. A., Chambers, J. C., Jamshidi, Y., Visel, A., Christoffels, V. M., Isaacs, A., Samani, N. J. & de Bakker, P. I. W., 27 Sep 2016, In: Journal of the American College of Cardiology. 68, 13, p. 1435-48 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

    van der Beek, C. M., Canfora, E. E., Kip, A. M., Gorissen, S. H. M., Damink, S. W. M. O., van Eijk, H. M., Holst, Jens Juul, Blaak, E. E., Dejong, C. H. C. & Lenaerts, K., Oct 2018, In: Metabolism. 87, p. 25-35

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

    van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Damink, S. W. M. O., Holst, Jens Juul, Masclee, A. A. M., Dejong, C. H. C. & Blaak, E. E., 11 Oct 2016, In: Clinical Science. 130, 22, p. 2073-2082 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

    van den Berg, R., Kooijman, S., Noordam, R., Ramkisoensing, A., Abreu-Vieira, G., Tambyrajah, L. L., Dijk, W., Ruppert, P., Mol, I. M., Kramar, B., Caputo, R., Puig, L. S., de Ruiter, E. M., Kroon, J., Hoekstra, M., van der Sluis, R. J., Meijer, O. C., Willems van Dijk, K., van Kerkhof, L. W. M., Christodoulides, C. & 8 others, Karpe, F., Gerhart-Hines, Zach, Kersten, S., Meijer, J. H., Coomans, C. P., van Heemst, D., Biermasz, N. R. & Rensen, P. C. N., 2018, In: Cell Reports. 22, 13, p. 3521-3533 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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