Novo Nordisk Foundation Center for Basic Metabolic Research

  1. 2024
  2. Accepted/In press

    Maternal obesity, interpregnancy weight changes and congenital heart defects in the offspring: a nationwide cohort study

    Hedermann, G., Hedley, P. L., Gadsbøll, K., Thagaard, I. N., Krebs, Lone, Hagen, C. M., Sørensen, Thorkild I.A., Christiansen, Michael & Ekelund, Charlotte Kvist, 2024, (Accepted/In press) In: International Journal of Obesity.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice

    Pendergrast, L. A., Ashcroft, Stephen Paul, Ehrlich, Amy M, Treebak, Jonas Thue, Krook, A., Dollet, L. & Zierath, Juleen R, 2024, In: Metabolism: Clinical and Experimental. 155, 12 p., 155834.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

    Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. Ỹ. G., Mohanty, S., Möller, A., Nieuwland, R., Ochiya, T. & 31 others, Sahoo, S., Torrecilhas, A. C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E. M., Brucale, M., Burger, D., Carney, R. P., Cocucci, E., Crescitelli, R., Hanser, E., Harris, A. L., Haughey, N. J., Benediktsdóttir, B. E., Gargiulo, E., Gori, A., Guo, W., Hufnagel, Antonia Sophie, Di Ianni, E., Jacobsen, Søren, Li, B., Mellergaard, M., Nejsum, P., Nolan, J. P., Østergaard, Ole, Yarani, R., Yin, H. & MISEV Consortium, M. C., 2024, In: Journal of Extracellular Vesicles. 13, 2, 84 p., e12404.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Moderate variations in the human diet impact the gut microbiota in humanized mice

    Schoeler, M., Chakaroun, R., Brolin, H., Larsson, I., Perkins, R., Marschall, H., Caesar, R. & Bäckhed, F., 2024, In: Acta Physiologica. 240, 3, 17 p., e14100.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91

    Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Lambrughi, M., Tiberti, M., Papaleo, E., Frimurer, Thomas Michael & Schwartz, Thue W., 2024, In: Molecular Cell. 84, 5, p. 955-966.e4 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

    Reddy, A., Winther, Sally, Tran, N., Xiao, H., Jakob, J., Garrity, R., Smith, A., Ordonez, M., Laznik-Bogoslavski, D., Rothstein, J. D., Mills, E. L. & Chouchani, E. T., 2024, In: Nature Metabolism. 6, 3, p. 567–577 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

    Meng, X., Navoly, G., Giannakopoulou, O., Levey, D. F., Koller, D., Pathak, G. A., Koen, N., Lin, K., Adams, M. J., Rentería, M. E., Feng, Y., Gaziano, J. M., Stein, D. J., Zar, H. J., Campbell, M. L., van Heel, D. A., Trivedi, B., Finer, S., McQuillin, A., Bass, N. & 58 others, Chundru, V. K., Martin, H. C., Huang, Q. Q., Valkovskaya, M., Chu, C. Y., Kanjira, S., Kuo, P. H., Chen, H. C., Tsai, S. J., Liu, Y. L., Kendler, K. S., Peterson, R. E., Cai, N., Fang, Y., Sen, S., Scott, L. J., Burmeister, M., Loos, Ruth, Preuss, M. H., Actkins, K. E. V., Davis, L. K., Uddin, M., Wani, A. H., Wildman, D. E., Aiello, A. E., Ursano, R. J., Kessler, R. C., Kanai, M., Okada, Y., Sakaue, S., Rabinowitz, J. A., Maher, B. S., Uhl, G., Eaton, W., Cruz-Fuentes, C. S., Martinez-Levy, G. A., Campos, A. I., Millwood, I. Y., Chen, Z., Li, L., Wassertheil-Smoller, S., Jiang, Y., Tian, C., Martin, N. G., Mitchell, B. L., Byrne, E. M., Awasthi, S., Coleman, J. R. I., Ripke, S., Sofer, T., Walters, R. G., McIntosh, A. M., Polimanti, R., Dunn, E. C., Stein, M. B., Gelernter, J., Lewis, C. M. & Kuchenbaecker, K., 2024, In: Nature Genetics. 56, 2, p. 222–233

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

    Sterenborg, R. B. T. M., Steinbrenner, I., Li, Y., Bujnis, M. N., Naito, T., Marouli, E., Galesloot, T. E., Babajide, O., Andreasen, L., Astrup, A., Åsvold, B. O., Bandinelli, S., Beekman, M., Beilby, J. P., Bork-Jensen, J., Boutin, T., Brody, J. A., Brown, S. J., Brumpton, B., Campbell, P. J. & 121 others, Cappola, A. R., Ceresini, G., Chaker, L., Chasman, D. I., Concas, M. P., Coutinho de Almeida, R., Cross, S. M., Cucca, F., Deary, I. J., Kjaergaard, A. D., Echouffo Tcheugui, J. B., Ellervik, Christina, Eriksson, J. G., Ferrucci, L., Freudenberg, J., Fuchsberger, C., Gieger, C., Giulianini, F., Gögele, M., Graham, S. E., Grarup, Niels, Gunjača, I., Hansen, Torben, Harding, B. N., Harris, S. E., Haunsø, Stig, Hayward, C., Hui, J., Ittermann, T., Jukema, J. W., Kajantie, E., Kanters, Jørgen K., Kårhus, L. L., Kiemeney, L. A. L. M., Kloppenburg, M., Kühnel, B., Lahti, J., Langenberg, C., Lapauw, B., Leese, G., Li, S., Liewald, D. C. M., Linneberg, Allan René, Lominchar, J. V. T., Luan, J., Martin, N. G., Matana, A., Meima, M. E., Meitinger, T., Meulenbelt, I., Mitchell, B. D., Møllehave, L. T., Mora, S., Naitza, S., Nauck, M., Netea-Maier, R. T., Noordam, R., Nursyifa, Casia, Okada, Y., Onano, S., Papadopoulou, A., Palmer, C. N. A., Pattaro, C., Pedersen, Oluf Borbye, Peters, A., Pietzner, M., Polašek, O., Pramstaller, P. P., Psaty, B. M., Punda, A., Ray, D., Redmond, P., Richards, J. B., Ridker, P. M., Russ, T. C., Ryan, K. A., Olesen, Morten Steen Salling, Schultheiss, U. T., Selvin, E., Siddiqui, M. K., Sidore, C., Slagboom, P. E., Sørensen, Thorkild I.A., Soto-Pedre, E., Spector, T. D., Spedicati, B., Srinivasan, S., Starr, J. M., Stott, D. J., Tanaka, T., Torlak, V., Trompet, S., Tuhkanen, J., Uitterlinden, A. G., van den Akker, E. B., van den Eynde, T., van der Klauw, M. M., van Heemst, D., Verroken, C., Visser, W. E., Vojinovic, D., Völzke, H., Waldenberger, M., Walsh, J. P., Wareham, N. J., Weiss, S., Willer, C. J., Wilson, S. G., Wolffenbuttel, B. H. R., Wouters, H. J. C. M., Wright, M. J., Yang, Q., Zemunik, T., Zhou, W., Zhu, G., Zöllner, S., Smit, J. W. A., Peeters, R. P., Köttgen, A., Teumer, A. & Medici, M., 2024, In: Nature Communications. 15, 1, 18 p., 888.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. E-pub ahead of print

    Myonuclear alterations associated with exercise are independent of age in humans

    Battey, E., Ross, J. A., Hoang, A., Wilson, D. G. S., Han, Y., Levy, Y., Pollock, R. D., Kalakoutis, M., Pugh, J. N., Close, G. L., Ellison-Hughes, G. M., Lazarus, N. R., Iskratsch, T., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Journal of Physiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    New Lessons from the gut: Studies of the role of gut peptides in weight loss and diabetes resolution after gastric bypass and sleeve gastrectomy

    Holst, Jens Juul, Madsbad, Sten, Bojsen-Møller, Kirstine Nyvold, Dirksen, C. & Svane, M., 2024, In: Peptides. 176, 9 p., 171199.

    Research output: Contribution to journalReviewResearchpeer-review

  12. E-pub ahead of print

    Opportunities and barriers in omics-based biomarker discovery for steatotic liver diseases

    Thiele, M., Villesen, I. F., Niu, L., Johansen, S., Sulek, K., Nishijima, S., Espen, L. V., Keller, M., Israelsen, M., Suvitaival, T., Zawadzki, A. D., Juel, H. B., Brol, M. J., Stinson, S. E., Huang, Y., Silva, M. C. A., Kuhn, M., Anastasiadou, E., Leeming, D. J., Karsdal, M. & 12 others, Matthijnssens, J., Arumugam, Mani, Dalgaard, L. T., Legido-Quigley, C., Mann, Matthias, Trebicka, J., Bork, P., Jensen, Lars Juhl, Hansen, Torben, Krag, A., MicrobLiver Consortium, M. C. & GALAXY Consortium, G. C., 2024, (E-pub ahead of print) In: Journal of Hepatology.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    PPARγ antagonists induce aromatase transcription in adipose tissue cultures

    Ardenkjær-Skinnerup, J., Saar, Daniel, Petersen, Patricia Stephanie S, Pedersen, M., Svingen, T., Kragelund, Birthe Brandt, Hadrup, N., Ravn-Haren, G., Emanuelli, Brice, Brown, K. A. & Vogel, U., 2024, In: Biochemical Pharmacology. 222, 13 p., 116095.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring

    Crean, A. J., Senior, A. M. N., Freire, T., Clark, T. D., Mackay, F., Austin, G., Pulpitel, T. J., Nobrega, M. A., Barrès, Romain & Simpson, S. J., 2024, In: Nature Communications. 15, 11 p., 2982.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome

    Zhu, J., Eliasen, A. U., Aris, I. M., Stinson, Sara, Holm, Jens-Christian, Hansen, Torben, Hivert, M., Bønnelykke, Klaus, Salem, R. M., Hirschhorn, J. N. & Chan, Y., 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 2, p. 380-388

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Persistent thinness and anorexia nervosa differ on a genomic level

    Hübel, C., Abdulkadir, M., Herle, M., Palmos, A. B., Loos, Ruth, Breen, G., Micali, Nadia & Bulik, C. M., 2024, In: European Journal of Human Genetics. 32, 1, p. 117-124

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Plasma metabolite predictors of metabolic syndrome incidence and reversion

    Semnani-Azad, Z., Toledo, E., Babio, N., Ruiz-Canela, M., Wittenbecher, C., Razquin, C., Wang, F., Dennis, C., Deik, A., Clish, C. B., Corella, D., Fitó, M., Estruch, R., Arós, F., Ros, E., García-Gavilan, J., Liang, L., Salas-Salvadó, J., Martínez-González, M. A., Hu, F. B. & 1 others, Guasch Ferre, Marta, 2024, In: Metabolism: Clinical and Experimental. 151, 155742.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease

    Margara-Escudero, H. J., Paz-Graniel, I., García-Gavilán, J., Ruiz-Canela, M., Sun, Q., Clish, C. B., Toledo, E., Corella, D., Estruch, R., Ros, E., Castañer, O., Arós, F., Fiol, M., Guasch-Ferré, M., Lapetra, J., Razquin, C., Dennis, C., Deik, A., Li, J., Gómez-Gracia, E. & 4 others, Babio, N., Martínez-González, M. A., Hu, F. B. & Salas-Salvadó, J., 2024, In: Cardiovascular Diabetology. 23, 1, 13 p., 38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies

    Tessier, A. J., Wang, F., Liang, L., Wittenbecher, C., Haslam, D. E., Eliassen, A. H., Tobias, D. K., Li, J., Zeleznik, O. A., Ascherio, A., Sun, Q., Stampfer, M. J., Grodstein, F., Rexrode, K. M., Manson, J. A. E., Balasubramanian, R., Clish, C. B., Martínez-González, M. A., Chavarro, J. E., Hu, F. B. & 1 others, Guasch Ferre, Marta, 2024, In: Med. 5, 3, p. 224-238.e5 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Plasma proteome profiling reveals metabolic and immunologic differences between Anorexia Nervosa subtypes

    Samodova, D., Hoel, A., Hansen, T. H., Clausen, L., Telléus, G. K., Marti, H. P., Pedersen, Oluf Borbye, Støving, R. K. & Deshmukh, Atul Shahaji, 2024, In: Metabolism: Clinical and Experimental. 152, 11 p., 155760.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Population genomics of post-glacial western Eurasia

    Allentoft, M. E., Sikora, M., Refoyo-Martínez, A., Irving-Pease, E. K., Fischer, A., Barrie, W., Ingason, A., Stenderup, J., Sjögren, K-G., Pearson, A., da Mota, B. S., Paulsson, B. S., Halgren, A., Macleod, R., Jørkov, M. L. S., Demeter, F., Sørensen, L., Nielsen, P. O., Henriksen, R. A., Vimala, T. & 144 others, McColl, Hugh, Margaryan, Ashot, Ilardo, M., Vaughn, A., Mortensen, M. F., Nielsen, A. B., Hede, M. U., Johannsen, N. N., Rasmussen, P., Vinner, Lasse, Renaud, Gabriel, Stern, A., Jensen, Theis Zetner Trolle, Scorrano, Gabriele, Schroeder, Hannes, Lysdahl, P., Ramsøe, Abigail Daisy, Skorobogatov, A., Schork, A. J., Rosengren, A., Ruter, Anthony Henry, Outram, A., Timoshenko, A. A., Buzhilova, A., Coppa, A., Zubova, A., Silva, A. M., Hansen, Anders Johannes, Gromov, A., Logvin, A., Gotfredsen, Anne Birgitte, Nielsen, B. H., González-Rabanal, B., Lalueza-Fox, C., McKenzie, C. J., Gaunitz, Charleen, Blasco, C., Liesau, C., Martinez-Labarga, C., Pozdnyakov, D. V., Cuenca-Solana, D., Lordkipanidze, D. O., En’shin, D., Salazar-García, D. C., Price, T. D., Borić, D., Kostyleva, E., Veselovskaya, E. V., Usmanova, E. R., Cappellini, Enrico, Petersen, Erik Brinch, Kannegaard, E., Radina, F., Yediay, Fulya Eylem, Duday, H., Gutiérrez-Zugasti, I., Merts, I., Potekhina, I., Shevnina, I., Altinkaya, Isin, Guilaine, J., Hansen, J., Tortosa, J. E. A., Zilhão, J., Vega, J., Pedersen, K. B., Tunia, K., Zhao, Lei, Mylnikova, L. N., Larsson, L., Metz, L., Yepiskoposyan, L., Pedersen, L., Sarti, L., Orlando, L., Slimak, L., Klassen, L., Blank, M., González-Morales, M., Silvestrini, M., Vretemark, M., Nesterova, M. S., Rykun, M., Rolfo, M. F., Szmyt, M., Przybyła, M., Calattini, M., Sablin, M., Dobisíková, M., Meldgaard, Morten, Johansen, M., Berezina, N., Card, N., Saveliev, N. A., Poshekhonova, O., Rickards, O., Lozovskaya, O. V., Gábor, O., Uldum, O. C., Aurino, P., Kosintsev, P., Courtaud, P., Ríos, P., Mortensen, P., Lotz, P., Persson, P., Bangsgaard, Pernille, de Barros Damgaard, P., Vang Petersen, P., Martinez, P. P., Włodarczak, P., Smolyaninov, R. V., Maring, R., Menduiña, R., Badalyan, R., Iversen, Rune, Turin, R., Vasilyev, S., Wåhlin, S., Borutskaya, S., Skochina, S., Sørensen, S. A., Andersen, S. H., Jørgensen, T., Serikov, Y. B., Molodin, V. I., Smrcka, V., Merts, V., Appadurai, V., Moiseyev, V., Magnusson, Y., Kjær, Kurt H., Lynnerup, Niels, Lawson, D. J., Sudmant, P. H., Rasmussen, Simon, Korneliussen, Thorfinn Sand, Durbin, R., Nielsen, Rasmus, Delaneau, O., Werge, Thomas, Racimo, Fernando, Kristiansen, Kristian & Willerslev, Eske, 2024, In: Nature. 625, 7994, p. 301-311

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism

    Wahlström, A., Brumbaugh, A., Sjöland, W., Olsson, L., Wu, H., Henricsson, M., Lundqvist, A., Makki, K., Hazen, S. L., Bergström, G., Marschall, H. U., Fischbach, M. A. & Bäckhed, F., 2024, In: Nature Communications. 15, 11 p., 4276.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Prognostic Value of Gut Microbe-Generated Metabolite Phenylacetylglutamine in Patients with Heart Failure

    Tang, W. H. W., Nemet, I., Li, X. S., Wu, Y., Haghikia, A., Witkowski, M., Koeth, R. A., Demuth, I., König, M., Steinhagen-Thiessen, E., Bäckhed, F., Fischbach, M. A., Deb, A., Landmesser, U. & Hazen, S. L., 2024, In: European Journal of Heart Failure. 26, 2, p. 233-241

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R

    Lund, Camilla, Ranea-Robles, Pablo, Falk, S., Belmont-Rausch, Dylan Matthew, Skovbjerg, G., Vibe-Petersen, V. K., Krauth, Nathalie, Skytte, J. L., Vana, V., Roostalu, U., Pers, Tune H, Lund, Jens & Clemmensen, Christoffer, 2024, In: Nature Communications. 15, 1192.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Protocol for flow cytometry-assisted single-nucleus RNA sequencing of human and mouse adipose tissue with sample multiplexing

    Gulko, A., Essene, A., Belmont-Rausch, Dylan Matthew, Veregge, M., Pant, D., Tenen, D., Kapel, Benedicte Schultz, Emont, M. P., Pers, Tune H, Rosen, E. D. & Tsai, L. T., 2024, In: STAR Protocols. 5, 1, 21 p., 102893.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort

    Bjørnsbo, K. S., Brøns, C., Aadahl, M., Kampmann, F. B., Friis Bryde Nielsen, C., Lundbergh, B., Christensen, R. W., Kårhus, L. L., Madsen, A. L., Hansen, C. S., Nørgaard, K., Jørgensen, N. R., Suetta, C., Kjaer, M., Grarup, N., Kanters, J., Larsen, M., Køber, L., Kofoed, K. F., Loos, R. & 3 others, Hansen, Torben, Linneberg, Allan René & Vaag, Allan, 2024, In: BMJ Open. 14, 1, 10 p., e078501.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Pten knockout in mouse preosteoblasts leads to changes in bone turnover and strength.

    Lorenz, J., Richter, S., Kirstein, A. S., Kolbig, F., Nebe, M., Schulze, M., Kiess, W., Spitzbarth, I., Kloting, N., Le Duc, D., Baschant, U. & Garten, A., 2024, In: JBMR Plus. 8, 3, 14 p., ziad016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

    Hansen, Signe Schmidt Kjølner, Krautz, Robert, Rago, D., Havelund, J., Stigliani, Arnaud, Færgeman, N. J., Prézelin, A., Rivière, J., Couturier-Tarrade, A., Akimov, V., Blagoev, B., Elfving, B., Neess, D., Vogel, U., Khodosevich, Konstantin, Hougaard, Karin Sørig & Sandelin, Albin Gustav, 2024, In: Nature Communications. 15, 24 p., 4711.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes

    Di Giuseppe, G., Soldovieri, L., Ciccarelli, G., Ferraro, P. M., Quero, G., Cinti, F., Capece, U., Moffa, S., Nista, E. C., Gasbarrini, A., Mari, A., Alfieri, S., Tondolo, V., Pontecorvi, A., Holst, Jens Juul, Giaccari, A. & Mezza, T., 2024, In: Journal of Clinical Investigation. 134, 8, 3 p., e175133.

    Research output: Contribution to journalComment/debateResearch

  30. E-pub ahead of print

    Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes

    Fuhri Snethlage, C. M., McDonald, T. J., Oram, R. D., de Groen, P., Rampanelli, E., Schimmel, A. W. M., Holleman, F., Siegelaar, S., Hoekstra, J., Brouwer, C. B., Knop, Filip Krag, Verchere, C. B., van Raalte, D. H., Roep, B. O., Nieuwdorp, M. & Hanssen, N. M. J., 2024, (E-pub ahead of print) In: Diabetes Care. 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Searching for information about stem cells online in an age of artificial intelligence: How should the stem cell community respond?

    Hoeyer, Klaus, Couturier, A., Barawi, K., Drew, C., Grundtvig, Anders, Lane, E., Munk, A. K., Whiteley, Louise & Munsie, M., 2024, In: Stem Cell Reports. 19, 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

    Lennon, N. J., Kottyan, L. C., Kachulis, C., Abul-Husn, N. S., Arias, J., Belbin, G., Below, J. E., Berndt, S. I., Chung, W. K., Cimino, J. J., Clayton, E. W., Connolly, J. J., Crosslin, D. R., Dikilitas, O., Velez Edwards, D. R., Feng, Q. P., Fisher, M., Freimuth, R. R., Ge, T., Glessner, J. T. & 59 others, Gordon, A. S., Patterson, C., Hakonarson, H., Harden, M., Harr, M., Hirschhorn, J., Hoggart, C., Hsu, L., Irvin, M. R., Jarvik, G. P., Karlson, E. W., Khan, A., Khera, A., Kiryluk, K., Kullo, I., Larkin, K., Limdi, N., Linder, J. E., Loos, Ruth, Luo, Y., Malolepsza, E., Manolio, T. A., Martin, L. J., McCarthy, L., McNally, E. M., Meigs, J. B., Mersha, T. B., Mosley, J. D., Musick, A., Namjou, B., Pai, N., Pesce, L. L., Peters, U., Peterson, J. F., Prows, C. A., Puckelwartz, M. J., Rehm, H. L., Roden, D. M., Rosenthal, E. A., Rowley, R., Sawicki, K. T., Schaid, D. J., Smit, Roelof Adriaan Johan, Smith, J. L., Smoller, J. W., Thomas, M., Tiwari, H., Toledo, D. M., Vaitinadin, N. S., Veenstra, D., Walunas, T. L., Wang, Z., Wei, W. Q., Weng, C., Wiesner, G. L., Yin, X., Kenny, E. E., Berndt, S. & Hirschhorn, J., 2024, In: Nature Medicine. 30, 2, p. 480-487 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Signs of Glucagon Resistance After a Two-Week Hypercaloric Diet Intervention

    Suppli, M. P., Høgedal, A., Bagger, J. I., Chabanova, E., van Hall, Gerrit, Forman, Julie Lyng, Christensen, Mikkel Bring, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 4, p. 955–967 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes

    Hartmann, Bolette, Longo, M., Mathiesen, D. S., Hare, Kristine Juul, Jørgensen, Niklas Rye, Esposito, K., Deacon, Carolyn F., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. e259-e265 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Sociodemographic characteristics and COVID-19 testing rates: spatiotemporal patterns and impact of test accessibility in Sweden

    Kennedy, B., Varotsis, G., Hammar, U., Nguyen, D., Carrasquilla, Germán D., van Zoest, V., Kristiansson, R. S., Fitipaldi, H., Dekkers, K. F., Daivadanam, M., Martinell, M., Björk, J. & Fall, T., 2024, In: European Journal of Public Health. 34, 1, p. 14-21

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Suboptimal Weight Loss 13 Years After Roux-en-Y Gastric Bypass Is Associated with Blunted Appetite Response

    Nymo, S., Lundanes, J., Eriksen, K., Aukan, M., Rehfeld, Jens Frederik, Holst, Jens Juul, Johnsen, G., Græslie, H., Kulseng, B., Sandvik, J. & Martins, C., 2024, In: Obesity Surgery. 34, 2, p. 592-601

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Sugar-sweetened or artificially-sweetened beverage consumption, physical activity, and risk of cardiovascular disease in adults: a prospective cohort study

    Pacheco, L. S., Tobias, D. K., Li, Y., Bhupathiraju, S. N., Willett, W. C., Ludwig, D. S., Ebbeling, C. B., Haslam, D. E., Drouin-Chartier, J. P., Hu, F. B. & Guasch Ferre, Marta, 2024, In: American Journal of Clinical Nutrition. 119, 3, p. 669-681 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published

    Temporal gut microbiota variability and association with dietary patterns: From the one-year observational Diet, Cancer, and Health - Next Generations MAX study

    Rostgaard-Hansen, Agnetha Linn, Esberg, A., Dicksved, J., Hansen, Torben, Pelve, E., Brunius, C., Halkjær, J., Tjønneland, Anne, Johansson, I. & Landberg, R., 2024, In: American Journal of Clinical Nutrition. 119, 4, p. 1015-1026 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions

    Lanfranchi, M., Yandiev, S., Meyer-Dilhet, G., Ellouze, S., Kerkhofs, M., Dos Reis, R., Garcia, A., Blondet, C., Amar, A., Kneppers, A., Polvèche, H., Plassard, D., Foretz, M., Viollet, B., Sakamoto, Kei, Mounier, R., Bourgeois, C. F., Raineteau, O., Goillot, E. & Courchet, J., 2024, In: Nature Communications. 15, 17 p., 2487.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    The Taste Liking Questionnaire (TasteLQ) – A tool for assessment of taste liking in the Danish population

    Haydar, Sara, Karlsson, Camilla Cederbye, Linneberg, Allan René, Kårhus, L. L., Ängquist, Lars, Hansen, Torben, Bredie, Wender & Grarup, Niels, 2024, In: Food Quality and Preference. 117, 12 p., 105176.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. E-pub ahead of print

    The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study

    Eriksen, R., White, M. C., Dawed, A. Y., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A. & 26 others, McDonald, T. J., Kokkola, T., Rutters, F., Beulens, J., Muilwijk, M., Blom, M., Elders, P., Hansen, T. H., Fernandez-Tajes, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, Oluf Borbye, Ruetten, H., Forgie, I., Holst, Jens Juul, Thomsen, Henrik S., Ridderstråle, M., Bell, J. D., Adamski, J., Franks, P. W., Hansen, Torben, Holmes, E., Frost, G. & Pearson, E. R., 2024, (E-pub ahead of print) In: Journal of Clinical Endocrinology and Metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    The effect of exogenous glucagon on circulating amino acids in individuals with and without type 2 diabetes and obesity

    Grøndahl, M. F. G., Bagger, J. I., Suppli, M. P., van Hall, Gerrit, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina, Christensen, Mikkel Bring, Lund, A. B. & Knop, Filip Krag, 2024, In: Endocrine Connections. 13, 3, 7 p., e230516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The impact of surgery and oncological treatment on risk of type 2 diabetes onset in patients with colorectal cancer: nationwide cohort study in Denmark

    Krag, C., Svane, M. S., Madsbad, Sten, Graversen, S. B., Christensen, J. F., Sørensen, Thorkild I.A., Lehrskov, L. L. & Laurberg, T., 2024, In: eLife. 12, 13 p., RP89354.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    The use of a systems approach to increase NAD+ in human participants

    Henderson, John David, Quigley, S. N. Z., Chachra, S. S., Conlon, N. & Ford, D., 2024, In: npj Aging. 10, 12 p., 7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

    Bradfield, J. P., Kember, R. L., Ulrich, A., Balkiyarova, Z., Alyass, A., Aris, I. M., Bell, J. A., Broadaway, K. A., Chen, Z., Chai, J-F., Davies, N. M., Fernandez-Orth, D., Bustamante, M., Fore, R., Ganguli, A., Heiskala, A., Hottenga, J-J., Íñiguez, C., Kobes, S., Leinonen, J. & 33 others, Lowry, E., Lyytikainen, L., Mahajan, A., Pitkänen, N., Schnurr, T. M., Have, C. T., Strachan, D. P., Thiering, E., Vogelezang, S., Wade, K. H., Wang, C. A., Wong, A., Holm, Louise Aas, Chesi, A., Choong, C., Cruz, M., Elliott, P., Franks, S., Frithioff-Bøjsøe, C., Gauderman, W. J., Glessner, J. T., Gilsanz, V., Griesman, K., Hanson, R. L., Kaakinen, M., Kalkwarf, H., Kelly, A., Hansen, Torben, Holm, Jens-Christian, Sørensen, Thorkild I.A., Grant, S. F. A., Cousminer, D. L. & Early Growth Genetics Consortium, E. G. G. C., 2024, In: Genome Biology. 25, 19 p., 22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

    Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., Garratt, E. S., Vasiloglou, M. F., Chanvillard, L., Dalbram, E., Ehrlich, A. M., Sanchez-Garcia, J. L., Canto, C., Karagounis, L. G., Treebak, J. T., Migaud, M. E. & 15 others, Heshmat, R., Razi, F., Karnani, N., Ostovar, A., Farzadfar, F., Tay, S. K. H., Sanders, M. J., Lillycrop, K. A., Godfrey, K. M., Nakagawa, T., Moco, S., Koopman, R., Lynch, G. S., Sorrentino, V. & Feige, J. N., 2024, In: Nature Metabolism. 6, 3, p. 433–447

    Research output: Contribution to journalLetterResearchpeer-review

  48. Published

    Understanding risk and causal mechanisms for developing obesity in infants and young children: A National Institutes of Health workshop

    Aagaard, K. M., Barkin, S. L., Burant, C. F., Carnell, S., Demerath, E., Donovan, S. M., Eneli, I., Francis, L. A., Gilbert-Diamond, D., Hivert, M. F., LeBourgeois, M. K., Loos, R. J. F., Lumeng, J. C., Miller, A. L., Okely, A. D., Osganian, S. K., Ramirez, A. G., Trasande, L., Van Horn, L. V., Wake, M. & 2 others, Wright, R. J. & Yanovski, S. Z., 2024, In: Obesity Reviews. 25, 4, 21 p., e13690.

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published

    Unique features of β-cell metabolism are lost in type 2 diabetes

    Muñoz, F., Fex, M., Moritz, Thomas, Mulder, H. & Cataldo Bascunan, Luis Rodrigo, 2024, In: Acta Physiologica. 240, 6, 21 p., e14148.

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    Variants at the Interleukin 1 Gene Locus and Pericarditis

    Thorolfsdottir, R. B., Jonsdottir, A. B., Sveinbjornsson, G., Aegisdottir, H. M., Oddsson, A., Stefansson, O. A., Halldorsson, G. H., Saevarsdottir, S., Thorleifsson, G., Stefansdottir, L., Pedersen, O. B., Sørensen, E., Ghouse, J., Raja, A. A., Zheng, C., Silajdzija, E., Rand, S. A., Erikstrup, C., Ullum, H., Mikkelsen, C. & 26 others, Banasik, Karina, Brunak, Søren, Ivarsdottir, E. V., Sigurdsson, A., Beyter, D., Sturluson, A., Einarsson, H., Tragante, V., Helgason, H., Lund, S. H., Halldorsson, B. V., Sigurpalsdottir, B. D., Olafsson, I., Arnar, D. O., Thorgeirsson, G., Knowlton, K. U., Nadauld, L. D., Gretarsdottir, S., Helgadottir, A., Ostrowski, Sisse Rye, Gudbjartssson, D. F., Jonsdottir, I., Bundgård, Henning, Holm, H., Sulem, P. & Stefansson, K., 2024, In: JAMA Cardiology. 9, 2, p. 165-172 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

    Phelps, N. H., Singleton, R. K., Zhou, B., Heap, R. A., Mishra, A., Bennett, J. E., Paciorek, C. J., Lhoste, V. PF., Carrillo-Larco, R. M., Stevens, G. A., Rodriguez-Martinez, A., Bixby, H., Baker, J. L., Aarestrup, J., Afzal, S., Allin, K., Andersen, L. B., Ängquist, L., Bjerregaard, P., Bojesen, S. E. & 31 others, Christensen, K., Damsgaard, Camilla Trab, Dantoft, T. M., Eriksen, L., Giwercman, A., Halkjær, J., Jørgensen, T., Kristensen, P. L., Lind, L., Linneberg, A., Liu, J., Liu, L., Madsen, A. L., Michaelsen, Kim F., Møllehave, Line Tang, Mortensen, Erik Lykke, Nordestgaard, Børge, Osler, Merete, Overvad, K., Schmidt, I. M., Schnohr, P., Schramm, S., Sobngwi, E., Sodemann, M., Sørensen, T. I., Tjonneland, A., Tolstrup, J. S., Wang, Q., Wang, Y. W., Yang, Y. & NCD Risk Factor Collaboration (NCD-RisC), N. R. F. C. (., 2024, In: The Lancet. 403, 10431, p. 1027-1050 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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