Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2024
  2. Published

    GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal

    Senftleber, N. K., Andersen, M. K., Jørsboe, E., Stæger, Frederik Filip Vinggaard, Nøhr, A. K., Garcia Erill, Genís, Meisner, Jonas, Santander, Cindy, Balboa, Renzo Fidel Ferdinando, Gilly, A., Bjerregaard, P., Larsen, C. V. L., Grarup, Niels, Jørgensen, M. E., Zeggini, E., Moltke, Ida, Hansen, Torben & Albrechtsen, Anders, 2024, In: European Journal of Human Genetics. 32, p. 215–223 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Genetic Variation and Obesity

    Loos, Ruth, 2024, Handbook of Obesity: Epidemiology, Etiology, and Physiopathology. Bray, G. A. & Bouchard, C. (eds.). 4 ed. CRC Press, Vol. 1. p. 113-122 10 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  4. Published

    Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

    Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., Schroeder, P., Vanderwerff, B. & 31 others, Kals, M., Bragg, F., Lin, K., Guo, X., Zhang, W., Yao, J., Kim, Y. J., Graff, M., Takeuchi, F., Nano, J., Lamri, A., Nakatochi, M., Moon, S., Scott, R. A., Cook, J. P., Lee, J., Pan, I., Taliun, D., Parra, E. J., Grarup, Niels, Chen, W., Bork-Jensen, J., Islam, M. T., Jørgensen, T., Linneberg, Allan René, Witte, D. R., Lind, L., Hansen, Torben, Pedersen, Oluf Borbye, Loos, Ruth & VA Million Veteran Program, V. M. V. P., 2024, In: Nature. 627, 8003, p. 347-357 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Accepted/In press

    Genetic underpinnings of fasting and oral glucose-stimulated based insulin sensitivity indices

    Suleman, Sufyan, Madsen, Anne Lundager, Ängquist, Lars, Schubert, Mikkel, Linneberg, Allan René, Loos, Ruth, Hansen, Torben & Grarup, Niels, 2024, (Accepted/In press) In: Journal of Clinical Endocrinology and Metabolism.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Genome-wide association study of preserved ratio impaired spirometry (PRISm)

    Higbee, D. H., Lirio, A., Hamilton, F., Granell, R., Wyss, A. B., London, S. J., Bartz, T. M., Gharib, S. A., Cho, M. H., Wan, E., Silverman, E., Crapo, J. D., Lominchar, J. V. T., Hansen, T., Grarup, N., Dantoft, T., Kårhus, L., Linneberg, A., O'Connor, G. T., Dupuis, J. & 25 others, Xu, H., De Vries, M. M., Hu, X., Rich, S. S., Barr, R. G., Manichaikul, A., Wijnant, S. R. A., Brusselle, G. G., Lahousse, L., Li, X., Hernández Cordero, A. I., Obeidat, M., Sin, D. D., Harris, S. E., Redmond, P., Taylor, A. M., Cox, S. R., Williams, A. T., Shrine, N., John, C., Guyatt, A. L., Hall, I. P., Davey Smith, G., Tobin, M. D. & Dodd, J. W., 2024, In: European Respiratory Journal. 63, 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas

    Hughes, O., Bentley, A. R., Breeze, C. E., Aguet, F., Xu, X., Nadkarni, G., Sun, Q., Lin, B. M., Gilliland, T., Meyer, M. C., Du, J., Raffield, L. M., Kramer, H., Morton, R. W., Gouveia, M. H., Atkinson, E. G., Valladares-Salgado, A., Wacher-Rodarte, N., Dueker, N. D., Guo, X. & 54 others, Hai, Y., Adeyemo, A., Best, L. G., Cai, J., Chen, G., Chong, M., Doumatey, A., Eales, J., Goodarzi, M. O., Ipp, E., Irvin, M. R., Jiang, M., Jones, A. C., Kooperberg, C., Krieger, J. E., Lange, E. M., Lanktree, M. B., Lash, J. P., Lotufo, P. A., Loos, Ruth, Ha My, V. T., Peralta-Romero, J., Qi, L., Raffel, L. J., Rich, S. S., Rodriquez, E. J., Tarazona-Santos, E., Taylor, K. D., Umans, J. G., Wen, J., Young, B. A., Yu, Z., Zhang, Y., Ida Chen, Y. D., Rundek, T., Rotter, J. I., Cruz, M., Fornage, M., Lima-Costa, M. F., Pereira, A. C., Paré, G., Natarajan, P., Cole, S. A., Carson, A. P., Lange, L. A., Li, Y., Perez-Stable, E. J., Do, R., Charchar, F. J., Tomaszewski, M., Mychaleckyj, J. C., Rotimi, C., Morris, A. P. & Franceschini, N., 2024, In: Cell Genomics. 4, 1, 13 p., 100468.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Giraffe lineages are shaped by major ancient admixture events

    Bertola, L. D., Quinn, L., Hanghøj, K., Garcia-Erill, G., Rasmussen, M. S., Balboa, R. F., Meisner, J., Bøggild, T., Wang, X., Lin, L., Nursyifa, C., Liu, X., Li, Z., Chege, M., Moodley, Y., Brüniche-Olsen, A., Kuja, J., Schubert, M., Agaba, M., Santander, C. G. & 7 others, Sinding, Mikkel Holger Strander, Muwanika, V., Masembe, C., Siegismund, Hans Redlef, Moltke, Ida, Albrechtsen, Anders & Heller, Rasmus, 2024, In: Current Biology. 34, 7, p. 1576-1586.e5 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Harnessing the power of proteomics in precision diabetes medicine

    Kurgan, Nigel Kilty, Larsen, Jeppe Kjærgaard & Deshmukh, Atul Shahaji, 2024, In: Diabetologia. 67, 5, p. 783–797

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Healthcare Burden in Greenland of Gastrointestinal Symptoms in Adults with Inherited Loss of Sucrase-Isomaltase Function

    Andersen, K., Hansen, Torben, Jørgensen, M. E. & Senftleber, N., 2024, In: Application of Clinical Genetics. 17, p. 15-21 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: a post-treatment analysis of a randomised placebo-controlled trial

    Jensen, Simon Birk Kjær, Blond, Martin Bæk, Sandsdal, Rasmus Michael, Olsen, L. M., Juhl, C. R., Lundgren, J. R., Janus, C., Stallknecht, Bente Merete, Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2024, In: EClinicalMedicine. 69, 12 p., 102475.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. E-pub ahead of print

    Hemostatic Effects of Exercise-Related Hypoglycemia in Male Persons With Type 1 Diabetes

    Hagelqvist, P. G., Andersen, A., Maytham, K., Andreasen, C. R., Engberg, S., Pedersen-Bjergaard, Ulrik, Forman, Julie Lyng, Jo­hans­son, Pär In­ge­mar , Lykkesfeldt, Jens, Knop, Filip Krag & Vilsbøll, Tina, 2024, (E-pub ahead of print) In: The Journal of clinical endocrinology and metabolism.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    High-density lipoprotein functionality, cardiovascular health, and patterns of alcohol consumption: new insights and future perspectives

    Trius-Soler, Marta, Mukamal, K. J. & Guasch Ferre, Marta, 2024, In: Current Opinion in Lipidology. 35, 1, p. 25-32 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    Human Genetic Variation at rs10071329 Correlates with Adiposity-related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function

    Huang, M., Prasad, R. B., Coral, D. E., Hjort, Line, Minja, D. T. R., Mulder, H., Franks, P. W. & Kalamajski, S., 2024, In: Diabetes. 73, 4, p. 637-645

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Identification of novel homozygous variants in FOXE3 and AP4M1 underlying congenital syndromic anophthalmia and microphthalmia

    Akbar, W., Ullah, A., Haider, N., Suleman, Sufyan, Khan, F. U., Shah, A. A., Sikandar, M. A., Basit, S. & Ahmad, W., 2024, In: Journal of Gene Medicine. 26, 1, 10 p., e3601.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Impact of acute alcohol consumption on circulating microbiome in asymptomatic alcohol-related liver disease

    Israelsen, M., Alvarez Silva, Maria Camila, Madsen, B. S., Hansen, C. D., Torp, N. C., Johansen, S., Hansen, J. K., Prier Lindvig, K., Insonere, J., Riviere, V., Juel, H. B., Brejnrod, A., Jensen, Lars Juhl, Thiele, M., Lelouvier, B., Hansen, Torben, Arumugam, Mani & Krag, A., 2024, In: Gut. 73, 6, p. 1041-1044 gutjnl-2023-330360.

    Research output: Contribution to journal › Letter › Research › peer-review

  17. Published

    In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice

    Smits, Mark, Galsgaard, Katrine Douglas, Jepsen, Sara Lind, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette & Holst, Jens Juul, 2024, In: Diabetes. 73, 5, p. 671-681

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Indole-3-carboxyaldehyde does not reverse the intestinal effects of fiber-free diet in mice

    Smits, Mark, Dreyer, S. I. L., Dal, Jenna Elizabeth Hunt, Drzazga, Anna Katarzyna, Modvig, Ida Marie, Holst, Jens Juul & Kissow, Hannelouise, 2024, In: Frontiers in Endocrinology. 15, 1362711.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Infections increase the risk of decompensation and death in patients with early alcohol-related liver disease

    Johansen, S., Langkjær, S., Rasmussen, D. N., Israelsen, M., Torp, N., Lindvig, K., Kjærgaard, M., Hansen, J. K., Hansen, C. D., Thorhauge, K., Andersen, P., Detlefsen, S., Juel, H. B., Justesen, U. S., Hansen, Torben, Krag, A., Thiele, M., GALAXY and MicrobLiver consortia, G. A. M. C. & MicrobLiver Consortium, M. C., 2024, In: JHEP Reports. 6, 4, 10 p., 101016.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Integrating a Multi-label Deep Learning Approach with Protein Information to Compare Bioactive Peptides in Brain and Plasma

    Grønning, Alexander GB & Schéele, Camilla Charlotte Nielsen, 2024, Peptidomics: Methods and Protocols. Schrader, M. & Fricker, L. D. (eds.). Humana Press, p. 179-195 17 p. (Methods in Molecular Biology, Vol. 2758).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  21. Published

    Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes

    Borges, M. C., Clayton, G. L., Freathy, R. M., Felix, J. F., Fernández-Sanlés, A., Soares, A. G., Kilpi, F., Yang, Q., McEachan, R. R. C., Richmond, R. C., Liu, X., Skotte, L., Irizar, A., Hattersley, A. T., Bodinier, B., Scholtens, D. M., Nohr, E. A., Bond, T. A., Hayes, M. G., West, J. & 20 others, Tyrrell, J., Wright, J., Bouchard, L., Murcia, M., Bustamante, M., Chadeau-Hyam, M., Jarvelin, M., Vrijheid, M., Perron, P., Magnus, P., Gaillard, R., Jaddoe, V. W. V., Lowe, W. L., Feenstra, B., Hivert, M., Sørensen, Thorkild I.A., Håberg, S. E., Serbert, S., Magnus, M. & Lawlor, D. A., 2024, In: BMC Medicine. 22, 14 p., 32.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. E-pub ahead of print

    Introduction: Laboratory times

    Hussey, Kristin D. & Douglas-Jones, R., 2024, (E-pub ahead of print) In: Time & Society.

    Research output: Contribution to journal › Journal article › Research

  23. Published

    Introgression and disruption of migration routes have shaped the genetic integrity of wildebeest populations

    Liu, X., Lin, L., Sinding, M. H. S., Bertola, L. D., Hanghøj, K., Quinn, L., Garcia-Erill, G., Rasmussen, M. S., Schubert, M., Pečnerová, P., Balboa, R. F., Li, Z., Heaton, M. P., Smith, T. P. L., Pinto, R. R., Wang, X., Kuja, J., Brüniche-Olsen, A., Meisner, J., Santander, C. G. & 8 others, Ogutu, J. O., Masembe, C., Rodrigues da Fonseca, Rute Andreia, Muwanika, V., Siegismund, Hans Redlef, Albrechtsen, Anders, Moltke, Ida & Heller, Rasmus, 2024, In: Nature Communications. 15, 1, 16 p., 2921.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review

    ADA/EASD PMDI, A. P., Merino, Jordi, Thuesen, Anne Cathrine Baun, Lepola, Mette Andersen, Clemmensen, Christoffer, Hansen, Torben, Nakabuye, Mariam, Loos, Ruth, Guasch Ferre, Marta & Vilsbøll, Tina, 2024, In: Communications Medicine. 4, 1, 8 p., 66.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

    Kjerulff, B., Dowsett, J., Jacobsen, R. L., Gladov, J., Larsen, M. H., Lundgaard, A. T., Banasik, K., Westergaard, D., Mikkelsen, S., Dinh, K. M., Hindhede, L., Kaspersen, K. A., Schwinn, M., Juul, A., Poulsen, B., Lindegaard, B., Pedersen, C. B., Sabel, C. E., Bundgaard, H., Nielsen, H. S. & 30 others, Møller, J. A., Boldsen, J. K., Burgdorf, Kristoffer Sølvsten, Kessing, Lars Vedel, Handgaard, L. J., Thørner, L. W., Didriksen, Maria, Nyegaard, Mette, Grarup, Niels, Ødum, Niels, Johansson, P. I., Jennum, Poul, Frikke-Schmidt, Ruth, Berger, S. S., Brunak, Søren, Jacobsen, Søren, Hansen, Thomas Folkmann, Lundquist, T. K., Hansen, Torben, Sørensen, Torben Lykke, Sigsgaard, T., Nielsen, K. R., Bruun, M. T., Hjalgrim, Henrik, Ullum, H., Rostgaard, K., Sørensen, E., Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye & Erikstrup, C., 2024, In: Communications Medicine. 4, 15 p., 50.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Lifetime Duration of Breastfeeding and Cardiovascular Risk in Women With Type 2 Diabetes or a History of Gestational Diabetes: Findings From Two Large Prospective Cohorts

    Birukov, A., Guasch Ferre, Marta, Ley, S. H., Tobias, D. K., Wang, F., Wittenbecher, C., Yang, J., Manson, J. E., Chavarro, J. E., Hu, F. B. & Zhang, C., 2024, In: Diabetes Care. 47, 4, p. 720-728 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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