Loos Group

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  1. 2022
  2. Published

    Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

    Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S-H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B-J., Chiou, J. & 31 others, Miguel-Escalada, I., Della Briotta Parolo, P., Lin, K., Bragg, F., Preuss, M. H., Takeuchi, F., Nano, J., Guo, X., Lamri, A., Nakatochi, M., Scott, R. A., Lee, J., Huerta-Chagoya, A., Graff, M., Chai, J., Parra, E. J., Yao, J., Bielak, L. F., Grarup, Niels, Chen, W., Bork-Jensen, J., Islam, M. T., Jørgensen, M. E., Jørgensen, T., Linneberg, Allan René, Witte, D. R., Lind, L., Loos, Ruth, Hansen, Torben, Pedersen, Oluf Borbye & FinnGen, F., 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential

    Nakao, T., Bick, A. G., Taub, M. A., Zekavat, S. M., Uddin, M. M., Niroula, A., Carty, C. L., Lane, J., Honigberg, M. C., Weinstock, J. S., Pampana, A., Gibson, C. J., Griffin, G. K., Clarke, S. L., Bhattacharya, R., Assimes, T. L., Emery, L. S., Stilp, A. M., Wong, Q., Broome, J. & 32 others, Laurie, C. A., Khan, A. T., Smith, A. V., Blackwell, T. W., Codd, V., Nelson, C. P., Yoneda, Z. T., Peralta, J. M., Bowden, D. W., Irvin, M. R., Boorgula, M., Zhao, W., Yanek, L. R., Wiggins, K. L., Hixson, J. E., Charles Gu, C., Peloso, G. M., Roden, D. M., Reupena, M. S., Hwu, C. M., DeMeo, D. L., North, K. E., Kelly, S., Musani, S. K., Bis, J. C., Lloyd-Jones, D. M., Johnsen, J. M., Preuss, M., Tracy, R. P., Loos, Ruth, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, T. S. O. L. A. G. A. S. (. G. & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, N. T. F. P. M. (. C., 2022, In: Science Advances. 8, 14, eabl6579.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

    Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C., Figueroa-Juarez, E., Schilbert, H., Virtue, S., Moreno-Navarrete, J. M., Bidault, G., Vázquez-Borrego, M. C., Dias, A. R., Pucker, B., Dale, M., Campbell, M., Carobbio, S., Lin, Y. H., Vacca, M., Aron-Wisnewsky, J., Mora, S., Masiero, M. M., Emmanouilidou, A. & 8 others, Mukhopadhyay, S., Dougan, G., den Hoed, M., Loos, Ruth, Fernández-Real, J. M., Chiarugi, D., Clément, K. & Vidal-Puig, A., 2022, In: Nature Metabolism. 4, 4, p. 476-494 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

    Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D. & 32 others, Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Zhao, J. H., Aadahl, Mette, Bork-Jensen, J., Møllehave, L. T., Liu, J., Wang, J., drb459, drb459, Jackson, R. D., Kovacs, P., Pedersen, Oluf Borbye, Hansen, Torben, Lind, L., Loos, Ruth, Christensen, K., Linneberg, Allan René, Grarup, Niels, Dantoft, T. M., Karpe, F., Wei, W. Q., Sun, Y. V., Million Veterans Program, M. V. P. & Global Lipids Genetics Consortium, G. L. G. C., 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Whole genome sequence analysis of blood lipid levels in >66,000 individuals

    Selvaraj, M. S., Li, X., Li, Z., Pampana, A., Zhang, D. Y., Park, J., Aslibekyan, S., Bis, J. C., Brody, J. A., Cade, B. E., Chuang, L. M., Chung, R. H., Curran, J. E., de las Fuentes, L., de Vries, P. S., Duggirala, R., Freedman, B. I., Graff, M., Guo, X., Heard-Costa, N. & 27 others, Hidalgo, B., Hwu, C. M., Irvin, M. R., Kelly, T. N., Kral, B. G., Lange, L., Li, X., Lisa, M., Lubitz, S. A., Manichaikul, A. W., Michael, P., Montasser, M. E., Morrison, A. C., Naseri, T., O’Connell, J. R., Palmer, N. D., Peyser, P. A., Reupena, M. S., Smith, J. A., Sun, X., Taylor, K. D., Tracy, R. P., Tsai, M. Y., Wang, Z., Wang, Y., Loos, Ruth & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, N. T. F. P. M. (. C., 2022, In: Nature Communications. 13, 18 p., 5995.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

    Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, Gieger, C., Graff, M., Hall, L. M., Haller, T., Hartwig, F. P., Hillis, D. A., Huikari, V., Heard-Costa, N., Holzapfel, C., Jackson, A. U., Johansson, A., Jorgensen, A. M., Kaakinen, M. A., Karlsson, R., Kerr, K. F., Kim, B., Koolhaas, C. M., Kutalik, Z., Pacolet, A., Zhao, J., Balslev-Harder, M. N., Grarup, Niels, Linneberg, Allan René, Hansen, Torben, Melbye, M., Pedersen, Oluf Borbye, Pers, Tune H, Sørensen, Thorkild I.A., Zierath, Juleen R, Kilpeläinen, Tuomas O., Loos, Ruth & LifeLines Cohort Study, L. C. S., 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations

    Wang, Z., Choi, S. W., Chami, N., Boerwinkle, E., Fornage, M., Redline, S., Bis, J. C., Brody, J. A., Psaty, B. M., Kim, W., McDonald, M. L. N., Regan, E. A., Silverman, E. K., Liu, C. T., Vasan, R. S., Kalyani, R. R., Mathias, R. A., Yanek, L. R., Arnett, D. K., Justice, A. E. & 21 others, North, K. E., Kaplan, R., Heckbert, S., de Andrade, M., Guo, X., Lange, L. A., Rich, S., Rotter, J. I., Ellinor, P. T., Lubitz, S. A., Blangero, J., Shoemaker, M. B., Darbar, D., Gladwin, M. T., Albert, C. M., Chasman, D. I., Jackson, R. D., Kooperberg, C., Reiner, A. P., O’Reilly, P. F. & Loos, Ruth, 2022, In: Frontiers in Endocrinology. 13, 12 p., 863893.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program

    Wheeler, M. M., Stilp, A. M., Rao, S., Halldórsson, B. V., Beyter, D., Wen, J., Mihkaylova, A. V., McHugh, C. P., Lane, J., Jiang, M. Z., Raffield, L. M., Jun, G., Sedlazeck, F. J., Metcalf, G., Yao, Y., Bis, J. B., Chami, N., de Vries, P. S., Desai, P., Floyd, J. S. & 39 others, Gao, Y., Kammers, K., Kim, W., Moon, J. Y., Ratan, A., Yanek, L. R., Almasy, L., Becker, L. C., Blangero, J., Cho, M. H., Curran, J. E., Fornage, M., Kaplan, R. C., Lewis, J. P., Loos, Ruth, Mitchell, B. D., Morrison, A. C., Preuss, M., Psaty, B. M., Rich, S. S., Rotter, J. I., Tang, H., Tracy, R. P., Boerwinkle, E., Abecasis, G. R., Blackwell, T. W., Smith, A. V., Johnson, A. D., Mathias, R. A., Nickerson, D. A., Conomos, M. P., Li, Y., Þorsteinsdóttir, U., Magnússon, M. K., Stefansson, K., Pankratz, N. D., Bauer, D. E., Auer, P. L. & Reiner, A. P., 2022, In: Nature Communications. 13, 18 p., 7592.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

    Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J-F., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., Wuttke, M. & 31 others, van der Most, P. J., Yang, Q., Ghasemi, S., Nutile, T., Li, Y., Pontali, G., Günther, F., Dehghan, A., Correa, A., Parsa, A., Feresin, A., de Vries, A. P. J., Zonderman, A. B., Smith, A. V., Oldehinkel, A. J., De Grandi, A., Rosenkranz, A. R., Franke, A., Teren, A., Metspalu, A., Hicks, A. A., Morris, A. P., Tönjes, A., Morgan, A., Podgornaia, A. I., Christensen, K., Lind, L., Kovacs, P., Rossing, Peter, Loos, Ruth & LifeLines Cohort Study, L. C. S., 2022, In: Communications Biology . 5, p. 580 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    A saturated map of common genetic variants associated with human height

    Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S-H., Ferreira, T., Highland, H. H., Ji, Y. & 37 others, Karaderi, Tugce, Lin, K., Lull, K., Malden, D. E., Lepola, Mette Andersen, Appadurai, V., Bork-Jensen, J., Burgdorf, Kristoffer Sølvsten, Hansen, Thomas Folkmann, Jonsson, Anna Elisabet, Jorgensen, T., Liu, J., Møllehave, Line Tang, Smit, Roelof Adriaan Johan, Zhao, J., Bisgaard, H., Bønnelykke, Klaus, Dantoft, T. M., Grarup, Niels, Hansen, Torben, Jackson, R. D., Karpe, F., Kovacs, P., Lind, L., Linneberg, Allan René, Pedersen, Oluf Borbye, Werge, Thomas, Sun, Y., Loos, Ruth, Winkler, T. W., 23andMe Res Team, 2. R. T., VA Million Vet Program, V. M. V. P., DiscovEHR DiscovEHR MyCode Communi, D. D. M. C., eEMERGE Elect Med Records Genomics, E. E. M. R. G., LifeLines Cohort Study, L. C. S., PRACTICAL consortium, P. C. & Understanding Soc Sci Grp, U. S. S. G., 2022, In: Nature. 610, p. 704–712

    Research output: Contribution to journal › Journal article › Research › peer-review

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