Loos Group

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  1. Published

    Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program

    Small, A. M., Peloso, G. M., Linefsky, J., Aragam, J., Galloway, A., Tanukonda, V., Wang, L. C., Yu, Z., Sunitha Selvaraj, M., Farber-Eger, E. H., Baker, M. T., Setia-Verma, S., Lee, S. S. K., Preuss, M., Ritchie, M. D., Damrauer, S. M., Rader, D. J., Wells, Q. S., Loos, R., Lubitz, S. A. & 5 others, Thanassoulis, G., Cho, K., Wilson, P. W. F., Natarajan, P. & O'Donnell, C. J., 2023, In: Circulation. 147, 12, p. 942-955 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations

    Stalbow, L. A., Preuss, M. H., Smit, Roelof Adriaan Johan, Chami, N., Bjørkhaug, L., Aukrust, I., Gloyn, A. L. & Loos, Ruth, 2023, In: Diabetologia. 66, p. 116-126 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Accepted/In press

    Genetic underpinnings of fasting and oral glucose-stimulated based insulin sensitivity indices

    Suleman, Sufyan, Madsen, Anne Lundager, Ängquist, Lars, Schubert, Mikkel, Linneberg, Allan René, Loos, Ruth, Hansen, Torben & Grarup, Niels, 2024, (Accepted/In press) In: Journal of Clinical Endocrinology and Metabolism.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

    Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., Schroeder, P., Vanderwerff, B. & 31 others, Kals, M., Bragg, F., Lin, K., Guo, X., Zhang, W., Yao, J., Kim, Y. J., Graff, M., Takeuchi, F., Nano, J., Lamri, A., Nakatochi, M., Moon, S., Scott, R. A., Cook, J. P., Lee, J., Pan, I., Taliun, D., Parra, E. J., Grarup, Niels, Chen, W., Bork-Jensen, J., Islam, M. T., Jørgensen, T., Linneberg, Allan René, Witte, D. R., Lind, L., Hansen, Torben, Pedersen, Oluf Borbye, Loos, Ruth & VA Million Veteran Program, V. M. V. P., 2024, In: Nature. 627, 8003, p. 347-357 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

    Tobias, D. K., Merino, J., Ahmad, A., Aiken, C., Benham, J. L., Bodhini, D., Clark, A. L., Colclough, K., Corcoy, R., Cromer, S. J., Duan, D., Felton, J. L., Francis, E. C., Gillard, P., Gingras, V., Gaillard, R., Haider, E., Hughes, A., Ikle, J. M., Jacobsen, L. M. & 180 others, Kahkoska, A. R., Kettunen, J. L. T., Kreienkamp, R. J., Lim, L. L., Männistö, J. M. E., Massey, R., Mclennan, N. M., Miller, R. G., Morieri, M. L., Most, J., Naylor, R. N., Ozkan, B., Patel, K. A., Pilla, S. J., Prystupa, K., Raghavan, S., Rooney, M. R., Schön, M., Semnani-Azad, Z., Sevilla-Gonzalez, M., Svalastoga, P., Takele, W. W., Tam, C. H. T., Thuesen, Anne Cathrine Baun, Tosur, M., Wallace, A. S., Wang, C. C., Wong, J. J., Yamamoto, J. M., Young, K., Amouyal, C., Lepola, Mette Andersen, Bonham, M. P., Chen, M., Cheng, F., Chikowore, T., Chivers, S. C., Clemmensen, Christoffer, Dabelea, D., Dawed, A. Y., Deutsch, A. J., Dickens, L. T., DiMeglio, L. A., Dudenhöffer-Pfeifer, M., Evans-Molina, C., Fernández-Balsells, M. M., Fitipaldi, H., Fitzpatrick, S. L., Gitelman, S. E., Goodarzi, M. O., Grieger, J. A., Guasch Ferre, Marta, Habibi, N., Hansen, Torben, Huang, C., Harris-Kawano, A., Ismail, H. M., Hoag, B., Johnson, R. K., Jones, A. G., Koivula, R. W., Leong, A., Leung, G. K. W., Libman, I. M., Liu, K., Long, S. A., Lowe, W. L., Morton, R. W., Motala, A. A., Onengut-Gumuscu, S., Pankow, J. S., Pathirana, M., Pazmino, S., Perez, D., Petrie, J. R., Powe, C. E., Quinteros, A., Jain, R., Ray, D., Ried-Larsen, M., Saeed, Z., Santhakumar, V., Kanbour, S., Sarkar, S., Monaco, G. S. F., Scholtens, D. M., Selvin, E., Sheu, W. H. H., Speake, C., Stanislawski, M. A., Steenackers, N., Steck, A. K., Stefan, N., Støy, J., Taylor, R., Tye, S. C., Ukke, G. G., Urazbayeva, M., Van der Schueren, B., Vatier, C., Wentworth, J. M., Hannah, W., White, S. L., Yu, G., Zhang, Y., Zhou, S. J., Beltrand, J., Polak, M., Aukrust, I., de Franco, E., Flanagan, S. E., Maloney, K. A., McGovern, A., Molnes, J., Nakabuye, Mariam, Njølstad, P. R., Pomares-Millan, H., Provenzano, M., Saint-Martin, C., Zhang, C., Zhu, Y., Auh, S., de Souza, R., Fawcett, A. J., Gruber, C., Mekonnen, E. G., Mixter, E., Sherifali, D., Eckel, R. H., Nolan, J. J., Philipson, L. H., Brown, R. J., Billings, L. K., Boyle, K., Costacou, T., Dennis, J. M., Florez, J. C., Gloyn, A. L., Gomez, M. F., Gottlieb, P. A., Greeley, S. A. W., Griffin, K., Hattersley, A. T., Hirsch, I. B., Hivert, M. F., Hood, K. K., Josefson, J. L., Kwak, S. H., Laffel, L. M., Lim, S. S., Loos, Ruth, Ma, R. C. W., Mathieu, C., Mathioudakis, N., Meigs, J. B., Misra, S., Mohan, V., Murphy, R., Oram, R., Owen, K. R., Ozanne, S. E., Pearson, E. R., Perng, W., Pollin, T. I., Pop-Busui, R., Pratley, R. E., Redman, L. M., Redondo, M. J., Reynolds, R. M., Semple, R. K., Sherr, J. L., Sims, E. K., Sweeting, A., Tuomi, T., Udler, M. S., Vesco, K. K., Vilsbøll, Tina, Wagner, R., Rich, S. S. & Franks, P. W., 2023, In: Nature Medicine. 29, 10, p. 2438-2457 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Genomic Disorders in CKD across the Lifespan

    Verbitsky, M., Krishnamurthy, S., Krithivasan, P., Hughes, D., Khan, A., Marasà, M., Vena, N., Khosla, P., Zhang, J., Lim, T. Y., Glessner, J. T., Weng, C., Shang, N., Shen, Y., Hripcsak, G., Hakonarson, H., Ionita-Laza, I., Levy, B., Kenny, E. E., Loos, R. J. F. & 11 others, Kiryluk, K., Sanna-Cherchi, S., Crosslin, D. R., Furth, S., Warady, B. A., Igo, R. P., Iyengar, S. K., Wong, C. S., Parsa, A., Feldman, H. I. & Gharavi, A. G., 2023, In: Journal of the American Society of Nephrology : JASN. 34, 4, p. 607-618 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

    Wang, Y., Namba, S., Lopera-Maya, E. A., Kerminen, S., Tsuo, K., Läll, K., Kanai, M., Zhou, W., Wu, K. H. H., Favé, M. J., Bhatta, L., Awadalla, P., Brumpton, B. M., Deelen, P., Hveem, K., Lo Faro, V., Mägi, R., Murakami, Y., Sanna, S., Smoller, J. W. & 49 others, Uzunovic, J., Wolford, B. N., Wu, K. H. H., Rasheed, H., Hirbo, J. B., Bhattacharya, A., Zhao, H., Surakka, I., Lopera-Maya, E. A., Chapman, S. B., Karjalainen, J., Kurki, M., Mutaamba, M., Partanen, J. J., Brumpton, B. M., Chavan, S., Chen, T. T., Daya, M., Ding, Y., Feng, Y. C. A., Gignoux, C. R., Graham, S. E., Hornsby, W. E., Ingold, N., Johnson, R., Laisk, T., Lin, K., Lv, J., Millwood, I. Y., Loos, Ruth, BBJ, B., BioMe, B., BioVU, B., Canadian Partnership for Tomorrow's Health/OHS, C. P. F. T. H., China Kadoorie Biobank Collaborative Group, C. K. B. C. G., Colorado Center for Personalized Medicine, C. C. F. P. M., deCODE Genetics, D. G., ESTBB, E., FinnGen, F., Generation Scotland, G. S., Genes & Health, G. &. H., LifeLines, L., Mass General Brigham Biobank, M. G. B. B., Michigan Genomics Initiative, M. G. I., QIMR Berghofer Biobank, Q. B. B., Taiwan Biobank, T. B., The HUNT Study, T. H. S., UCLA ATLAS Community Health Initiative, U. A. C. H. I. & UKBB, U., 2023, In: Cell Genomics. 3, 1, 18 p., 100241.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study

    Wang, Y., Selvaraj, M. S., Li, X., Li, Z., Holdcraft, J. A., Arnett, D. K., Bis, J. C., Blangero, J., Boerwinkle, E., Bowden, D. W., Cade, B. E., Carlson, J. C., Carson, A. P., Chen, Y. D. I., Curran, J. E., de Vries, P. S., Dutcher, S. K., Ellinor, P. T., Floyd, J. S., Fornage, M. & 31 others, Freedman, B. I., Gabriel, S., Germer, S., Gibbs, R. A., Guo, X., He, J., Heard-Costa, N., Hildalgo, B., Hou, L., Irvin, M. R., Joehanes, R., Kaplan, R. C., Kardia, S. L., Kelly, T. N., Kim, R., Kooperberg, C., Kral, B. G., Levy, D., Li, C., Liu, C., Lloyd-Jone, D., Loos, Ruth, Mahaney, M. C., Martin, L. W., Mathias, R. A., Minster, R. L., Mitchell, B. D., Montasser, M. E., Morrison, A. C., Murabito, J. M. & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, N. T. F. P. M. (. C., 2023, In: American Journal of Human Genetics. 110, 10, p. 1704-1717 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Distilling causality between physical activity traits and obesity via Mendelian randomization

    Wang, Z., Davey Smith, G., Loos, Ruth & den Hoed, M., 2023, In: Communications Medicine. 3, 6 p., 173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

    Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, Gieger, C., Graff, M., Hall, L. M., Haller, T., Hartwig, F. P., Hillis, D. A., Huikari, V., Heard-Costa, N., Holzapfel, C., Jackson, A. U., Johansson, A., Jorgensen, A. M., Kaakinen, M. A., Karlsson, R., Kerr, K. F., Kim, B., Koolhaas, C. M., Kutalik, Z., Pacolet, A., Zhao, J., Balslev-Harder, M. N., Grarup, Niels, Linneberg, Allan René, Hansen, Torben, Melbye, M., Pedersen, Oluf Borbye, Pers, Tune H, Sørensen, Thorkild I.A., Zierath, Juleen R, Kilpeläinen, Tuomas O., Loos, Ruth & LifeLines Cohort Study, L. C. S., 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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