- 2024
- Published
Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
Dollet, L., Lundell, L. S., Chibalin, A. V., Pendergrast, L. A., Pillon, N. J., Lansbury, Elizabeth Laura, Elmastas, M., Frendo-Cumbo, S., Jalkanen, J., de Castro Barbosa, T., Cervone, D. T., Caidahl, K., Dmytriyeva, O., Deshmukh, Atul Shahaji, Barrès, Romain, Rydén, M., Wallberg-Henriksson, H., Zierath, Juleen R & Krook, A., 2024, In: Cell Reports Medicine. 5, 1, 20 p., 101348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R
Lund, Camilla, Ranea-Robles, Pablo, Falk, S., Belmont-Rausch, Dylan Matthew, Skovbjerg, G., Vibe-Petersen, V. K., Krauth, Nathalie, Skytte, J. L., Vana, V., Roostalu, U., Pers, Tune H, Lund, Jens & Clemmensen, Christoffer, 2024, In: Nature Communications. 15, 1192.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Lambrughi, M., Tiberti, M., Papaleo, E., Frimurer, Thomas Michael & Schwartz, Thue W., 2024, In: Molecular Cell. 84, 5, p. 955-966.e4 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle
Abdelmoez, A. M., Dmytriyeva, O., Zurke, Y. X., Trauelsen, Mette, Marica, A. A., Savikj, M., Smith, J. A. B., Monaco, C., Schwartz, Thue W., Krook, A. & Pillon, N. J., 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 324, 4, p. E289-E298 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
Backe, M. B., Andersen, Rita Chan, Jensen, M., Jin, C., Hundahl, C., Dmytriyeva, O., Treebak, Jonas Thue, Hansen, J. B., Gerhart-Hines, Zach, Madsen, Kenneth Lindegaard & Holst, Birgitte, 2023, In: Journal of the endocrine society. 7, 6, p. 1-13 bvad057.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity
Falk, S., Petersen, Jonas Odgaard, Svendsen, C. S. A., Leguizamon, Cesar Ramon Romero, Jørgensen, Søren Heide, Krauth, Nathalie, Ludwig, M. Q., Jørgensen, Kathrine Lundø, Roostalu, U., Hjort-Gregersen, G. S., Nielsen, D. A. G., Ejdrup, Aske Lykke, Pers, Tune H, Dmytriyeva, O., Hecksher-Soerensen, J., Gether, Ulrik, Kohlmeier, Kristi Anne & Clemmensen, Christoffer, 2023, In: Cell Reports. 42, 5, 18 p., 112466.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
Forteza, M. J., Berg, M., Edsfeldt, A., Sun, J., Baumgartner, R., Kareinen, I., Casagrande, F. B., Hedin, U., Zhang, S., Vuckovic, I., Dzeja, P. P., Polyzos, K. A., Gisterå, A., Trauelsen, M., Schwartz, T. W., Dib, L., Herrmann, J., Monaco, C., Matic, L., Gonçalves, I. & 1 others, , 2023, In: Cardiovascular Research. 119, 7, p. 1524-1536 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dietary regulation of LEAP2 depends on meal composition in mice
Gradel, Anna Katrina Jógvansdóttir, Holm, Stephanie Kjærulff, Byberg, Sarah, Merkestein, M., Hogendorf, W. F. J., Lund, M. L., Buijink, Jesse A., Damgaard, J., Lykkesfeldt, Jens & Holst, Birgitte, 2023, In: FASEB Journal. 37, 6, 21 p., 22923.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice
Griepke, S., Trauelsen, Mette, Nilsson, M. D., Hansen, J., Steffensen, L. B., Schwartz, Thue W. & Ketelhuth, D. F. J., 2023, In: Cells. 12, 21, 14 p., 2580.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization
Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery
Lappa, D., Meijnikman, A. S., Krautkramer, K. A., Olsson, L. M., Aydin, Ö., Van Rijswijk, A. S., Acherman, Y. I. Z., De Brauw, M. L., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Hjorth, Siv Annegrethe, Ji, B., Gerdes, V. E. A., Groen, A. K., Schwartz, Thue W., Nieuwdorp, M., Bäckhed, F. & Nielsen, J., 2023, In: PLoS ONE. 18, 3, 26 p., e0279335.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors
Madsen, J. J., Petersen, Jacob Emil, Christensen, D. P., Hansen, J. B., Schwartz, Thue W., Frimurer, Thomas Michael & Olsen, O. H., 2023, In: Journal of Biological Chemistry. 299, 12, 11 p., 105438.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice
Makki, K., Brolin, H., Petersen, N., Henricsson, M., Christensen, D. P., Khan, M. T., Wahlström, A., Bergh, P., Tremaroli, V., Schoonjans, K., Marschall, H. & Bäckhed, F., 2023, In: Gut. 72, p. 314-324 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2
Petersen, Jacob Emil, Pedersen, M. H., Dmytriyeva, O., Nellemose, E., Arora, Tulika, Engelstoft, M. S., Asher, W. B., Javitch, J. A., Schwartz, Thue W. & Trauelsen, Mette, 2023, In: Molecular Metabolism. 74, 10 p., 101757.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice
Toft, P. B., Vanslette, A. M., Trošt, K., Moritz, Thomas, Gillum, M. P., Bäckhed, F. & Arora, Tulika, 2023, In: Frontiers in Endocrinology. 14, 7 p., 1200391.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Paracrine relationship between incretin hormones and endogenous 5-hydroxytryptamine in the small and large intestine
Tough, I. R., Lund, M. L., Patel, B. A., Schwartz, Thue W. & Cox, H. M., 2023, In: Neurogastroenterology and Motility. 35, 8, 14 p., e14589.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets
Henriksen, Nicole Lind, Hansen, S. H., Lycas, M. D., Pan, X., Eriksen, Thomas, Johansen, L. S., Sprenger, R. R., Ejsing, C. S., Burrin, D. G., Skovgaard, K., Christensen, Vibeke Brix, Thymann, Thomas & Pankratova, Stanislava, 2022, In: Physiological Reports. 10, 13, 15 p., e15368.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2
Holm, Stephanie Kjærulff, Husted, Anna Sofie, Skov, Louise Julie, Morville, T. H., Hagemann, C. A., Jorsal, T., Dall, M., Jakobsen, A., Klein, A. B., Treebak, Jonas Thue, Knop, Filip Krag, Schwartz, Thue W., Clemmensen, Christoffer & Holst, Birgitte, 2022, In: Endocrinology. 163, 6, 13 p., bqac038.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz
Keen, A. C., Pedersen, M. H., Lemel, L., Scott, D. J., Canals, M., Littler, D. R., Beddoe, T., Ono, Y., Shi, L., Inoue, A., Javitch, J. A. & Lane, J. R., 2022, In: Communications Biology . 5, 1, 10 p., 256.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Outrunning obesity with Lac-Phe?
Lund, Jens, Clemmensen, Christoffer & Schwartz, Thue W., 2022, In: Cell Metabolism. 34, 8, p. 1085-1087 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
Lückmann, Michael, Iliyaz, Aslihan Shenol, Nissen, T. A. D., Petersen, Jacob Emil, Kouvchinov, David, Schwartz, Thue W. & Frimurer, Thomas Michael, 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity
Meijnikman, A. S., Lappa, D., Herrema, H., Aydin, O., Krautkramer, K. A., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Bruin, S., Acherman, Y., Verheij, J., Hjorth, Siv Annegrethe, Gerdes, V. E. A., Schwartz, Thue W., Groen, A. K., Bäckhed, F., Nielsen, J. & Nieuwdorp, M., 2022, In: iScience. 25, 8, 18 p., 104828.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts
Meijnikman, A. S., van Olden, C. C., Aydin, Ö., Herrema, H., Kaminska, D., Lappa, D., Männistö, V., Tremaroli, V., Olofsson, L. E., de Brauw, M., van de Laar, A., Verheij, J., Gerdes, V. E. A., Schwartz, T. W., Nielsen, J., Bäckhed, F., Pajukanta, P., Pihlajamäki, J., Tchkonia, T., Kirkland, J. L. & 3 others, , 2022, In: Diabetes. 71, 9, p. 1929-1936 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microbiome-derived ethanol in nonalcoholic fatty liver disease
Meijnikman, A. S., Davids, M., Herrema, H., Aydin, O., Tremaroli, V., Rios-Morales, M., Levels, H., Bruin, S., de Brauw, M., Verheij, J., Kemper, M., Holleboom, A. G., Tushuizen, M. E., Schwartz, T. W., Nielsen, J., Brandjes, D., Dirinck, E., Weyler, J., Verrijken, A., De Block, C. E. M. & 7 others, , 2022, In: Nature Medicine. 28, p. 2100-2106Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 1 (GLP-1)
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L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
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Aberrant intestinal microbiota in individuals with prediabetes
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Latest publications
Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R
Research output: Contribution to journal › Journal article › Research › peer-review
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
Research output: Contribution to journal › Journal article › Research › peer-review