CBMR publications and media appearances in June & July 2024

Media Appearances

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Professor Juleen R. Zierath (Zierath Group)

The San Diego Union Tribune, 04/06/2024
'When is the best time to work out?'

 

Professor Jens Juul Holst (Juul Holst Group)

Nature, 18/06/2024
'Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions'

 

Professor Torben Hansen (Hansen Group)

Jyllands Posten, 09/07/2024, Section 4, page 9
'Novo Nordisks vækstrater bøjer af - større forudsigelighed i sigte'

 

Associate Professor Christoffer Clemmensen (Clemmensen Group)

Videnskab.dk, 01/06/2024
'Sådan fungerer Wegovy i din krop'

BT, 13/06/2024
'Lisbeth tog Wegovy og mistede lysten til sex: 'Skræmmende og virkelig mærkeligt''

Ugeskrift for Læger, 15/07/2024
'Anmeldelse: Glimrende indspark i debatten om vægttab og krop'

 

Associate Professor Niels Grarup (Hansen Group)

University of Copenhagen, 09/07/2024
'Sister hormone of GLP-1 can lead to better weight-loss drugs'

POV International, 17/07/2024
'Søsterhormon til GLP-1 kan gøre overvægtsmedicin bedre'

 

Associate Professor Adam Bencard (Medical Museion)

Videnskab.dk, 12/07/2024
'Podcast: Av! Hvad var smerte ifølge Aristoteles?'

Videnskab.dk, 19/07/2024
'Podcast: Eksperimenter på dyr og gravide kvinder gjorde 1800-talsforskere klogere på smerte'

 

Postdoc Sara Stinson (Hansen Group)

Medical Xpress, 24/06/2024
'Children born underweight found to be at increased risk of disease if they develop obesity'

 

Publications

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Arumugam, Hansen Groups & Data Analytics Platform

Stankevic E, et al. Genome-wide association study identifies host genetic variants influencing oral microbiota diversity and metabolic health. Sci Rep. 2024 Jun 26;14(1):14738. doi: 10.1038/s41598-024-65538-8.

 

Clemmensen Group

Cao Y, et al. Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis. Mol Metab. 2024 Jul 15;87:101991. doi: 10.1016/j.molmet.2024.101991. Epub ahead of print.

 

Emanuelli Group

Ardenkjær-Skinnerup J, et al. Effects of ethanol or ethylene glycol exposure on PPARγ and aromatase expression in adipose tissue. Biochem Biophys Rep. 2024 May 30;38:101742. doi: 10.1016/j.bbrep.2024.101742.

 

Gerhart-Hines & Hansen Groups

Friedman MI, et al. Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning. Obes Rev. 2024 Jul 3. doi: 10.1111/obr.13795. Epub ahead of print.

 

Guasch Group

Bui LP, et al. Planetary Health Diet Index and risk of total and cause-specific mortality in three prospective cohorts. Am J Clin Nutr. 2024 Jul;120(1):80-91. doi: 10.1016/j.ajcnut.2024.03.019. Epub 2024 Jun 10.

Eichelmann F, et al. Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition. Nat Med. 2024 Jul 11. doi: 10.1038/s41591-024-03124-1. Epub ahead of print.

 

Hansen Group

Jørgensen TSH, et al. Cognitive ability, education, height and body mass index in relation to risk of schizophrenia and mortality following its diagnosis. Eur J Epidemiol. 2024 Jul 27. doi: 10.1007/s10654-024-01140-6. Epub ahead of print.

Maagensen H, et al. Clinical effects of SGLT2 inhibitors in seven persons with HNF1A-MODY (MODY3). Diabet Med. 2024 Jun 14:e15387. doi: 10.1111/dme.15387. Epub ahead of print.

Stinson SE, et al. The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk. EBioMedicine. 2024 Jul;105:105205. doi: 10.1016/j.ebiom.2024.105205. Epub 2024 Jun 24.

 

Hansen & Juul Holst Groups

Kizilkaya HS, et al. Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes. Nat Metab. 2024 Jul;6(7):1268-1281. doi: 10.1038/s42255-024-01061-4. Epub 2024 Jun 13.

 

Juul Holst Group

Achter JS, et al. In- depth phosphoproteomic profiling of the insulin signaling response in heart tissue and cardiomyocytes unveils canonical and specialized regulation. Cardiovasc Diabetol. 2024 Jul 18;23(1):258. doi: 10.1186/s12933-024-02338-4.

Anjom-Shoae J, et al. Intraduodenal calcium enhances the effects of L-tryptophan to stimulate gut hormone secretion and suppress energy intake in healthy males: a randomized, crossover, clinical trial. Am J Clin Nutr. 2024 Jul 10:S0002-9165(24)00602-6. doi: 10.1016/j.ajcnut.2024.07.006. Epub ahead of print.

Bang Henriksen M, et al. Lung cancer among outpatients with COPD: a 7-year cohort study. ERJ Open Res. 2024 Jul 22;10(4):00064-2024. doi: 10.1183/23120541.00064-2024.

Fink-Jensen A, et al. Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male vervet monkeys. Psychopharmacology (Berl). 2024 Jun 17. doi: 10.1007/s00213-024-06637-2. Epub ahead of print.

Fiorenza M, et al. Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids. Cell Rep Med. 2024 Jul 16;5(7):101629. doi: 10.1016/j.xcrm.2024.101629. Epub 2024 Jul 2.

Gasbjerg LS, et al. Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge. Br J Pharmacol. 2024 Jul 1. doi: 10.1111/bph.16478. Epub ahead of print.

Grøndahl MFG, et al. Glucagon Clearance is Decreased in Chronic Kidney Disease, but Preserved in Liver Cirrhosis. Diabetes. 2024 Jul 25:db240305. doi: 10.2337/db24-0305. Epub ahead of print.

Hansen LS, et al. The role of glucagon-like peptide 1 in the postprandial effects of metformin in type 2 diabetes: a randomized crossover trial. Eur J Endocrinol. 2024 Jul 25:lvae095. doi: 10.1093/ejendo/lvae095. Epub ahead of print.

Hedbäck N, et al. Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2024 Jul 31. doi: 10.1152/ajpendo.00177.2024. Epub ahead of print.

Hunt JE, et al. The Severity of DSS-Induced Colitis Is Independent of the SCFA-FFAR2/3-GLP-1 Pathway Despite SCFAs Inducing GLP-1 Secretion via FFAR2/3. Metabolites. 2024 Jul 20;14(7):395. doi: 10.3390/metabo14070395.

Jensen SBK, et al. Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 Jun 3;7(6):e2416775. doi: 10.1001/jamanetworkopen.2024.16775.

Kjeldsen SAS, et al. Glucagon resistance in individuals with obesity and hepatic steatosis can be measured using the GLUSENTIC test and index. Diabetes. 2024 Jul 8:db230858. doi: 10.2337/db23-0858. Epub ahead of print.

Lange AH, et al. Exogenous glucagon-like peptide 2 counteracts exogenous cholecystokinin-induced gallbladder contraction in healthy men. J Clin Endocrinol Metab. 2024 Jun 18:dgae421. doi: 10.1210/clinem/dgae421. Epub ahead of print.

London A, et al. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutr. 2024 Jun 22:S0002-9165(24)00540-9. doi: 10.1016/j.ajcnut.2024.06.006. Epub ahead of print.

Lubberding AF, et al. GLP-1 increases heart rate by a direct action on the sinus node. Cardiovasc Res. 2024 Jun 4:cvae120. doi: 10.1093/cvr/cvae120. Epub ahead of print.

Meessen ECE, et al. Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans. J Clin Endocrinol Metab. 2024 Jun 12:dgae399. doi: 10.1210/clinem/dgae399. Epub ahead of print.

Modvig IM, et al. L-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels. Nutr Diabetes. 2024 Jun 11;14(1):43. doi: 10.1038/s41387-024-00303-4.

Winther JB & Holst JJ. Glucagon agonism in the treatment of metabolic diseases including type 2 diabetes mellitus and obesity. Diabetes Obes Metab. 2024 Jun 9. doi: 10.1111/dom.15693. Epub ahead of print.

 

Kilpeläinen Group

Mleczko JE, et al. Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism. J Extracell Biol. 2022 Mar 15;1(2):e32. doi: 10.1002/jex2.32.

 

Loos & Merino Group

Lim SS, et al. Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist. Nat Med. 2024 Jul;30(7):1874-1881. doi: 10.1038/s41591-024-03033-3. Epub 2024 Jul 19.

 

Moritz Group

Mattanovich M, et al. INCAWrapper: a Python wrapper for INCA for seamless data import, -export, and -processing. Bioinform Adv. 2024 Jul 4;4(1):vbae100. doi: 10.1093/bioadv/vbae100.

Lecoutre S, et al. Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health. Nat Metab. 2024 Jul;6(7):1329-1346. doi: 10.1038/s42255-024-01083-y. Epub 2024 Jul 15.

 

Moritz & Rasmuseen Groups

Beltrao P, et al. Proceedings of the EuBIC-MS developers meeting 2023. J Proteomics. 2024 Jul 2:105246. doi: 10.1016/j.jprot.2024.105246. Epub ahead of print.

 

Pers Group

Sotelo-Hitschfeld T, et al. GABAergic disinhibition from the BNST to PNOC^ARC neurons promotes HFD-induced hyperphagia. Cell Rep. 2024 Jun 25;43(6):114343. doi: 10.1016/j.celrep.2024.114343. Epub 2024 Jun 11.

 

Rasmussen Group

Christensen MA, et al. An assessment of the value of deep neural networks in genetic risk prediction for surgically relevant outcomes. PLoS One. 2024 Jul 15;19(7):e0294368. doi: 10.1371/journal.pone.0294368.

Webel H, et al. Imputation of label-free quantitative mass spectrometry-based proteomics data using self-supervised deep learning. Nat Commun. 2024 Jun 26;15(1):5405. doi: 10.1038/s41467-024-48711-5.

 

Rodent Metabolic Phenotyping Platform

Nicolaisen TS, et al. Greater molecular potential for glucose metabolism in adipose tissue and skeletal muscle of women compared with men. FASEB J. 2024 Aug 15;38(15):e23845. doi: 10.1096/fj.202302377R.

 

Sakamoto Group

Zhao JF, et al. Targeted dephosphorylation of TFEB promotes its nuclear translocation. iScience. 2024 Jun 29;27(8):110432. doi: 10.1016/j.isci.2024.110432.

 

Schéele Group

Engelhard S, et al. Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration. Cell Rep. 2024 Jul 23;43(7):114475. doi: 10.1016/j.celrep.2024.114475. Epub 2024 Jul 10.

Wang T, et al. Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes. Cell Metab. 2024 Jul 26:S1550-4131(24)00276-6. doi: 10.1016/j.cmet.2024.07.005. Epub ahead of print.

 

Schwartz Group

Apuschkin M, et al. An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake. Cell Rep. 2024 Jul 23;43(7):114509. doi: 10.1016/j.celrep.2024.114509. Epub 2024 Jul 13.

 

Schwartz Group & Computational Chemistry Unit

Shenol A, et al. Multiple recent HCAR2 structures demonstrate a highly dynamic ligand binding and G protein activation mode. Nat Commun. 2024 Jun 25;15(1):5364. doi: 10.1038/s41467-024-49536-y.

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