CBMR publications and media appearances in June/July 2025
Every month we release a full list of publications from the Center, as well as media appearances by the Center scientists
Media Appearances
Novo Nordisk Foundation Center for Basic Metabolic Research
Dagens Medicin, 25/06/2025
'Overblik: Danske forskere viste sig flot frem på verdens største diabeteskongres'
Dagens Medicin, 25/06/2025
'Martin Holst Lange: Vi begynder først nu at forstå svær overvægt'
Dagens Medicin, 25/06/2025
'GIP har ingen effekt på hverken på blodsukker eller vægt hos personer med type 2-diabetes'
The Danish Precision Health Initiative (DELPHI)
ComputerWorld, 22/07/2025
'Lille dansk it-virksomhed fra Vanløse lander drømmekontrakt, der rækker langt in i stifterens pension'
Professor Torben Hansen
Diabetes Behandler, 16/06/2025
'MODERN-MODY-projektet: Bedre diagnostik og behandling af personer med monogenetisk diabetes'
Professor Ruth Loos
Berlingske, 21/07/2025
'Dine gener har stor betydning for overvægt. Ny metode kan afsløre risikoen for, om en »hvilken som helst person« i verden vil udvikle overvægt'
The New York Times, 21/07/2025
'Obesity Prediction Could Be Guided by Genetic Risk Scores'
The Independent, 21/07/2025
'New tool can predict which children are likely to become obese'
THIP: The Healthy Indian Project, 21/07/2025
'New genetic test can predict obesity risk in adulthood by age 5'
Daily Record, 21/07/2025
'New tool can identify children who are likely to become obese in adulthood'
Medical Xpress, 21/07/2025
'Genetic test predicts obesity in childhood'
NBC News, 21/07/2025
'A genetic test could predict the odds of obesity, allowing for early interventions'
Daily Mail, 21/07/2025
'New genetic test could predict if you'll get condition suffered by 100 million Americans decades before it develops'
ANSA Latina, 21/07/2025
'Una prueba genética que puede prevenir la obesidad infantil'
Pharmacy Business, 22/07/2025
'Predictive tool discovered for early identification of obesity risk in children'
USA Today, 23/07/2025
'A new genetic test may be able to predict obesity in early childhood. What to know'
Santé le Figaro, 24/07/2025
'Un test génétique pour prédire si un enfant sera obèse à l’âge adulte'
Knowridge Scientific Report, 31/07/2025
'This DNA test can predict a child’s obesity risk in adulthood'
Associate Professor Christoffer Clemmensen
Berlingske, 24/07/2025
'En »exceptionelt stærk« mekanisme er styrende for vores vægt. Men det er tilsyneladende svært at erkende, fortæller forsker'
Associate Professor Jonas Thue Treebak
Vitafoods Insights, 11/06/2025
'Muscle ageing: Does NAD+ metabolism need more nuanced research?'
Researcher Yong Fan (Pers Group)
Ritzau, 31/07/2025
'Grøn energigrød-professoren bag nyt gennembrud: Tarmbakterie kan måske producere fremtidens medicin mod udbredte folkesygdomme'
Politiken, 31/07/2025
'Ny forskning: Dine tarme kan måske lave fremtidens supermedicin selv'
Medical Xpress, 31/07/2025
'Newly discovered gut bacteria proteins influence hormones, metabolism and bone density'
Postdoc Xuan Zhou (Merino Group)
Dagens Medicin, 25/06/2025
'Tre af otte genetiske dispositioner for type 2-diabetes øger også risikoen for kolorektalkræft'
Publications
Arumugam Group
Dodge N, et al. Heterologous Production of the Structurally Complex Diterpenoid Forskolin in Synechocystis sp. PCC. 6803. Bioengineering (Basel). 2025 Jun 23;12(7):683. doi: 10.3390/bioengineering12070683.
Kamounah S, et al. Microbial signatures in oral sites of patients with primary Sjögren's syndrome: Association with salivary gland hypofunction. J Microbiol. 2025 Jun;63(6):e2501030. doi: 10.71150/jm.2501030. Epub 2025 Jun 30.
Arumugam & Hansen Group
Hansen JK, et al. The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial. Nat Commun. 2025 Jul 1;16(1):5969. doi: 10.1038/s41467-025-60755-9.
Arumugam & Treebak Groups
Choi BS, et al. Housing matters: Experimental variables shaping metabolism in obese mice. Mol Metab. 2025 Aug;98:102190. doi: 10.1016/j.molmet.2025.102190. Epub 2025 Jun 18.
Barrès Group
Macartney EL, et al. Dietary macronutrients modulate the proteome of brown adipose tissue in males and their female offspring. Cell Rep. 2025 Jul 24;44(8):116050. doi: 10.1016/j.celrep.2025.116050. Epub ahead of print.
Smith JAB, et al. Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis. Mol Metab. 2025 Sep;99:102200. doi: 10.1016/j.molmet.2025.102200. Epub 2025 Jul 1.
Clemmensen Group
Holm SK, et al. Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice. Diabetes. 2025 Jul 1:db241056. doi: 10.2337/db24-1056. Epub ahead of print.
Clemmensen, Gerhart-Hines, Sakamoto, Schwartz & Zierath Groups
Clemmensen C, et al. Shaping the future of cardiometabolic innovation: advances and opportunities. Nat Metab. 2025 Jul 11. doi: 10.1038/s42255-025-01343-5. Epub ahead of print.
Deshmukh Group
Wong JPH, et al. Skeletal muscle proteomics: considerations and opportunities. NPJ Metab Health Dis. 2025 Jul 2;3(1):30. doi: 10.1038/s44324-025-00073-2.
Deshmukh, Kilpeläinen, Treebak & Zierath Groups
Kjærgaard J, et al. Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake. Cell Rep Med. 2025 Jun 17;6(6):102163. doi: 10.1016/j.xcrm.2025.102163. Epub 2025 Jun 6.
Emanuelli Group
Toft FB, et al. Phosphate concentration is exceptionally high in seminal fluid and is linked with semen quality but not influenced by vitamin D and calcium supplementation. Eur J Endocrinol. 2025 Jul 31;193(2):240-246. doi: 10.1093/ejendo/lvaf146.
Hansen Group
Dhurandhar EJ, et al. Food noise: definition, measurement, and future research directions. Nutr Diabetes. 2025 Jul 8;15(1):30. doi: 10.1038/s41387-025-00382-x.
Hansen CD, et al. Prevalence, severity and determinants of steatotic liver disease among individuals with metabolic and alcohol risk from the community. J Hepatol. 2025 Jul 4:S0168-8278(25)02319-0. doi: 10.1016/j.jhep.2025.06.020. Epub ahead of print.
Haydar S, et al. A Genome-Wide Association Study of Taste Liking in the Danish Population. J Nutr. 2025 Aug;155(8):2591-2601. doi: 10.1016/j.tjnut.2025.06.001. Epub 2025 Jun 7.
Howey R, et al. Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. PLoS Genet. 2025 Jul 15;21(7):e1011776. doi: 10.1371/journal.pgen.1011776.
Nielsen H, et al. Societal and biological approaches to diabetes prevention and care for Inuit populations: a narrative review. Diabetologia. 2025 Jul 15. doi: 10.1007/s00125-025-06487-3. Epub ahead of print.
Hansen & Juul Holst Groups
Maagensen H, et al. Effect of SGLT2 Inhibition on Glucosuria During a Hyperglycemic Clamp in HNF1A-MODY (MODY3) and Type 2 Diabetes. Diabetes Care. 2025 Jul 3:dc250737. doi: 10.2337/dc25-0737. Epub ahead of print.
Hansen, Kilpeläinen & Loos Groups
Smit RAJ, et al. Polygenic prediction of body mass index and obesity through the life course and across ancestries. Nat Med. 2025 Jul 21. doi: 10.1038/s41591-025-03827-z. Epub ahead of print.
Hansen & Pers Groups
Lyu L, et al. The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients-an IMI-DIRECT prospective study. Genome Med. 2025 Jul 15;17(1):78. doi: 10.1186/s13073-025-01508-7.
Juul Holst Group
Andrade S, et al. GLP-1 and GIP may play a role in long-term weight trajectories after gastric bypass. Front Endocrinol (Lausanne). 2025 Jul 4;16:1624001. doi: 10.3389/fendo.2025.1624001.
Ciccarelli G, et al. Incretin system and glucagon secretion in patients with chronic pancreatitis. Eur J Clin Invest. 2025 Jun 19:e70093. doi: 10.1111/eci.70093. Epub ahead of print.
Gasbjerg LS, et al. Proglucagon-derived Peptides: Human Physiology and Therapeutic Potential. Physiol Rev. 2025 Jul 28. doi: 10.1152/physrev.00057.2024. Epub ahead of print.
Gether IM, et al. Oxytocin mRNA is expressed throughout the small intestine in individuals with and without type 2 diabetes, and circulating neurophysin I declines after Roux-en-Y gastric bypass surgery. Diabetes Obes Metab. 2025 Sep;27(9):5373-5377. doi: 10.1111/dom.16571. Epub 2025 Jul 2.
Klümpen L, et al. GLP-1 Responses to a Single Meal Fortified With Oyster Mushroom Powder in Adults With Impaired Glucose Tolerance Depend on the Gut Microbiota Composition Before the Meal. Mol Nutr Food Res. 2025 Jun 29:e70159. doi: 10.1002/mnfr.70159. Epub ahead of print.
Nymo S, et al. Homeostatic Appetite and Hedonic Hunger 13 Years After Roux-en-Y Gastric Bypass: Potential Associations and Predictive Value in Determining Long-Term Weight Loss Outcomes. Obes Surg. 2025 Jul;35(7):2719-2726. doi: 10.1007/s11695-025-07955-w. Epub 2025 Jun 9.
Omary L, et al. Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity. Cell Rep Med. 2025 Jul 15;6(7):102237. doi: 10.1016/j.xcrm.2025.102237.
Rosenkilde MM, et al. GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale. Diabetes. 2025 Aug 1;74(8):1334-1338. doi: 10.2337/dbi24-0027.
Svane MS, et al. β-Cell Function and Sensitivity to Incretins Before and After Roux-en-Y Gastric Bypass in Individuals With Type 2 Diabetes. Diabetes. 2025 Jul 3:db241054. doi: 10.2337/db24-1054. Epub ahead of print.
Kilpeläinen Group
Bentley AR, et al. Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids. Transl Psychiatry. 2025 Jun 20;15(1):207. doi: 10.1038/s41398-025-03418-z.
Loos Group
Lundin JI, et al. Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease. Atherosclerosis. 2025 Aug;407:120219. doi: 10.1016/j.atherosclerosis.2025.120219. Epub 2025 May 20.
Midya V, et al. Exposure to per- and poly- fluoroalkyl substances in association to later occurrence of type 2 diabetes and metabolic pathway dysregulation in a multiethnic US population. EBioMedicine. 2025 Jul 9:105838. doi: 10.1016/j.ebiom.2025.105838. Epub ahead of print.
Medical Museion
Bencard A. An Account of a Research Expedition to Greenland in 1908 by Marie and August Krogh-Early 20th Century Experimental Physiology in the Field. APMIS. 2025 Jun;133(6):e70032. doi: 10.1111/apm.70032.
Friis T, et al. 'One time my gut and psyche talked to each other': The flexible use of mind-body dualism to articulate socially situated selves. Health (London). 2025 Jul 28:13634593251358046. doi: 10.1177/13634593251358046. Epub ahead of print.
Metabolomics Platform
Gao Q, et al. A diagnostic algorithm for inherited metabolic disorders using untargeted metabolomics. Metabolomics. 2025 Jul 27;21(4):101. doi: 10.1007/s11306-025-02302-7.
Merino Group
Corbin LJ, et al. Raising the bar for publication of Mendelian randomisation studies in Diabetologia. Diabetologia. 2025 Jul 1. doi: 10.1007/s00125-025-06484-6. Epub ahead of print.
Moritz Group
Anagho-Mattanovich HA, et al. Multi-omics Characterization of Acquired Olaparib Resistance in BRCA1 and BRCA2 Mutant Breast Cancer Cell Lines. Mol Cell Proteomics. 2025 Jul 14;24(8):101034. doi: 10.1016/j.mcpro.2025.101034. Epub ahead of print.
Moritz, Treebak & Zierath Groups
Ehrlich AM, et al. HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2504080122. doi: 10.1073/pnas.2504080122. Epub 2025 Jul 8.
Pers Group
Carvas AO, et al. Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3. EBioMedicine. 2025 Jul 2;118:105836. doi: 10.1016/j.ebiom.2025.105836. Epub ahead of print.
Fan Y, et al. Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism. Nat Microbiol. 2025 Aug;10(8):1918-1939. doi: 10.1038/s41564-025-02064-x. Epub 2025 Jul 31.
Rasmussen Group
Meisner J, et al. Towards precision psychiatry utilizing large-scale multimodal data paving the way for improved prevention and treatment of mental disorders. Neurosci Appl. 2022 Dec 22;2:101017. doi: 10.1016/j.nsa.2022.101017.
Sakamoto Group
Biswas D. Glycogen metabolism: not just a one-trick pony. Nat Rev Endocrinol. 2025 Sep;21(9):527. doi: 10.1038/s41574-025-01152-6.
Schéele Group
Abildgaard J, et al. Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes. Mol Metab. 2025 Aug;98:102189. doi: 10.1016/j.molmet.2025.102189. Epub 2025 Jun 16.