Spinal astroglial cannabinoid receptors control pathological tremor

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Spinal astroglial cannabinoid receptors control pathological tremor. / Carlsen, Eva Maria Meier; Falk, Sarah; Skupio, Urszula; Robin, Laurie; Zottola, Antonio C.Pagano; Marsicano, Giovanni; Perrier, Jean François.

In: Nature Neuroscience, Vol. 24, 2021, p. 658–666.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Carlsen, EMM, Falk, S, Skupio, U, Robin, L, Zottola, ACP, Marsicano, G & Perrier, JF 2021, 'Spinal astroglial cannabinoid receptors control pathological tremor', Nature Neuroscience, vol. 24, pp. 658–666. https://doi.org/10.1038/s41593-021-00818-4

APA

Carlsen, E. M. M., Falk, S., Skupio, U., Robin, L., Zottola, A. C. P., Marsicano, G., & Perrier, J. F. (2021). Spinal astroglial cannabinoid receptors control pathological tremor. Nature Neuroscience, 24, 658–666. https://doi.org/10.1038/s41593-021-00818-4

Vancouver

Carlsen EMM, Falk S, Skupio U, Robin L, Zottola ACP, Marsicano G et al. Spinal astroglial cannabinoid receptors control pathological tremor. Nature Neuroscience. 2021;24:658–666. https://doi.org/10.1038/s41593-021-00818-4

Author

Carlsen, Eva Maria Meier ; Falk, Sarah ; Skupio, Urszula ; Robin, Laurie ; Zottola, Antonio C.Pagano ; Marsicano, Giovanni ; Perrier, Jean François. / Spinal astroglial cannabinoid receptors control pathological tremor. In: Nature Neuroscience. 2021 ; Vol. 24. pp. 658–666.

Bibtex

@article{b8a3a8db682741e9aefbcfef3f4cdf47,
title = "Spinal astroglial cannabinoid receptors control pathological tremor",
abstract = "Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated by cannabinoid receptors on astrocytes in the ventral horn of the spinal cord, where alternating limb movements are initiated. We first demonstrate that tremor is reduced in a mouse model of essential tremor after intrathecal injection of the cannabinoid analog WIN55,212-2. We investigate the underlying mechanism using electrophysiological recordings in spinal cord slices and show that endocannabinoids released from depolarized interneurons activate astrocytic cannabinoid receptors, causing an increase in intracellular Ca2+, subsequent release of purines and inhibition of excitatory neurotransmission. Finally, we show that the anti-tremor action of WIN55,212-2 in the spinal cords of mice is suppressed after knocking out CB1 receptors in astrocytes. Our data suggest that cannabinoids reduce tremor via their action on spinal astrocytes.",
author = "Carlsen, {Eva Maria Meier} and Sarah Falk and Urszula Skupio and Laurie Robin and Zottola, {Antonio C.Pagano} and Giovanni Marsicano and Perrier, {Jean Fran{\c c}ois}",
year = "2021",
doi = "10.1038/s41593-021-00818-4",
language = "English",
volume = "24",
pages = "658–666",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Spinal astroglial cannabinoid receptors control pathological tremor

AU - Carlsen, Eva Maria Meier

AU - Falk, Sarah

AU - Skupio, Urszula

AU - Robin, Laurie

AU - Zottola, Antonio C.Pagano

AU - Marsicano, Giovanni

AU - Perrier, Jean François

PY - 2021

Y1 - 2021

N2 - Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated by cannabinoid receptors on astrocytes in the ventral horn of the spinal cord, where alternating limb movements are initiated. We first demonstrate that tremor is reduced in a mouse model of essential tremor after intrathecal injection of the cannabinoid analog WIN55,212-2. We investigate the underlying mechanism using electrophysiological recordings in spinal cord slices and show that endocannabinoids released from depolarized interneurons activate astrocytic cannabinoid receptors, causing an increase in intracellular Ca2+, subsequent release of purines and inhibition of excitatory neurotransmission. Finally, we show that the anti-tremor action of WIN55,212-2 in the spinal cords of mice is suppressed after knocking out CB1 receptors in astrocytes. Our data suggest that cannabinoids reduce tremor via their action on spinal astrocytes.

AB - Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated by cannabinoid receptors on astrocytes in the ventral horn of the spinal cord, where alternating limb movements are initiated. We first demonstrate that tremor is reduced in a mouse model of essential tremor after intrathecal injection of the cannabinoid analog WIN55,212-2. We investigate the underlying mechanism using electrophysiological recordings in spinal cord slices and show that endocannabinoids released from depolarized interneurons activate astrocytic cannabinoid receptors, causing an increase in intracellular Ca2+, subsequent release of purines and inhibition of excitatory neurotransmission. Finally, we show that the anti-tremor action of WIN55,212-2 in the spinal cords of mice is suppressed after knocking out CB1 receptors in astrocytes. Our data suggest that cannabinoids reduce tremor via their action on spinal astrocytes.

U2 - 10.1038/s41593-021-00818-4

DO - 10.1038/s41593-021-00818-4

M3 - Journal article

C2 - 33737752

AN - SCOPUS:85102999027

VL - 24

SP - 658

EP - 666

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

ER -

ID: 259425209