The biochemistry and physiology of long-chain dicarboxylic acid metabolism

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The biochemistry and physiology of long-chain dicarboxylic acid metabolism. / Ranea-Robles, Pablo; Houten, Sander M.

In: Biochemical Journal, Vol. 480, No. 9, 2023, p. 607-627.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ranea-Robles, P & Houten, SM 2023, 'The biochemistry and physiology of long-chain dicarboxylic acid metabolism', Biochemical Journal, vol. 480, no. 9, pp. 607-627. https://doi.org/10.1042/BCJ20230041

APA

Ranea-Robles, P., & Houten, S. M. (2023). The biochemistry and physiology of long-chain dicarboxylic acid metabolism. Biochemical Journal, 480(9), 607-627. https://doi.org/10.1042/BCJ20230041

Vancouver

Ranea-Robles P, Houten SM. The biochemistry and physiology of long-chain dicarboxylic acid metabolism. Biochemical Journal. 2023;480(9):607-627. https://doi.org/10.1042/BCJ20230041

Author

Ranea-Robles, Pablo ; Houten, Sander M. / The biochemistry and physiology of long-chain dicarboxylic acid metabolism. In: Biochemical Journal. 2023 ; Vol. 480, No. 9. pp. 607-627.

Bibtex

@article{48b6abd71ff64b718b1b30b882dd94ef,
title = "The biochemistry and physiology of long-chain dicarboxylic acid metabolism",
abstract = "Mitochondrial β-oxidation is the most prominent pathway for fatty acid oxidation but alternative oxidative metabolism exists. Fatty acid ω-oxidation is one of these pathways and forms dicarboxylic acids as products. These dicarboxylic acids are metabolized through peroxisomal β-oxidation representing an alternative pathway, which could potentially limit the toxic effects of fatty acid accumulation. Although dicarboxylic acid metabolism is highly active in liver and kidney, its role in physiology has not been explored in depth. In this review, we summarize the biochemical mechanism of the formation and degradation of dicarboxylic acids through ω- and β-oxidation, respectively. We will discuss the role of dicarboxylic acids in different (patho)physiological states with a particular focus on the role of the intermediates and products generated through peroxisomal β-oxidation. This review is expected to increase the understanding of dicarboxylic acid metabolism and spark future research.",
author = "Pablo Ranea-Robles and Houten, {Sander M.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.",
year = "2023",
doi = "10.1042/BCJ20230041",
language = "English",
volume = "480",
pages = "607--627",
journal = "Biochemical Journal",
issn = "0264-6021",
publisher = "Portland Press Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - The biochemistry and physiology of long-chain dicarboxylic acid metabolism

AU - Ranea-Robles, Pablo

AU - Houten, Sander M.

N1 - Publisher Copyright: © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

PY - 2023

Y1 - 2023

N2 - Mitochondrial β-oxidation is the most prominent pathway for fatty acid oxidation but alternative oxidative metabolism exists. Fatty acid ω-oxidation is one of these pathways and forms dicarboxylic acids as products. These dicarboxylic acids are metabolized through peroxisomal β-oxidation representing an alternative pathway, which could potentially limit the toxic effects of fatty acid accumulation. Although dicarboxylic acid metabolism is highly active in liver and kidney, its role in physiology has not been explored in depth. In this review, we summarize the biochemical mechanism of the formation and degradation of dicarboxylic acids through ω- and β-oxidation, respectively. We will discuss the role of dicarboxylic acids in different (patho)physiological states with a particular focus on the role of the intermediates and products generated through peroxisomal β-oxidation. This review is expected to increase the understanding of dicarboxylic acid metabolism and spark future research.

AB - Mitochondrial β-oxidation is the most prominent pathway for fatty acid oxidation but alternative oxidative metabolism exists. Fatty acid ω-oxidation is one of these pathways and forms dicarboxylic acids as products. These dicarboxylic acids are metabolized through peroxisomal β-oxidation representing an alternative pathway, which could potentially limit the toxic effects of fatty acid accumulation. Although dicarboxylic acid metabolism is highly active in liver and kidney, its role in physiology has not been explored in depth. In this review, we summarize the biochemical mechanism of the formation and degradation of dicarboxylic acids through ω- and β-oxidation, respectively. We will discuss the role of dicarboxylic acids in different (patho)physiological states with a particular focus on the role of the intermediates and products generated through peroxisomal β-oxidation. This review is expected to increase the understanding of dicarboxylic acid metabolism and spark future research.

U2 - 10.1042/BCJ20230041

DO - 10.1042/BCJ20230041

M3 - Review

C2 - 37140888

AN - SCOPUS:85159555685

VL - 480

SP - 607

EP - 627

JO - Biochemical Journal

JF - Biochemical Journal

SN - 0264-6021

IS - 9

ER -

ID: 348165752