Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults

Research output: Contribution to journalJournal articleResearchpeer-review

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Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults. / Kurmaeva, Diyora; Ye, Yongxin; Bakhytkyzy, Inal; Aru, Violetta; Dalimova, Dilbar; Turdikulova, Shahlo; Dragsted, Lars Ove; Engelsen, Søren Balling; Khakimov, Bekzod.

In: Metabolomics, Vol. 19, No. 5, 46, 2023.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kurmaeva, D, Ye, Y, Bakhytkyzy, I, Aru, V, Dalimova, D, Turdikulova, S, Dragsted, LO, Engelsen, SB & Khakimov, B 2023, 'Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults', Metabolomics, vol. 19, no. 5, 46. https://doi.org/10.1007/s11306-023-02005-x

APA

Kurmaeva, D., Ye, Y., Bakhytkyzy, I., Aru, V., Dalimova, D., Turdikulova, S., Dragsted, L. O., Engelsen, S. B., & Khakimov, B. (2023). Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults. Metabolomics, 19(5), [46]. https://doi.org/10.1007/s11306-023-02005-x

Vancouver

Kurmaeva D, Ye Y, Bakhytkyzy I, Aru V, Dalimova D, Turdikulova S et al. Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults. Metabolomics. 2023;19(5). 46. https://doi.org/10.1007/s11306-023-02005-x

Author

Kurmaeva, Diyora ; Ye, Yongxin ; Bakhytkyzy, Inal ; Aru, Violetta ; Dalimova, Dilbar ; Turdikulova, Shahlo ; Dragsted, Lars Ove ; Engelsen, Søren Balling ; Khakimov, Bekzod. / Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults. In: Metabolomics. 2023 ; Vol. 19, No. 5.

Bibtex

@article{80ab306e95b447a49eb6f8f08119cbee,
title = "Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults",
abstract = "Introduction: Uzbekistan is one of the countries with the highest number of diet-related chronic diseases, which is believed to be associated with high animal fat intake. Sheep meat is high in fats (~ 5% in muscle), including saturated and monounsaturated fatty acids, and it contains nearly twice the higher amounts of n-3 polyunsaturated fatty acids and conjugated linoleic acids compared to beef. Nevertheless, sheep meat is considered health promoting by the locals in Uzbekistan and it accounts for around 1/3 of red meat intake in the country.Objectives: The aim of this study was to apply a metabolomics approach to investigate if sheep meat intake frequency (SMIF) is associated with alterations in fasting blood plasma metabolites and lipoproteins in healthy Uzbek adults.Methods: The study included 263 subjects, 149 females and 114 males. For each subject a food intake questionnaire, including SMIF, was recorded and fasting blood plasma samples were collected for metabolomics. Blood plasma metabolites and lipoprotein concentrations were determined using 1H NMR spectroscopy.Results and Conclusion: The results showed that SMIF was confounded by nationality, sex, body mass index (BMI), age, intake frequency of total meat and fish in ascending order (p < 0.01). Multivariate and univariate data analyses showed differences in the levels of plasma metabolites and lipoproteins with respect to SMIF. The effect of SMIF after statistical adjustment by nationality, sex, BMI, age, intake frequency of total meat and fish decreased but remained significant. Pyruvic acid, phenylalanine, ornithine, and acetic acid remained significantly lower in the high SMIF group, whereas choline, asparagine, and dimethylglycine showed an increasing trend. Levels of cholesterol, apolipoprotein A1, as well as low- and high-density lipoprotein subfractions all displayed a decreasing trend with increased SMIF although the difference were not significant after FDR correction.",
keywords = "Faculty of Science, Meat intake, Sheep meat, NMR, Metabolomics, Lipoproteins, Choline, Uzbekistan",
author = "Diyora Kurmaeva and Yongxin Ye and Inal Bakhytkyzy and Violetta Aru and Dilbar Dalimova and Shahlo Turdikulova and Dragsted, {Lars Ove} and Engelsen, {S{\o}ren Balling} and Bekzod Khakimov",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
doi = "10.1007/s11306-023-02005-x",
language = "English",
volume = "19",
journal = "Metabolomics",
issn = "1573-3882",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Associations between sheep meat intake frequency and blood plasma levels of metabolites and lipoproteins in healthy Uzbek adults

AU - Kurmaeva, Diyora

AU - Ye, Yongxin

AU - Bakhytkyzy, Inal

AU - Aru, Violetta

AU - Dalimova, Dilbar

AU - Turdikulova, Shahlo

AU - Dragsted, Lars Ove

AU - Engelsen, Søren Balling

AU - Khakimov, Bekzod

N1 - © 2023. The Author(s).

PY - 2023

Y1 - 2023

N2 - Introduction: Uzbekistan is one of the countries with the highest number of diet-related chronic diseases, which is believed to be associated with high animal fat intake. Sheep meat is high in fats (~ 5% in muscle), including saturated and monounsaturated fatty acids, and it contains nearly twice the higher amounts of n-3 polyunsaturated fatty acids and conjugated linoleic acids compared to beef. Nevertheless, sheep meat is considered health promoting by the locals in Uzbekistan and it accounts for around 1/3 of red meat intake in the country.Objectives: The aim of this study was to apply a metabolomics approach to investigate if sheep meat intake frequency (SMIF) is associated with alterations in fasting blood plasma metabolites and lipoproteins in healthy Uzbek adults.Methods: The study included 263 subjects, 149 females and 114 males. For each subject a food intake questionnaire, including SMIF, was recorded and fasting blood plasma samples were collected for metabolomics. Blood plasma metabolites and lipoprotein concentrations were determined using 1H NMR spectroscopy.Results and Conclusion: The results showed that SMIF was confounded by nationality, sex, body mass index (BMI), age, intake frequency of total meat and fish in ascending order (p < 0.01). Multivariate and univariate data analyses showed differences in the levels of plasma metabolites and lipoproteins with respect to SMIF. The effect of SMIF after statistical adjustment by nationality, sex, BMI, age, intake frequency of total meat and fish decreased but remained significant. Pyruvic acid, phenylalanine, ornithine, and acetic acid remained significantly lower in the high SMIF group, whereas choline, asparagine, and dimethylglycine showed an increasing trend. Levels of cholesterol, apolipoprotein A1, as well as low- and high-density lipoprotein subfractions all displayed a decreasing trend with increased SMIF although the difference were not significant after FDR correction.

AB - Introduction: Uzbekistan is one of the countries with the highest number of diet-related chronic diseases, which is believed to be associated with high animal fat intake. Sheep meat is high in fats (~ 5% in muscle), including saturated and monounsaturated fatty acids, and it contains nearly twice the higher amounts of n-3 polyunsaturated fatty acids and conjugated linoleic acids compared to beef. Nevertheless, sheep meat is considered health promoting by the locals in Uzbekistan and it accounts for around 1/3 of red meat intake in the country.Objectives: The aim of this study was to apply a metabolomics approach to investigate if sheep meat intake frequency (SMIF) is associated with alterations in fasting blood plasma metabolites and lipoproteins in healthy Uzbek adults.Methods: The study included 263 subjects, 149 females and 114 males. For each subject a food intake questionnaire, including SMIF, was recorded and fasting blood plasma samples were collected for metabolomics. Blood plasma metabolites and lipoprotein concentrations were determined using 1H NMR spectroscopy.Results and Conclusion: The results showed that SMIF was confounded by nationality, sex, body mass index (BMI), age, intake frequency of total meat and fish in ascending order (p < 0.01). Multivariate and univariate data analyses showed differences in the levels of plasma metabolites and lipoproteins with respect to SMIF. The effect of SMIF after statistical adjustment by nationality, sex, BMI, age, intake frequency of total meat and fish decreased but remained significant. Pyruvic acid, phenylalanine, ornithine, and acetic acid remained significantly lower in the high SMIF group, whereas choline, asparagine, and dimethylglycine showed an increasing trend. Levels of cholesterol, apolipoprotein A1, as well as low- and high-density lipoprotein subfractions all displayed a decreasing trend with increased SMIF although the difference were not significant after FDR correction.

KW - Faculty of Science

KW - Meat intake

KW - Sheep meat

KW - NMR

KW - Metabolomics

KW - Lipoproteins

KW - Choline

KW - Uzbekistan

U2 - 10.1007/s11306-023-02005-x

DO - 10.1007/s11306-023-02005-x

M3 - Journal article

C2 - 37099187

VL - 19

JO - Metabolomics

JF - Metabolomics

SN - 1573-3882

IS - 5

M1 - 46

ER -

ID: 344909635