Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. / Fang, Bin; Everett, Logan J.; Jager, Jennifer; Briggs, Erika; Armour, Sean M.; Feng, Dan; Roy, Ankur; Gerhart-Hines, Zachary; Sun, Zheng; Lazar, Mitchell A.

In: Cell, Vol. 159, No. 5, 20.11.2014, p. 1140-1152.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fang, B, Everett, LJ, Jager, J, Briggs, E, Armour, SM, Feng, D, Roy, A, Gerhart-Hines, Z, Sun, Z & Lazar, MA 2014, 'Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo', Cell, vol. 159, no. 5, pp. 1140-1152. https://doi.org/10.1016/j.cell.2014.10.022

APA

Fang, B., Everett, L. J., Jager, J., Briggs, E., Armour, S. M., Feng, D., Roy, A., Gerhart-Hines, Z., Sun, Z., & Lazar, M. A. (2014). Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. Cell, 159(5), 1140-1152. https://doi.org/10.1016/j.cell.2014.10.022

Vancouver

Fang B, Everett LJ, Jager J, Briggs E, Armour SM, Feng D et al. Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. Cell. 2014 Nov 20;159(5):1140-1152. https://doi.org/10.1016/j.cell.2014.10.022

Author

Fang, Bin ; Everett, Logan J. ; Jager, Jennifer ; Briggs, Erika ; Armour, Sean M. ; Feng, Dan ; Roy, Ankur ; Gerhart-Hines, Zachary ; Sun, Zheng ; Lazar, Mitchell A. / Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. In: Cell. 2014 ; Vol. 159, No. 5. pp. 1140-1152.

Bibtex

@article{140e2e49ec054161911e413d15849ec0,
title = "Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo",
abstract = "Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock. We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased examination of enhancer RNAs (eRNAs) that cluster in specific circadian phases identified functional enhancers driven by distinct transcription factors (TFs). We further identify on a global scale the components of the TF cistromes that function to orchestrate circadian gene expression. Integrated genomic analyses also revealed mechanisms by which a single circadian factor controls opposing transcriptional phases. These findings shed light on the diversity and specificity of TF function in the generation of multiple phases of circadian gene transcription in a mammalian organ.",
author = "Bin Fang and Everett, {Logan J.} and Jennifer Jager and Erika Briggs and Armour, {Sean M.} and Dan Feng and Ankur Roy and Zachary Gerhart-Hines and Zheng Sun and Lazar, {Mitchell A.}",
note = "Funding Information: We thank the Functional Genomics Core (J. Schug and K. Kaestner) and Viral Vector Core (J. Johnston and A. Sandhu) of the Penn Diabetes Research Center (P30 DK19525) for next-generation sequencing and AAV production, respectively. We also thank the Penn Microarray Core for microarray analysis. We thank Dr. Ken Zaret for critical reading of the manuscript. This work was supported by NIH grants R01 DK45586 (M.A.L.), F32 DK095526 (L.J.E.), K99 DK099443 (Z.S.), and F32 DK095563 (Z.G.H.), and the JPB Foundation. Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = nov,
day = "20",
doi = "10.1016/j.cell.2014.10.022",
language = "English",
volume = "159",
pages = "1140--1152",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo

AU - Fang, Bin

AU - Everett, Logan J.

AU - Jager, Jennifer

AU - Briggs, Erika

AU - Armour, Sean M.

AU - Feng, Dan

AU - Roy, Ankur

AU - Gerhart-Hines, Zachary

AU - Sun, Zheng

AU - Lazar, Mitchell A.

N1 - Funding Information: We thank the Functional Genomics Core (J. Schug and K. Kaestner) and Viral Vector Core (J. Johnston and A. Sandhu) of the Penn Diabetes Research Center (P30 DK19525) for next-generation sequencing and AAV production, respectively. We also thank the Penn Microarray Core for microarray analysis. We thank Dr. Ken Zaret for critical reading of the manuscript. This work was supported by NIH grants R01 DK45586 (M.A.L.), F32 DK095526 (L.J.E.), K99 DK099443 (Z.S.), and F32 DK095563 (Z.G.H.), and the JPB Foundation. Publisher Copyright: © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/11/20

Y1 - 2014/11/20

N2 - Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock. We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased examination of enhancer RNAs (eRNAs) that cluster in specific circadian phases identified functional enhancers driven by distinct transcription factors (TFs). We further identify on a global scale the components of the TF cistromes that function to orchestrate circadian gene expression. Integrated genomic analyses also revealed mechanisms by which a single circadian factor controls opposing transcriptional phases. These findings shed light on the diversity and specificity of TF function in the generation of multiple phases of circadian gene transcription in a mammalian organ.

AB - Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock. We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased examination of enhancer RNAs (eRNAs) that cluster in specific circadian phases identified functional enhancers driven by distinct transcription factors (TFs). We further identify on a global scale the components of the TF cistromes that function to orchestrate circadian gene expression. Integrated genomic analyses also revealed mechanisms by which a single circadian factor controls opposing transcriptional phases. These findings shed light on the diversity and specificity of TF function in the generation of multiple phases of circadian gene transcription in a mammalian organ.

UR - http://www.scopus.com/inward/record.url?scp=84911865436&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2014.10.022

DO - 10.1016/j.cell.2014.10.022

M3 - Journal article

C2 - 25416951

AN - SCOPUS:84911865436

VL - 159

SP - 1140

EP - 1152

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -

ID: 347793971