Metabolic adaptations through the PGC-1α and SIRT1 pathways
Research output: Contribution to journal › Journal article › Research › peer-review
Energy homeostasis in mammals is achieved through tight regulation of tissue-specific metabolic pathways that become dysregulated in metabolic diseases including diabetes and obesity. At the molecular level, main nutrient and hormonal signaling pathways impinge on expression of genes encoding for metabolic enzymes. Among the major components of this transcriptional circuitry are the PGC-1α transcriptional complexes. An important regulatory mechanism of this complex is through acetylation and SIRT1-mediated lysine de-acetylation under low nutrient conditions. Activation of SIRT1 can mimic several metabolic aspects of calorie restriction that target selective nutrient utilization and mitochondrial oxidative function to regulate energy balance. Thus, understanding the PGC-1α and SIRT1 pathways might have important implications for comprehending metabolic and age-associated diseases.
Original language | English |
---|---|
Journal | FEBS Letters |
Volume | 582 |
Issue number | 1 |
Pages (from-to) | 46-53 |
Number of pages | 8 |
ISSN | 0014-5793 |
DOIs | |
Publication status | Published - 9 Jan 2008 |
Bibliographical note
Funding Information:
We thank other members of the Puigserver laboratory for insightful discussions and comments on this manuscript. Work in this laboratory is supported in part by an Ellison Medical Foundation New Scholar Award, the American Diabetes Association, the U.S. Department of Defense, and National Institutes of Health Grant R01 DK069966 (to P.P.). Due to space limitations, we apologize for not including additional information or references that are related to studies discussed in this review.
- Aging, Glucose metabolism, Lipid metabolism, Mitochondrial oxidation, PGC-1α, SIRT1
Research areas
ID: 347794719