Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α

Research output: Contribution to journal › Journal article › Research › peer-review

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α. / Gerhart-Hines, Zachary; Rodgers, Joseph T.; Bare, Olivia; Lerin, Carles; Kim, Seung Hee; Mostoslavsky, Raul; Alt, Frederick W.; Wu, Zhidan; Puigserver, Pere.

In: EMBO Journal, Vol. 26, No. 7, 04.04.2007, p. 1913-1923.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gerhart-Hines, Z, Rodgers, JT, Bare, O, Lerin, C, Kim, SH, Mostoslavsky, R, Alt, FW, Wu, Z & Puigserver, P 2007, 'Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α', EMBO Journal, vol. 26, no. 7, pp. 1913-1923. https://doi.org/10.1038/sj.emboj.7601633

APA

Gerhart-Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S. H., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007). Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α. EMBO Journal, 26(7), 1913-1923. https://doi.org/10.1038/sj.emboj.7601633

Vancouver

Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α. EMBO Journal. 2007 Apr 4;26(7):1913-1923. https://doi.org/10.1038/sj.emboj.7601633

Author

Gerhart-Hines, Zachary ; Rodgers, Joseph T. ; Bare, Olivia ; Lerin, Carles ; Kim, Seung Hee ; Mostoslavsky, Raul ; Alt, Frederick W. ; Wu, Zhidan ; Puigserver, Pere. / Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α. In: EMBO Journal. 2007 ; Vol. 26, No. 7. pp. 1913-1923.

Bibtex

@article{9c14e286c65345698b294dcf7fe1099b,
title = "Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α",
abstract = "In mammals, maintenance of energy and nutrient homeostasis during food deprivation is accomplished through an increase in mitochondrial fatty acid oxidation in peripheral tissues. An important component that drives this cellular oxidative process is the transcriptional coactivator PGC-1α. Here, we show that fasting induced PGC-1α deacetylation in skeletal muscle and that SIRT1 deacetylation of PGC-1α is required for activation of mitochondrial fatty acid oxidation genes. Moreover, expression of the acetyltransferase, GCN5, or the SIRT1 inhibitor, nicotinamide, induces PGC-1α acetylation and decreases expression of PGC-1α target genes in myotubes. Consistent with a switch from glucose to fatty acid oxidation that occurs in nutrient deprivation states, SIRT1 is required for induction and maintenance of fatty acid oxidation in response to low glucose concentrations. Thus, we have identified SIRT1 as a functional regulator of PGC-1α that induces a metabolic gene transcription program of mitochondrial fatty acid oxidation. These results have implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes.",
keywords = "Caloric restriction, Gene transcription, Lipid metabolism, Mitochondrial oxidation, Sirtuins",
author = "Zachary Gerhart-Hines and Rodgers, {Joseph T.} and Olivia Bare and Carles Lerin and Kim, {Seung Hee} and Raul Mostoslavsky and Alt, {Frederick W.} and Zhidan Wu and Pere Puigserver",
year = "2007",
month = apr,
day = "4",
doi = "10.1038/sj.emboj.7601633",
language = "English",
volume = "26",
pages = "1913--1923",
journal = "E M B O Journal",
issn = "0261-4189",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α

AU - Gerhart-Hines, Zachary

AU - Rodgers, Joseph T.

AU - Bare, Olivia

AU - Lerin, Carles

AU - Kim, Seung Hee

AU - Mostoslavsky, Raul

AU - Alt, Frederick W.

AU - Wu, Zhidan

AU - Puigserver, Pere

PY - 2007/4/4

Y1 - 2007/4/4

N2 - In mammals, maintenance of energy and nutrient homeostasis during food deprivation is accomplished through an increase in mitochondrial fatty acid oxidation in peripheral tissues. An important component that drives this cellular oxidative process is the transcriptional coactivator PGC-1α. Here, we show that fasting induced PGC-1α deacetylation in skeletal muscle and that SIRT1 deacetylation of PGC-1α is required for activation of mitochondrial fatty acid oxidation genes. Moreover, expression of the acetyltransferase, GCN5, or the SIRT1 inhibitor, nicotinamide, induces PGC-1α acetylation and decreases expression of PGC-1α target genes in myotubes. Consistent with a switch from glucose to fatty acid oxidation that occurs in nutrient deprivation states, SIRT1 is required for induction and maintenance of fatty acid oxidation in response to low glucose concentrations. Thus, we have identified SIRT1 as a functional regulator of PGC-1α that induces a metabolic gene transcription program of mitochondrial fatty acid oxidation. These results have implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes.

AB - In mammals, maintenance of energy and nutrient homeostasis during food deprivation is accomplished through an increase in mitochondrial fatty acid oxidation in peripheral tissues. An important component that drives this cellular oxidative process is the transcriptional coactivator PGC-1α. Here, we show that fasting induced PGC-1α deacetylation in skeletal muscle and that SIRT1 deacetylation of PGC-1α is required for activation of mitochondrial fatty acid oxidation genes. Moreover, expression of the acetyltransferase, GCN5, or the SIRT1 inhibitor, nicotinamide, induces PGC-1α acetylation and decreases expression of PGC-1α target genes in myotubes. Consistent with a switch from glucose to fatty acid oxidation that occurs in nutrient deprivation states, SIRT1 is required for induction and maintenance of fatty acid oxidation in response to low glucose concentrations. Thus, we have identified SIRT1 as a functional regulator of PGC-1α that induces a metabolic gene transcription program of mitochondrial fatty acid oxidation. These results have implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes.

KW - Caloric restriction

KW - Gene transcription

KW - Lipid metabolism

KW - Mitochondrial oxidation

KW - Sirtuins

UR - http://www.scopus.com/inward/record.url?scp=34247259630&partnerID=8YFLogxK

U2 - 10.1038/sj.emboj.7601633

DO - 10.1038/sj.emboj.7601633

M3 - Journal article

C2 - 17347648

AN - SCOPUS:34247259630

VL - 26

SP - 1913

EP - 1923

JO - E M B O Journal

JF - E M B O Journal

SN - 0261-4189

IS - 7

ER -

ID: 347794564