Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α. / Lagouge, Marie; Argmann, Carmen; Gerhart-Hines, Zachary; Meziane, Hamid; Lerin, Carles; Daussin, Frederic; Messadeq, Nadia; Milne, Jill; Lambert, Philip; Elliott, Peter; Geny, Bernard; Laakso, Markku; Puigserver, Pere; Auwerx, Johan.

In: Cell, Vol. 127, No. 6, 15.12.2006, p. 1109-1122.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lagouge, M, Argmann, C, Gerhart-Hines, Z, Meziane, H, Lerin, C, Daussin, F, Messadeq, N, Milne, J, Lambert, P, Elliott, P, Geny, B, Laakso, M, Puigserver, P & Auwerx, J 2006, 'Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α', Cell, vol. 127, no. 6, pp. 1109-1122. https://doi.org/10.1016/j.cell.2006.11.013

APA

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., & Auwerx, J. (2006). Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α. Cell, 127(6), 1109-1122. https://doi.org/10.1016/j.cell.2006.11.013

Vancouver

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α. Cell. 2006 Dec 15;127(6):1109-1122. https://doi.org/10.1016/j.cell.2006.11.013

Author

Lagouge, Marie ; Argmann, Carmen ; Gerhart-Hines, Zachary ; Meziane, Hamid ; Lerin, Carles ; Daussin, Frederic ; Messadeq, Nadia ; Milne, Jill ; Lambert, Philip ; Elliott, Peter ; Geny, Bernard ; Laakso, Markku ; Puigserver, Pere ; Auwerx, Johan. / Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α. In: Cell. 2006 ; Vol. 127, No. 6. pp. 1109-1122.

Bibtex

@article{398dc6f1815e457fae1ff628c4f772fa,
title = "Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α",
abstract = "Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1α acetylation and an increase in PGC-1α activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1-/- MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.",
author = "Marie Lagouge and Carmen Argmann and Zachary Gerhart-Hines and Hamid Meziane and Carles Lerin and Frederic Daussin and Nadia Messadeq and Jill Milne and Philip Lambert and Peter Elliott and Bernard Geny and Markku Laakso and Pere Puigserver and Johan Auwerx",
note = "Funding Information: This work was supported by grants of CNRS, INSERM, ULP, H{\^o}pital Universitaire de Strasbourg, NIH (DK59820 and DK069966), EU FP6 (EUGENE2; LSHM-CT-2004-512013), and Sirtris Pharmaceuticals. M.L. and C.A. received fellowships from Institut Danone and Marie-Curie, respectively. The authors thank Fred Alt (Harvard Medical School) for the gift of SIRT1 −/− and +/+ MEFs, the members of the Auwerx, Laakso, and Puigserver labs for discussions and technical assistance, the ICS, and the Affymetrics platform of IGBMC. ",
year = "2006",
month = dec,
day = "15",
doi = "10.1016/j.cell.2006.11.013",
language = "English",
volume = "127",
pages = "1109--1122",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

AU - Lagouge, Marie

AU - Argmann, Carmen

AU - Gerhart-Hines, Zachary

AU - Meziane, Hamid

AU - Lerin, Carles

AU - Daussin, Frederic

AU - Messadeq, Nadia

AU - Milne, Jill

AU - Lambert, Philip

AU - Elliott, Peter

AU - Geny, Bernard

AU - Laakso, Markku

AU - Puigserver, Pere

AU - Auwerx, Johan

N1 - Funding Information: This work was supported by grants of CNRS, INSERM, ULP, Hôpital Universitaire de Strasbourg, NIH (DK59820 and DK069966), EU FP6 (EUGENE2; LSHM-CT-2004-512013), and Sirtris Pharmaceuticals. M.L. and C.A. received fellowships from Institut Danone and Marie-Curie, respectively. The authors thank Fred Alt (Harvard Medical School) for the gift of SIRT1 −/− and +/+ MEFs, the members of the Auwerx, Laakso, and Puigserver labs for discussions and technical assistance, the ICS, and the Affymetrics platform of IGBMC.

PY - 2006/12/15

Y1 - 2006/12/15

N2 - Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1α acetylation and an increase in PGC-1α activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1-/- MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.

AB - Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1α acetylation and an increase in PGC-1α activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1-/- MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=33845399894&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2006.11.013

DO - 10.1016/j.cell.2006.11.013

M3 - Journal article

C2 - 17112576

AN - SCOPUS:33845399894

VL - 127

SP - 1109

EP - 1122

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -

ID: 347794400