Grarup Group

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  1. 2011
  2. Published

    Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome

    Lohmueller, K. E., Albrechtsen, Anders, Li, Y., Kim, S. Y., Korneliussen, Thorfinn Sand, Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Feder, A. F., Grarup, Niels, Jørgensen, T., Jiang, T., Witte, D. R., Sandbæk, A., Hellmann, I., Lauritzen, T., Hansen, Torben, Pedersen, Oluf Borbye, Wang, J. & Nielsen, Rasmus, 2011, In: P L o S Genetics. 7, 10, 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans

    Burgdorf, K. S., Grarup, Niels, Justesen, Johanne Marie, Harder, M. N., Witte, D. R., Jørgensen, T., Sandbæk, A., Lauritzen, T., Madsbad, Sten, Hansen, Torben, DIAGRAM Consortium, D. C. & Pedersen, Oluf Borbye, 2011, In: P L o S One. 6, 1, p. e15813 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

    Grarup, Niels, Overvad, M., Sparsø, T., Witte, D. R., Pisinger, C., Jørgensen, T., Yamauchi, T., Hara, K., Maeda, S., Kadowaki, T., Hansen, T. & Pedersen, Oluf Borbye, 2011, In: Diabetologica. 54, 4, p. 789-94 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease

    Banasik, Karina, Justesen, Johanne Marie, Hornbak, M., Krarup, N. T., Gjesing, A. P., Sandholt, C. H., Søndergaard Jensen, T., Grarup, Niels, Andersson, Åsa, Jørgensen, T., Witte, D. R., Sandbæk, A., Lauritzen, T., Thorens, B., Brunak, Søren, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2011, In: P L o S One. 6, 1, p. e16542

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

    Gjesing, A. P., Kjems, L. L., Vestmar, M. A., Grarup, Niels, Linneberg, Allan René, Deacon, Carolyn F., Holst, Jens Juul, Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2011, In: Diabetologia. 54, 1, p. 103-10 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

    Hornbak, M., Banasik, Karina, Justesen, Johanne Marie, Krarup, N. T., Sandholt, C. H., Andersson, Åsa, Sandbaek, A., Lauritzen, T., Pisinger, C., Witte, D. R., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 6 Jan 2011, In: BMC Medical Genetics. 12, 1, p. 4 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

    Nielsen, T., Sparsø, T., Grarup, Niels, Jørgensen, T., Pisinger, C. H., Witte, D. R., Hansen, T., Pedersen, Oluf Borbye & Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, D. G. R. A. M. (. C., 1 May 2011, In: Diabetologica. 54, 5, p. 1052-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes

    Bille, D. S., Banasik, Karina, Justesen, Johanne Marie, Sandholt, C. H., Sandbæk, A., Lauritzen, T., Jørgensen, T., Witte, D. R., Holm, Jens-Christian, Hansen, Torben & Pedersen, Oluf Borbye, 1 Jun 2011, In: P L o S One. 6, 6, p. e20640 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals

    Burgdorf, K. S., Gjesing, A. P., Grarup, Niels, Justesen, Johanne Marie, Sandholt, C. H., Witte, D. R., Jørgensen, T., Madsbad, Sten, Hansen, Torben & Pedersen, Oluf Borbye, 28 Sep 2011, In: Diabetologia. 55, 1, p. 105-13 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge

    Andersson, E. A., Harder, M. N., Pilgaard, K., Pisinger, C., Stancáková, A., Kuusisto, J., Grarup, Niels, Færch, K., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, Allan, Laakso, M., Pedersen, Oluf Borbye & Hansen, Torben, Nov 2011, In: P L o S One. 6, 11, p. e27096 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2012
  13. Published

    A genome-wide association search for type 2 diabetes genes in African Americans

    Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., Rotimi, C. N. & 31 others, Ng, M. C. Y., Langefeld, C. D., Freedman, B. I., Bowden, D. W., Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Langenberg, C., Grarup, Niels, Jørgensen, T., Sparsø, T., Hansen, Torben, Pedersen, Oluf Borbye, Schwarz, Peter, Karpe, F. & DIAGRAM Consortium, D. C., 2012, In: P L o S One. 7, 1, p. e29202

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

    Helgadottir, A., Gretarsdottir, S., Thorleifsson, G., Holm, H., Patel, R. S., Gudnason, T., Jones, G. T., van Rij, A. M., Eapen, D. J., Baas, A. F., Tregouet, D-A., Morange, P-E., Emmerich, J., Lindblad, B., Gottsäter, A., Kiemeny, L. A., Lindholt, J. S., Sakalihasan, N., Ferrell, R. E., Carey, D. J. & 63 others, Elmore, J. R., Tsao, P. S., Grarup, Niels, Jørgensen, T., Witte, D. R., Hansen, Torben, Pedersen, Oluf Borbye, Pola, R., Gaetani, E., Magnadottir, H. B., Wijmenga, C., Tromp, G., Ronkainen, A., Ruigrok, Y. M., Blankensteijn, J. D., Mueller, T., Wells, P. S., Corral, J., Soria, J. M., Souto, J. C., Peden, J. F., Jalilzadeh, S., Mayosi, B. M., Keavney, B., Strawbridge, R. J., Sabater-Lleal, M., Gertow, K., Baldassarre, D., Nyyssönen, K., Rauramaa, R., Smit, A. J., Mannarino, E., Giral, P., Tremoli, E., de Faire, U., Humphries, S. E., Hamsten, A., Haraldsdottir, V., Olafsson, I., Magnusson, M. K., Samani, N. J., Levey, A. I., Markus, H. S., Kostulas, K., Dichgans, M., Berger, K., Kuhlenbäumer, G., Ringelstein, E. B., Stoll, M., Seedorf, U., Rothwell, P. M., Powell, J. T., Kuivaniemi, H., Onundarson, P. T., Valdimarsson, E., Matthiasson, S. E., Gudbjartsson, D. F., Thorgeirsson, G., Quyyumi, A. A., Watkins, H., Farrall, M., Thorsteinsdottir, U. & Stefansson, K., 2012, In: Journal of the American College of Cardiology. 60, 8, p. 722-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

    Snogdal, L. S., Wod, M., Grarup, Niels, Vestmar, M., Sparsø, T. H., Jørgensen, T., Lauritzen, T., Beck-Nielsen, H., Henriksen, J. E., Pedersen, Oluf Borbye, Hansen, Torben & Højlund, K., 2012, In: Diabetologia. 55, 2, p. 340-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Genetic Variant SLC2A2 Is Associated with Risk of Cardiovascular Disease - Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants

    Borglykke, A., Grarup, Niels, Sparsø, T., Linneberg, Allan René, Fenger, M., Jeppesen, J., Hansen, Torben, Pedersen, Oluf Borbye & Jørgensen, T., 2012, In: P L o S One. 7, 11, p. e50418

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

    Scott, R. A., Chu, A. Y., Grarup, N., Manning, A. K., Hivert, M-F., Shungin, D., Tönjes, A., Yesupriya, A., Barnes, D., Bouatia-Naji, N., Glazer, N. L., Jackson, A. U., Kutalik, Z., Lagou, V., Marek, D., Rasmussen-Torvik, L. J., Stringham, H. M., Tanaka, T., Aadahl, M., Arking, D. E. & 87 others, Bergmann, S., Boerwinkle, E., Bonnycastle, L. L., Bornstein, S. R., Brunner, E., Bumpstead, S. J., Brage, S., Carlson, O. D., Chen, H., Chen, Y. I., Chines, P. S., Collins, F. S., Couper, D. J., Dennison, E. M., Dowling, N. F., Egan, J. S., Ekelund, U., Erdos, M. R., Forouhi, N. G., Fox, C. S., Goodarzi, M. O., Grässler, J., Gustafsson, S., Hallmans, G., Hansen, Torben, Hingorani, A., Holloway, J. W., Hu, F. B., Isomaa, B., Jameson, K. A., Johansson, I., Jonsson, Anna Elisabet, Jørgensen, T., Kivimaki, M., Kovacs, P., Kumari, M., Kuusisto, J., Laakso, M., Lecoeur, C., Lévy-Marchal, C., Li, G., Loos, R. J. F., Lyssenko, V., Marmot, M., Marques-Vidal, P., Morken, M. A., Müller, G., North, K. E., Pankow, J. S., Payne, F., Prokopenko, I., Psaty, B. M., Renström, F., Rice, K., Rotter, J. I., Rybin, D., Sandholt, C. H., Sayer, A. A., Shrader, P., Schwarz, P. E. H., Siscovick, D. S., Stancáková, A., Stumvoll, M., Teslovich, T. M., Waeber, G., Williams, G. H., Witte, D. R., Wood, A. R., Xie, W., Boehnke, M., Cooper, C., Ferrucci, L., Froguel, P., Groop, L., Kao, W. H. L., Vollenweider, P., Walker, M., Watanabe, R. M., Pedersen, Oluf Borbye, Meigs, J. B., Ingelsson, E., Barroso, I., Florez, J. C., Franks, P. W., Dupuis, J., Wareham, N. J. & Langenberg, C., 2012, In: Diabetes. 61, 5, p. 1291-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

    Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S. & 31 others, Pankow, J. S., Uh, H., Wu, Y., Bidulescu, A., Rasmussen-Torvik, L. J., Greenwood, C. M. T., Ladouceur, M., Grimsby, J., Manning, A. K., Liu, C., Kooner, J., Mooser, V. E., Vollenweider, P., Kapur, K. A., Chambers, J., Wareham, N. J., Langenberg, C., Frants, R., Willems-Vandijk, K., Oostra, B. A., Willems, S. M., Lamina, C., Winkler, T. W., Grarup, Niels, Jørgensen, T., Sparsø, T., Hansen, Torben, Pedersen, Oluf Borbye, Karpe, F., Kyvik, K. O. & DIAGRAM+ Consortium, D. C., 2012, In: P L o S Genetics (Online). 8, 3, p. e1002607

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation

    Krarup, N. T., Grarup, Niels, Banasik, Karina, Friedrichsen, M., Færch, K., Sandholt, C. H., Jørgensen, T., Poulsen, P., Witte, D. R., Vaag, Allan, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 2012, In: P L o S One. 7, 7, 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17¿636 Danes

    Andersen, G., Dalgaard, L. T., Justesen, Johanne Marie, Anthonsen, S., Nielsen, T., Thørner, L. W., Witte, D., Jørgensen, T., Clausen, J. O., Lauritzen, T., Holmkvist, J., Hansen, Torben & Pedersen, Oluf Borbye, 2012, In: International Journal of Obesity.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. 2013
  22. Published

    Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

    Albrechtsen, A., Grarup, N., Li, Y., Sparsø, T. H., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T. S., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stancáková, A., Andersen, G., Astrup, A., Banasik, K. & 86 others, Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M., Groves, C. J., Gui, Y., Hallmans, G., Hattersley, A. T., He, K., Hitman, G. A., Holmkvist, J., Huang, S., Jiang, H., Jin, X., Justesen, Johanne Marie, Kristiansen, Karsten, Kuusisto, J., Lajer, M., Lantieri, O., Li, W., Liang, H., Liao, Q., Liu, X., Ma, T., Ma, X., Manijak, M. P., Marre, M., Mokrosinski, J., Morris, A. D., Mu, B., Nielsen, A. A., Nijpels, G., Nilsson, P., Palmer, C. N. A., Rayner, N. W., Renström, F., Ribel-Madsen, R., Robertson, N., Rolandsson, O., Rossing, P., Schwartz, Thue W., Slagboom, P. E., Sterner, M., Tang, M., Tarnow, L., Tuomi, T., Van't Riet, E., van Leeuwen, N., V Varga, Tibor, Vestmar, M. A., Walker, M., Wang, B., Wang, Y., Wu, H., Xi, F., Yengo, L., Yu, C., Zhang, X., Zhang, J., Zhang, Q., Zhang, W., Zheng, H., Zhou, Y., Altshuler, D., 't Hart, L. M., Franks, P. W., Balkau, B., Froguel, P., McCarthy, M. I., Laakso, M., Groop, L., Christensen, C., Brandslund, I., Lauritzen, T., Witte, D. R., Linneberg, A., Jørgensen, T., Hansen, Torben, Wang, J., Nielsen, Rasmus & Pedersen, Oluf Borbye, 2013, In: Diabetologia. 56, 2, p. 298-310 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets

    Grarup, N., Sulem, P., Sandholt, C. H., Thorleifsson, G., Ahluwalia, T. V. S., Steinthorsdottir, V., Bjarnason, H., Gudbjartsson, D. F., Magnusson, O. T., Sparsø, T., Albrechtsen, A., Kong, A., Masson, G., Tian, G., Cao, H., Nie, C., Kristiansen, K., Husemoen, L. L., Thuesen, B., Li, Y. & 10 others, Nielsen, Rasmus, Linneberg, Allan René, Olafsson, I., Eyjolfsson, G. I., Jørgensen, T., Wang, J., Hansen, Torben, Thorsteinsdottir, U., Stefánsson, K. & Pedersen, Oluf Borbye, 2013, In: P L o S Genetics. 9, 6, 12 p., e1003530.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Richness of human gut microbiome correlates with metabolic markers

    Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J-M., Kennedy, S., Leonard, P., Li, J., Burgdorf, K. S., Grarup, N., Jørgensen, T., Brandslund, I., Nielsen, H. B., Juncker, A., dos Santos, M. B. Q., Levenez, F. & 62 others, Pons, N., Rasmussen, Simon, Sunagawa, S., Tap, J., Tims, S., Zoetendal, E. G., Brunak, S., Clément, K., Doré, J., Kleerebezem, M., Kristiansen, Karsten, Renault, P., Sicheritz-Ponten, T., de Vos, W. M., Zucker, J., Raes, J., Hansen, Torben, Bork, P., Wang, J., Ehrlich, S. D., Pedersen, Oluf Borbye, Guedon, E., Delorme, C., Layec, S., Khaci, G., van de Guchte, M., Vandemeulebrouck, G., Jamet, A., Dervyn, R., Sanchez, N., Maguin, E., Haimet, F., Winogradski, Y., Cultrone, A., Leclerc, M., Juste, C., Blottière, H., Pelletier, E., LePaslier, D., Artiguenave, F., Bruls, T., Weissenbach, J., Turner, K., Parkhill, J., Antolin, M., Manichanh, C., Casellas, F., Boruel, N., Varela, E., Torrejon, A., Guarner, F., Denariaz, G., Derrien, M., van Hylckama Vlieg, J. E. T., Veiga, P., Oozeer, R., Knol, J., Rescigno, M., Brechot, C., Mérieux, A., M'Rini, C. & Yamada, T., 2013, In: Nature. 500, 7464, p. 541-546 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease

    Vazquez-Chantada, M., Gonzalez-Lahera, A., Martinez-Arranz, I., Garcia-Monzon, C., Regueiro, M. M., Garcia-Rodriguez, J. L., Schlangen, K. A., Mendibil, I., Rodriguez-Ezpeleta, N., Lozano, J. J., Banasik, K., Justesen, J. M., Jørgensen, T., Witte, D. R., Lauritzen, T., Hansen, T., Pedersen, O., Veyrie, N., Clement, K., Tordjman, J. & 12 others, Tran, A., Le Marchand-Brustel, Y., Buque, X., Aspichueta, P., Echevarria-Uraga, J. J., Martin-Duce, A., Caballeria, J., Gual, P., Castro, A., Mato, J. M., Martinez-Chantar, M. L. & Aransay, A. M., Feb 2013, In: Hepatology. 57, 2, p. 505-514 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

    Bonnefond, A., Saulnier, P., Stathopoulou, M. G., Grarup, Niels, Ndiaye, N. C., Roussel, R., Nezhad, M. A., Dechaume, A., Lantieri, O., Hercberg, S., Lauritzen, T., Balkau, B., El-Sayed Moustafa, J. S., Hansen, Torben, Pedersen, Oluf Borbye, Froguel, P., Charpentier, G., Marre, M., Hadjadj, S. & Visvikis-Siest, S., Feb 2013, In: P L o S One. 8, 2, p. e55921

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased ß-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort

    Harder, M. N., Ribel-Madsen, R., Justesen, Johanne Marie, Sparsø, T., Galijatovic, E. A. A., Grarup, Niels, Jørgensen, T., Linneberg, Allan René, Hansen, Torben & Pedersen, Oluf Borbye, 1 Apr 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 4, p. 801-806

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

    Esserlind, A., Christensen, A. F., Le, H., Kirchmann, M., Hauge, A. W., Toyserkani, N. M., Hansen, Torben, Grarup, Niels, Werge, Thomas, Steinberg, S., Bettella, F., Stefansson, H. & Olesen, Jes, May 2013, In: European Journal of Neurology. 20, 5, p. 765-772 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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