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A genome-wide association search for type 2 diabetes genes in African Americans. / Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N; Ng, Maggie C Y; Langefeld, Carl D; Freedman, Barry I; Bowden, Donald W; Voight, Benjamin F; Scott, Laura J; Steinthorsdottir, Valgerdur; Morris, Andrew P; Dina, Christian; Welch, Ryan P; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii S; Thorleifsson, Gudmar; McCulloch, Laura J; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen J; Raychaudhuri, Soumya; McCarroll, Steve A; Langenberg, Claudia; Grarup, Niels; Jørgensen, Torben; Sparsø, Thomas; Hansen, Torben; Pedersen, Oluf; Schwarz, Peter; Karpe, Fredrik; DIAGRAM Consortium.
In:
P L o S One, Vol. 7, No. 1, 2012, p. e29202.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, Voight, BF, Scott, LJ, Steinthorsdottir, V, Morris, AP, Dina, C, Welch, RP, Zeggini, E, Huth, C, Aulchenko, YS, Thorleifsson, G, McCulloch, LJ, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, CJ, Raychaudhuri, S, McCarroll, SA, Langenberg, C
, Grarup, N, Jørgensen, T, Sparsø, T
, Hansen, T, Pedersen, O, Schwarz, P, Karpe, F & DIAGRAM Consortium 2012, '
A genome-wide association search for type 2 diabetes genes in African Americans',
P L o S One, vol. 7, no. 1, pp. e29202.
https://doi.org/10.1371/journal.pone.0029202APA
Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., ... DIAGRAM Consortium (2012).
A genome-wide association search for type 2 diabetes genes in African Americans.
P L o S One,
7(1), e29202.
https://doi.org/10.1371/journal.pone.0029202Vancouver
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS et al.
A genome-wide association search for type 2 diabetes genes in African Americans.
P L o S One. 2012;7(1):e29202.
https://doi.org/10.1371/journal.pone.0029202Author
Palmer, Nicholette D ; McDonough, Caitrin W ; Hicks, Pamela J ; Roh, Bong H ; Wing, Maria R ; An, S Sandy ; Hester, Jessica M ; Cooke, Jessica N ; Bostrom, Meredith A ; Rudock, Megan E ; Talbert, Matthew E ; Lewis, Joshua P ; Ferrara, Assiamira ; Lu, Lingyi ; Ziegler, Julie T ; Sale, Michele M ; Divers, Jasmin ; Shriner, Daniel ; Adeyemo, Adebowale ; Rotimi, Charles N ; Ng, Maggie C Y ; Langefeld, Carl D ; Freedman, Barry I ; Bowden, Donald W ; Voight, Benjamin F ; Scott, Laura J ; Steinthorsdottir, Valgerdur ; Morris, Andrew P ; Dina, Christian ; Welch, Ryan P ; Zeggini, Eleftheria ; Huth, Cornelia ; Aulchenko, Yurii S ; Thorleifsson, Gudmar ; McCulloch, Laura J ; Ferreira, Teresa ; Grallert, Harald ; Amin, Najaf ; Wu, Guanming ; Willer, Cristen J ; Raychaudhuri, Soumya ; McCarroll, Steve A ; Langenberg, Claudia ; Grarup, Niels ; Jørgensen, Torben ; Sparsø, Thomas ; Hansen, Torben ; Pedersen, Oluf ; Schwarz, Peter ; Karpe, Fredrik ; DIAGRAM Consortium. / A genome-wide association search for type 2 diabetes genes in African Americans. In: P L o S One. 2012 ; Vol. 7, No. 1. pp. e29202.
Bibtex
@article{e8a5c4f7ddef42f393c84c6969bb7a92,
title = "A genome-wide association search for type 2 diabetes genes in African Americans",
abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n¿=¿550 independent loci) were genotyped in a replication cohort and 122 SNPs (n¿=¿98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",
keywords = "Adult, African Americans, Aged, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Validation Studies as Topic",
author = "Palmer, {Nicholette D} and McDonough, {Caitrin W} and Hicks, {Pamela J} and Roh, {Bong H} and Wing, {Maria R} and An, {S Sandy} and Hester, {Jessica M} and Cooke, {Jessica N} and Bostrom, {Meredith A} and Rudock, {Megan E} and Talbert, {Matthew E} and Lewis, {Joshua P} and Assiamira Ferrara and Lingyi Lu and Ziegler, {Julie T} and Sale, {Michele M} and Jasmin Divers and Daniel Shriner and Adebowale Adeyemo and Rotimi, {Charles N} and Ng, {Maggie C Y} and Langefeld, {Carl D} and Freedman, {Barry I} and Bowden, {Donald W} and Voight, {Benjamin F} and Scott, {Laura J} and Valgerdur Steinthorsdottir and Morris, {Andrew P} and Christian Dina and Welch, {Ryan P} and Eleftheria Zeggini and Cornelia Huth and Aulchenko, {Yurii S} and Gudmar Thorleifsson and McCulloch, {Laura J} and Teresa Ferreira and Harald Grallert and Najaf Amin and Guanming Wu and Willer, {Cristen J} and Soumya Raychaudhuri and McCarroll, {Steve A} and Claudia Langenberg and Niels Grarup and Torben J{\o}rgensen and Thomas Spars{\o} and Torben Hansen and Oluf Pedersen and Peter Schwarz and Fredrik Karpe and {DIAGRAM Consortium}",
year = "2012",
doi = "10.1371/journal.pone.0029202",
language = "English",
volume = "7",
pages = "e29202",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",
}
RIS
TY - JOUR
T1 - A genome-wide association search for type 2 diabetes genes in African Americans
AU - Palmer, Nicholette D
AU - McDonough, Caitrin W
AU - Hicks, Pamela J
AU - Roh, Bong H
AU - Wing, Maria R
AU - An, S Sandy
AU - Hester, Jessica M
AU - Cooke, Jessica N
AU - Bostrom, Meredith A
AU - Rudock, Megan E
AU - Talbert, Matthew E
AU - Lewis, Joshua P
AU - Ferrara, Assiamira
AU - Lu, Lingyi
AU - Ziegler, Julie T
AU - Sale, Michele M
AU - Divers, Jasmin
AU - Shriner, Daniel
AU - Adeyemo, Adebowale
AU - Rotimi, Charles N
AU - Ng, Maggie C Y
AU - Langefeld, Carl D
AU - Freedman, Barry I
AU - Bowden, Donald W
AU - Voight, Benjamin F
AU - Scott, Laura J
AU - Steinthorsdottir, Valgerdur
AU - Morris, Andrew P
AU - Dina, Christian
AU - Welch, Ryan P
AU - Zeggini, Eleftheria
AU - Huth, Cornelia
AU - Aulchenko, Yurii S
AU - Thorleifsson, Gudmar
AU - McCulloch, Laura J
AU - Ferreira, Teresa
AU - Grallert, Harald
AU - Amin, Najaf
AU - Wu, Guanming
AU - Willer, Cristen J
AU - Raychaudhuri, Soumya
AU - McCarroll, Steve A
AU - Langenberg, Claudia
AU - Grarup, Niels
AU - Jørgensen, Torben
AU - Sparsø, Thomas
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Schwarz, Peter
AU - Karpe, Fredrik
AU - DIAGRAM Consortium
PY - 2012
Y1 - 2012
N2 - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n¿=¿550 independent loci) were genotyped in a replication cohort and 122 SNPs (n¿=¿98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P
AB - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n¿=¿550 independent loci) were genotyped in a replication cohort and 122 SNPs (n¿=¿98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P
KW - Adult
KW - African Americans
KW - Aged
KW - Case-Control Studies
KW - Cohort Studies
KW - Diabetes Mellitus, Type 2
KW - Female
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Genotype
KW - Humans
KW - Male
KW - Meta-Analysis as Topic
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Validation Studies as Topic
U2 - 10.1371/journal.pone.0029202
DO - 10.1371/journal.pone.0029202
M3 - Journal article
C2 - 22238593
VL - 7
SP - e29202
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 1
ER -
