Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

Research output: Contribution to journal › Journal article › Research › peer-review

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Causal relationship between obesity and serum testosterone status in men : A bi-directional mendelian randomization analysis. / Eriksson, Joel; Haring, Robin; Grarup, Niels; Vandenput, Liesbeth; Wallaschofski, Henri; Lorentzen, Erik; Hansen, Torben; Mellström, Dan; Pedersen, Oluf; Nauck, Matthias; Lorentzon, Mattias; Nystrup Husemoen, Lise Lotte; Völzke, Henry; Karlsson, Magnus; Baumeister, Sebastian E; Linneberg, Allan; Ohlsson, Claes.

In: PloS one, Vol. 12, No. 4, e0176277, 2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Eriksson, J, Haring, R, Grarup, N, Vandenput, L, Wallaschofski, H, Lorentzen, E, Hansen, T, Mellström, D, Pedersen, O, Nauck, M, Lorentzon, M, Nystrup Husemoen, LL, Völzke, H, Karlsson, M, Baumeister, SE, Linneberg, A & Ohlsson, C 2017, 'Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis', PloS one, vol. 12, no. 4, e0176277. https://doi.org/10.1371/journal.pone.0176277

APA

Eriksson, J., Haring, R., Grarup, N., Vandenput, L., Wallaschofski, H., Lorentzen, E., Hansen, T., Mellström, D., Pedersen, O., Nauck, M., Lorentzon, M., Nystrup Husemoen, L. L., Völzke, H., Karlsson, M., Baumeister, S. E., Linneberg, A., & Ohlsson, C. (2017). Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PloS one, 12(4), [e0176277]. https://doi.org/10.1371/journal.pone.0176277

Vancouver

Eriksson J, Haring R, Grarup N, Vandenput L, Wallaschofski H, Lorentzen E et al. Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PloS one. 2017;12(4). e0176277. https://doi.org/10.1371/journal.pone.0176277

Author

Eriksson, Joel ; Haring, Robin ; Grarup, Niels ; Vandenput, Liesbeth ; Wallaschofski, Henri ; Lorentzen, Erik ; Hansen, Torben ; Mellström, Dan ; Pedersen, Oluf ; Nauck, Matthias ; Lorentzon, Mattias ; Nystrup Husemoen, Lise Lotte ; Völzke, Henry ; Karlsson, Magnus ; Baumeister, Sebastian E ; Linneberg, Allan ; Ohlsson, Claes. / Causal relationship between obesity and serum testosterone status in men : A bi-directional mendelian randomization analysis. In: PloS one. 2017 ; Vol. 12, No. 4.

Bibtex

@article{54fa10bcb1a0476695e20683d38168ea,
title = "Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis",
abstract = "CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).PARTICIPANTS: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.MAIN OUTCOME MEASURES: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.RESULTS: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).CONCLUSIONS: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.",
keywords = "Adolescent, Adult, Aged, Body Mass Index, Genetic Predisposition to Disease, Humans, Male, Mendelian Randomization Analysis, Obesity, Phenotype, Polymorphism, Single Nucleotide, Testosterone, Young Adult, Journal Article",
author = "Joel Eriksson and Robin Haring and Niels Grarup and Liesbeth Vandenput and Henri Wallaschofski and Erik Lorentzen and Torben Hansen and Dan Mellstr{\"o}m and Oluf Pedersen and Matthias Nauck and Mattias Lorentzon and {Nystrup Husemoen}, {Lise Lotte} and Henry V{\"o}lzke and Magnus Karlsson and Baumeister, {Sebastian E} and Allan Linneberg and Claes Ohlsson",
year = "2017",
doi = "10.1371/journal.pone.0176277",
language = "English",
volume = "12",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Causal relationship between obesity and serum testosterone status in men

T2 - A bi-directional mendelian randomization analysis

AU - Eriksson, Joel

AU - Haring, Robin

AU - Grarup, Niels

AU - Vandenput, Liesbeth

AU - Wallaschofski, Henri

AU - Lorentzen, Erik

AU - Hansen, Torben

AU - Mellström, Dan

AU - Pedersen, Oluf

AU - Nauck, Matthias

AU - Lorentzon, Mattias

AU - Nystrup Husemoen, Lise Lotte

AU - Völzke, Henry

AU - Karlsson, Magnus

AU - Baumeister, Sebastian E

AU - Linneberg, Allan

AU - Ohlsson, Claes

PY - 2017

Y1 - 2017

N2 - CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).PARTICIPANTS: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.MAIN OUTCOME MEASURES: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.RESULTS: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).CONCLUSIONS: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.

AB - CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).PARTICIPANTS: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.MAIN OUTCOME MEASURES: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.RESULTS: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).CONCLUSIONS: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.

KW - Adolescent

KW - Adult

KW - Aged

KW - Body Mass Index

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Mendelian Randomization Analysis

KW - Obesity

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Testosterone

KW - Young Adult

KW - Journal Article

U2 - 10.1371/journal.pone.0176277

DO - 10.1371/journal.pone.0176277

M3 - Journal article

C2 - 28448539

VL - 12

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 4

M1 - e0176277

ER -

ID: 182972768