Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes
Research output: Contribution to journal › Journal article › Research › peer-review
The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.
| Original language | English |
|---|---|
| Journal | International Journal of Obesity |
| Volume | 31 |
| Issue number | 2 |
| Pages (from-to) | 365-70 |
| Number of pages | 6 |
| ISSN | 0307-0565 |
| DOIs | |
| Publication status | Published - 2007 |
- Aged, Anthropometry, Blood Glucose, Body Constitution, Chromosomes, Human, Pair 11, DNA Mutational Analysis, Diabetes Mellitus, Type 2, Estrogen Receptor alpha, Female, Genetic Predisposition to Disease, Heat-Shock Proteins, Humans, Insulin, Linkage Disequilibrium, Lipids, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Transcription Factors
Research areas
ID: 40246606