Genetic Determinants of Weight Loss After Bariatric Surgery

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genetic Determinants of Weight Loss After Bariatric Surgery. / Aasbrenn, Martin; Schnurr, Theresia Maria; Have, Christian Theil; Svendstrup, Mathilde; Hansen, Dorte Lindqvist; Worm, Dorte; Balslev-Harder, Marie; Hollensted, Mette; Grarup, Niels; Burgdorf, Kristoffer Sølvsten; Vestergaard, Henrik; Pedersen, Oluf; Sørensen, Thorkild I. A.; Fenger, Mogens; Madsbad, Sten; Hansen, Torben.

In: Obesity Surgery, Vol. 29, No. 8, 2019, p. 2554-2561.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Aasbrenn, M, Schnurr, TM, Have, CT, Svendstrup, M, Hansen, DL, Worm, D, Balslev-Harder, M, Hollensted, M, Grarup, N, Burgdorf, KS, Vestergaard, H, Pedersen, O, Sørensen, TIA, Fenger, M, Madsbad, S & Hansen, T 2019, 'Genetic Determinants of Weight Loss After Bariatric Surgery', Obesity Surgery, vol. 29, no. 8, pp. 2554-2561. https://doi.org/10.1007/s11695-019-03878-5

APA

Aasbrenn, M., Schnurr, T. M., Have, C. T., Svendstrup, M., Hansen, D. L., Worm, D., Balslev-Harder, M., Hollensted, M., Grarup, N., Burgdorf, K. S., Vestergaard, H., Pedersen, O., Sørensen, T. I. A., Fenger, M., Madsbad, S., & Hansen, T. (2019). Genetic Determinants of Weight Loss After Bariatric Surgery. Obesity Surgery, 29(8), 2554-2561. https://doi.org/10.1007/s11695-019-03878-5

Vancouver

Aasbrenn M, Schnurr TM, Have CT, Svendstrup M, Hansen DL, Worm D et al. Genetic Determinants of Weight Loss After Bariatric Surgery. Obesity Surgery. 2019;29(8):2554-2561. https://doi.org/10.1007/s11695-019-03878-5

Author

Aasbrenn, Martin ; Schnurr, Theresia Maria ; Have, Christian Theil ; Svendstrup, Mathilde ; Hansen, Dorte Lindqvist ; Worm, Dorte ; Balslev-Harder, Marie ; Hollensted, Mette ; Grarup, Niels ; Burgdorf, Kristoffer Sølvsten ; Vestergaard, Henrik ; Pedersen, Oluf ; Sørensen, Thorkild I. A. ; Fenger, Mogens ; Madsbad, Sten ; Hansen, Torben. / Genetic Determinants of Weight Loss After Bariatric Surgery. In: Obesity Surgery. 2019 ; Vol. 29, No. 8. pp. 2554-2561.

Bibtex

@article{ec8ed899b3334934964383079834903f,
title = "Genetic Determinants of Weight Loss After Bariatric Surgery",
abstract = "BACKGROUND: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.METHODS: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.RESULTS: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.",
author = "Martin Aasbrenn and Schnurr, {Theresia Maria} and Have, {Christian Theil} and Mathilde Svendstrup and Hansen, {Dorte Lindqvist} and Dorte Worm and Marie Balslev-Harder and Mette Hollensted and Niels Grarup and Burgdorf, {Kristoffer S{\o}lvsten} and Henrik Vestergaard and Oluf Pedersen and S{\o}rensen, {Thorkild I. A.} and Mogens Fenger and Sten Madsbad and Torben Hansen",
year = "2019",
doi = "10.1007/s11695-019-03878-5",
language = "English",
volume = "29",
pages = "2554--2561",
journal = "Obesity Surgery",
issn = "0960-8923",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Genetic Determinants of Weight Loss After Bariatric Surgery

AU - Aasbrenn, Martin

AU - Schnurr, Theresia Maria

AU - Have, Christian Theil

AU - Svendstrup, Mathilde

AU - Hansen, Dorte Lindqvist

AU - Worm, Dorte

AU - Balslev-Harder, Marie

AU - Hollensted, Mette

AU - Grarup, Niels

AU - Burgdorf, Kristoffer Sølvsten

AU - Vestergaard, Henrik

AU - Pedersen, Oluf

AU - Sørensen, Thorkild I. A.

AU - Fenger, Mogens

AU - Madsbad, Sten

AU - Hansen, Torben

PY - 2019

Y1 - 2019

N2 - BACKGROUND: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.METHODS: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.RESULTS: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.

AB - BACKGROUND: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.METHODS: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.RESULTS: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.

U2 - 10.1007/s11695-019-03878-5

DO - 10.1007/s11695-019-03878-5

M3 - Journal article

C2 - 31001758

VL - 29

SP - 2554

EP - 2561

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

IS - 8

ER -

ID: 222319712