Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. / Saxena, Richa; Hivert, Marie-France; Langenberg, Claudia; Tanaka, Toshiko; Pankow, James S; Vollenweider, Peter; Lyssenko, Valeriya; Bouatia-Naji, Nabila; Dupuis, Josée; Jackson, Anne U; Kao, W H Linda; Li, Man; Glazer, Nicole L; Manning, Alisa K; Luan, Jian'an; Stringham, Heather M; Prokopenko, Inga; Johnson, Toby; Grarup, Niels; Boesgaard, Trine W; Lecoeur, Cécile; Shrader, Peter; O'Connell, Jeffrey; Ingelsson, Erik; Couper, David J; Rice, Kenneth; Song, Kijoung; Andreasen, Camilla H; Dina, Christian; Köttgen, Anna; Le Bacquer, Olivier; Pattou, François; Taneera, Jalal; Steinthorsdottir, Valgerdur; Rybin, Denis; Ardlie, Kristin; Sampson, Michael; Qi, Lu; van Hoek, Mandy; Weedon, Michael N; Aulchenko, Yurii S; Voight, Benjamin F; Grallert, Harald; Balkau, Beverley; Bergman, Richard N; Borch-Johnsen, Knut; Jørgensen, Torben; Sparsø, Thomas; Hansen, Torben; Pedersen, Oluf; GIANT Consortium.

In: Nature Genetics, Vol. 42, No. 2, 01.02.2010, p. 142-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Saxena, R, Hivert, M-F, Langenberg, C, Tanaka, T, Pankow, JS, Vollenweider, P, Lyssenko, V, Bouatia-Naji, N, Dupuis, J, Jackson, AU, Kao, WHL, Li, M, Glazer, NL, Manning, AK, Luan, J, Stringham, HM, Prokopenko, I, Johnson, T, Grarup, N, Boesgaard, TW, Lecoeur, C, Shrader, P, O'Connell, J, Ingelsson, E, Couper, DJ, Rice, K, Song, K, Andreasen, CH, Dina, C, Köttgen, A, Le Bacquer, O, Pattou, F, Taneera, J, Steinthorsdottir, V, Rybin, D, Ardlie, K, Sampson, M, Qi, L, van Hoek, M, Weedon, MN, Aulchenko, YS, Voight, BF, Grallert, H, Balkau, B, Bergman, RN, Borch-Johnsen, K, Jørgensen, T, Sparsø, T, Hansen, T, Pedersen, O & GIANT Consortium 2010, 'Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge', Nature Genetics, vol. 42, no. 2, pp. 142-8. https://doi.org/10.1038/ng.521

APA

Saxena, R., Hivert, M-F., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A. U., Kao, W. H. L., Li, M., Glazer, N. L., Manning, A. K., Luan, J., Stringham, H. M., Prokopenko, I., Johnson, T., Grarup, N., ... GIANT Consortium (2010). Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics, 42(2), 142-8. https://doi.org/10.1038/ng.521

Vancouver

Saxena R, Hivert M-F, Langenberg C, Tanaka T, Pankow JS, Vollenweider P et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics. 2010 Feb 1;42(2):142-8. https://doi.org/10.1038/ng.521

Author

Saxena, Richa ; Hivert, Marie-France ; Langenberg, Claudia ; Tanaka, Toshiko ; Pankow, James S ; Vollenweider, Peter ; Lyssenko, Valeriya ; Bouatia-Naji, Nabila ; Dupuis, Josée ; Jackson, Anne U ; Kao, W H Linda ; Li, Man ; Glazer, Nicole L ; Manning, Alisa K ; Luan, Jian'an ; Stringham, Heather M ; Prokopenko, Inga ; Johnson, Toby ; Grarup, Niels ; Boesgaard, Trine W ; Lecoeur, Cécile ; Shrader, Peter ; O'Connell, Jeffrey ; Ingelsson, Erik ; Couper, David J ; Rice, Kenneth ; Song, Kijoung ; Andreasen, Camilla H ; Dina, Christian ; Köttgen, Anna ; Le Bacquer, Olivier ; Pattou, François ; Taneera, Jalal ; Steinthorsdottir, Valgerdur ; Rybin, Denis ; Ardlie, Kristin ; Sampson, Michael ; Qi, Lu ; van Hoek, Mandy ; Weedon, Michael N ; Aulchenko, Yurii S ; Voight, Benjamin F ; Grallert, Harald ; Balkau, Beverley ; Bergman, Richard N ; Borch-Johnsen, Knut ; Jørgensen, Torben ; Sparsø, Thomas ; Hansen, Torben ; Pedersen, Oluf ; GIANT Consortium. / Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. In: Nature Genetics. 2010 ; Vol. 42, No. 2. pp. 142-8.

Bibtex

@article{36f6efd02bbd47f3ac7a31b5e240b149,
title = "Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge",
abstract = "Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 x 10(-17); ratio of insulin to glucose area under the curve, P = 1.3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7.1 x 10(-11)) and TCF7L2 (rs7903146, P = 4.2 x 10(-10)) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)).",
keywords = "Adenylate Cyclase, Body Mass Index, Denmark, Diabetes Mellitus, Type 2, Female, Gene Expression Profiling, Gene Expression Regulation, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Glucose, Glucose Tolerance Test, Humans, Incretins, Insulin, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Proteins, RNA, Messenger, Receptors, Gastrointestinal Hormone",
author = "Richa Saxena and Marie-France Hivert and Claudia Langenberg and Toshiko Tanaka and Pankow, {James S} and Peter Vollenweider and Valeriya Lyssenko and Nabila Bouatia-Naji and Jos{\'e}e Dupuis and Jackson, {Anne U} and Kao, {W H Linda} and Man Li and Glazer, {Nicole L} and Manning, {Alisa K} and Jian'an Luan and Stringham, {Heather M} and Inga Prokopenko and Toby Johnson and Niels Grarup and Boesgaard, {Trine W} and C{\'e}cile Lecoeur and Peter Shrader and Jeffrey O'Connell and Erik Ingelsson and Couper, {David J} and Kenneth Rice and Kijoung Song and Andreasen, {Camilla H} and Christian Dina and Anna K{\"o}ttgen and {Le Bacquer}, Olivier and Fran{\c c}ois Pattou and Jalal Taneera and Valgerdur Steinthorsdottir and Denis Rybin and Kristin Ardlie and Michael Sampson and Lu Qi and {van Hoek}, Mandy and Weedon, {Michael N} and Aulchenko, {Yurii S} and Voight, {Benjamin F} and Harald Grallert and Beverley Balkau and Bergman, {Richard N} and Knut Borch-Johnsen and Torben J{\o}rgensen and Thomas Spars{\o} and Torben Hansen and Oluf Pedersen and {GIANT Consortium}",
year = "2010",
month = feb,
day = "1",
doi = "10.1038/ng.521",
language = "English",
volume = "42",
pages = "142--8",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

AU - Saxena, Richa

AU - Hivert, Marie-France

AU - Langenberg, Claudia

AU - Tanaka, Toshiko

AU - Pankow, James S

AU - Vollenweider, Peter

AU - Lyssenko, Valeriya

AU - Bouatia-Naji, Nabila

AU - Dupuis, Josée

AU - Jackson, Anne U

AU - Kao, W H Linda

AU - Li, Man

AU - Glazer, Nicole L

AU - Manning, Alisa K

AU - Luan, Jian'an

AU - Stringham, Heather M

AU - Prokopenko, Inga

AU - Johnson, Toby

AU - Grarup, Niels

AU - Boesgaard, Trine W

AU - Lecoeur, Cécile

AU - Shrader, Peter

AU - O'Connell, Jeffrey

AU - Ingelsson, Erik

AU - Couper, David J

AU - Rice, Kenneth

AU - Song, Kijoung

AU - Andreasen, Camilla H

AU - Dina, Christian

AU - Köttgen, Anna

AU - Le Bacquer, Olivier

AU - Pattou, François

AU - Taneera, Jalal

AU - Steinthorsdottir, Valgerdur

AU - Rybin, Denis

AU - Ardlie, Kristin

AU - Sampson, Michael

AU - Qi, Lu

AU - van Hoek, Mandy

AU - Weedon, Michael N

AU - Aulchenko, Yurii S

AU - Voight, Benjamin F

AU - Grallert, Harald

AU - Balkau, Beverley

AU - Bergman, Richard N

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Sparsø, Thomas

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - GIANT Consortium

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 x 10(-17); ratio of insulin to glucose area under the curve, P = 1.3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7.1 x 10(-11)) and TCF7L2 (rs7903146, P = 4.2 x 10(-10)) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)).

AB - Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 x 10(-17); ratio of insulin to glucose area under the curve, P = 1.3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7.1 x 10(-11)) and TCF7L2 (rs7903146, P = 4.2 x 10(-10)) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)).

KW - Adenylate Cyclase

KW - Body Mass Index

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Genetic Loci

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Glucose

KW - Glucose Tolerance Test

KW - Humans

KW - Incretins

KW - Insulin

KW - Male

KW - Meta-Analysis as Topic

KW - Polymorphism, Single Nucleotide

KW - Proteins

KW - RNA, Messenger

KW - Receptors, Gastrointestinal Hormone

U2 - 10.1038/ng.521

DO - 10.1038/ng.521

M3 - Journal article

C2 - 20081857

VL - 42

SP - 142

EP - 148

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 2

ER -

ID: 33507836