Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium
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Investigating the causal effect of smoking on hay fever and asthma : a Mendelian randomization meta-analysis in the CARTA consortium. / Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K; Paternoster, Lavinia; Thuesen, Betina H; Ahluwalia, Tarunveer S; Larsen, Sofus C; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken E; Bjørngaard, Johan H; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J; Tang Møllehave, Line; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N; Noordam, Raymond; Mook-Kanamori, Dennis O; Taube, Christian; Jessen, Leon E; McConnachie, Alex; Sattar, Naveed; Upton, Mark N; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A; Kivimaki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål R; Skorpen, Frank; Kaprio, Jaakko; R Munafò, Marcus; Linneberg, Allan.
In: Scientific Reports, Vol. 7, No. 1, 2224, 2017.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Investigating the causal effect of smoking on hay fever and asthma
T2 - a Mendelian randomization meta-analysis in the CARTA consortium
AU - Skaaby, Tea
AU - Taylor, Amy E
AU - Jacobsen, Rikke K
AU - Paternoster, Lavinia
AU - Thuesen, Betina H
AU - Ahluwalia, Tarunveer S
AU - Larsen, Sofus C
AU - Zhou, Ang
AU - Wong, Andrew
AU - Gabrielsen, Maiken E
AU - Bjørngaard, Johan H
AU - Flexeder, Claudia
AU - Männistö, Satu
AU - Hardy, Rebecca
AU - Kuh, Diana
AU - Barry, Sarah J
AU - Tang Møllehave, Line
AU - Cerqueira, Charlotte
AU - Friedrich, Nele
AU - Bonten, Tobias N
AU - Noordam, Raymond
AU - Mook-Kanamori, Dennis O
AU - Taube, Christian
AU - Jessen, Leon E
AU - McConnachie, Alex
AU - Sattar, Naveed
AU - Upton, Mark N
AU - McSharry, Charles
AU - Bønnelykke, Klaus
AU - Bisgaard, Hans
AU - Schulz, Holger
AU - Strauch, Konstantin
AU - Meitinger, Thomas
AU - Peters, Annette
AU - Grallert, Harald
AU - Nohr, Ellen A
AU - Kivimaki, Mika
AU - Kumari, Meena
AU - Völker, Uwe
AU - Nauck, Matthias
AU - Völzke, Henry
AU - Power, Chris
AU - Hyppönen, Elina
AU - Hansen, Torben
AU - Jørgensen, Torben
AU - Pedersen, Oluf
AU - Salomaa, Veikko
AU - Grarup, Niels
AU - Langhammer, Arnulf
AU - Romundstad, Pål R
AU - Skorpen, Frank
AU - Kaprio, Jaakko
AU - R Munafò, Marcus
AU - Linneberg, Allan
PY - 2017
Y1 - 2017
N2 - Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0·958, 95% CI: 0·920, 0·998; P = 0·041), a lower risk of allergic sensitization (OR = 0·92, 95% CI: 0·84, 1·02; P = 0·117), but higher risk of asthma (OR = 1·06, 95% CI: 1·01, 1·11; P = 0·020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.
AB - Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0·958, 95% CI: 0·920, 0·998; P = 0·041), a lower risk of allergic sensitization (OR = 0·92, 95% CI: 0·84, 1·02; P = 0·117), but higher risk of asthma (OR = 1·06, 95% CI: 1·01, 1·11; P = 0·020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.
KW - Journal Article
U2 - 10.1038/s41598-017-01977-w
DO - 10.1038/s41598-017-01977-w
M3 - Journal article
C2 - 28533558
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 2224
ER -
ID: 182889229