Standard
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. / Scott, Robert A; Chu, Audrey Y; Grarup, Niels; Manning, Alisa K; Hivert, Marie-France; Shungin, Dmitry; Tönjes, Anke; Yesupriya, Ajay; Barnes, Daniel; Bouatia-Naji, Nabila; Glazer, Nicole L; Jackson, Anne U; Kutalik, Zoltán; Lagou, Vasiliki; Marek, Diana; Rasmussen-Torvik, Laura J; Stringham, Heather M; Tanaka, Toshiko; Aadahl, Mette; Arking, Dan E; Bergmann, Sven; Boerwinkle, Eric; Bonnycastle, Lori L; Bornstein, Stefan R; Brunner, Eric; Bumpstead, Suzannah J; Brage, Soren; Carlson, Olga D; Chen, Han; Chen, Yii-Der Ida; Chines, Peter S; Collins, Francis S; Couper, David J; Dennison, Elaine M; Dowling, Nicole F; Egan, Josephine S; Ekelund, Ulf; Erdos, Michael R; Forouhi, Nita G; Fox, Caroline S; Goodarzi, Mark O; Grässler, Jürgen; Gustafsson, Stefan; Hallmans, Göran; Hansen, Torben; Hingorani, Aroon; Holloway, John W; Hu, Frank B; Isomaa, Bo; Jameson, Karen A; Johansson, Ingegerd; Jonsson, Anna Elisabet; Jørgensen, Torben; Kivimaki, Mika; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Laakso, Markku; Lecoeur, Cécile; Lévy-Marchal, Claire; Li, Guo; Loos, Ruth J F; Lyssenko, Valeri; Marmot, Michael; Marques-Vidal, Pedro; Morken, Mario A; Müller, Gabriele; North, Kari E; Pankow, James S; Payne, Felicity; Prokopenko, Inga; Psaty, Bruce M; Renström, Frida; Rice, Ken; Rotter, Jerome I; Rybin, Denis; Sandholt, Camilla H; Sayer, Avan A; Shrader, Peter; Schwarz, Peter E H; Siscovick, David S; Stancáková, Alena; Stumvoll, Michael; Teslovich, Tanya M; Waeber, Gérard; Williams, Gordon H; Witte, Daniel R; Wood, Andrew R; Xie, Weijia; Boehnke, Michael; Cooper, Cyrus; Ferrucci, Luigi; Froguel, Philippe; Groop, Leif; Kao, W H Linda; Vollenweider, Peter; Walker, Mark; Watanabe, Richard M; Pedersen, Oluf; Meigs, James B; Ingelsson, Erik; Barroso, Inês; Florez, Jose C; Franks, Paul W; Dupuis, Josée; Wareham, Nicholas J; Langenberg, Claudia.
In:
Diabetes, Vol. 61, No. 5, 2012, p. 1291-6.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Scott, RA, Chu, AY
, Grarup, N, Manning, AK, Hivert, M-F, Shungin, D, Tönjes, A, Yesupriya, A, Barnes, D, Bouatia-Naji, N, Glazer, NL, Jackson, AU, Kutalik, Z, Lagou, V, Marek, D, Rasmussen-Torvik, LJ, Stringham, HM, Tanaka, T, Aadahl, M, Arking, DE, Bergmann, S, Boerwinkle, E, Bonnycastle, LL, Bornstein, SR, Brunner, E, Bumpstead, SJ, Brage, S, Carlson, OD, Chen, H, Chen, Y-DI, Chines, PS, Collins, FS, Couper, DJ, Dennison, EM, Dowling, NF, Egan, JS, Ekelund, U, Erdos, MR, Forouhi, NG, Fox, CS, Goodarzi, MO, Grässler, J, Gustafsson, S, Hallmans, G
, Hansen, T, Hingorani, A, Holloway, JW, Hu, FB, Isomaa, B, Jameson, KA, Johansson, I
, Jonsson, AE, Jørgensen, T, Kivimaki, M, Kovacs, P, Kumari, M, Kuusisto, J, Laakso, M, Lecoeur, C, Lévy-Marchal, C, Li, G, Loos, RJF, Lyssenko, V, Marmot, M, Marques-Vidal, P, Morken, MA, Müller, G, North, KE, Pankow, JS, Payne, F, Prokopenko, I, Psaty, BM, Renström, F, Rice, K, Rotter, JI, Rybin, D, Sandholt, CH, Sayer, AA, Shrader, P, Schwarz, PEH, Siscovick, DS, Stancáková, A, Stumvoll, M, Teslovich, TM, Waeber, G, Williams, GH, Witte, DR, Wood, AR, Xie, W, Boehnke, M, Cooper, C, Ferrucci, L, Froguel, P, Groop, L, Kao, WHL, Vollenweider, P, Walker, M, Watanabe, RM
, Pedersen, O, Meigs, JB, Ingelsson, E, Barroso, I, Florez, JC, Franks, PW, Dupuis, J, Wareham, NJ & Langenberg, C 2012, '
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels',
Diabetes, vol. 61, no. 5, pp. 1291-6.
https://doi.org/10.2337/db11-0973APA
Scott, R. A., Chu, A. Y.
, Grarup, N., Manning, A. K., Hivert, M-F., Shungin, D., Tönjes, A., Yesupriya, A., Barnes, D., Bouatia-Naji, N., Glazer, N. L., Jackson, A. U., Kutalik, Z., Lagou, V., Marek, D., Rasmussen-Torvik, L. J., Stringham, H. M., Tanaka, T., Aadahl, M., ... Langenberg, C. (2012).
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Diabetes,
61(5), 1291-6.
https://doi.org/10.2337/db11-0973Vancouver
Scott RA, Chu AY
, Grarup N, Manning AK, Hivert M-F, Shungin D et al.
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Diabetes. 2012;61(5):1291-6.
https://doi.org/10.2337/db11-0973Author
Scott, Robert A ; Chu, Audrey Y ; Grarup, Niels ; Manning, Alisa K ; Hivert, Marie-France ; Shungin, Dmitry ; Tönjes, Anke ; Yesupriya, Ajay ; Barnes, Daniel ; Bouatia-Naji, Nabila ; Glazer, Nicole L ; Jackson, Anne U ; Kutalik, Zoltán ; Lagou, Vasiliki ; Marek, Diana ; Rasmussen-Torvik, Laura J ; Stringham, Heather M ; Tanaka, Toshiko ; Aadahl, Mette ; Arking, Dan E ; Bergmann, Sven ; Boerwinkle, Eric ; Bonnycastle, Lori L ; Bornstein, Stefan R ; Brunner, Eric ; Bumpstead, Suzannah J ; Brage, Soren ; Carlson, Olga D ; Chen, Han ; Chen, Yii-Der Ida ; Chines, Peter S ; Collins, Francis S ; Couper, David J ; Dennison, Elaine M ; Dowling, Nicole F ; Egan, Josephine S ; Ekelund, Ulf ; Erdos, Michael R ; Forouhi, Nita G ; Fox, Caroline S ; Goodarzi, Mark O ; Grässler, Jürgen ; Gustafsson, Stefan ; Hallmans, Göran ; Hansen, Torben ; Hingorani, Aroon ; Holloway, John W ; Hu, Frank B ; Isomaa, Bo ; Jameson, Karen A ; Johansson, Ingegerd ; Jonsson, Anna Elisabet ; Jørgensen, Torben ; Kivimaki, Mika ; Kovacs, Peter ; Kumari, Meena ; Kuusisto, Johanna ; Laakso, Markku ; Lecoeur, Cécile ; Lévy-Marchal, Claire ; Li, Guo ; Loos, Ruth J F ; Lyssenko, Valeri ; Marmot, Michael ; Marques-Vidal, Pedro ; Morken, Mario A ; Müller, Gabriele ; North, Kari E ; Pankow, James S ; Payne, Felicity ; Prokopenko, Inga ; Psaty, Bruce M ; Renström, Frida ; Rice, Ken ; Rotter, Jerome I ; Rybin, Denis ; Sandholt, Camilla H ; Sayer, Avan A ; Shrader, Peter ; Schwarz, Peter E H ; Siscovick, David S ; Stancáková, Alena ; Stumvoll, Michael ; Teslovich, Tanya M ; Waeber, Gérard ; Williams, Gordon H ; Witte, Daniel R ; Wood, Andrew R ; Xie, Weijia ; Boehnke, Michael ; Cooper, Cyrus ; Ferrucci, Luigi ; Froguel, Philippe ; Groop, Leif ; Kao, W H Linda ; Vollenweider, Peter ; Walker, Mark ; Watanabe, Richard M ; Pedersen, Oluf ; Meigs, James B ; Ingelsson, Erik ; Barroso, Inês ; Florez, Jose C ; Franks, Paul W ; Dupuis, Josée ; Wareham, Nicholas J ; Langenberg, Claudia. / No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. In: Diabetes. 2012 ; Vol. 61, No. 5. pp. 1291-6.
Bibtex
@article{e51401b9f0524bd0bde943b21aaa5334,
title = "No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels",
abstract = "Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals ({\ss} = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose ({\ss} = 0.06-0.12 mmol/allele, P = 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P = 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.",
author = "Scott, {Robert A} and Chu, {Audrey Y} and Niels Grarup and Manning, {Alisa K} and Marie-France Hivert and Dmitry Shungin and Anke T{\"o}njes and Ajay Yesupriya and Daniel Barnes and Nabila Bouatia-Naji and Glazer, {Nicole L} and Jackson, {Anne U} and Zolt{\'a}n Kutalik and Vasiliki Lagou and Diana Marek and Rasmussen-Torvik, {Laura J} and Stringham, {Heather M} and Toshiko Tanaka and Mette Aadahl and Arking, {Dan E} and Sven Bergmann and Eric Boerwinkle and Bonnycastle, {Lori L} and Bornstein, {Stefan R} and Eric Brunner and Bumpstead, {Suzannah J} and Soren Brage and Carlson, {Olga D} and Han Chen and Chen, {Yii-Der Ida} and Chines, {Peter S} and Collins, {Francis S} and Couper, {David J} and Dennison, {Elaine M} and Dowling, {Nicole F} and Egan, {Josephine S} and Ulf Ekelund and Erdos, {Michael R} and Forouhi, {Nita G} and Fox, {Caroline S} and Goodarzi, {Mark O} and J{\"u}rgen Gr{\"a}ssler and Stefan Gustafsson and G{\"o}ran Hallmans and Torben Hansen and Aroon Hingorani and Holloway, {John W} and Hu, {Frank B} and Bo Isomaa and Jameson, {Karen A} and Ingegerd Johansson and Jonsson, {Anna Elisabet} and Torben J{\o}rgensen and Mika Kivimaki and Peter Kovacs and Meena Kumari and Johanna Kuusisto and Markku Laakso and C{\'e}cile Lecoeur and Claire L{\'e}vy-Marchal and Guo Li and Loos, {Ruth J F} and Valeri Lyssenko and Michael Marmot and Pedro Marques-Vidal and Morken, {Mario A} and Gabriele M{\"u}ller and North, {Kari E} and Pankow, {James S} and Felicity Payne and Inga Prokopenko and Psaty, {Bruce M} and Frida Renstr{\"o}m and Ken Rice and Rotter, {Jerome I} and Denis Rybin and Sandholt, {Camilla H} and Sayer, {Avan A} and Peter Shrader and Schwarz, {Peter E H} and Siscovick, {David S} and Alena Stanc{\'a}kov{\'a} and Michael Stumvoll and Teslovich, {Tanya M} and G{\'e}rard Waeber and Williams, {Gordon H} and Witte, {Daniel R} and Wood, {Andrew R} and Weijia Xie and Michael Boehnke and Cyrus Cooper and Luigi Ferrucci and Philippe Froguel and Leif Groop and Kao, {W H Linda} and Peter Vollenweider and Mark Walker and Watanabe, {Richard M} and Oluf Pedersen and Meigs, {James B} and Erik Ingelsson and In{\^e}s Barroso and Florez, {Jose C} and Franks, {Paul W} and Jos{\'e}e Dupuis and Wareham, {Nicholas J} and Claudia Langenberg",
year = "2012",
doi = "10.2337/db11-0973",
language = "English",
volume = "61",
pages = "1291--6",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "5",
}
RIS
TY - JOUR
T1 - No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
AU - Scott, Robert A
AU - Chu, Audrey Y
AU - Grarup, Niels
AU - Manning, Alisa K
AU - Hivert, Marie-France
AU - Shungin, Dmitry
AU - Tönjes, Anke
AU - Yesupriya, Ajay
AU - Barnes, Daniel
AU - Bouatia-Naji, Nabila
AU - Glazer, Nicole L
AU - Jackson, Anne U
AU - Kutalik, Zoltán
AU - Lagou, Vasiliki
AU - Marek, Diana
AU - Rasmussen-Torvik, Laura J
AU - Stringham, Heather M
AU - Tanaka, Toshiko
AU - Aadahl, Mette
AU - Arking, Dan E
AU - Bergmann, Sven
AU - Boerwinkle, Eric
AU - Bonnycastle, Lori L
AU - Bornstein, Stefan R
AU - Brunner, Eric
AU - Bumpstead, Suzannah J
AU - Brage, Soren
AU - Carlson, Olga D
AU - Chen, Han
AU - Chen, Yii-Der Ida
AU - Chines, Peter S
AU - Collins, Francis S
AU - Couper, David J
AU - Dennison, Elaine M
AU - Dowling, Nicole F
AU - Egan, Josephine S
AU - Ekelund, Ulf
AU - Erdos, Michael R
AU - Forouhi, Nita G
AU - Fox, Caroline S
AU - Goodarzi, Mark O
AU - Grässler, Jürgen
AU - Gustafsson, Stefan
AU - Hallmans, Göran
AU - Hansen, Torben
AU - Hingorani, Aroon
AU - Holloway, John W
AU - Hu, Frank B
AU - Isomaa, Bo
AU - Jameson, Karen A
AU - Johansson, Ingegerd
AU - Jonsson, Anna Elisabet
AU - Jørgensen, Torben
AU - Kivimaki, Mika
AU - Kovacs, Peter
AU - Kumari, Meena
AU - Kuusisto, Johanna
AU - Laakso, Markku
AU - Lecoeur, Cécile
AU - Lévy-Marchal, Claire
AU - Li, Guo
AU - Loos, Ruth J F
AU - Lyssenko, Valeri
AU - Marmot, Michael
AU - Marques-Vidal, Pedro
AU - Morken, Mario A
AU - Müller, Gabriele
AU - North, Kari E
AU - Pankow, James S
AU - Payne, Felicity
AU - Prokopenko, Inga
AU - Psaty, Bruce M
AU - Renström, Frida
AU - Rice, Ken
AU - Rotter, Jerome I
AU - Rybin, Denis
AU - Sandholt, Camilla H
AU - Sayer, Avan A
AU - Shrader, Peter
AU - Schwarz, Peter E H
AU - Siscovick, David S
AU - Stancáková, Alena
AU - Stumvoll, Michael
AU - Teslovich, Tanya M
AU - Waeber, Gérard
AU - Williams, Gordon H
AU - Witte, Daniel R
AU - Wood, Andrew R
AU - Xie, Weijia
AU - Boehnke, Michael
AU - Cooper, Cyrus
AU - Ferrucci, Luigi
AU - Froguel, Philippe
AU - Groop, Leif
AU - Kao, W H Linda
AU - Vollenweider, Peter
AU - Walker, Mark
AU - Watanabe, Richard M
AU - Pedersen, Oluf
AU - Meigs, James B
AU - Ingelsson, Erik
AU - Barroso, Inês
AU - Florez, Jose C
AU - Franks, Paul W
AU - Dupuis, Josée
AU - Wareham, Nicholas J
AU - Langenberg, Claudia
PY - 2012
Y1 - 2012
N2 - Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (ß = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (ß = 0.06-0.12 mmol/allele, P = 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P = 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
AB - Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (ß = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (ß = 0.06-0.12 mmol/allele, P = 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P = 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
U2 - 10.2337/db11-0973
DO - 10.2337/db11-0973
M3 - Journal article
C2 - 22415877
VL - 61
SP - 1291
EP - 1296
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 5
ER -
