Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

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Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. / Vogelezang, Suzanne; Bradfield, Jonathan P; Ahluwalia, Tarun S; Curtin, John A; Grarup, Niels; Schnurr, Theresia Maria; Hansen, Torben; Michaelsen, Kim F.; Pedersen, Oluf Borbye; Stokholm, Jakob; Lind, Mads Vendelbo; Frithioff-Bøjsøe, Christine; Holm, Jens-Christian; Felix, Janine F; Early Growth Genetics Consortium.

In: P L o S Genetics, Vol. 16, No. 10, e1008718, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vogelezang, S, Bradfield, JP, Ahluwalia, TS, Curtin, JA, Grarup, N, Schnurr, TM, Hansen, T, Michaelsen, KF, Pedersen, OB, Stokholm, J, Lind, MV, Frithioff-Bøjsøe, C, Holm, J-C, Felix, JF & Early Growth Genetics Consortium 2020, 'Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits', P L o S Genetics, vol. 16, no. 10, e1008718. https://doi.org/10.1371/journal.pgen.1008718

APA

Vogelezang, S., Bradfield, J. P., Ahluwalia, T. S., Curtin, J. A., Grarup, N., Schnurr, T. M., Hansen, T., Michaelsen, K. F., Pedersen, O. B., Stokholm, J., Lind, M. V., Frithioff-Bøjsøe, C., Holm, J-C., Felix, J. F., & Early Growth Genetics Consortium (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. P L o S Genetics, 16(10), [e1008718]. https://doi.org/10.1371/journal.pgen.1008718

Vancouver

Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Grarup N, Schnurr TM et al. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. P L o S Genetics. 2020;16(10). e1008718. https://doi.org/10.1371/journal.pgen.1008718

Author

Vogelezang, Suzanne ; Bradfield, Jonathan P ; Ahluwalia, Tarun S ; Curtin, John A ; Grarup, Niels ; Schnurr, Theresia Maria ; Hansen, Torben ; Michaelsen, Kim F. ; Pedersen, Oluf Borbye ; Stokholm, Jakob ; Lind, Mads Vendelbo ; Frithioff-Bøjsøe, Christine ; Holm, Jens-Christian ; Felix, Janine F ; Early Growth Genetics Consortium. / Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. In: P L o S Genetics. 2020 ; Vol. 16, No. 10.

Bibtex

@article{1eece023da9c4a5d9e02ff44627fff8a,
title = "Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits",
abstract = "The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.",
author = "Suzanne Vogelezang and Bradfield, {Jonathan P} and Ahluwalia, {Tarun S} and Curtin, {John A} and Lakka, {Timo A.} and Niels Grarup and Markus Scholz and {van der Most}, {Peter J.} and Claire Monnereau and Evie Stergiakouli and Anni Heiskala and Momoko Horikoshi and Fedko, {Iryna O.} and Natalia Vilor-Tejedor and Cousminer, {Diana L.} and Marie Standl and Wang, {Carol A.} and Jorma Viikari and Frank Geller and Carmen {\'I}{\~n}iguez and Niina Pitk{\"a}nen and Alessandra Chesi and Jonas Bacelis and Loic Yengo and Maties Torrent and Ioanna Ntalla and {\O}yvind Helgeland and Saskia Selzam and Vonk, {Judith M.} and Zafarmand, {Mohammed H.} and Barbara Heude and Farooqi, {Ismaa Sadaf} and Akram Alyass and Have, {Christian T.} and Schnurr, {Theresia Maria} and Klaus B{\o}nnelykke and Lisbeth Carstensen and Bo Chawes and Torben Hansen and Mette Hollensted and Mads Melbye and Michaelsen, {Kim F.} and Morgen, {Camilla Schmidt} and Pedersen, {Oluf Borbye} and Jakob Stokholm and Lind, {Mads Vendelbo} and Christine Frithioff-B{\o}js{\o}e and Nohr, {Ellen A.} and S{\o}rensen, {Thorkild I.A.} and Jens-Christian Holm and Hans Bisgaard and Felix, {Janine F} and {Early Growth Genetics Consortium}",
note = "CURIS 2020 NEXS 336",
year = "2020",
doi = "10.1371/journal.pgen.1008718",
language = "English",
volume = "16",
journal = "P L o S Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

AU - Vogelezang, Suzanne

AU - Bradfield, Jonathan P

AU - Ahluwalia, Tarun S

AU - Curtin, John A

AU - Lakka, Timo A.

AU - Grarup, Niels

AU - Scholz, Markus

AU - van der Most, Peter J.

AU - Monnereau, Claire

AU - Stergiakouli, Evie

AU - Heiskala, Anni

AU - Horikoshi, Momoko

AU - Fedko, Iryna O.

AU - Vilor-Tejedor, Natalia

AU - Cousminer, Diana L.

AU - Standl, Marie

AU - Wang, Carol A.

AU - Viikari, Jorma

AU - Geller, Frank

AU - Íñiguez, Carmen

AU - Pitkänen, Niina

AU - Chesi, Alessandra

AU - Bacelis, Jonas

AU - Yengo, Loic

AU - Torrent, Maties

AU - Ntalla, Ioanna

AU - Helgeland, Øyvind

AU - Selzam, Saskia

AU - Vonk, Judith M.

AU - Zafarmand, Mohammed H.

AU - Heude, Barbara

AU - Farooqi, Ismaa Sadaf

AU - Alyass, Akram

AU - Have, Christian T.

AU - Schnurr, Theresia Maria

AU - Bønnelykke, Klaus

AU - Carstensen, Lisbeth

AU - Chawes, Bo

AU - Hansen, Torben

AU - Hollensted, Mette

AU - Melbye, Mads

AU - Michaelsen, Kim F.

AU - Morgen, Camilla Schmidt

AU - Pedersen, Oluf Borbye

AU - Stokholm, Jakob

AU - Lind, Mads Vendelbo

AU - Frithioff-Bøjsøe, Christine

AU - Nohr, Ellen A.

AU - Sørensen, Thorkild I.A.

AU - Holm, Jens-Christian

AU - Bisgaard, Hans

AU - Felix, Janine F

AU - Early Growth Genetics Consortium

N1 - CURIS 2020 NEXS 336

PY - 2020

Y1 - 2020

N2 - The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.

AB - The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.

UR - http://www.scopus.com/inward/record.url?scp=85092931223&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.1008718

DO - 10.1371/journal.pgen.1008718

M3 - Journal article

C2 - 33045005

AN - SCOPUS:85092931223

VL - 16

JO - P L o S Genetics

JF - P L o S Genetics

SN - 1553-7390

IS - 10

M1 - e1008718

ER -

ID: 250382815