Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

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Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. / Chen, Ming-Huei; Raffield, Laura M.; Mousas, Abdou; Sakaue, Saori; Huffman, Jennifer E.; Moscati, Arden; Trivedi, Bhavi; Jiang, Tao; Akbari, Parsa; Vuckovic, Dragana; Bao, Erik L.; Zhong, Xue; Manansala, Regina; Laplante, Veronique; Chen, Minhui; Lo, Ken Sin; Qian, Huijun; Lareau, Caleb A.; Beaudoin, Melissa; Hunt, Karen A.; Akiyama, Masato; Bartz, Traci M.; Ben-Shlomo, Yoav; Beswick, Andrew; Bork-Jensen, Jette; Bottinger, Erwin P.; Brody, Jennifer A.; van Rooij, Frank J. A.; Chitrala, Kumaraswamynaidu; Cho, Kelly; Choquet, Helene; Correa, Adolfo; Danesh, John; Di Angelantonio, Emanuele; Dimou, Niki; Ding, Jingzhong; Elliott, Paul; Esko, Tonu; Evans, Michele K.; Floyd, James S.; Broer, Linda; Grarup, Niels; Guo, Michael H.; Greinacher, Andreas; Haessler, Jeff; Hansen, Torben; Howson, Joanna M. M.; Linneberg, Allan; Pedersen, Oluf; Loos, Ruth J. F.; VA Million Veteran Program.

In: Cell, Vol. 182, No. 5, 2020, p. 1198-+.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chen, M-H, Raffield, LM, Mousas, A, Sakaue, S, Huffman, JE, Moscati, A, Trivedi, B, Jiang, T, Akbari, P, Vuckovic, D, Bao, EL, Zhong, X, Manansala, R, Laplante, V, Chen, M, Lo, KS, Qian, H, Lareau, CA, Beaudoin, M, Hunt, KA, Akiyama, M, Bartz, TM, Ben-Shlomo, Y, Beswick, A, Bork-Jensen, J, Bottinger, EP, Brody, JA, van Rooij, FJA, Chitrala, K, Cho, K, Choquet, H, Correa, A, Danesh, J, Di Angelantonio, E, Dimou, N, Ding, J, Elliott, P, Esko, T, Evans, MK, Floyd, JS, Broer, L, Grarup, N, Guo, MH, Greinacher, A, Haessler, J, Hansen, T, Howson, JMM, Linneberg, A, Pedersen, O, Loos, RJF & VA Million Veteran Program 2020, 'Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations', Cell, vol. 182, no. 5, pp. 1198-+. https://doi.org/10.1016/j.cell.2020.06.045

APA

Chen, M-H., Raffield, L. M., Mousas, A., Sakaue, S., Huffman, J. E., Moscati, A., Trivedi, B., Jiang, T., Akbari, P., Vuckovic, D., Bao, E. L., Zhong, X., Manansala, R., Laplante, V., Chen, M., Lo, K. S., Qian, H., Lareau, C. A., Beaudoin, M., ... VA Million Veteran Program (2020). Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell, 182(5), 1198-+. https://doi.org/10.1016/j.cell.2020.06.045

Vancouver

Chen M-H, Raffield LM, Mousas A, Sakaue S, Huffman JE, Moscati A et al. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell. 2020;182(5):1198-+. https://doi.org/10.1016/j.cell.2020.06.045

Author

Chen, Ming-Huei ; Raffield, Laura M. ; Mousas, Abdou ; Sakaue, Saori ; Huffman, Jennifer E. ; Moscati, Arden ; Trivedi, Bhavi ; Jiang, Tao ; Akbari, Parsa ; Vuckovic, Dragana ; Bao, Erik L. ; Zhong, Xue ; Manansala, Regina ; Laplante, Veronique ; Chen, Minhui ; Lo, Ken Sin ; Qian, Huijun ; Lareau, Caleb A. ; Beaudoin, Melissa ; Hunt, Karen A. ; Akiyama, Masato ; Bartz, Traci M. ; Ben-Shlomo, Yoav ; Beswick, Andrew ; Bork-Jensen, Jette ; Bottinger, Erwin P. ; Brody, Jennifer A. ; van Rooij, Frank J. A. ; Chitrala, Kumaraswamynaidu ; Cho, Kelly ; Choquet, Helene ; Correa, Adolfo ; Danesh, John ; Di Angelantonio, Emanuele ; Dimou, Niki ; Ding, Jingzhong ; Elliott, Paul ; Esko, Tonu ; Evans, Michele K. ; Floyd, James S. ; Broer, Linda ; Grarup, Niels ; Guo, Michael H. ; Greinacher, Andreas ; Haessler, Jeff ; Hansen, Torben ; Howson, Joanna M. M. ; Linneberg, Allan ; Pedersen, Oluf ; Loos, Ruth J. F. ; VA Million Veteran Program. / Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. In: Cell. 2020 ; Vol. 182, No. 5. pp. 1198-+.

Bibtex

@article{8b0d8214846c4ee0b79e8ffbe79ba2b7,
title = "Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations",
abstract = "Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p <5310(-9), including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EURmeta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these blood phenotypes between populations. Altogether, our results for hematological traits highlight the value of a more global representation of populations in genetic studies.",
keywords = "GENOME-WIDE ASSOCIATION, FREQUENCY CODING VARIANTS, POLYGENIC RISK SCORES, HUMAN HEMATOPOIESIS, AFRICAN-AMERICANS, SINGLE-CELL, BIOBANK, LOCI, DISEASE, TRAIT",
author = "Ming-Huei Chen and Raffield, {Laura M.} and Abdou Mousas and Saori Sakaue and Huffman, {Jennifer E.} and Arden Moscati and Bhavi Trivedi and Tao Jiang and Parsa Akbari and Dragana Vuckovic and Bao, {Erik L.} and Xue Zhong and Regina Manansala and Veronique Laplante and Minhui Chen and Lo, {Ken Sin} and Huijun Qian and Lareau, {Caleb A.} and Melissa Beaudoin and Hunt, {Karen A.} and Masato Akiyama and Bartz, {Traci M.} and Yoav Ben-Shlomo and Andrew Beswick and Jette Bork-Jensen and Bottinger, {Erwin P.} and Brody, {Jennifer A.} and {van Rooij}, {Frank J. A.} and Kumaraswamynaidu Chitrala and Kelly Cho and Helene Choquet and Adolfo Correa and John Danesh and {Di Angelantonio}, Emanuele and Niki Dimou and Jingzhong Ding and Paul Elliott and Tonu Esko and Evans, {Michele K.} and Floyd, {James S.} and Linda Broer and Niels Grarup and Guo, {Michael H.} and Andreas Greinacher and Jeff Haessler and Torben Hansen and Howson, {Joanna M. M.} and Allan Linneberg and Oluf Pedersen and Loos, {Ruth J. F.} and {VA Million Veteran Program}",
year = "2020",
doi = "10.1016/j.cell.2020.06.045",
language = "English",
volume = "182",
pages = "1198--+",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

AU - Chen, Ming-Huei

AU - Raffield, Laura M.

AU - Mousas, Abdou

AU - Sakaue, Saori

AU - Huffman, Jennifer E.

AU - Moscati, Arden

AU - Trivedi, Bhavi

AU - Jiang, Tao

AU - Akbari, Parsa

AU - Vuckovic, Dragana

AU - Bao, Erik L.

AU - Zhong, Xue

AU - Manansala, Regina

AU - Laplante, Veronique

AU - Chen, Minhui

AU - Lo, Ken Sin

AU - Qian, Huijun

AU - Lareau, Caleb A.

AU - Beaudoin, Melissa

AU - Hunt, Karen A.

AU - Akiyama, Masato

AU - Bartz, Traci M.

AU - Ben-Shlomo, Yoav

AU - Beswick, Andrew

AU - Bork-Jensen, Jette

AU - Bottinger, Erwin P.

AU - Brody, Jennifer A.

AU - van Rooij, Frank J. A.

AU - Chitrala, Kumaraswamynaidu

AU - Cho, Kelly

AU - Choquet, Helene

AU - Correa, Adolfo

AU - Danesh, John

AU - Di Angelantonio, Emanuele

AU - Dimou, Niki

AU - Ding, Jingzhong

AU - Elliott, Paul

AU - Esko, Tonu

AU - Evans, Michele K.

AU - Floyd, James S.

AU - Broer, Linda

AU - Grarup, Niels

AU - Guo, Michael H.

AU - Greinacher, Andreas

AU - Haessler, Jeff

AU - Hansen, Torben

AU - Howson, Joanna M. M.

AU - Linneberg, Allan

AU - Pedersen, Oluf

AU - Loos, Ruth J. F.

AU - VA Million Veteran Program

PY - 2020

Y1 - 2020

N2 - Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p <5310(-9), including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EURmeta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these blood phenotypes between populations. Altogether, our results for hematological traits highlight the value of a more global representation of populations in genetic studies.

AB - Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p <5310(-9), including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EURmeta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these blood phenotypes between populations. Altogether, our results for hematological traits highlight the value of a more global representation of populations in genetic studies.

KW - GENOME-WIDE ASSOCIATION

KW - FREQUENCY CODING VARIANTS

KW - POLYGENIC RISK SCORES

KW - HUMAN HEMATOPOIESIS

KW - AFRICAN-AMERICANS

KW - SINGLE-CELL

KW - BIOBANK

KW - LOCI

KW - DISEASE

KW - TRAIT

U2 - 10.1016/j.cell.2020.06.045

DO - 10.1016/j.cell.2020.06.045

M3 - Journal article

C2 - 32888493

VL - 182

SP - 1198-+

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -

ID: 250075688