Hansen Group

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  1. 2016
  2. Published

    Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

    Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Stergiakouli, E., Chesi, A., Gaillard, R., Feenstra, B., Thiering, E., Kreiner-Møller, E., Mahajan, A., Pitkänen, N., Joro, R., Cavadino, A., Huikari, V., Franks, S., Groen-Blokhuis, M. M., Cousminer, D. L., Marsh, J. A., Lehtimäki, T. & 31 others, Curtin, J. A., Vioque, J., Ahluwalia, Tarun Veer Singh, Myhre, R., Price, T. S., Vilor-Tejedor, N., Yengo, L., Grarup, Niels, Ntalla, I., Ang, W., Atalay, M., Bisgaard, H., Blakemore, A. I., Bonnefond, A., Carstensen, L., Eriksson, J., Flexeder, C., Franke, L., Geller, F., Geserick, M., Hartikainen, A., Haworth, C. M. A., Hirschhorn, J. N., Holm, Jens-Christian, Kadarmideen, H. N., Pers, Tune H, Pedersen, Oluf Borbye, Hansen, Torben, Melbye, M., Sørensen, Thorkild I.A. & Bone Mineral Density in Childhood Study (BMDCS) Consortium, B. M. D. I. C. S. (. C., 2016, In: Human Molecular Genetics. 25, 2, p. 389-403

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

    Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., Zhao, W., Wang, X., Huerta-Chagoya, A., Hu, C., Moon, S., Long, J., Kwak, S. H., Rasheed, A., Saxena, R., Ma, R. C. W., Okada, Y., Iwata, M., Hosoe, J., Shojima, N. & 43 others, Iwasaki, M., Fujita, H., Suzuki, K., Danesh, J., Jørgensen, T., Jørgensen, M. E., Witte, D. R., Brandslund, I., Christensen, C., Hansen, Torben, Mercader, J. M., Flannick, J., Moreno-Macías, H., Burtt, N. P., Zhang, R., Kim, Y. J., Zheng, W., Singh, J. R., Tam, C. H. T., Hirose, H., Maegawa, H., Ito, C., Kaku, K., Watada, H., Tanaka, Y., Tobe, K., Kawamori, R., Kubo, M., Cho, Y. S., Chan, J. C. N., Sanghera, D., Frossard, P., Park, K. S., Shu, X., Kim, B., Florez, J. C., Tusié-Luna, T., Jia, W., Tai, E. S., Pedersen, Oluf Borbye, Saleheen, D., Maeda, S. & Kadowaki, T., 2016, In: Nature Communications. 7, 12 p., 10531.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

    Kilpeläinen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., Hedman, Å. K., Drong, A. W., Hayes, J. E., Zhao, J., Pers, T. H., Schick, U., Grarup, N., Kutalik, Z., Trompet, S., Mangino, M., Kristiansson, K., Beekman, M., Lyytikäinen, L-P., Eriksson, J. & 157 others, Henneman, P., Lahti, J., Tanaka, T., Luan, J., Greco M, F. D., Pasko, D., Renström, F., Willems, S. M., Mahajan, A., Rose, L. M., Guo, X., Liu, Y., Kleber, M. E., Pérusse, L., Gaunt, T., Ahluwalia, Tarun Veer Singh, Ju Sung, Y., Ramos, Y. F., Amin, N., Amuzu, A., Barroso, I., Bellis, C., Blangero, J., Buckley, B. M., Böhringer, S., I Chen, Y., de Craen, A. J. N., Crosslin, D. R., Dale, C. E., Dastani, Z., Day, F. R., Deelen, J., Delgado, G. E., Demirkan, A., Finucane, F. M., Ford, I., Garcia, M. E., Gieger, C., Gustafsson, S., Hallmans, G., Hankinson, S. E., Havulinna, A. S., Herder, C., Hernandez, D., Hicks, A. A., Hunter, D. J., Illig, T., Ingelsson, E., Ioan-Facsinay, A., Jansson, J., Jenny, N. S., Jørgensen, M. E., Jørgensen, T., Karlsson, M., Koenig, W., Kraft, P., Kwekkeboom, J., Laatikainen, T., Ladwig, K., LeDuc, C. A., Lowe, G., Lu, Y., Marques-Vidal, P., Meisinger, C., Menni, C., Morris, A. P., Myers, R. H., Männistö, S., Nalls, M. A., Paternoster, L., Peters, A., Pradhan, A. D., Rankinen, T., Rasmussen-Torvik, L. J., Rathmann, W., Rice, T. K., Brent Richards, J., Ridker, P. M., Sattar, N., Savage, D. B., Söderberg, S., Timpson, N. J., Vandenput, L., van Heemst, D., Uh, H., Vohl, M., Walker, M., Wichmann, H., Widén, E., Wood, A. R., Yao, J., Zeller, T., Zhang, Y., Meulenbelt, I., Kloppenburg, M., Astrup, A., Sørensen, Thorkild I.A., Sarzynski, M. A., Rao, D. C., Jousilahti, P., Vartiainen, E., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Kajantie, E., Osmond, C., Palotie, A., Eriksson, J. G., Heliövaara, M., Knekt, P. B., Koskinen, S., Jula, A., Perola, M., Huupponen, R. K., Viikari, J. S., Kähönen, M., Lehtimäki, T., Raitakari, O. T., Mellström, D., Lorentzon, M., Casas, J. P., Bandinelli, S., März, W., Isaacs, A., van Dijk, K. W., van Duijn, C. M., Harris, T. B., Bouchard, C., Allison, M. A., Chasman, D. I., Ohlsson, C., Lind, L., Scott, R. A., Langenberg, C., Wareham, N. J., Ferrucci, L., Frayling, T. M., Pramstaller, P. P., Borecki, I. B., Waterworth, D. M., Bergmann, S., Waeber, G., Vollenweider, P., drb459, drb459, Hansen, Torben, Pedersen, Oluf Borbye, Hu, F. B., Eline Slagboom, P., Grallert, H., Spector, T. D., Jukema, J. W., Klein, R. J., Schadt, E. E., Franks, P. W., Lindgren, C. M., Leibel, R. L. & Loos, Ruth, 2016, In: Nature Communications. 7, 14 p., 10494.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Human gut microbes impact host serum metabolome and insulin sensitivity

    Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S. & 14 others, Jørgensen, T., Holm, J. B., Trošt, K., Kristiansen, Karsten, Brix, Susanne, Raes, J., Wang, J., Hansen, Torben, Bork, P., Brunak, Søren, Oresic, M., Ehrlich, S. D., Pedersen, Oluf Borbye & MetaHIT Consortium, M. C., 2016, In: Nature. 535, 7612, p. 376-381 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Identification of novel genetic determinants of erythrocyte membrane fatty acid composition among Greenlanders

    Lepola, Mette Andersen, Jørsboe, E., Sandholt, C. H., Grarup, Niels, Jørgensen, M. E., Færgeman, N. J., Bjerregaard, P., Pedersen, Oluf Borbye, Moltke, Ida, Hansen, Torben & Albrechtsen, Anders, 2016, In: P L o S Genetics. 12, 6, 19 p., e1006119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference

    Olsen, N. J., Ängquist, Lars, Larsen, S. C., Linneberg, Allan René, Skaaby, T., Husemoen, L. L. N., Toft, Ulla Marie Nørgaard, Tjønneland, A., Halkjær, J., Hansen, Torben, Pedersen, Oluf Borbye, Overvad, K., Ahluwalia, T. S., Sørensen, Thorkild I.A. & Heitmann, Berit, 2016, In: American Journal of Clinical Nutrition. 104, 3, p. 816-826 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Physiology insights

    Watanabe, R. M. & Hansen, Torben, 2016, The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer, p. 207-221 15 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  9. Published

    Plasma alkylresorcinols reflect gluten intake and distinguish between gluten-rich and gluten-poor diets in a population at risk of metabolic syndrome

    Lind, M. V., Madsen, M. L., Rumessen, J. J., drb459, drb459, Gøbel, R. J., Hansen, Torben, Lauritzen, Lotte, Pedersen, Oluf Borbye, Kristensen, M. B. & Ross, A. B., 2016, In: Journal of Nutrition. 146, 10, p. 1991-1998 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Reference values for serum leptin in healthy non-obese children and adolescents

    Lausten-Thomsen, U., Christiansen, M., Louise Hedley, P., Fonvig, C. E., Stjernholm, T., Pedersen, Oluf Borbye, Hansen, Torben & Holm, Jens-Christian, 2016, In: Scandinavian Journal of Clinical & Laboratory Investigation. 76, 7, p. 561-567 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

    Palleja, A., Kashani, A., Allin, K. H., Nielsen, T., Zhang, C., Li, Y., Brach, Thorsten, Liang, S., Feng, Q., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Burgdorf, Kristoffer Sølvsten, Holst, Jens Juul, Madsbad, Sten, Wang, J., Pedersen, Oluf Borbye, Hansen, Torben & Arumugam, Mani, 2016, In: Genome Medicine. 8, 13 p., 67.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample

    Esserlind, A., Christensen, A. F., Steinberg, S., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Werge, Thomas, Hansen, T. F., Husemoen, L. L. N., Linneberg, Allan René, Budtz-Joergensen, Esben, Westergaard, M. L., Stefansson, H. & Olesen, Jes, 2016, In: Cephalalgia : an international journal of headache. 36, 7, p. 1-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2015
  14. Published

    Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

    Gaulton, K. J., Ferreira, T., Lee, Y., Raimondo, A., Mägi, R., Reschen, M. E., Mahajan, A., Locke, A., William Rayner, N., Robertson, N., Scott, R. A., Prokopenko, I., Scott, L. J., Green, T., Sparso, T., Thuillier, D., Yengo, L., Grallert, H., Wahl, S., Frånberg, M. & 31 others, Strawbridge, R. J., Kestler, H., Chheda, H., Eisele, L., Gustafsson, S., Steinthorsdottir, V., Thorleifsson, G., Qi, L., Karssen, L. C., van Leeuwen, E. M., Willems, S. M., Li, M., Chen, H., Fuchsberger, C., Kwan, P., Ma, C., Linderman, M., Lu, Y., Thomsen, S. K., Rundle, J. K., Grarup, Niels, Have, C. T., Jonsson, Anna Elisabet, Jørgensen, M. E., Jørgensen, T., Linneberg, Allan René, Storm, P., Njølstad, I., Hansen, Torben, Pedersen, Oluf Borbye & Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, D. G. R. A. M. (. C., Dec 2015, In: Nature Genetics. 47, 12, p. 1415-25, 3 unpag. pages 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism

    Mikkelsen, K. H., Frost, M., Bahl, M. I., Licht, T. R., Jensen, U. S., Rosenberg, Jacob, Pedersen, Oluf Borbye, Hansen, Torben, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, 12 Nov 2015, In: PLOS ONE. 10, 11, p. 1-14 e0142352.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Intake of macro- and micronutrients in Danish vegans

    Kristensen, N. B., Madsen, M. L., Hansen, T. H., Allin, K. H., Hoppe, C., Fagt, S., Lausten, M. S., Gøbel, R. J., drb459, drb459, Hansen, Torben & Pedersen, Oluf Borbye, 30 Oct 2015, In: Nutrition Journal. 14, 1, p. 1-10 10 p., 115.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Reference values for serum total adiponectin in healthy non-obese children and adolescents

    Lausten-Thomsen, U., Christiansen, M., Fonvig, C. E., Trier, C., Pedersen, Oluf Borbye, Hansen, Torben & Holm, Jens-Christian, 23 Oct 2015, In: Clinica Chimica Acta. 450, p. 11-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Rare genetic variants previously associated with congenital forms of long QT syndrome have little or no effect on the QT interval

    Ghouse, Jonas, Have, C. T., Weeke, P., Nielsen, J. B., Ahlberg, G., Balslev-Harder, M., Appel, E. V., Skaaby, T., Olesen, S., Grarup, Niels, Linneberg, Allan René, Pedersen, Oluf Borbye, Haunsø, Stig, Svendsen, Jesper Hastrup, Hansen, Torben, Kanters, Jørgen K. & Salling Olesen, M., 1 Oct 2015, In: European Heart Journal. 36, 37, p. 2523-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

    Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpeläinen, T. O., Lu, Y., Mägi, R., Mihailov, E., Pers, T. H., Rüeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J. & 31 others, Lagou, V., Mahajan, A., Neinast, M. D., Prokopenko, I., Simino, J., Teslovich, T. M., Jansen, R., Westra, H., White, C. C., Absher, D., Ahluwalia, Tarun Veer Singh, Ahmad, S., Albrecht, E., Alves, A. C., Bragg-Gresham, J. L., de Craen, A. J. M., Bis, J. C., Bonnefond, A., Boucher, G., Banasik, Karina, Grarup, Niels, Hansen, Torben, Jørgensen, T., Krarup, N. T., Linneberg, Allan René, Ribel-Madsen, R., Sparsø, T. H., Melbye, M., Pedersen, Oluf Borbye, Sørensen, Thorkild I.A. & CHARGE Consortium, C. C., 1 Oct 2015, In: P L o S Genetics. 11, 10, p. 1-42 42 p., e1005378.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Pharmacogenetics and individual responses to treatment of hyperglycemia in type 2 diabetes.

    pjx571, pjx571, Galijatovic, E. A. A., Roepstorff, S., Hansen, Torben & drb459, drb459, Oct 2015, In: Pharmacogenetics and Genomics. 25, 10, p. 475-84 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Response to Comment on Færch et al. GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study. Diabetes 2015;64:2513–2525

    Ferch, K., Torekov, Signe Sørensen, Vistisen, D., Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Sandbek, A., Holst, Jens Juul & Jørgensen, M. E., 1 Sep 2015, In: Diabetes. 64, 9, p. e30-e31

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  22. Published

    A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease

    Gretarsdottir, S., Helgason, H., Helgadottir, A., Sigurdsson, A., Thorleifsson, G., Magnusdottir, A., Oddsson, A., Steinthorsdottir, V., Rafnar, T., de Graaf, J., Daneshpour, M. S., Hedayati, M., Azizi, F., Grarup, N., Jørgensen, T., Vestergaard, H., Hansen, T., Eyjolfsson, G., Sigurdardottir, O., Olafsson, I. & 8 others, Kiemeney, L. A., Pedersen, Oluf Borbye, Sulem, P., Thorgeirsson, G., Gudbjartsson, D. F., Holm, H., Thorsteinsdottir, U. & Stefansson, K., Sep 2015, In: P L o S Genetics. 11, 9, 20 p., e1005379.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young

    Østoft, S. H., Bagger, J. I., Hansen, Torben, Hartmann, Bolette, Pedersen, Oluf Borbye, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 1 Aug 2015, In: European Journal of Endocrinology. 173, 2, p. 205-215 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes

    Thomsen, S. B., Gjesing, A. M. P., Rathcke, C. N., Ekstrøm, Claus Thorn, Eiberg, Hans Rudolf Lytchoff, Hansen, T., Pedersen, Oluf Borbye & drb459, drb459, 21 Jul 2015, In: PLOS ONE. 10, 7, p. 1-10 10 p., e0133672.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

    Rönn, T., Volkov, P., Gillberg, L., Kokosar, M., Perfilyev, A., Jacobsen, A. L., Jørgensen, S. W., Brøns, C., Jansson, P., Eriksson, K., Pedersen, Oluf Borbye, Hansen, Torben, Groop, L., Stener-Victorin, E., Vaag, Allan, Nilsson, E. & Ling, C., 1 Jul 2015, In: Human Molecular Genetics. 24, 13, p. 3792-813 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Glucagon-Like Peptide-1 (GLP-1) Response to Oral Glucose is Reduced in Pre-diabetes, Screen-detected Type 2 Diabetes and Obesity, and Influenced by Sex: The ADDITION-PRO Study

    Færch, K., Torekov, Signe Sørensen, Vistisen, D., Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Sandbæk, A., Holst, Jens Juul & Jørgensen, M. E., Jul 2015, In: Diabetes. 64, p. 2513-25 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

    Yaghootkar, H., Stancáková, A., Freathy, R. M., Vangipurapu, J., Weedon, M. N., Xie, W., Wood, A. R., Ferrannini, E., Mari, A., Ring, S. M., Lawlor, D. A., Davey Smith, G., Jørgensen, T., Hansen, T., Pedersen, O., Steinthorsdottir, V., Guðbjartsson, D. F., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K. & 7 others, Hattersley, A. T., Walker, M., Morris, A. D., McCarthy, M. I., Palmer, C. N. A., Laakso, M. & Frayling, T. M., Jun 2015, In: Diabetes. 64, 6, p. 2279-85 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Specific gut microbiota features and metabolic markers in postmenopausal women with obesity

    Brahe, L. K., Le Chatelier, E., Prifti, E., Pons, N., Kennedy, S., Hansen, Torben, Pedersen, Oluf Borbye, Astrup, A., Ehrlich, S. D. & Larsen, L. H., 15 May 2015, In: Nutrition and Diabetes. 5, 7 p., e159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Genetic and phenotypic correlations between surrogate measures of insulin release obtained from OGTT data

    Gjesing, A. M. P., Ribel-Madsen, R., Harder, M. N., Eiberg, Hans Rudolf Lytchoff, Grarup, Niels, Jørgensen, T., Ekstrøm, Claus Thorn, Pedersen, Oluf Borbye & Hansen, Torben, May 2015, In: Diabetologia. 58, 5, p. 1006-1012 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Discovery of coding genetic variants influencing diabetes-related serum biomarkers and their impact on risk of type 2 diabetes

    Ahluwalia, Tarun Veer Singh, Allin, K. H., Sandholt, C. H., Sparsø, T. H., Jørgensen, M. E., Rowe, M., Christensen, C., Brandslund, I., Lauritzen, T., Linneberg, Allan René, Husemoen, L., Jørgensen, T., Hansen, Torben, Grarup, Niels & Pedersen, Oluf Borbye, Apr 2015, In: The Journal of clinical endocrinology and metabolism. 100, 4, p. E664-71

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes

    Hansen, T. H., drb459, drb459, Jørgensen, T., Jørgensen, M. E., Lauritzen, T., Brandslund, I., Christensen, C., Pedersen, Oluf Borbye, Hansen, Torben & Gjesing, A. M. P., 20 Mar 2015, In: BMC Medical Genetics. 16, p. 1-9 9 p., 17.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Interactions of Lipid Genetic Risk Scores with Estimates of Metabolic Health in a Danish Population

    Justesen, Johanne Marie, Allin, K. H., Sandholt, C. H., Borglykke, A., Krarup, N. T., Grarup, Niels, Linneberg, Allan René, Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 24 Feb 2015, In: Circulation. Cardiovascular genetics. 8, p. 465-72 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    In vivo efficacy of HD0471953: A novel GPR119 agonist for the treatment of type 2 diabetes mellitus

    'T Hart, L. M., Fritsche, A., Nijpels, G., Van Leeuwen, N., Donnelly, L. A., Dekker, J. M., Alssema, M., Fadista, J., Carlotti, F., Gjesing, A. P., Palmer, C. N., Van Haeften, T. W., Herzberg-Schäfer, S. A., Simonis-Bik, A. M., Houwing-Duistermaat, J. J., Helmer, Q., Deelen, J., Guigas, B., Hansen, T., MacHicao, F. & 14 others, Willemsen, G., Heine, R. J., Kramer, M. H., Holst, Jens Juul, De Koning, E. J., Häring, H. U., Pedersen, O., Groop, L., De Geus, E. J., Slagboom, P. E., Boomsma, D. I., Eekhoff, E. M., Pearson, E. R. & Diamant, M., 1 Feb 2015, In: Diabetes Technology & Therapeutics. 17, p. S131-S133

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  34. Published

    Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

    Wessel, J., Chu, A. Y., Willems, S. M., Wang, S., Yaghootkar, H., Brody, J. A., Dauriz, M., Hivert, M-F., Raghavan, S., Lipovich, L., Hidalgo, B., Fox, K., Huffman, J. E., An, P., Lu, Y., Rasmussen-Torvik, L. J., Grarup, N., Ehm, M. G., Li, L., Baldridge, A. S. & 31 others, Stančáková, A., Abrol, R., Besse, C., Boland, A., Bork-Jensen, J., Fornage, M., Freitag, D. F., Garcia, M. E., Guo, X., Hara, K., Isaacs, A., Jakobsdottir, J., Lange, L. A., Layton, J. C., Li, M., Hua Zhao, J., Meidtner, K., Morrison, A. C., Nalls, M. A., Peters, M. J., Sabater-Lleal, M., Schurmann, C., Silveira, A., Smith, A. V., Southam, L., Allin, K. H., Jørgensen, T., Linneberg, Allan René, Hansen, Torben, Pedersen, Oluf Borbye & EPIC-InterAct Consortium, E. C., 29 Jan 2015, In: Nature Communications. 6, p. 5897

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

    Dashti, H. S., Follis, J. L., Smith, C. E., Tanaka, T., Cade, B. E., Gottlieb, D. J., Hruby, A., Jacques, P. F., Lamon-Fava, S., Richardson, K., Saxena, R., Scheer, F. A. J. L., Kovanen, L., Bartz, T. M., Perälä, M-M., Jonsson, A. E., Frazier-Wood, A. C., Kalafati, I-P., Mikkilä, V., Partonen, T. & 34 others, Lemaitre, R. N., Lahti, J., Hernandez, D. G., Toft, Ulla Marie Nørgaard, Johnson, W. C., Kanoni, S., Raitakari, O. T., Perola, M., Psaty, B. M., Ferrucci, L., Grarup, Niels, Highland, H. M., Rallidis, L., Kähönen, M., Havulinna, A. S., Siscovick, D. S., Räikkönen, K., Jørgensen, T., Rotter, J. I., Deloukas, P., Viikari, J. S. A., Mozaffarian, D., Linneberg, Allan René, Seppälä, I., Hansen, Torben, Salomaa, V., Gharib, S. A., Eriksson, J. G., Bandinelli, S., Pedersen, Oluf Borbye, Rich, S. S., Dedoussis, G., Lehtimäki, T. & Ordovás, J. M., Jan 2015, In: The American Journal of Clinical Nutrition. 101, 1, p. 135-43 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

    Mahajan, A., Sim, X., Ng, H. J., Manning, A., Rivas, M. A., Highland, H. M., Locke, A. E., Grarup, N., Im, H. K., Cingolani, P., Flannick, J., Fontanillas, P., Fuchsberger, C., Gaulton, K. J., Teslovich, T. M., Rayner, N. W., Robertson, N. R., Beer, N. L., Rundle, J. K., Bork-Jensen, J. & 31 others, Ladenvall, C., Blancher, C., Buck, D., Buck, G., Burtt, N. P., Gabriel, S., Gjesing, A. M. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, Johanne Marie, Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Syvänen, A., Trakalo, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Linneberg, Allan René, Jørgensen, T., Hansen, Torben, Pedersen, Oluf Borbye & T2D-GENES consortium and GoT2D consortium, T. C. A. G. C., Jan 2015, In: P L o S Genetics. 11, 1, p. 1-25 25 p., e1004876.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents

    Fonvig, C. E., Chabanova, E., Andersson, E. A., Ohrt, J. D., Pedersen, Oluf Borbye, Hansen, Torben, Thomsen, Henrik S. & Holm, Jens-Christian, 2015, In: PLOS ONE. 10, 8, 15 p., e0135018.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    A glycogene mutation map for discovery of diseases of glycosylation

    Hansen, Lars, Lind-Thomsen, A., Joshi, Hiren Jitendra, Pedersen, N. B., Have, C. T., Kong, Y., Wang, S., Sparso, T., Grarup, Niels, Vester-Christensen, M. B., Schjoldager, Katrine Ter-Borch Gram, Freeze, H. H., Hansen, Torben, Pedersen, Oluf Borbye, Henrissat, B., Mandel, Ulla, Clausen, Henrik, Wandall, Hans H. & Bennett, Eric Paul, 2015, In: Glycobiology. 25, 2, p. 211-224 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study

    Hollensted, M., Ahluwalia, Tarun Veer Singh, Have, C. T., Grarup, Niels, Fonvig, C. E., Nielsen, T. R. H., Trier, C., Paternoster, L., Pedersen, Oluf Borbye, Holm, Jens-Christian, Sørensen, Thorkild I.A. & Hansen, Torben, 2015, In: BMC Medical Genetics. 16, 9 p., 105.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Diabetes in population isolates: lessons from Greenland

    Grarup, Niels, Moltke, Ida, Albrechtsen, Anders & Hansen, Torben, 2015, In: The Review of Diabetic Studies. 12, 3-4, p. 320-329 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  41. Published

    Dietary modulation of the gut microbiota - a randomised controlled trial in obese postmenopausal women

    Brahe, L. K., Le Chatelier, E., Prifti, E., Pons, N., Kennedy, S., Blædel, T., Håkansson, J., Dalsgaard, T. K., Hansen, Torben, Pedersen, Oluf Borbye, Astrup, A., Ehrlich, S. D. & Larsen, L. H., 2015, In: British Journal of Nutrition. 114, 3, p. 406-417 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

    Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., Pedersen, H. K., Arumugam, M., Kristiansen, K., Yvonne Voigt, A., Vestergaard, H., Hercog, R., Igor Costea, P., Roat Kultima, J., Li, J., Jørgensen, T., Levenez, F. & 9 others, Dore, J., Nielsen, H. B., Brunak, Søren, Raes, J., Hansen, Torben, Wang, J., Dusko Ehrlich, S., Bork, P. & Pedersen, Oluf Borbye, 2015, In: Nature. 528, 7581, p. 262-266 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Fasting serum levels of ferritin are associated with impaired pancreatic beta cell function and decreased insulin sensitivity: a population-based study

    Bonfils, L., Ellervik, Christina, Friedrich, N., Linneberg, Allan René, Sandholt, C. H., Jørgensen, M. E., Jørgensen, T., Hansen, Torben, Pedersen, Oluf Borbye & Allin, K. H., 2015, In: Diabetologia. 58, 3, p. 523-533 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women

    Iepsen, E. P. W., Lundgren, J. R., Hartmann, Bolette, Pedersen, Oluf Borbye, Hansen, Torben, Jørgensen, Niklas Rye, Jensen, J. B., Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2015, In: The Journal of clinical endocrinology and metabolism. 100, 8, p. 2909 –2917 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Genome-wide association studies of human adiposity: Zooming in on synapses.

    Sandholt, C. H., Grarup, Niels, Pedersen, Oluf Borbye & Hansen, Torben, 2015, In: Molecular and Cellular Endocrinology. 418, Part 2, p. 90-100 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy

    Kelstrup, L., Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Hansen, Torben, Holst, Jens Juul & Damm, Peter, 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 5, p. 1967-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

    Xu, H., Zhang, H., Yang, W., Yadav, R., Morrison, A. C., Qian, M., Devidas, M., Liu, Y., Perez-Andreu, V., Zhao, X., Gastier-Foster, J. M., Lupo, P. J., Neale, G., Raetz, E., Larsen, E., Bowman, W. P., Carroll, W. L., Winick, N., Williams, R., Hansen, T. & 13 others, Holm, Jens-Christian, Mardis, E., Fulton, R., Pui, C., Zhang, J., Mullighan, C. G., Evans, W. E., Hunger, S. P., Gupta, R., Schmiegelow, Kjeld, Loh, M. L., Relling, M. V. & Yang, J. J., 2015, In: Nature Communications. 6, p. 1-7 7 p., 7553.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    MECHANISMS IN ENDOCRINOLOGY: Gut microbiota in patients with type 2 diabetes mellitus

    Allin, K. H., Nielsen, T. & Pedersen, Oluf Borbye, 2015, In: European Journal of Endocrinology. 172, 4, p. R167-R177 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Multidisciplinary care of obese children and adolescents for one year reduces ectopic fat content in liver and skeletal muscle

    Fonvig, C. E., Chabanova, E., Ohrt, J. D., Nielsen, L. A., Pedersen, Oluf Borbye, Hansen, Torben, Thomsen, Henrik S. & Holm, Jens-Christian, 2015, In: B M C Pediatrics. 15, p. 1-9 9 p., 196.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios

    Besenbacher, S., Liu, S., Gonzalez-Izarzugaza, J. M., Grove, J., Belling, K. G., Bork-Jensen, J., Huang, S., Als, T. D., Li, S., Yadav, R., Rubio García, A., Lescai, F., Demontis, D., Rao, J., Ye, W., Mailund, T., Møllegaard Friborg, R., Pedersen, C. N. S., Xu, R., Sun, J. & 27 others, Liu, H., Wang, O., Cheng, X., Flores, D., Rydza, E. K., Rapacki, K., Sørensen, J. D., Chmura, P. J., Westergaard, David, Dworzynski, P., Sørensen, Thorkild I.A., Lund, O., Hansen, Torben, Xu, X., Li, N., Bolund, L., Pedersen, Oluf Borbye, Eiberg, Hans Rudolf Lytchoff, Krogh, Anders, Børglum, A. D., Brunak, Søren, Kristiansen, Karsten, Schierup, M. H., Wang, J., Gupta, R., Villesen, P. & Rasmussen, Simon, 2015, In: Nature Communications. 6, 9 p., 5969.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Reduced CD300LG mRNA tissue expression, increased intramyocellular lipid content and impaired glucose metabolism in healthy male carriers of Arg82Cys in CD300LG: a novel genometabolic cross-link between CD300LG and common metabolic phenotypes

    Støy, J., Kampmann, U., Mengel, A., Magnusson, N. E., Jessen, N., Grarup, Niels, Rungby, Jørgen, Stødkilde-Jørgensen, H., Brandslund, I., Christensen, C., Hansen, Torben, Pedersen, Oluf Borbye & Møller, N., 2015, In: BMJ open diabetes research & care. 3, 1, p. 1-12 12 p., e000095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    The Type 2 Diabetes Risk Allele of TMEM154-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes

    Balslev-Harder, M., Appel, E. V. R., Grarup, Niels, Gjesing, A. M. P., Ahluwalia, Tarun Veer Singh, Jørgensen, T., Christensen, C., Brandslund, I., Linneberg, Allan René, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 2015, In: PLOS ONE. 10, 3, p. 1-13 13 p., e0120890.

    Research output: Contribution to journal › Journal article › Research › peer-review

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