Hansen Group

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Goodrich, J. K., Singer-Berk, M., Son, R., Sveden, A., Wood, J., England, E., Cole, J. B., Weisburd, B., Watts, N., Caulkins, L., Dornbos, P., Koesterer, R., Zappala, Z., Zhang, H., Maloney, K. A., Dahl, A., Aguilar-Salinas, C. A., Atzmon, G., Barajas-Olmos, F., Barzilai, N. & 31 others, Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E., Bowden, D. W., Centeno-Cruz, F., Chambers, J. C., Chami, N., Chan, E., Chan, J., Cheng, C. Y., Cho, Y. S., Contreras-Cubas, C., Córdova, E., Correa, A., DeFronzo, R. A., Duggirala, R., Dupuis, J., Garay-Sevilla, M. E., García-Ortiz, H., Gieger, C., Glaser, B., González-Villalpando, C., Gonzalez, M. E., Grarup, Niels, Groop, L., Gross, M., Hansen, Torben, Linneberg, Allan René, Pedersen, Oluf Borbye & AMP-T2D-GENES Consortia, A. C., 2021, In: Nature Communications. 12, 15 p., 3505.

Research output: Contribution to journal › Journal article › Research › peer-review

The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., Trivedi, B. & 504 others, Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Ruotsalainen, S. E., Havulinna, A. S., Veturi, Y., Feng, Q., Rosenthal, E. A., Lingren, T., Pacheco, J. A., Pendergrass, S. A., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Hindy, G., Rasheed, A., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J., Matsuda, F., Jang, H., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Willemsen, G., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Mitchell, R. E., Chai, J. F., Aadahl, Mette, Yao, J., Manichaikul, A., Warren, H. R., Ramirez, J., Bork-Jensen, J., Karhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Sidore, C., Fiorillo, E., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, Line Tang, Thuesen, B. H., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Daw, E. W., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Feitosa, M. F., Wojczynski, M. K., Preuss, M., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Kember, R. L., Slieker, R. C., Lo, K. S., Zilhao, N. R., Phuong Le, Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Leonard, H. L., Marten, J., Schmidt, B., Arendt, M., Smyth, L. J., Canadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kahonen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Ahmed, M., Jackson, A. U., Irvin, M. R., Oldmeadow, C., Kim, H., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Chai, X., Prasad, G., Lores-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Hung, Y., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Gorski, M., Brumat, M., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A., Hofer, E., Lin, M., Xue, C., Zhang, J., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkanen, N., Cade, B. E., Lee, J., van Der Laan, S. W., Chitrala, K. N., Weiss, S., Zimmermann, M. E., Lee, J. Y., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S., Wang, J., Couture, C., Lyytikainen, L., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hildalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Schwander, K., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Highland, H. M., Young, K. L., Kawaguchi, T., Thiery, J., Bis, J. C., Nadkarni, G. N., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jager, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., Bhatti, F., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X., Rallidis, L. S., Pedersen, Oluf Borbye, Hansen, Torben, Mitchell, P., Hewitt, A. W., Kahonen, M., Perusse, L., Bouchard, C., Tonjes, A., Chen, Y. I., Pennell, C. E., Mori, T. A., Lieb, W., Franke, A., Ohlsson, C., Mellstrom, D., Cho, Y. S., Lee, H., Yuan, J., Koh, W., Rhee, S. Y., Woo, J., Heid, I. M., Stark, K. J., Volzke, H., Homuth, G., Evans, M. K., Zonderman, A. B., Polasek, O., Pasterkamp, G., Hoefer, I. E., Redline, S., Pahkala, K., Oldehinkel, A. J., Snieder, H., Biino, G., Schmidt, R., Schmidt, H., Chen, Y. E., Bandinelli, S., Dedoussis, G., Thanaraj, T. A., Kardia, S. L. R., Kato, N., Schulze, M. B., Girotto, G., Jung, B., Boger, C. A., Joshi, P. K., Bennett, D. A., De Jager, P. L., Lu, X., Mamakou, V., Brown, M., Caulfield, M. J., Munroe, P. B., Guo, X., Ciullo, M., Jonas, J. B., Samani, N. J., Kaprio, J., Pajukanta, P., Adair, L. S., Bechayda, S. A., de Silva, H. J., Wickremasinghe, A. R., Krauss, R. M., Wu, J., Zheng, W., den Hollander, A. I., Bharadwaj, D., Correa, A., Wilson, J. G., Lind, L., Heng, C., Nelson, A. E., Golightly, Y. M., Wilson, J. F., Penninx, B., Kim, H., Attia, J., Scott, R. J., Rao, D. C., Arnett, D. K., Walker, M., Koistinen, H. A., Chandak, G. R., Yajnik, C. S., Mercader, J. M., Tusie-Luna, T., Aguilar-Salinas, C. A., Villalpando, C. G., Orozco, L., Fornage, M., Tai, E. S., van Dam, R. M., Lehtimaki, T., Chaturvedi, N., Yokota, M., Liu, J., Reilly, D. F., McKnight, A. J., Kee, F., Jockel, K., McCarthy, M. I., Palmer, C. N. A., Vitart, V., Hayward, C., Simonsick, E., van Duijn, C. M., Lu, F., Qu, J., Hishigaki, H., Lin, X., Marz, W., Parra, E. J., Cruz, M., Gudnason, V., Tardif, J., Lettre, G., 't Hart, L. M., Elders, P. J. M., Damrauer, S. M., Kumari, M., Kivimaki, M., van der Harst, P., Spector, T. D., Loos, R. J. F., Province, M. A., Psaty, B. M., Brandslund, I., Pramstaller, P. P., Christensen, K., Ripatti, S., Widen, E., Hakonarson, H., Grant, S. F. A., Kiemeney, L. A. L. M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, Allan René, Jukema, J. W., Khera, A. V., Mannikko, M., Jarvelin, M., Kutalik, Z., Cucca, F., Mook-Kanamori, D. O., van Dijk, K. W., Watkins, H., Strachan, D. P., Grarup, Niels, Sever, P., Poulter, N., Rotter, J. I., Dantoft, T. M., Karpe, F., Neville, M. J., Timpson, N. J., Cheng, C., Wong, T., Khor, C. C., Sabanayagam, C., Peters, A., Gieger, C., Hattersley, A. T., Pedersen, N. L., Magnusson, P. K. E., Boomsma, D. I., de Geus, E. J. C., Cupples, L. A., van Meurs, J. B. J., Ghanbari, M., Rsen, P. G., Huang, W., Kim, Y. J., Tabara, Y., Wareham, N. J., Langenberg, C., Zeggini, E., Kuusisto, J., Laakso, M., Ingelsson, E., Abecasis, G., Chambers, J. C., Kooner, J. S., de Vries, P. S., Morrison, A. C., North, K. E., Daviglus, M., Kraft, P., Martin, N. G., Whitfield, J. B., Abbas, S., Saleheen, D., Walters, R. G., Holmes, M. V., Black, C., Smith, B. H., Justice, A. E., Baras, A., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Wei, W., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Asvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Thorsteinsdottir, U., Stefansson, K., Ho, Y., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K., Cho, K., O'Donnell, C. J., Gaziano, J. M., Wilson, P., Rotimi, C. N., Hazelhurst, S., Ramsay, M., Trembath, R. C., van Heel, D. A., Tamiya, G., Yamamoto, M., Kim, B., Mohlke, K. L., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Boehnke, M., Natarajan, P., Peloso, G. M., Brown, C. D., Morris, A. P., Assimes, T. L., Deloukas, P., Sun, Y. V. & Willer, C. J., 2021, In: Nature. 600, p. 675-679

Research output: Contribution to journal › Journal article › Research › peer-review

Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

Hicks, S. A., Isaksen, Jonas L., Thambawita, V., Ghouse, Jonas, Ahlberg, Gustav, Linneberg, Allan René, Grarup, Niels, Strümke, I., Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., von Holstein-Rathlou, Niels-Henrik, Halvorsen, P., Maleckar, M. M., Riegler, M. A. & Kanters, Jørgen K., 2021, In: Scientific Reports. 11, 1, 11 p., 10949.

Research output: Contribution to journal › Journal article › Research › peer-review

Do genetic risk scores for childhood adiposity operate independent of BMI of their mothers?

Huang, L. O., Morgen, C. S., Ängquist, Lars, Nohr, E. A., Kilpeläinen, Tuomas O., Hansen, Torben, Sørensen, Thorkild I.A. & Schnurr, T. M., 2021, In: International Journal of Obesity. 45, 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication

Israelsen, M., Kim, M., Suvitaival, T., Madsen, B. S., Hansen, C. D., Torp, N., Trost, K., Thiele, M., Hansen, Torben, Legido-Quigley, C., Krag, A. & MicrobLiver Consortium, M. C., 2021, In: JHEP Reports. 3, 5, 11 p., 100325.

Research output: Contribution to journal › Journal article › Research › peer-review

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3⁺RORγt⁺IL-17⁺ Tregs and improve metabolism

Jensen, B. A. H., Holm, J. B., Larsen, I. S., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S. A., Rivollier, A., Agrinier, A. L., Sulek, K., Arnoldussen, Y. J., Fjære, E., Marette, A., Angell, I. L., Rudi, K., Treebak, J. T., Madsen, L., Åkesson, C. P. & 5 others, Agace, W., Sina, C., Kleiveland, C. R., Kristiansen, Karsten & Lea, T. E., 2021, In: Nature Communications. 12, 19 p., 1093.

Research output: Contribution to journal › Journal article › Research › peer-review

Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies

Jensen, J. B., Møller, A. B., Just, J., Mose, M., de Paoli, F. V., Billeskov, T. B., Fred, Rikard Göran, Pers, Tune H, Pedersen, S. B., Petersen, K. K., Bjerre, M., Farup, J. & Jessen, N., 2021, In: American Journal of Physiology - Cell Physiology. 321, 2, p. C257-C268 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Amyotrophic lateral sclerosis in the Faroe Islands - a genealogical study

Johansen, M., Svenstrup, K., Mortensen, O., Andorsdottir, G., Steig, B. A., Joensen, P., Hansen, Torben & Petersen, M. S., 2021, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 22, 7-8, p. 571-575 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

r-cubed: Guiding the overwhelmed scientist from random wrangling to Reproducible Research in R

Johnston, L., Juel, H., Lengger, B., Witte, D., Chatwin, H., Christiansen, Malene Revsbech & Isaksen, A., 2021, In: Journal of Open Source Education. 4, 44, 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

Jonsson, Anna Elisabet, Stinson, Sara, Torekov, Signe Sørensen, Clausen, Tine Dalsgaard, Færch, K., Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth, Damm, Peter, Witte, D. R., Jørgensen, M. E., Pedersen, Oluf Borbye, Holst, Jens Juul & Hansen, Torben, 2021, In: BMC Medical Genomics. 14, 7 p., 3.

Research output: Contribution to journal › Journal article › Research › peer-review

Acute metabolic effects of melatonin - A randomized crossover study in healthy young men

Kampmann, U., Lauritzen, E. S., Grarup, Niels, Jessen, N., Hansen, Torben, Møller, N. & Stoy, J., 2021, In: Journal of Pineal Research. 70, 2, 13 p., 12706.

Research output: Contribution to journal › Journal article › Research › peer-review

Editorial: non-selective beta blockers—in and out of circulation

Kimer, N., Mortensen, C. & Hobolth, L., Mar 2021, In: Alimentary Pharmacology and Therapeutics. 53, 5, p. 632-633 2 p.

Research output: Contribution to journal › Editorial › Research › peer-review

Revision rates of trapeziometacarpal total joint arthroplasty in relation to occupational hand force requirements

Kirkeby, L., Frost, Poul, Svendsen, S. W. & Hansen, Torben, 2021, In: Journal of Hand Surgery: European Volume. 46, 9, p. 968-974 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota

Koeninger, L., Osbelt, L., Berscheid, A., Wendler, J., Berger, J., Hipp, K., Lesker, T. R., Pils, M. C., Malek, N. P., Jensen, Benjamin Anderschou Holbech, Brötz-Oesterhelt, H., Strowig, T. & Jan Wehkamp, W., 2021, In: Communications Biology . 4, 1, 11 p., 47.

Research output: Contribution to journal › Journal article › Research › peer-review

Novel Anti-inflammatory Treatments in Cirrhosis. A Literature-Based Study

Kronborg, T. M., Lambert, Henriette Ytting, Hobolth, L., Møller, Søren & Kimer, N., 2021, In: Frontiers in Medicine. 8, 718896.

Research output: Contribution to journal › Review › Research › peer-review

Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Rühlemann, M. C., Turpin, W., Moon, J. Y., Kim, H. N., Lüll, K., Barkan, E. & 84 others, Shah, S. A., Fornage, M., Szopinska-Tokov, J., Wallen, Z. D., Borisevich, D., Agreus, L., Andreasson, A., Bang, C., Bedrani, L., Bell, J. T., Bisgaard, H., Boehnke, M., Boomsma, D. I., Burk, R. D., Claringbould, A., Croitoru, K., Davies, G. E., van Duijn, C. M., Duijts, L., Falony, G., Fu, J., van der Graaf, A., Hansen, Torben, Homuth, G., Hughes, D. A., Ijzerman, R. G., Jackson, M. A., Jaddoe, V. W. V., Joossens, M., Jørgensen, T., Keszthelyi, D., Knight, R., Laakso, M., Laudes, M., Launer, L. J., Lieb, W., Lusis, A. J., Masclee, A. A. M., Moll, H. A., Mujagic, Z., Qibin, Q., Rothschild, D., Shin, H., Sørensen, Søren Johannes, Steves, C. J., Thorsen, Jonathan Jan Ilve, Timpson, N. J., Tito, R. Y., Vieira-Silva, S., Völker, U., Völzke, H., Võsa, U., Wade, K. H., Walter, S., Watanabe, K., Weiss, S., Weiss, F. U., Weissbrod, O., Westra, H. J., Willemsen, G., Payami, H., Jonkers, D. M. A. E., Arias Vasquez, A., de Geus, E. J. C., Meyer, K. A., Stokholm, Jakob, Segal, E., Org, E., Wijmenga, C., Kim, H. L., Kaplan, R. C., Spector, T. D., Uitterlinden, A. G., Rivadeneira, F., Franke, A., Lerch, M. M., Franke, L., Sanna, S., D’Amato, M., Pedersen, Oluf Borbye, Paterson, A. D., Kraaij, R., Raes, J. & Zhernakova, A., 2021, In: Nature Genetics. 53, p. 156-165 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Fungal lysozyme leverages the gut microbiota to curb DSS-induced colitis

Larsen, I. S., Jensen, Benjamin Anderschou Holbech, Bonazzi, E., Choi, Beatrice So-Yun, Kristensen, N. N., Schmidt, E. G. W., Süenderhauf, A., Morin, L., Olsen, P. B., Hansen, L. B. S., Schröder, T., Sina, C., Chassaing, B. & Marette, A., 2021, In: Gut Microbes. 13, 1, 20 p., 1988836.

Research output: Contribution to journal › Journal article › Research › peer-review

The effect of melatonin on incretin hormones: results from experimental and randomized clinical studies

Lauritzen, E. S., Støy, J., Bæch-Laursen, C., Grarup, Niels, Jessen, N., Hansen, Torben, Møller, N., Hartmann, Bolette, Holst, Jens Juul & Kampmann, U., 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 12, p. e5109-e5123 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Fecal microbiota transplantation in hepatic encephalopathy: a systematic review

Madsen, M., Kimer, N., Bendtsen, Flemming & Petersen, Andreas Munk, 2021, In: Scandinavian Journal of Gastroenterology. 56, 5, p. 560-569 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transcriptome analysis uncover differential regulation in cell cycle, immunity, and metabolism in Anopheles albimanus during immune priming with Plasmodium berghei

Maya-Maldonado, K., Cime-Castillo, J., Maya, Otoniel, Argotte-Ramos, R., Rodríguez, M. C. & Lanz-Mendoza, H., 2021, In: Developmental and Comparative Immunology. 120, 104046.

Research output: Contribution to journal › Journal article › Research › peer-review

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M., Bretherick, A. D., Richardson, T. G., Klughammer, J., Iotchkova, V., Sharp, G., Al Khleifat, A., Shatunov, A., Iacoangeli, A., McArdle, W. L., Ho, K. M. & 31 others, Kumar, A., Söderhäll, C., Soriano-Tárraga, C., Giralt-Steinhauer, E., Kazmi, N., Mason, D., McRae, A. F., Corcoran, D. L., Sugden, K., Kasela, S., Cardona, A., Day, F. R., Cugliari, G., Viberti, C., Guarrera, S., Lerro, M., Gupta, R., Bollepalli, S., Mandaviya, P., Zeng, Y., Clarke, T. K., Walker, R. M., Schmoll, V., Czamara, D., Ruiz-Arenas, C., Elliott, H. R., Nohr, E. A., Sørensen, Thorkild I.A., Hansen, Torben, Morgen, C. S. & BIOS Consortium, B. C., 2021, In: Nature Genetics. 53, 9, p. 1311-1321 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of a traditional and western diet on glucose homeostasis in Greenlandic Inuit carriers and non-carriers of type 2 diabetes variant in the TBC1D4 gene: A protocol for a randomized clinical trial

Møller, G., Lind, M. V., Hauptmann, A. L., Senftleber, N., Hansen, C. B., Hansen, Torben, Jørgensen, M. E. & Lauritzen, Lotte, 2021, In: Contemporary Clinical Trials Communications. 21, 6 p., 100734.

Research output: Contribution to journal › Journal article › Research › peer-review

Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms

Møller, Søren, Kimer, N., Kronborg, T., Grandt, J., Hove, Jens Dahlgaard, Barløse, Mads Christian Johannes & Gluud, Lise Lotte, 2021, In: Seminars in Liver Disease. 41, 03, p. 235-247

Research output: Contribution to journal › Journal article › Research › peer-review

Mapping the human genetic architecture of COVID-19

Niemi, M. E. K., Karjalainen, J., Liao, R. G., Neale, B. M., Daly, M., Ganna, A., Pathak, G. A., Andrews, S. J., Kanai, M., Veerapen, K., Fernandez-Cadenas, I., Schulte, E. C., Striano, P., Marttila, M., Minica, C., Marouli, E., Karim, M. A., Wendt, F. R., Savage, J., Sloofman, L. & 41 others, Butler-Laporte, G., Kim, H., Kanoni, S., Okada, Y., Byun, J., Han, Y., Uddin, M. J., Smith, G. D., Willer, C. J., Buxbaum, J. D., Karjalainen, J., Mehtonen, J., Folkersen, L., Moltke, Ida, Hinney, A., Wang, C., Ellinghaus, D., Brunak, Søren, Castro, P., Guindo Martínez, Marta, Lee, J. Y., Loos, Ruth, Zhao, J. H., Sun, Y. V., Wang, B., Parker, R., Garcia, S. M., Smith, O., Davis, C., COVID-19 Host Genetics Initiative, C. H. G. I., 23andMe COVID-19 Team, 2. C. T., Norwegian SARS-CoV-2 Study Grp, N. S. S. G., Humanitas COVID-19 Task Force, H. C. T. F., Humanitas Gavazzeni COVID-19 Task, H. G. C. T., FHoGID, F., RegCOVID, R., P-PredictUs, P., SeroCOVID, S., CRiPSI, C., Genes & Hlth Res Team, G. &. H. R. T. & UCLA Hlth ATLAS Data Mart Working, U. H. A. D. M. W., 2021, In: Nature. 600, p. 472-477

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial

Nordklint, A. K., Almdal, Thomas Peter, Vestergaard, P., Lundby-Christensen, L., Boesgaard, T. W., Breum, Leif, Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Perrild, Hans, Madsbad, Sten, Mathiesen, Elisabeth, Tarnow, L., Thorsteinsson, B., drb459, drb459, Lund, S. S. & Eiken, P., 2021, In: Osteoporosis International. 32, p. 1837–1848

Research output: Contribution to journal › Journal article › Research › peer-review

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: An IMI-DIRECT study

Obura, M., Beulens, J. W. J., Slieker, R., Koopman, A. D. M., Hoekstra, T., Nijpels, G., Elders, P., Dekker, J. M., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A., McCarthy, M. I. & 7 others, Walker, M., McDonald, T. J., Perry, M. H., Pearson, E. R., Franks, P. W., 't Hart, L. M. & Rutters, F., 2021, In: Diabetic Medicine. 38, 2, 10 p., 14428.

Research output: Contribution to journal › Journal article › Research › peer-review

Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice

Perazza, L. R., Mitchell, P. L., Lizotte, F., Jensen, Benjamin Anderschou Holbech, St-Pierre, P., Trottier, J., Barbier, O., Mathieu, P., Geraldes, P. M. & Marette, A., 2021, In: FASEB Journal. 35, 5, 18 p., 21559.

Research output: Contribution to journal › Journal article › Research › peer-review

Reply to: “Dietary sucrose induces atherosclerotic diseases more than dietary fat in LDLr^−/− ApoB^100/100 mice: Is it independent of differences in plasma cholesterol levels?”

Perazza, L. R., Daniel, N., Mitchell, P. L., Jensen, Benjamin Anderschou Holbech & Marette, A., 2021, In: Atherosclerosis. 325, p. 118-120 3 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

Petersen, A. Ø., Julienne, H., Hyötyläinen, T., Sen, P., Fan, Yong, Pedersen, H. K., Jäntti, S., Hansen, T. H., Nielsen, T., Jørgensen, T., Hansen, Torben, Myers, P. N., Nielsen, H. B., Ehrlich, S. D., Orešič, M. & Pedersen, Oluf Borbye, 2021, In: Scientific Reports. 11, 1, 11 p., 13252.

Research output: Contribution to journal › Journal article › Research › peer-review

Venous thromboembolism after fast-track elective revision hip and knee arthroplasty – A multicentre cohort study of 2814 unselected consecutive procedures

Lundbeck Foundation Centre for Fast-track Hip and Knee Arthroplasty collaborating group, L. F. C. F. F. H. A. K. A. C. G., Mar 2021, In: Thrombosis Research. 199, p. 101-105 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Human beta-defensin-2 suppresses key features of asthma in murine models of allergic airways disease

Pinkerton, J. W., Kim, R. Y., Koeninger, L., Armbruster, N. S., Hansbro, N. G., Brown, A. C., Jayaraman, R., Shen, S., Malek, N., Cooper, M. A., Nordkild, P., Horvat, J. C., Jensen, Benjamin Anderschou Holbech, Wehkamp, J. & Hansbro, P. M., 2021, In: Clinical and Experimental Allergy. 51, 1, p. 120-131 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

Pinna, N. K., Anjana, R. M., Saxena, S., Dutta, A., Gnanaprakash, V., Rameshkumar, G., Aswath, S., Raghavan, S., Rani, C. S. S., Radha, V., Balasubramanyam, M., Pant, A., Nielsen, T., Jørgensen, T., Færch, K., Kashani, A., Silva, M. C. A., Vestergaard, H., Hansen, T. H., Hansen, T. & 6 others, Arumugam, Mani, Nair, G. B., Das, B., Pedersen, Oluf Borbye, Mohan, V. & Mande, S. S., 2021, In: Genome Medicine. 13, 20 p., 36.

Research output: Contribution to journal › Journal article › Research › peer-review

Prognostic performance of 7 biomarkers compared to liver biopsy in early alcohol-related liver disease

Rasmussen, D. N., Thiele, M., Johansen, S., Kjærgaard, M., Lindvig, K. P., Israelsen, M., Antonsen, S., Detlefsen, S., Krag, A., Anastasiadou, E., Arumugam, M., Bork, P., Hansen, T., Hartoft, C., Israelsen, H., Karsdal, M., Legido-Quigley, C., Melberg, H. O., Trebicka, J., Mann, M. & 2 others, Matthijnssens, J. & MicrobLiver consortia, M. C., 2021, In: Journal of Hepatology. 75, 5, p. 1017-1025 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Evidence for shared genetics between physical activity, sedentary behaviour and adiposity-related traits

Schnurr, T. M., Stallknecht, Bente Merete, Sørensen, Thorkild I.A., Kilpeläinen, Tuomas O. & Hansen, Torben, 2021, In: Obesity Reviews. 22, 4, 12 p., e13182.

Research output: Contribution to journal › Journal article › Research › peer-review

Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers

Schnurr, T. M., Jørsboe, E., Chadt, A., Dahl-Petersen, I. K., Kristensen, Jonas Møller, Wojtaszewski, Jørgen F P, Springer, C., Bjerregaard, P., Brage, S., Pedersen, Oluf Borbye, Moltke, Ida, Grarup, Niels, Al-Hasani, H., Albrechtsen, Anders, Jørgensen, M. E. & Hansen, Torben, 2021, In: Diabetologia. 64, p. 1795-1804

Research output: Contribution to journal › Journal article › Research › peer-review

Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts

Silventoinen, K., Bogl, L. H., Jelenkovic, A., Vuoksimaa, E., Latvala, A., Li, W., Tan, Q., Zhang, D., Pang, Z., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Rebato, E., Corley, R. P., Huibregtse, B. M., Hopper, J. L., Tyler, J. & 34 others, Duncan, G. E., Buchwald, D., Silberg, J. L., Maes, H. H., Kandler, C., Cozen, W., Hwang, A. E., Mack, T. M., Nelson, T. L., Whitfield, K. E., Medda, E., Nisticò, L., Toccaceli, V., Krueger, R. F., McGue, M., Pahlen, S., Martin, N. G., Medland, S. E., Montgomery, G. W., Heikkilä, K., Derom, C. A., Vlietinck, R. F., Loos, Ruth, Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Hotopf, M., Sumathipala, A., Rijsdijk, F., Siribaddana, S. H., Rose, R. J., Sørensen, Thorkild I.A., Boomsma, D. I. & Kaprio, J., 2021, In: Hormones and Behavior. 136, 105054.

Research output: Contribution to journal › Journal article › Research › peer-review

Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

Skals, R., Krogager, M. L., Appel, E. V. R., Schnurr, T. M., Have, C. T., Gislason, Gunnar Hilmar, Poulsen, Henrik Enghusen, Køber, Lars Valeur, Engstrøm, Thomas, Stender, Steen, Hansen, Torben, Grarup, Niels, Lee, C. J., Andersson, C., Torp-Pedersen, Christian & Weeke, P. E., 2021, In: PLoS ONE. 16, 6, 11 p., 0252855.

Research output: Contribution to journal › Journal article › Research › peer-review

Fasting plasma GLP-1 associates with overweight/obesity and cardiometabolic risk factors in children and adolescents

Stinson, Sara, Jonsson, Anna Elisabet, Lund, M. A. V., Frithioff-Bøjsøe, C., Holm, L. A., Pedersen, Oluf Borbye, Ängquist, Lars, Sørensen, Thorkild I.A., Holst, Jens Juul, Christiansen, M., Holm, Jens-Christian, Hartmann, Bolette & Hansen, Torben, 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 6, p. 1718-1727

Research output: Contribution to journal › Journal article › Research › peer-review

A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans

Sun, E. W., Iepsen, E. W., Pezos, N., Lumsden, A. L., Martin, A. M., Schober, G., Isaacs, N. J., Rayner, C. K., Nguyen, N. Q., de Fontgalland, D., Rabbitt, P., Hollington, P., Wattchow, D. A., Hansen, Torben, Holm, Jens-Christian, Liou, A. P., Jackson, V. M., Torekov, Signe Sørensen, Young, R. L. & Keating, D. J., 2021, In: Gastroenterology. 161, 2, p. 536-547.e2 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

Research output: Contribution to journal › Journal article › Research › peer-review

DeepFake electrocardiograms using generative adversarial networks are the beginning of the end for privacy issues in medicine

Thambawita, Vajira Lasantha Bandara, Isaksen, Jonas L., Hicks, S. A., Ghouse, Jonas, Ahlberg, G., Linneberg, Allan René, Grarup, Niels, Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., Holstein-Rathlou, N., Strümke, I., Hammer, H. L., Maleckar, M. M., Halvorsen, P., Riegler, M. A. & Kanters, Jørgen K., 2021, In: Scientific Reports. 11, 1, 8 p., 21896.

Research output: Contribution to journal › Journal article › Research › peer-review

FGL1 as a modulator of plasma D-dimer levels: exome-wide marker analysis of plasma tPA, PAI-1 and D-dimer

Thibord, F., Song, C., Pattee, J., Rodriguez, B. A. T., Chen, M-H., O'Donnell, C. J., Kleber, M. E., Delgado, G. E., Guo, X., Yao, J., Taylor, K. D., Ozel, A. B., Brody, J. A., McKnight, B., Gyorgy, B., Simonsick, E., Leonard, H. L., Carrasquilla, G. D., Guindo-Martinez, M., Silveira, A. & 30 others, Temprano-Sagrera, G., Yanek, L. R., Becker, D. M., Mathias, R. A., Becker, L. C., Raffield, L. M., Kilpeläinen, Tuomas O., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Linneberg, Allan René, Hamsten, A., Watkins, H., Sabater-Lleal, M., Nalls, M. A., Trégouët, D., Morange, P., Psaty, B. M., Tracy, R. P., Smith, N. L., Desch, K. C., Cushman, M., Rotter, J. I., de Vries, P. S., Pankratz, N. D., Folsom, A. R., Morrison, A. C., März, W., Tang, W. & Johnson, A. D., 2021, In: Journal of Thrombosis and Haemostasis. 19, 8, p. 2019-2028

Research output: Contribution to journal › Journal article › Research › peer-review

Binge drinking induces an acute release of markers of hepatic fibrogenesis

Torp, N., Israelsen, M., Nielsen, M. J., Astrand, C. P., Juhl, P., Johansen, S., Hansen, C. D., Madsen, B. S., Villesen, I., Leeming, D., Hansen, Torben, Karsdal, M. & Krag, A., 2021, In: Journal of Hepatology. 75, Suppl. 2, p. S313 1 p., PO-487.

Research output: Contribution to journal › Conference abstract in journal › Research

Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations

Trier, C., Hollensted, M., Schnurr, T. M., Lund, Morten Asp Vonsild, Nielsen, T. R. H., Rui, G., Andersson, E. A., Svendstrup, M., Bille, D. S., Gjesing, A. P., Fonvig, Cilius Esmann, Frithioff-Bojsoe, C., Balslev-Harder, M., Quan, S., Gamborg, Michael Orland, Pedersen, Oluf Borbye, Ängquist, Lars, Holm, Jens-Christian & Hansen, Torben, 2021, In: International Journal of Obesity. 45, p. 66-76 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A. & 17 others, Mahajan, A., McDonald, T. J., Kokkola, T., Vangipurapu, J., Cederberg, H., Laakso, M., Rutters, F., Elders, P. J. M., Koopman, A. D. M., Beulens, J. W., Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, Torben, drb459, drb459, Mari, A. & IMI-DIRECT consortium, I. C., 2021, In: Diabetes. 70, 6, db210227.

Research output: Contribution to journal › Journal article › Research › peer-review

A Previously Undescribed Highly Prevalent Phage Identified in a Danish Enteric Virome Catalog

Van Espen, L., Bak, E. G., Beller, L., Close, L., Deboutte, W., Juel, H. B., Nielsen, T., Sinar, D., De Coninck, L., Frithioff-Bøjsøe, C., Fonvig, C. E., Jacobsen, S., Kjærgaard, M., Thiele, M., Fullam, A., Kuhn, M., Holm, J. C., Bork, P., Krag, A., Hansen, T. & 2 others, Arumugam, Mani & Matthijnssens, J., 2021, In: mSystems. 6, 5, 20 p., e00382-21.

Research output: Contribution to journal › Journal article › Research › peer-review

Population-based pediatric reference values for serum parathyroid hormone, vitamin D, calcium, and phosphate in Danish/North-European white children and adolescents

Vissing Landgrebe, A., Lund, Morten Asp Vonsild, Lausten-Thomsen, U., Frithioff-Bøjsøe, C., Fonvig, Cilius Esmann, Lind Plesner, J., Aas Holm, L., Jespersen, Thomas, Hansen, Torben & Holm, Jens-Christian, 2021, In: Clinica Chimica Acta. 523, p. 483-490

Research output: Contribution to journal › Journal article › Research › peer-review

The genetic history of Greenlandic-European contact

Waples, R. K., Hauptmann, A. L., Seiding, I. H., Jørsboe, E., Jørgensen, M. E., Grarup, Niels, Andersen, M. K., Larsen, C. V. L., Bjerregaard, P., Hellenthal, G., Hansen, Torben, Albrechtsen, Anders & Moltke, Ida, 2021, In: Current Biology. 31, 10, p. 2214-2219.e4

Research output: Contribution to journal › Journal article › Research › peer-review

Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis

Aarestrup, J., Jensen, B. W., Ulrich, L. G., Hartwell, D., Trabert, B. & Baker, J. L., 2020, In: Annals of Human Biology. 47, 2, p. 173-180

Research output: Contribution to journal › Journal article › Research › peer-review

Birthweight, childhood overweight, height and growth and adult cancer risks: a review of studies using the Copenhagen School Health Records Register

Aarestrup, J., Bjerregaard, L. G., Meyle, K. D., Pedersen, D. C., Gjaerde, L. K., Jensen, B. W. & Baker, J. L., 2020, In: International Journal of Obesity. p. 1546-1560

Research output: Contribution to journal › Review › Research › peer-review

FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

Ahluwalia, T. S., Eliasen, A. U., Sevelsted, A., Pedersen, C-E. T., Stokholm, J., Chawes, B., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Sharma, A., Weiss, S. T., Evans, M. D., Jackson, D. J., Morin, A., Krogfelt, K. A., Schjørring, S., Mortensen, P. B., Hougaard, D. M. & 13 others, Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, Merete, Børglum, A. D., Werge, Thomas, Agerbo, E., Gern, J. E., Lemanske, R. F., Ober, C., Pedersen, A. G., Bisgaard, H. & Bønnelykke, Klaus, 2020, In: Nature Communications. 11, 12 p., 6398.

Research output: Contribution to journal › Journal article › Research › peer-review

New Insights into the Genetics of Latent Autoimmune Diabetes in Adults

Lepola, Mette Andersen, 2020, In: Current Diabetes Reports. 20, 10 p., 43.

Research output: Contribution to journal › Review › Research › peer-review

The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

Andersen, M. K., Jørsboe, E., Skotte, L., Hanghøj, K., Sandholt, C. H., Moltke, I., Grarup, N., Kern, T., Mahendran, Y., Søborg, B., Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Tiwari, H. K., Feenstra, B., Koch, A., Wiener, H. W., Hopkins, S. E., Pedersen, O., Melbye, M. & 4 others, Boyer, B. B., Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 2020, In: PLOS Genetics. 16, 1, 17 p., e1008544.

Research output: Contribution to journal › Journal article › Research › peer-review

Hidradenitis suppurativa in a cohort of overweight and obese children and adolescents

Andersen, P. L., Kromann, C., Fonvig, Cilius Esmann, Riis, P. T., Jemec, Gregor & Holm, Jens-Christian, 2020, In: International Journal of Dermatology. 59, 1, p. 47-51

Research output: Contribution to journal › Journal article › Research › peer-review

Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity

Anhê, F. F., Jensen, Benjamin Anderschou Holbech, Varin, T. V., Servant, F., Van Blerk, S., Richard, D., Marceau, S., Surette, M., Biertho, L., Lelouvier, B., Schertzer, J. D., Tchernof, A. & Marette, A., 2020, In: Nature Metabolism. 2, 3, p. 233-242 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E. & 30 others, Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M., Elders, P. J. M., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R. S., Sharma, S., Thomsen, Henrik S., Vangipurapu, J., Vestergaard, H., Adamski, J., Musholt, P. B., Brage, S., Brunak, Søren, Dermitzakis, E., Frost, G., Hansen, Torben, Laakso, M., Pedersen, Oluf Borbye & IMI-DIRECT consortium, I. C., 2020, In: PLoS Medicine. 17, 6, 27 p., e1003149.

Research output: Contribution to journal › Journal article › Research › peer-review

Estimating narrow-sense heritability using family data from admixed populations

Athanasiadis, G., Speed, D., Lepola, Mette Andersen, Appel, E. V. R., Grarup, Niels, Brandslund, I., Jørgensen, M. E., Larsen, C. V. L., Bjerregaard, P., Hansen, Torben & Albrechtsen, Anders, 2020, In: Heredity. 124, 6, p. 751-762 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Body mass index and height in relation to type 2 diabetes by levels of intelligence and education in a large cohort of Danish men

Bjerregaard, L. G., Damborg, M. L., Osler, Merete, Sørensen, Thorkild I.A. & Baker, J. L., 2020, In: European Journal of Epidemiology. 35, p. 1167–1175 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Change in body mass index from childhood onwards and risk of adult cardiovascular disease

Bjerregaard, L. G., Adelborg, K. & Baker, J. L., 2020, In: Trends in Cardiovascular Medicine. 30, 1, p. 39-45 7 p.

Research output: Contribution to journal › Review › Research › peer-review

Associations between body mass index trajectories in childhood and cardiovascular risk factors in adulthood

Blond, K., Aarestrup, J., Vistisen, D., Bjerregaard, L. G., Jensen, G. B., Petersen, Janne, Nordestgaard, Børge, Jørgensen, M. E., Jensen, B. W. & Baker, J. L., 2020, In: Atherosclerosis. 314, p. 10-17 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Maturity-Onset Diabetes of the Young Identified Among Algerian Probands with Early-Onset Diabetes

Bouldjennet, F., Gjesing, A. P., Azzouz, M., Abderrahman, S. A., El Guecier, A., Ali, S., Oudjit, B., Mennadi-Lacete, F., Yargui, L., Boudiba, A., Chibane, A., Touil-Boukoffa, C., Hansen, Torben & Raache, R., 2020, In: Diabetes, Metabolic Syndrome and Obesity. 13, p. 4829-4837 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Chen, M-H., Raffield, L. M., Mousas, A., Sakaue, S., Huffman, J. E., Moscati, A., Trivedi, B., Jiang, T., Akbari, P., Vuckovic, D., Bao, E. L., Zhong, X., Manansala, R., Laplante, V., Chen, M., Lo, K. S., Qian, H., Lareau, C. A., Beaudoin, M., Hunt, K. A. & 31 others, Akiyama, M., Bartz, T. M., Ben-Shlomo, Y., Beswick, A., Bork-Jensen, J., Bottinger, E. P., Brody, J. A., van Rooij, F. J. A., Chitrala, K., Cho, K., Choquet, H., Correa, A., Danesh, J., Di Angelantonio, E., Dimou, N., Ding, J., Elliott, P., Esko, T., Evans, M. K., Floyd, J. S., Broer, L., Grarup, Niels, Guo, M. H., Greinacher, A., Haessler, J., Hansen, Torben, Howson, J. M. M., Linneberg, Allan René, Pedersen, Oluf Borbye, Loos, R. J. F. & VA Million Veteran Program, V. M. V. P., 2020, In: Cell. 182, 5, p. 1198-+ 30 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA)

Christensen, A. S., Haedersdal, S., Stoy, J., Storgaard, H., Kampmann, U., Forman, Julie Lyng, Seghieri, M., Holst, Jens Juul, Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes Care. 43, 9, p. 2025-2033 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1 alpha Mutation Carriers

Christensen, A. S., Haedersdal, S., Storgaard, H., Rose, K., Hansen, N. L., Holst, Jens Juul, Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 9, p. 1989-2002 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Impact of abdominal obesity on postprandial lipid concentrations

Christiansen, Malene Revsbech, Sørensen, Thorkild I.A., Hansen, Torben & Kilpeläinen, Tuomas O., 2020, In: European Journal of Human Genetics. 28, Suppl. 1, p. 279-280 2 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Role of fasting duration and weekday in incretin and glucose regulation

Clemmensen, K. K. B., Quist, J. S., Vistisen, D., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Holst, Jens Juul, Lauritzen, T., Jørgensen, M. E., Torekov, Signe Sørensen & Færch, K., 2020, In: Endocrine Connections. 9, 4, p. 279-288

Research output: Contribution to journal › Journal article › Research › peer-review

Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum

Crusell, M. K. W., Brink, L. R., Nielsen, T., Allin, K. H., Hansen, Torben, Damm, Peter, Lauenborg, J., Hansen, T. H. & Pedersen, Oluf Borbye, 2020, In: BMC Pregnancy and Childbirth. 20, 12 p., 69.

Research output: Contribution to journal › Journal article › Research › peer-review

Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes

Crusell, Mie Korslund Wiinblad, Hansen, T. H., Nielsen, T., Allin, K. H., Rühlemann, M. C., Damm, Peter, Vestergaard, H., Rørbye, Christina, Jørgensen, Niklas Rye, Christiansen, O. B., Heinsen, F. A., Franke, A., Hansen, Torben, Lauenborg, J. & Pedersen, Oluf Borbye, 2020, In: Frontiers in Cellular and Infection Microbiology. 10, 14 p., 536282.

Research output: Contribution to journal › Journal article › Research › peer-review

Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria

Ehmann, D., Koeninger, L., Wendler, J., Malek, N. P., Stange, E. F., Wehkamp, J. & Jensen, Benjamin Anderschou Holbech, 2020, In: Frontiers in Microbiology. 11, 10 p., 1147.

Research output: Contribution to journal › Journal article › Research › peer-review

The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets

Fjære, E., Myrmel, L. S., Dybing, K., Kuda, O., Jensen, Benjamin Anderschou Holbech, Rossmeisl, M., Frøyland, L., Kristiansen, Karsten & Madsen, L., 2020, In: Nutrients. 12, 10, 18 p., 3038.

Research output: Contribution to journal › Journal article › Research › peer-review

Disturbed eating behaviours do not impact treatment response in a paediatric obesity chronic care treatment programme

Fogh, M., Lund, Morten Asp Vonsild, Mollerup, P. M., Johansen, M. O., Melskens, R. H., Trier, C., Kloppenborg, J. T., Hansen, Torben & Holm, Jens-Christian, 2020, In: Journal of Paediatrics and Child Health. 56, 4, p. 542-549 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

Frithioff-Bojsoe, C., Lund, Morten Asp Vonsild, Lausten-Thomsen, U., Hedley, P. L., Pedersen, Oluf Borbye, Christiansen, M., Baker, J. L., Hansen, Torben & Holm, Jens-Christian, 2020, In: Pediatric Diabetes. 21, 2, p. 194-202

Research output: Contribution to journal › Journal article › Research › peer-review

Next Generation Diabetes Scientists Shape Global Research Culture: A reflective proposal from postdoctoral researchers in diabetes research

Gonzalez-Franquesa, A., Carrasquilla Lopez, G. D., Mamidi, A., Ghiasi, S. M., Juel, H. B., Falk, S., Isidor, M. S., Gillberg, L. M. E., Huang, L. O., Quist, J. S., Knudsen, J. R., Quaranta, R., Tozzi, M., Mikkelsen, R. B., Dall, M., Drag, M. H., Small, L. B., Altıntaş, A., Osborne, B., Modvig, I. M. & 11 others, Husted, Anna Sofie, Brown, E. L., Bak, Emilie Glad, Bastos Peluso, A. A., Finger, Fabian Michael, Grunddal, Kaare Villum, Rupar, K., Henningsen, J. B., Pedersen, M. H., Plucinska, Kaja & Attendees of the Danish Diabetes Academy Winter School 2019, A. O. T. D. D. A. W. S. 2., 2020, In: Acta Physiologica. 229, 2, 5 p., e13455.

Research output: Contribution to journal › Comment/debate › Research

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

Gudmundsdottir, V., Pedersen, H. K., Mazzoni, G., Allin, K. H., Artati, A., Beulens, J. W., Banasik, K., Brorsson, C., Cederberg, H., Chabanova, E., De Masi, F., Elders, P. J., Forgie, I., Giordano, G. N., Grallert, H., Gupta, R., Haid, M., Hansen, T., Hansen, T. H., Hattersley, A. T. & 36 others, Heggie, A., Hong, M., Jones, A. G., Koivula, R., Kokkola, T., Laakso, M., Løngreen, P., Mahajan, A., Mari, A., McDonald, T. J., McEvoy, D., Musholt, P. B., Pavo, I., Prehn, C., Ruetten, H., Ridderstrale, M., Rutters, F., Sharma, S., Slieker, R. C., Syed, A., Tajes, J. F., Thomas, Cecilia Engel, Thomsen, Henrik S., Vangipurapu, J., Vestergaard, H., Vinuela, A., Wesolowska-Andersen, A., Walker, M., Adamski, J., Schwenk, J. M., McCarthy, M., Pearson, E., Dermitzakis, E., Franks, P. W., Pedersen, Oluf Borbye & Brunak, Søren, 2020, In: Genome Medicine. 12, 1, 17 p., 109.

Research output: Contribution to journal › Journal article › Research › peer-review

A mutation map for human glycoside hydrolase genes

Hansen, Lars, Husein, D. M., Gericke, B., Hansen, Torben, Pedersen, Oluf Borbye, Tambe, M. A., Freeze, H. H., Naim, H. Y., Henrissat, B., Wandall, Hans H., Clausen, Henrik & Bennett, Eric Paul, 2020, In: Glycobiology. 30, 8, p. 500-515 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Adults with pathogenic MC4R mutations have increased final height and thereby increased bone mass

Iepsen, E. W., Zhang, J., Hollensted, M., Madsbad, Sten, Hansen, Torben, Holst, Jens Juul, Jørgensen, Niklas Rye, Holm, Jens-Christian & Torekov, Signe Sørensen, 2020, In: Journal of Bone and Mineral Metabolism. 38, 1, p. 117-125 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

Iepsen, E. W., Have, C. T., Veedfald, Simon, Madsbad, Sten, Holst, Jens Juul, Grarup, Niels, Pedersen, Oluf Borbye, Brandslund, I., Holm, Jens-Christian, Hansen, Torben & Torekov, Signe Sørensen, 2020, In: Cell Reports Medicine. 1, 1, 8 p., 100006.

Research output: Contribution to journal › Journal article › Research › peer-review

Microbial translocation in type 2 diabetes: when bacterial invaders overcome host defence in human obesity

Jensen, Benjamin Anderschou Holbech & Marette, A., 2020, In: Gut. 69, p. 1724-1726

Research output: Contribution to journal › Comment/debate › Research

Early life body size in relation to risk of renal cell carcinoma in adulthood: a Danish observational cohort study

Jensen, B. W., Meyle, K. D., Madsen, K., Sørensen, Thorkild I.A. & Baker, J. L., 2020, In: European Journal of Epidemiology. 35, p. 251–258 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents

Johansen, M. J., Gade, J., Stender, Stefan, Frithioff-Bojsoe, C., Lund, M. A., Chabanova, E., Thomsen, Henrik S., Pedersen, Oluf Borbye, Fonvig, C. E., Hansen, Torben & Holm, Jens-Christian, 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 2, p. 430-442 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents

Jors, A., Lund, M. A. ,. V., Jespersen, Thomas, Hansen, Torben, Poulsen, Henrik Enghusen & Holm, Jens-Christian, 2020, In: Free Radical Biology and Medicine. 155, p. 81-86

Research output: Contribution to journal › Journal article › Research › peer-review

Association of Birth Weight, Childhood Body Mass Index, and Height with Risk of Hidradenitis Suppurativa

Jørgensen, A. H. R., Aarestrup, J., Baker, J. L. & Thomsen, Simon Francis, 2020, In: JAMA Dermatology. 156, 7, p. 746-753

Research output: Contribution to journal › Journal article › Research › peer-review

Structured exercise alters the gut microbiota in humans with overweight and obesity - A randomized controlled trial

Kern, T., Blond, Martin Bæk, Hansen, T. H., Rosenkilde, M., Quist, Jonas Salling, Gram, A. S., Ekstrøm, Claus Thorn, Hansen, Torben & Stallknecht, Bente Merete, 2020, In: International Journal of Obesity. 44, p. 125-135 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Atorvastatin for prevention of disease progression and hospitalisation in liver cirrhosis: protocol for a randomised, double-blind, placebo-controlled trial

Kimer, N., Grønbæk, H., Fred, Rikard Göran, Hansen, Torben, Deshmukh, Atul Shahaji, Mann, Matthias & Bendtsen, Flemming, 2020, In: BMJ Open. 10, 1, 7 p., e035284.

Research output: Contribution to journal › Journal article › Research › peer-review

Statins for cirrhosis: almost ready for clinical application

Kimer, N., Kronborg, T. M., Bendtsen, Flemming & Møller, Søren, 2020, In: Digestive Medicine Research. 3, 4 p., 111.

Research output: Contribution to journal › Editorial › Research

Tunneled peritoneal catheter for refractory ascites in cirrhosis: A randomized case-series

Kimer, N., Nordheim Riedel, A., Hobolth, L., Mortensen, C., Madsen, Lone Galmstrup, Andersen, M. L., Schiødt, Frank Vinholt, Møller, Søren & Gluud, Lise Lotte, 2020, In: Medicina. 56, 11, 9 p., 565.

Research output: Contribution to journal › Journal article › Research › peer-review

Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis

Koeninger, L., Armbruster, N. S., Brinch, K. S., Kjaerulf, S., Andersen, B., Langnau, C., Autenrieth, S. E., Schneidawind, D., Stange, E. F., Malek, N. P., Nordkild, P., Jensen, Benjamin Anderschou Holbech & Wehkamp, J., 2020, In: Frontiers in Immunology. 11, 16 p., 93.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

Koivula, R. W., Atabaki-Pasdar, N., Giordano, G. N., White, T., Adamski, J., Bell, J. D., Beulens, J., Brage, S., Brunak, S., De Masi, F., Dermitzakis, E. T., Forgie, I. M., Frost, G., Hansen, T., Hansen, T. H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A. & 15 others, McDonald, T. J., Pedersen, Oluf Borbye, Rutters, F., Schwenk, J. M., Teare, H. J. A., Thomas, E. L., Vinuela, A., Mahajan, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Pavo, I., Franks, P. W. & IMI-DIRECT consortium, I. C., 2020, In: Diabetologia. 63, 4, p. 744-756 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Experience from a COVID-19 first-line referral clinic in Greater Copenhagen

Kronborg, T. M., Kimer, N., Junker, A. E., Werge, M. P., Gluud, Lise Lotte & Ytting, H., 7 Aug 2020, In: Danish Medical Journal. 67, 9, 10 p., A05200343.

Research output: Contribution to journal › Journal article › Research › peer-review

A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study

Lakka, T. A., Lintu, N., Väistö, J., Viitasalo, A., Sallinen, T., Haapala, E. A., Tompuri, T. T., Soininen, S., Karjalainen, P., Schnurr, T. M., Mikkonen, S., Atalay, M., Kilpeläinen, T. O., Laitinen, T., Laaksonen, D. E., Savonen, K., Brage, S., Schwab, U., Jääskeläinen, J., Lindi, V. & 1 others, Eloranta, A., 2020, In: Diabetologia. 63, p. 2270-2281

Research output: Contribution to journal › Journal article › Research › peer-review

Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

Lund, M. A., Thostrup, A. H., Frithioff-Bojsoe, C., Lausten-Thomsen, U., Hedley, P. L., Pedersen, Oluf Borbye, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2020, In: Nutrition, Metabolism & Cardiovascular Diseases. 30, 9, p. 1544-1553

Research output: Contribution to journal › Journal article › Research › peer-review

Authors' reply to Sert's comment on low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

Lund, M. A. V., Thostrup, A. H., Frithioff-Bojsoe, C., Lausten-Thomsen, U., Hedley, P. L., Pedersen, Oluf Borbye, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2020, In: Nutrition, Metabolism & Cardiovascular Diseases. 30, 12, p. 2422-2424

Research output: Contribution to journal › Letter › Research › peer-review

Population genomics of the Viking world: [incl. correction]

Margaryan, A., Lawson, D. J., Sikora, M., Racimo, F., Rasmussen, S., Moltke, I., Cassidy, L. M., Jørsboe, E., Ingason, A., Pedersen, M. W., Korneliussen, T., Wilhelmson, H., Buś, M. M., de Barros Damgaard, P., Martiniano, R., Renaud, G., Bhérer, C., Moreno-Mayar, J. V., Fotakis, A. K., Allen, M. & 30 others, Allmäe, R., Molak, M., Cappellini, Enrico, Scorrano, Gabriele, McColl, Hugh, Buzhilova, A., Fox, A., Albrechtsen, Anders, Schütz, B., Skar, B., Arcini, C., Lundstrøm, I., Cheng, J., Stenderup, Jesper Tandberg, Iversen, K. H., Arge, S. V., Ellingvåg, S., Orlando, L., Pentz, P., Jessen, M. D., Pedersen, A., Jørkov, M L S, Lynnerup, Niels, Gilbert, M Thomas P, Allentoft, Morten Erik, Sindbæk, S. M., Kristiansen, K., Nielsen, Rasmus, Werge, Thomas & Willerslev, Eske, 2020, In: Nature. 585, 7825, p. 390-396 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic variation, adipokines, and cardiometabolic disease

Metz, Sophia, Huang, L. O. & Kilpeläinen, Tuomas O., 2020, In: Current Opinion in Pharmacology. 52, p. 33-39 7 p.

Research output: Contribution to journal › Review › Research › peer-review

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Molinaro, A., Bel Lassen, P., Henricsson, M., Wu, H., Adriouch, S., Belda, E., Chakaroun, R., Nielsen, T., Bergh, P-O., Rouault, C., Andre, S., Marquet, F., Andreelli, F., Salem, J-E., Assmann, K., Bastard, J-P., Forslund, S., Le Chatelier, E., Falony, G., Pons, N. & 26 others, Prifti, E., Quinquis, B., Roume, H., Vieira-Silva, S., Hansen, T. H., Pedersen, H. K., Lewinter, C., Sønderskov, N. B., Køber, Lars Valeur, Vestergaard, H., Hansen, Torben, Zucker, J., Galan, P., Dumas, M., Raes, J., Oppert, J., Letunic, I., Nielsen, J., Bork, P., Ehrlich, S. D., Stumvoll, M., Pedersen, Oluf Borbye, Aron-Wisneswky, J., Clement, K., Baeckhed, F. & MetaCardis Consortium, M. C., 2020, In: Nature Communications. 11, 1, 10 p., 5881.

Research output: Contribution to journal › Journal article › Research › peer-review

Pathophysiological-based treatments of complications of cirrhosis

Møller, Søren, Kimer, N., Barløse, Mads Christian Johannes & Bendtsen, Flemming, 2020, In: Scandinavian Journal of Gastroenterology. 55, 4, p. 383-394

Research output: Contribution to journal › Review › Research › peer-review

Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures

Nielsen, M. S., Christensen, Bodil Just, Schmidt, J. B., Tækker, L., Holm, Lotte, Lunn, Susanne, Ritz, C., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Schnurr, T. M., Hansen, Torben, le Roux, C. W., Lund, Thomas Bøker, Floyd, A. K. & Sjödin, Anders Mikael, 2020, In: International Journal of Obesity. 44, 11, p. 2291-2302 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Data integration for prediction of weight loss in randomized controlled dietary trials

Nielsen, R. L., Helenius, M., Garcia, S. L., Roager, H. M., Aytan-Aktug, D., Hansen, L. B. S., Lind, M. V., Vogt, J. K., Dalgaard, M. D., Bahl, M. I., Jensen, C. B., Muktupavela, R., Warinner, C., Aaskov, V., Gøbel, R., Kristensen, M. B., Frøkiær, H., Sparholt, M. H., Christensen, A. F., Vestergaard, H. & 8 others, Hansen, Torben, Kristiansen, Karsten, Brix, Susanne, Petersen, T. N., Lauritzen, Lotte, Licht, T. R., Pedersen, Oluf Borbye & Gupta, R., 2020, In: Scientific Reports. 10, 15 p., 20103.

Research output: Contribution to journal › Journal article › Research › peer-review

Ambulant opfølgning og rehabilitering af dekompenseret levercirrose bør være et tværfagligt samarbejde

O'Connell, M. B., Hobolth, L., Teisner, A. S., Andersen, M. L. & Kimer, N., 2020, In: Ugeskrift for Laeger. 182, 13, 8 p., V08190459.

Research output: Contribution to journal › Journal article › Research › peer-review