Antibiotic exposure in early life and childhood overweight and obesity: A systematic review and meta-analysis
Research output: Contribution to journal › Review › Research › peer-review
Standard
Antibiotic exposure in early life and childhood overweight and obesity : A systematic review and meta-analysis. / Rasmussen, Sara H; Shrestha, Sarita; Bjerregaard, Lise G; Ängquist, Lars H; Baker, Jennifer L; Jess, Tine; Allin, Kristine H.
In: Diabetes, Obesity and Metabolism, Vol. 20, No. 6, 2018, p. 1508–1514.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Antibiotic exposure in early life and childhood overweight and obesity
T2 - A systematic review and meta-analysis
AU - Rasmussen, Sara H
AU - Shrestha, Sarita
AU - Bjerregaard, Lise G
AU - Ängquist, Lars H
AU - Baker, Jennifer L
AU - Jess, Tine
AU - Allin, Kristine H.
N1 - Funding information Danish Council for Independent Research | Medical Sciences (DFF – 6110‐00075) and the Novo Nordisk Foundation (NNF15OC0017740)
PY - 2018
Y1 - 2018
N2 - We conducted a systematic review and meta-analysis of observational studies investigating the association between antibiotic exposure in infancy and risk of childhood overweight and obesity. Thirteen studies counting a total of 527,504 children were included in the systematic review and eight were included in meta-analyses. Exposure to antibiotics in infancy was associated with an increased odds ratio (OR) of childhood overweight and obesity (OR = 1.11 [95% CI 1.02-1.20]). Whereas exposure to one treatment only and exposure between 6 and 24 months were not associated with increased risk of childhood overweight and obesity, exposure to more than one treatment was associated with an OR of 1.24 (95% CI 1.09-1.43) and exposure within the first six months of life was associated with an OR of 1.20 (95% CI 1.04-1.37). In conclusion, antibiotic exposure in infancy is associated with a slightly increased risk of childhood overweight and obesity, mainly if children are exposed to repeated treatments or treatment within the first six months of life. It remains elusive whether this association is mediated via direct effects of antibiotics on the gut microbiota.
AB - We conducted a systematic review and meta-analysis of observational studies investigating the association between antibiotic exposure in infancy and risk of childhood overweight and obesity. Thirteen studies counting a total of 527,504 children were included in the systematic review and eight were included in meta-analyses. Exposure to antibiotics in infancy was associated with an increased odds ratio (OR) of childhood overweight and obesity (OR = 1.11 [95% CI 1.02-1.20]). Whereas exposure to one treatment only and exposure between 6 and 24 months were not associated with increased risk of childhood overweight and obesity, exposure to more than one treatment was associated with an OR of 1.24 (95% CI 1.09-1.43) and exposure within the first six months of life was associated with an OR of 1.20 (95% CI 1.04-1.37). In conclusion, antibiotic exposure in infancy is associated with a slightly increased risk of childhood overweight and obesity, mainly if children are exposed to repeated treatments or treatment within the first six months of life. It remains elusive whether this association is mediated via direct effects of antibiotics on the gut microbiota.
KW - Journal Article
U2 - 10.1111/dom.13230
DO - 10.1111/dom.13230
M3 - Review
C2 - 29359849
VL - 20
SP - 1508
EP - 1514
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 6
ER -
ID: 189765860